Masood Ahmad Rizvi

University of Kashmir · Department of Chemistry

A titration curve with multiple inflection points results when a mixture of two or more reducing agents with sufficiently different reduction potentials are titrated. In this experiment iron(II) complexes are combined into a mixture of reducing agents and are oxidized to the corresponding iron(III) complexes. As all of the complexes involve the iro...

A pseudo-indicator electrode based potentiometric method for estimation of non-redox metal ions is presented. In the proposed method, nature and concentration specific impact of analyte over the redox potential of ideally polarisable Pt/pregenerated-redox-couple interface forms the basis of quantification. Utility of the method in estimation of six...

Dopant engineering can be a very selective approach in designing hybrid materials for aimed applications.

A photoredox approach for synthesizing sulfur-substituted analogues of isocytosine via coupling of modular phenyl propargyl chloride with thiourea has been reported.

Persistent water contaminants include a variety of substances that evade natural cleaning processes posing severe risks to ecosystems. Their adsorptive elimination is a key approach to safer attenuation. Herein we present the design and development of Prussian blue incorporated polypyrrole (PPY/PB) hybrid nanocomposite as a high-performance adsorbe...

The Cover Feature illustrates a photoredox approach for synthesising (E)-β-iodovinyl sulfones, using alkynes and thiophenols as coupling partners. The reaction features a tandem introduction of C􀀀 S and C􀀀 I bonds onto the terminal alkynes and the direct conversion of thiol into sulfones. The reaction proceeds in the presence of [Ru(bpy)3Cl2] as a...

Isomer effects on the capping propensity of biogenic agents used in nanomaterial synthesis.

This study envisages the utilization of unique properties of Gd 2 S 3 and 2D graphitic carbon nitride towards the development of novel multiutility nanomaterial with sensing and water treatment application.

HER2 is the membrane receptor tyrosine kinase showing overexpression in several human malignancies, particularly breast cancer. HER2 overexpression causes the activation of Ras- MAPK and PI3K/Akt/ NF-κB cellular signal transduction pathways that lead to cancer development and progression. HER2 is, therefore, presumed as one of the key targets for t...

In the present work, volumetric, rheological, and thermodynamic analysis has been carried out for varied compositions of diphenyldiselenide in dimethyl sulfoxide/(5-25)% w/w of ethanol in dimethyl sulfoxide at seven distinct temperatures varying from 288.15 K to 318.15 K and ambient pressure (0.1 MPa). Through the acquired density data, the volumet...

Decorating symmetric aromatic diselenide motif such as in diphenyldise-lenide (DPDSe) with diverse supra-functionalities provides a plethora of bioactivities for pharmacological applications. Solvent studies of bioactive molecules are vital descriptors for their drug development as these can predict the drug-target interaction. This study aims to e...

The concerning rise in emergence and prevalence of resistant strains to drugs of M. tuberculosis has ,the prompted researchers to look for new and effective treatments. With this motive, biscoumarins were identified as the lead molecules on a whole-cell-based screening of several less explored low molecular weight bioactive compounds against M. tub...

In this work, 1-(4-bromophenyl)-2a,8a-dihydrocyclobuta[b]naphthalene-3,8‑dione (1-(4-BP)DHCBN-3,8-D) has been characterized by single crystal X-ray to get it's crystal structure with R(all data) - R1 = 0.0569, wR2 = 0.0824, 13C and 1HNMR, as well as UV-Vis and IR spectroscopy. Quantum chemical calculations via DFT were used to predict the compound...

Density functional theory is applied to account the ligand effect on modification in the redox potential of coordination of three NN bidentate ligands (bpy/phen) to the metal ion (Fe2+/3+/Co2+/3+). Also, the role of the ligand framework for the stabilization of [M(bpy/phen)3]2+/3+ species is discussed in detail. In this work, we have found that the...

Background: DprE1, which is a flavoenzyme, is very important for cell wall biosynthesis in Mycobacterium tuberculosis (Mtb) and for the pathogenesis, virulence, lethality, and stress resistance of the host. Drug-resistant tuberculosis is a challenging global human health issue, necessitating the development of novel, more effective treatment regime...

Solvothermal synthesis of hierarchical orthorhombic Sb 2 WO 6 nanostructures on layered GO for heavy metal ion sensing and photocatalysis.

