Mashiur Rahman

National University of Singapore | NUS

Background: The habenula consists of an evolutionarily conserved set of nuclei that control neuromodulator release. In lower vertebrates, the dorsal habenula receives innervation from sensory regions, but the significance of this is unclear. Here, we address the role of the habenula in olfaction by imaging neural activity in larval zebrafish expre...

Here we report efforts towards fabrication of DNA based nanosensors, where DNA molecules were immobilized on gold-dot arrays. AFM was used as the main characterization tool. Two major challenges associated with characterizing these nanosensors are: 1) constructing small (<10 nm high) attachment sites on a flat surface to resolve the details of the...

We have developed two basic technologies for fabrication of supported planar lipid bilayer membrane ion channel biosensors: a defect-free lipid bilayer formation on the substrate surface with electrode pores and a patterning technique for the hydrophobic self-assembled-monolayer to form the guard ring that reduces the lipid bilayer edge-leak curren...

The effect of the electrostatic attractive force between giant unilamellar vesicles (GUVs) and the SiO2 surface on the formation of a Ca2+-free supported lipid bilayer (SLB) was investigated by atomic force microscopy and fluorescence microscopy. When negatively charged GUVs were incubated for 1 h without Ca2+, the surface coverage of lipid bilayer...

The convergence of terahertz spectroscopy and single molecule experimentation offer significant promise of enhancement in sensitivity and selectivity in molecular recognition, identification and quantitation germane to military and security applications. This presentation reports the results of experiments which address fundamental barriers to the...

Elucidating the genetic, and neuronal bases for learned behavior is a central problem in neuroscience. A leading system for neurogenetic discovery is the vinegar fly Drosophila melanogaster; fly memory research has identified genes and circuits that mediate aversive and appetitive learning. However, methods to study adaptive food-seeking behavior i...

The development of strategies for the robust attachment of organized patterns of nanostructures to a variety of surfaces has been a major objective of this laboratory. One of the significant impediments to single molecule, as opposed to multiple molecule, attachment arises from the size gap or intrinsic mismatch between the size of readily obtainab...

The precise placement of molecular and nanoparticle species at predetermined locations on a substrate surface remains a current challenge. Some barriers are particularly relevant to soft matter such as biomolecules. The advent of DNA Origami, invented by Rothemund, provides partial solutions to some challenges while raising new challenges. In this...

This paper reports progress in an approach to create a general purpose platform to be used in the reproducible assembly of molecular electronic devices. We describe a method in which DNA molecules were immobilized on patterned neutravidin surfaces. First, a silicon wafer was functionalized with (3- aminopropyl)triethoxysilane (APTES) to produce an...

Spin-on-glass (SOG) is an important material in semiconductor integrated circuit fabrication and widely used for flattering of the inter level dielectrics. Typical thickness of SOG films are hundreds of nanometers. It is usually cured with reducing the thickness by heating to high temperatures in the last stage of the processes. In this paper, we h...

Summary form only given. Microfabrication technology has made a considerable impact on recent biotechnological research. The area-selective integration of self-assembled monolayer (SAM) on patterned substrates is important to biosensor fabrications, cell studies, and tissue engineering applications. The combination of them will be an interesting fi...

Applicationof a scanning probe microscope(SPM) to organic molecules gives evidence for structural and electronic properties of molecules adsorbed onto substrate surfaces. The nanotechnology for bio -organismwill play animportant role in future device technology. In this study we have investigated an adenosine molecule onto a flat basal plane of h...

The aim of this solar system is to use in outdoors and in the place where the electric power plant is not available such as in a very rural area.

Adsorbed structure of adenosine molecules was observed on a flat basal plane of highly oriented pyrolytic graphite (HOPG) surface by using a scanning tunneling microscopy (STM). We obtained STM images and I-V spectra of the molecules. By using the STM we obtained the width and length of an adenosine molecule is about 3 Å and 7 Å. Molecular orbital...