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Publications
Publications (50)
Background: Due to the important role played by knowledge in controlling and managing diabetes in most educational interventions, the assessment of the individuals’ levels of knowledge is regarded as a key variable when planning the given interventions. Objectives: This study aimed to design and evaluate the psychometric properties of the Diabetic...
Background: concerning ascending trend in prevalence of chronic type Ⅱ diabetes, prevention and the development of an effective approach after recognition of at risk individuals are crucial. The aim of this study is to investigate the influence of lifestyle modification and metformin interventions in the prevention of type Ⅱ diabetes developments....
Background
Body Fat percentage (BFP) and body mass index (BMI) are used to measure obesity-related metabolic syndrome risk. The present study aimed to determine the values of percent body Fat and body mass index for predicting metabolic syndrome risk factors in diabetic patients of Yazd, Iran.
Methods
A total of 1022 (499 males and 523 females) di...
Objective: Obesity is a major public health concern and there are different ways to detect it in population. The aim of the present study is to evaluate the neck circumference (NC) in a simple and practical way.
Materials and Methods: This cross-sectional survey utilized data from the Yazd Health Study (YaHS) which is a population-based cohort stud...
Background: Almost 90% of people with diabetes have type 2 diabetes and the upward trend of this chronic disease is still ongoing, so that after about four decades, this disease is still one of the top 10 causes of death, while half of these deaths occur in people under 60 years of age. Therefore, prevention is essential and the implementation of t...
Background: A new sweetener with the commercial name of Lacritose has been recently produced, which is a combination of four simple sugars (lactose, fructose, sucrose, erythritol), with specific ingredients and percentages. This study aimed to assess glycemic response and short term gastrointestinal reactions in type 2 diabetic patients. Methods: I...
Introduction: Psychiatric problems like suicide, self-harm, and injurious behaviors are important and common in chronic diseases like diabetes. This study aimed to compare suicidal ideations and self-injurious behaviors in patients with type 2 diabetes with and without complications referring to diabetes research center in Yazd, 2017.
Methods: In t...
Objective: Obesity is a factor in the development of insulin resistance and type 2 diabetes. Obesity contributes a wide variety of metabolic changes such as insulin resistance. The insulin signal mechanism to intra-cells occurs in insulin resistance, primarily in adipose tissue cells, which can be appropriate targets for therapeutic approaches by r...
The prevalence of type 2 diabetes mellitus (T2DM) is increasing dramatically worldwide. Dysregulation of microRNA (miRNA) as key regulators of gene expression, has been reported in numerous diseases including diabetes. The aim of this study was to investigate the expression levels of miRNA-122, miRNA-126-3p and miRNA-146a in diabetic and pre-diabet...
Background:
Recent investigations have proposed that sesame and canola oils might affect body fat distribution. This study aimed to examine the effects of sesame, canola, and sesame-canola (a blend of sesame and canola oils) oils on body weight and composition in adults with type 2 diabetes mellitus (T2DM) in the context of a randomized, triple-bl...
Objective: Oxidative stress plays an important role in the onset and progression of diabetic nephropathy. So antioxidant agents may be one of the key treatment strategies for prevention of diabetic nephropathy progression .The aim of this study was to determine the effect of selenium (Se) on micro-albuminuria in type 2 diabetic (T2DM) patients. Mat...
Aims and designs:
Metformin, an anti-diabetic drug, is the first line medication for the treatment of type 2 diabetes mellitus and some studies show its relationship with micro-RNAs. This study set up to determine the effect of metformin on miR223 expression and content of AKT/GLUT4 proteins in insulin resistant signaling in 3T3L1 cells and adipoc...
Introduction
L-Carnitine is a substance produced from endogenous synthesis and dietary sources. This amino acid has antioxidant properties by reducing the effects of oxidative stress. The purpose of this study was to investigate the effects of L-carnitine supplementation on oxidative and metabolic status in patients with Type 2 diabetes mellitus (T...
The present study aimed to examine the effect of replacing edible oils with sesame oil (SO), canola oil (CO) and sesame-canola oil (SCO) on body weight and composition in adults. Adults without any chronic diseases (n = 77) were entered a 4-week run-in period and then were randomised to receive SO, CO and SCO for their household use in 9-week inter...
Objective: Insulin resistance (IR) is the major cause in Type 2 diabetes mellitus (T2DM). Expression of some miRNAs can be changed in response to a drug treatment for IR, and used as the biomarker in IR. This study set out to determine the effect of cinnamon extract (cinnamaldehyde) on some miRNAs expression in IR adipocytes. Materials and Methods:...