The discovery of novel drug candidates is one of the preeminent tasks in biomedical research. In recent decades, the ubiquity of computers and computational methods has been widely used in the drug discovery process. Advances in informatics and computational biology have increased productivity in the drug discovery field in contrast to traditional...

A mild photoredox approach enabling the first one-step synthesis of thiolated 2-aminothiazoles has been reported. Notably, the incorporation of thio group on electron-rich heteroarenes such as aminothiazoles via conventional nucleophilic aromatic substitution (SNAr) presents a significant challenge owing to polarity mismatch. Herein, we present a r...

The Cover Feature illustrates a photoredox approach for synthesising (E)‐β‐iodovinyl sulfones, using alkynes and thiophenols as coupling partners. The reaction features a tandem introduction of C−S and C−I bonds onto the terminal alkynes and the direct conversion of thiol into sulfones. The reaction proceeds in the presence of [Ru(bpy)3Cl2] as a ph...

Coordination compounds as dopants to conducting polymers combine desirable properties of individual components for a synergistic effect. Prussian red (PR) a low spin iron (III) coordination compound was doped in polythiophene (PTP) matrix to explore the propensity of this inorganic-organic hybrid composite material towards wastewater treatment....

A photoredox thioformylation of terminal alkynes using nitromethane as a formyl anion equivalent, thereby leading to the synthesis of (E)-1,2-difunctionalized acrylaldehyde, has been described. The current strategy introduces an adaptable aldehyde function across an alkyne and offers a new route to synthesizing α-alkyl/aryl aldehydes.

A photoredox mediated approach enabling the synthesis of (E)‐β‐iodovinyl sulfones at room temperature using simple alkynes and thiols as the coupling partners in the presence of TBAI as iodine source is reported. The direct conversion of thiols into sulfones following the tandem introduction of C−I and C−S bonds is achieved using SeO2 as an oxidizi...

A photoredox approach enabling one-step synthesis of oxazetidines with free -NH group via the combined use of alkyne, thiophenol, and azide has been reported. The synthesized oxazetidine with the free...

Sustainable agricultural production is critically antagonistic by fluctuating unfavorable environmental conditions. The introduction of mineral elements emerged as the most exciting and magical aspect, apart from the novel intervention of traditional and applied strategies to defend the abiotic stress conditions. The silicon (Si) has ameliorating i...

Diphenyldiselenide (PhSe)2 was envisaged as a unique dopant for observing modulation in charge transport dynamics, impedance spectroscopy and temperature sensing behaviour of polythiophene (PTh). The [PTh/(PhSe)2] nanocomposite was synthesized via non-aqueous oxidative polymerization route in presence of ball milled diphenyldiselenide dopant. Therm...

A visible light-mediated approach enabling the use of alcohols as nucleophiles in a one-step synthesis of a-alkoxy/hydroxy diarylacetaldehydes is reported. The method allows the construction of a highly functionalized quaternary center via oxidative coupling of alkynes with benzoquinone and alcohols at room temperature. The use of alcohols as a nuc...

A visible‐light‐assisted approach for the synthesis of α‐halomethyl ketones from terminal alkynes has been developed. The reaction introduces halogen at the α‐position of terminal alkynes using N‐halosuccinimides as the halogen source. It relies on the photodegradation of N‐halosuccinimides obviating the requirement for a photocatalyst. The procedu...

A novel transition metal‐free photosensitized protocol has been developed for the synthesis of α‐ketoamides via oxidative coupling of alkynes and amines in the presence of thiophenol under visible light irradiation and rose bengal dye. A series of alkynes with both electron‐donating and electron‐withdrawing groups were successfully employed for the...

The activation of caspases is central to apoptotic process in living systems. Defects in apoptosis have been implicated with carcinogenesis. Need to develop smart agents capable of inducing apoptosis in tumor cells is obvious. With this motive , diversity oriented synthesis of 1-benzylpyrrolidin-3-ol analogues was envisaged. The multi component Ugi...

Anthropogenic CO2 emissions from fossil fuel combustion have led to the serious environmental consequence of global warming and associated climate change. Valorization of CO2 to value-added chemicals by electrochemical reduction has been suggested as one of the promising approaches of CO2 attenuation owing to its simple operational requirements and...

A target synthesis of selected biocompatible chiral Thiazolidine-4-carboxylic acid derivatives was attempted to investigate the influence of number, type and position of hydrogen bonding functionalities and solvent molecules in the crystal lattice on the supramolecular aggregation behaviour leading to formation of molecular assemblies. The single c...

