Masoumeh Asle-Rousta

• PhD
• Islamic Azad University of Zanjan

Imbalanced lipid metabolism and increase in the ceramide-to-S1P ratio in the brain have been postulated to play a role in amyloidogenesis, neuroinflammatory reactions, and neuronal apoptosis in Alzheimer's disease (AD) pathology. FTY720, the immunomodulatory sphingosine 1-phosphate (S1P) analog, has recently gained interest because of its CNS-direc...

Sphingosine-1 phosphate (S1P) is involved in a variety of cellular processes via activation of S1P receptors (S1PRs; S1PR1 to S1PR5) that are highly expressed in the brain. It has been shown that the level of S1P is reduced in the brain of Alzheimer's disease (AD) patients. However, there is no study designed to evaluate the expression of S1PRs in...

FTY720 (fingolimod), the sphingosine-1-phosphate (S1P) analogue, has been experimentally indicated to exert substantial ameliorating effects in animal models of Alzheimer's disease (AD). The present work aims to answer whether central S1P receptor 1 (S1P1) plays significant role in the impact of fingolimod in AD. To verify the prominence of central...

Lead is an environmental pollutant that possesses harmful effects on the nervous system. The current study was conducted to investigate the impacts of eucalyptol, a type of monoterpene, on anxiety behaviors, oxidative stress, neuroinflammation, and neuronal death in the hippocampus of rats exposed to lead and its possible protective mechanism. Adul...

Objective(s) A monoterpene alpha-pinene possesses anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Here, we investigated the effect of alpha-pinene on molecular, biochemical, and histological changes induced by carbon tetrachloride (CCl4) in the liver of male Wistar rats. Materials and Methods Animals were divided into four groups:...

The research was conducted to examine the neuroprotective effect of thymol and its precursor p-cymene on chronic immobility stress in adult male Wistar rats. The rats were subjected to 2.5 h of stress every day for 14 consecutive days by placing them inside a restrainer. Thymol (10 mg/kg) and p-cymene (50 mg/kg) were given to the rats during the sa...

This study aimed to investigate the effects of the monoterpenes thymol and p‐cymene on the liver of rats subjected to prolonged immobilization stress and to discover the possible mechanism behind this effect. For 14 consecutive days, the rats were placed in a restrainer for 2.5 h every day to expose them to stress. During the same period, thymol (1...

Objective(s) Renal and testicular disorders are primarily associated with oxidative damage and inflammation. Here, alpha-pinene (a type of monoterpene) was investigated for its effect on oxidative/nitrosative stress and the expression of inflammatory and apoptotic factors in the kidneys and testes of rats treated with CCl4. Materials and Methods C...

Objective(s) This study was conducted to explore the impact of 1, 8-cineole (eucalyptol) on the biochemical, molecular, and histological changes caused by lead acetate in the liver of adult male Wistar rats. The research also investigated the potential involvement of the TLR4 signaling pathway in this effect. Materials and Methods Rats were orally...

Background and Objective: Studies have shown that liver damage is linked to apoptosis. Carbon tetrachloride is a powerful toxin that is used to induce liver fibrosis and cirrhosis in animal models. The purpose of this study was to investigate the effect of alpha-pinene on the expression of apoptosis-related factors Bax and Bcl-2 in the liver of adu...

There are some differences between mammals and birds in terms of central food intake regulation. In avian species, the hypophagic role of nesfatin-1 has not been investigated with other neurotransmitters. Therefore, this study aimed to determine the alteration of feeding behavior following intracerebroventricular (ICV) injection of nesfatin-1 and i...

This study aims to investigate the effect of Viola tricolor extract on hippocampal neuronal death, interleukin (IL) -6 and IL-10 expression, spatial memory, anxiety, and depression in rats exposed to chronic immobilization stress. Rats were divided into groups Control, Viola300, Viola600, Stress, Stress-Viola300, and Stress-Viola600. Animals were p...

Background & Objective: Lead entry into the body causes considerable damages to the brain in the long term. We aimed to investigate the effects of exercise (treadmill running) and flaxseed oil on lead acetate-induced behavioral deficits in male rats. Materials & Methods: 60 rats were divided into 6 groups: Control (C), Exercise (Ex), Flaxseed oil (...

Monoterpene alpha-pinene possesses antioxidant, cardioprotective, and neuroprotective properties. We evaluated the effect of alpha-pinene on oxidative/nitrosative stress, neuroinflammation, and molecular and behavioral changes induced by beta-amyloid (Aβ)1-42 in rats and investigated the possible mechanisms of these outcomes. Male Wistar rats recei...