Objective: We conducted this study to compare the psychological effects between diabetic patients taking fast and non-fasting counterparts to better investigate the effects of fasting on mental health of diabetes sufferers.
Materials and Methods: This study was a prospective cohort conducted among diabetic patients. In this study, two types of fast...
Background:
The dramatic increase in the prevalence of type 2 diabetes mellitus (T2DM) is a global major challenge to health. Circulating microRNAs have been suggested as promising biomarkers for different disorders such as diabetes. Imbalances in the gut microbiome have been revealed to contribute to the progression of multiple diseases including...
Objective(s)
Diabetic patients with hypertension are at a high risk of cardiovascular complications. The present study made an attempt to determine the effect of oral L-carnitine supplementation on blood pressure in patients with type 2 diabetes mellitus (T2DM).
Materials and methods
In this randomized, double-blind, placebo-controlled trial, 70 p...
The present study sought to investigate the effect of micronized resveratrol supplementation on serum levels of asymmetric de‐methyl‐arginine (ADMA) and paraoxonase‐1 (PON1) activity in patients with type 2 diabetes (T2D). In this double‐blinded randomized trial, 76 patients with T2D were recruited. Participants were randomly assigned to consume 1,...
Background:
Type 2 diabetes mellitus (T2DM) is a serious public health issue with significantly increasing rates across the world. The genome-wide association studies (GWAS) have previously manifested involved genes that remarkably enhance the risk of T2DM. In this study, the association of common variants with T2DM risk has been identified among...
Ninety individuals were included in this case-control study:30 type 2 diabetes mellitus, 30 pre-diabetes and 30 healthy individuals (males and females, age: 25-65, body mass index: 25-35). MicroRNAs expression was determined by real-time polymerase chain reaction. Furthermore, plasma concentrations of tumor necrosis factor alpha (TNF-α) and interle...
Introduction: Fatigue is one of the most common causes of disability in most elderly people affected with diabetes. Considering the growing population of this group, the present study aimed to determine the effect of warm foot bath on the fatigue of the elderly people with diabetes.
Methods: The randomized clinical trial study was carried out on 6...
BACKGROUND: Both canola and sesame oils consumption have been associated with favorable effects on cardio-metabolic biomarkers. However, to the best of our knowledge, no study has compared their effects on cardiovascular risk factors. The present study aimed to assess the effect of canola, sesame, and sesame-canola oils consumption on cardio-metabo...
Introduction
Over the past decades, the number of people with type 2 diabetes (T2D) has increased globally. One of the major complications in these patients is cardiovascular disease; it seems that the cell proliferation inhibition can improve vascular function in these patients. It is proposed that peroxisome proliferator-activated receptor alpha...
Background: The prevalence of overweight and obesity in all age groups, especially in childhood, has become alarming. Identification, intervention, and prevention are important factors affecting it.
Objectives: The purpose of this study was to investigate the association the body mass index (BMI) in children and transportation to school in greater...
Background: It is suggested that combining healthy diet with physical activity during and before pregnancy have a significant effect on insulin sensitivity. This study aimed to investigate the relationship between physical activity and diet before and during pregnancy with the risk of gestational diabetes mellitus (GDM).
Methods: A case-control stu...
Background and objectives:
Diabetes Mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, which occurs due to insufficient production of insulin by the pancreas or resistance to insulin produced by the body. The most dangerous and Long-term complications of diabetes include renal failure, heart failure, cardiovascular diseas...
Background: Gestational diabetes mellitus (GDM) is known as a degree of glucose intolerance that occurs for the first time during pregnancy. There is paucity of evidence regarding the effect of oat bran on GDM. Oat as a source of β-glucan can be effective in reducing the blood sugar levels. This study aimed to investigate the effect of oat bran on...
Introduction: Taking into consideration the high impact of Diabetes Mellitus type II (DM II) on human's health, identification of risk factors to prevent its development seems essential. Further studies are needed to ensure the positive role of uric acid in the onset of diabetes. This study targeted at investigating the attributed risk of hyperuric...
Objective
Peripheral neuropathy is a common complication of diabetes mellitus. This study was set to assess the effect of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes (T2DM).
Materials and methods
This study was a quasi-experimental trial in Yazd diabetic research center. Sixty T2DM subjects (30–65 years old)...