Density, speed of sound and viscosity for varying concentrations of 3,3-(phenylmethylene)bis(4-hydroxy-2H-chromen-2-one) in DMSO and solvent media containing (5, 10, 15, 20, 25)% w/w of ethanol in DMSO have been measured. These properties have been deliberated over a wide range of temperatures ranging from 288.15 K to 313.15 K and at p = 0.1 MPa. F...

In this study, we prepared a polypyrrole-diphenyl diselenide [PPy/(PhSe)2] nanocomposite by oxidative chemical polymerization for the purpose of temperature sensing applications. Fourier transform infrared spectroscopy, X-ray diffraction and scanning transmission electron microscopy confirmed the synthesis of the above material. Thermogravimetry (T...

Monoclinic Copper oxide (CuO) nanoparticles were prepared by simple co-precipitation method. The structural and morphological crystals of CuO nanoparticles were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. To check the bonding between metal and oxide, FTIR was done. In order to study the band gap and op...

Acetylcholinesterase (AChE) inhibitors are actively used for the effective treatment of Alzheimer's disease. In recent years, the neuroprotective effects of organoselenium compounds such as ebselen and diselenides on the AChE activity have been investigated as potential therapeutic agents. In this work, we have carried out systematic kinetic and in...

Acetylcholinesterase (AChE) inhibitors are actively used for the effective treatment of Alzheimer’s disease. In recent years, the neuroprotective effects of organoselenium compounds such as ebselen and diselenides on the AChE activity have been investigated as potential therapeutic agents. In this work, we have carried out systematic kinetic and in...

A single‐step visible light mediated synthesis of β‐hydroxydithioacetals via oxidative coupling of terminal alkynes with thiophenol is reported. Compared to other multistep strategies, this work presents a rare tandem introduction of disulfides and a hydroxy group at the β‐position in one pot. The reaction is enabled by aerial oxidation, features h...

Natural attenuation mimics nature's own cleansing mechanism and offers an effective solution for contaminant treatment under prevalent environmental conditions without generating secondary toxins. Despite obvious advantages, these processes are restricted by a narrow range of reduction potential available within natural water systems. Complexation...

Rheumatoid arthritis (RA) is an autoimmune disease associated with severe joint pain. Herein, we report lornoxicam loaded cellulosic microsponge gel formulation with sustained anti-inflammatory effects that are required to manage arthritic pain. The microsponges were formulated using quasi emulsion-solvent diffusion method employing four different...

A photoredox-mediated protocol for the synthesis of α-alkoxy-β-ketosulfoxides and α,β-dialkoxysulfoxides using alkynes, thiol, and alcohols is reported. This work presents a rare single-step synthesis of α-substituted sulfoxides, involving tandem introduction of a thiol and alcohol as a key enabling advancement. Furthermore, the method can be easil...

Hybrid materials of conducting polymers with coordination compound dopants offer a desirable combination of properties for targeted applications. This work presents polythiophene/prussian red (PTH/PR) nanocomposites as hybrid materials using PTH as a polymer matrix and PR nanoparticles as a readily available dopant with photo-reactive and magnetica...

A tandem one-pot solvent free approach for the direct conversion of benzyl alcohols to α-amino phosphonates and dihydropyrimidones is reported. The method relies on a metal free photo-oxidation of benzyl alcohols to benzaldehydes under UV irradiation using ammonium perchlorate followed by Kabachnik–Fields and Biginelli reactions. The reaction condi...

A pharmacophoric motif decorated with supramolecular functionalities (TZT) was designed for potential interaction with biological targets. Main insights of this work are correlation of supra functionalities and binding ability of TZT to restructure proteins for bioactivity modulation as promising perspective in the field of cellular protection from...

The design and development of synthetic fluorescent molecular architectures for sensing of nucleic acids and related species in living cells is an area of enormous interest. For the first time a novel compilation of single molecular abiotic fluorescent receptors for nucleic acid detection in living cells have been reviewed. Selected reports have be...

The ‘2R,4R’‐2‐aryl thiazolidine‐4‐carboxylic acid anilides (ATCAAs) were synthesized using cyanuric chloride (CC) as a clean and substoichiometric acid‐amine coupling agent under optimized reaction conditions. The diesterphenol intermediate based mechanism is proposed and supported by spectral characterization of the intermediate. The single crysta...