Animal research indicates the neuropeptide Y (NPY), corticotrophin and melanocortin systems have a mediatory role in reward, however, how these substances interact with phenytoin-14 (PNX-14) induced food intake in birds remains to be identified. Accordingly, in this research eight tests were carried out to investigate the potential interactions of...

This study aimed to investigate the effect of flavonoid morin on oxidative/nitrosative stress, neuroinflammation, and histological, molecular, and behavioral changes caused by amyloid-beta (Aβ)1-42 in male Wistar rats (Alzheimer's disease model). Rats received morin (20 mg/kg, oral gavage) for 14 consecutive days after intrahippocampal injection of...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects many older people around the world. Numerous studies are underway to evaluate the protective effects of natural products in AD. Alpha-linoleic acid (ALA) is an essential unsaturated fatty acid that exhibits neuroprotective outcomes in rat models of ischemic stroke and...

Previous studies have shown that oxidative stress plays a crucial role in behavioral changes due to social isolation. The influence of natural products for the treatment of nervous system damages has been the subject of several investigations. For example, sesame oil and its major compound -oleic acid- have a neuroprotective effect. Therefore, we s...

Introduction: The deposition of amyloid beta peptide (Aβ) in the brain is one of the hallmarks of Alzheimer's disease. In addition to inducing oxidative stress and inflammation, beta-amyloid reduces the expression of brain-derived neurotropic factor (BDNF) and causes behavioral disorders such as anxiety even before memory impairment. Alpha-linoleic...

Objective The investigation of the effect of carvone (a natural monoterpene) on liver damage caused by chronic immobilisation. Methods Male Wistar rats were divided into four groups: control, carvone, stress, and stress-carvone. To induce stress, rats were placed in a restrainer (6 h/21 day) and carvone was treated by gavage at a dose of 20 mg/kg....

Prolonged immobilization may impair the physiological functions of various organs of the body, including the liver, brain, and heart. In this study, we investigated the hepatoprotective effect of limonene (a monoterpene) in male rats exposed to chronic immobilization. Rats were exposed to immobilization stress (6 h/21 days) and received limonene (1...

Social isolation damages the nervous system by weakening the antioxidant system and leading to behavioral disorders. Fennel ( Foeniculum vulgare Mill.) is an herbal plant that has antioxidant and neuroprotective properties. The objective of this study was to evaluate the effect of fennel methanol extract and its major component trans-anethole on sp...

Background: Restraint stress causes inflammation in nervous system that leads to emersion of neurodegenerative diseases. Spinach (Spinacia oleracea L.) contains different agents with antioxidant, antiapoptosis, and hepatoprotective properties. This study examined the effect of spinach hydroalcoholic extract (SHE) on TNF-α and IL-1β expression in hi...

Limonene is a natural monoterpene having antioxidant, anti-inflammatory, and neuro-protective properties. We investigated the effects of limonene on memory impairment, hippocampal damage, and high anxiety induced by chronic immobilization stress in male rats. Fourty male Wistar rats were divided into the control (C), limonene (L), stress (S), and s...

Introduction: Resistin is a peptide hormone, secreted by adipose tissue. Increased secretion of resistin results in insulin resistance and metabolic syndrome. The aim of this study was to determine the effect of hydro-alcoholic spinach (Spinacia oleraceae L.) extract on the expression of resistin mRNA in the visceral adipose tissue of rats exposed...

Background and Aim: Lead is one of the environmental pollutants that enters the nervous system and leads to neurological disorders such as depression and anxiety. Cinnamon (Cinnamomum verum) has antioxidant, anti-inflammatory and neuro-protective properties. The purpose of this study was to investigate the effect of cinnamon hydroalcoholic extracts...

Tarragon (Artemisia dracunculus L.) has antioxidant, anti-diabetic, anti-bacterial and anti-inflammatory proper-ties. The aim of this study was to evaluate the effect of tarragon hydro-alcoholic extract on anxiety and depression in male rats exposed to chronic restraint stress. Forty eight male rats were randomly divided into six groups including 1...

Recent evidence suggests that an extreme shift may occur in sphingosine metabolism in neuroinflammatory contexts. Sphingosine 1-phosphate (S1P)-metabolizing enzymes (SMEs) regulate the level of S1P. We recently found that FTY720, a S1P analogue, and SEW2871, a selective S1P receptor 1 (S1P1) agonist, provide protection against neural damage and mem...