Purpose:
Diabetes mellitus (DM) is a heterogeneous group of metabolic disorders characterized by chronic hyperglycemia that results by relative or absolute insulin deficiency. Hearing disorders is common otological disorders in diabetic patients. This study aimed to investigate the frequency of hearing impairment among DM patients and its associat...
Introduction: Insulin resistance has a strong relationship with the incidence of type II diabetes. It also has a direct relationship with other risk factors of diabetes, which together are known as metabolic syndrome. The aim of this study was to investigate the relationship between insulin resistance and hypertension.
Materials and Methods: In th...
In this study, our aim was to assess the impact of fasting during Ramadan on biochemical and anthropological factors in patients with type 2 diabetes and compare them with those who did not fast. This was a prospective study. It was carried out in the city of Yazd, Iran, during Ramadan of 2016. Body weight, height, waist circumference, blood pressu...
Objective: Diabetes is a chronic disease that influences mental and
physical health. Regarding the importance of diabetic patients’
psychological status, this research studied the effect of group
positive psychotherapy on life expectancy and general health of type
2 diabetic patients.
Materials and Methods: This clinical-trial study was done on 30...
Background:
Type 2 diabetes mellitus (T2DM) is one of the most important leading causes of disability, premature mortality and Diabetic Retinopathy (DR) that is one of the diabetes-related complications in diabetic patients and the most common cause of vision loss in diabetic patients. The aim of the study was to evaluate the association between D...
Background:
Gestational diabetes mellitus (GDM) has occurred in Fourteen percent of all pregnancies in the world. Epidemiological evidences about risk factors of GDM may be different from region to region and are unknown, exactly. This study examines the role of clinical factors in the association of gestational diabetes in Yazd, Iran.
Methods:...
Objective
Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis o...
The present study was conducted to explore the efficacy and safety of a herbal combination in the treatment of women with hyperlipidemic type 2 diabetes. The herbal combination capsule (600 mg) contained Terminalia chebula fruit extract (200 mg), Commiphora mukul (200 mg), and Commiphora myrrha oleo-gum-resin (200 mg), and the placebo capsule conta...
Type 2 diabetes (T2D) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. Linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. However, they were largely unsuccessful while applying to the more common form...
Background
Migraine headache prevalence and triggers in type2 diabetes mellitus (T2DM) were investigated in previous studies but the results are contradictory. Therefore, in this study we examined the prevalence of migraine headache in diabetic patients in comparison with non-diabetic persons and its predisposing factors in 2014. Methods
We enrolle...
Arterial thrombosis or emboli have rarely been reported in Cushing syndrome (CS). Here we describe the first case of mesenteric ischaemia secondary to ventricular emboli in a patient with CS. Laboratory evaluation showed increased fibrinogen and factor VIII. Previous studies showed that venous thromboembolism (VTE) increases in CS. This case for th...
Diabetes is one of the somatic diseases that cause mental health. So, considering the effective factors on diabetic patient's psychological status, the present study evaluates the relationship between life expectancy with general well-being and general health of type 2 diabetic patients. This research was an analytic and cross-sectional study, with...
Hypothyroidism is an endocrine disease with various clinical manifestations. It is a rare cause for rhabdomyolysis and massive pericardial effusion. We describe a case of severe hypothyroidism secondary to autoimmune hashimoto thyroiditis with massive pericardial effusion and rhabdomyolysis. Improvement of mentioned complications after hypothyroidi...
Our aim was to compare changes of body mass index (BMI) and waist circumference (WC) curves of Iranian children by comparing the results of two national surveys of a surveillance program, i.e. CASPIAN-I (2003-2004) and CASPIAN-III (2009-2010). The second objective was to evaluate the prevalence of obesity, overweight and underweight among 10-18-yea...
Multiple endocrine neoplasia type 1(MEN1) is an autosomal dominant syndrome. Although thymic carcinoid tumor is recognized as a part of MEN1 syndrome but functioning thymic carcinoid tumor as the first presentation of the MEN1 seems to be very rare. In this report, we present a 29-year-old male who developed ectopic Cushing syndrome secondary to th...
“Invasive giant prolactinoma” is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/dL and mass related clinical symptoms. Here we report a patient with a giant prolactinoma presented with central hypogonadism, suppressed adrenal and thyroid function, supra sellar extension, visual field impairment and high...
Projects
Projects (2)
According to the authors' knowledge, there are no human studies have tried to examine effects of resveratrol through the PPARα pathways related to vascular function, therefore, this study is designed to investigate the effects of resveratrol supplementation on the expression of PPARα, factors associated with cellular senescence and sCD163/sTWEAK ratio in T2DM patients.