The growing environment, health, and economic concerns about using organic solvents have led to efforts for the search of unconventional solvents. Water, ionic liquids (ILs), and supercritical fluids (SCFs) are driving attention for their use as alternative solvents. SCFs are desirable as they combine the properties of both liquid and gaseous state...

A single-step synthesis of 4-hydroxy functionalized bi-aryl and aryl-alkyl ketones via oxidative coupling of terminal alkynes with benzoquinones is reported. Furthermore, with naphthoquinones, owing to cross-resonance of carbonyl with aromatic ring, alkene-alkyne cycloaddition is more favoured to give 4-membered carbocyclic adducts, thereby preclud...

A computational exploration of fungi produced pigment bikaverin as a biosensor towards bioavailable metal ions is presented. Systematic studies of the optimized ground and excited state geometries were attempted for exploring metal ion binding pocket, comparative binding propensity and optical properties of the bikaverin and its adducts with studie...

A photoredox-mediated gem-difunctionalization of alkynes leading to the synthesis of α,α-aminothio-substituted carbonyl compounds is reported. The work presents concomitant introduction of α-C-N and C-S bonds as a key enabling advance. Furthermore, the low bond dissociation energy of the C-S bond compared to that of C-N or C-C bonds has been exploi...

A new Cu(II)–iminodiacetate complex was synthesized and characterized by various spectroscopic (UV–vis, FTIR, EPR, single XRD) and analytical methods. Complex 1 crystallized in the monoclinic C2/c space group possessing lattice parameters, a = 15.58 Å, b = 6.37 Å, c = 13.33 Å, α = γ = 90°, β = 95.38° per unit cell. The DFT and TDFT studies were car...

A photoredox catalyzed approach enabling use of alkynes as surrogate of 2-oxoaldehydes/1,2-diones is reported. The method overcomes the difficulty associated with application of unsubstituted aliphatic α-oxoaldehydes, which has hitherto limited their general use. Indoles, tryptamine and tryptophan methyl ester participated in the reaction to give a...

A photoredox-mediated acylation reaction of electron deficient heteroarenes with terminal alkynes is reported. The method relies on oxidative cleavage of phenylacetylenes for generation of acyl radicals as a key enabling feature. The reaction is regioselective with broad substrate scope. Quantum yield investigations support a radical chain mechanis...

The electron transfer reaction between two oxidation states of a transition metal redox couple is amazingly interesting. The present study describes a combined spectropho-tometric and potentiometric investigation of redox reaction involving iron (III) and iron(II) oxidation states. The electron transfer reaction is seen to occur between iron-(III)p...

A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.

The electron transfer reaction between two oxidation states of a transition metal redox couple is amazingly interesting. The present study describes a combined spectrophotometric and potentiometric investigation of redox reaction involving iron (III) and iron(II) oxidation states. The electron transfer reaction is seen to occur between iron-(III)ph...

A simple and efficient synthesis of 2H-indazoles is achieved from 2-primary amines, bromobenzaldehydes and sodium azide through domino condensation, C–N and N–N bond formations, catalyzed by a heterogeneous Cu(II)-Clay catalyst. The recyclable heterogeneous Cu(II)-Clay catalyst exhibited a remarkable activity for the title reaction without any addi...

An environmentally benign, catalyst free, aqueous phase, microwave assisted method for the synthesis of biscoumarin derivatives using 4-hydroxycoumarin and different aldehydes is reported. The comparative investigation of the same synthetic methodology under conventional refluxing, domestic and scientific programmable microwave synthesizer has been...

The present work describes strength modulation of carboxymethylcellulose (CMC) hydrogel on addition of biodegradable diester-bonded gemini surfactants. These CMC-surfactant hybrid hydrogels were prepared using carboxymethylcellulose sodium salt and gemini surfactants in urea solution. The structure and morphology of the synthesized hybrid hydrogels...

The electron transfer reaction between two oxidation states of a transition metal redox couple is amazingly interesting. The present study describes a combined spectropho- tometric and potentiometric investigation of redox reaction involving iron (III) and iron(II) oxidation states. The electron transfer reaction is seen to occur between iron-(III)...

A method for regio-selective phosphation and phopshonation at 9-position of fluorenones has been developed. The outcome of reaction can be controlled by varying temperature viz., at low temperature phosphonate is the exclusive product, whereas at high temperature phosphate is the favoured product. The reaction is easy to set up, involves mild condi...