Masato Hada

Masato Hada
Masato Hada's Lab · oncology

Bachelor of Medicine and pharmacy
My current activity is to introduce treatments for COVID-19 and underlying diseases with thalidomide and celecoxib.

About

42
Publications
18,167
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41
Citations
Introduction
I am a retired surgeon. Currently, I am fully committed to the spread of severe COVID-19 pneumonia treatment using thalidomide and celecoxib. I synthesized highly purified thalidomide in 1999 and treated the patients since 2000. But we are ordered to recall every capsule from the Ministry of Health, Labor and Welfare in 2002. In 2005, we submitted a clinical trial, using thalidomide, celecoxib. and low dose gemcitabine for pancreatic cancer. But this clinical trial was rejected.
Additional affiliations
February 1983 - March 2009
Hada Clinic
Position
  • Administrator
Description
  • 73 year old retired oncologist now.

Publications

Publications (42)
Preprint
Full-text available
Nontuberculous mycobacteria (NTM) are ubiquitously living in the environment worldwide. These organisms are identified more than 170, including Mycobacterium tuberculosis (TB) and Mycobacterium leprae. NTM are common among immune competent children and adults, partially immunocompromised conditions, infecting at increasing rates through the lung wi...
Preprint
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In recent years, worldwide, hepatitis of unknown origin has become prevalent in young children. The cause is not clear, but it is suspected to be caused by adenovirus, especially F41. Liver transplantation (OLT) is considered to be the only treatment because it tends to become serious at an early age. In the case of hepatitis virus, Interleukin-10...
Preprint
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Sarcopenia is defined as a generalized loss of muscle mass and function during an age-related process in older people. Dynapenia is the age-related decline of muscle strength before sarcopenia without relevance to neurologic or muscular diseases. Histological change of muscle occurs predominantly in type II (fast-twitch) muscles than in type I (slo...
Preprint
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Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disorder with muscle weakness, disability, and eventually death, without known medicines. ALS becomes severe and fatal by many different pro-inflammatory cytokines. The transcription factor NF-κB plays a major role in production of inflammatory cytokines. I wrote t...
Preprint
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Malignant pleural mesothelioma (MPM) is an aggressive malignancy caused by mainly asbestos. Prognosis is extremely poor with about one year from diagnosis without the use of molecular targeted agents. The main pathological cause of many diseases including MPM is activated or dysregulated nuclear factor kappa B (NF-κB). Chemotherapy with molecular-...
Preprint
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The current chemotherapeutic options for Rheumatoid Arthritis are chemotherapy with monoclonal antibody drugs (MCDs) and inhibitory drugs (HDs: small molecular protein kinase inhibitor), the former bind with receptors, and the latter suppress a variety of signal pathways. In many articles, the pathways of MCDs and HDs are not clearly described betw...
Preprint
Full-text available
The current chemotherapeutic option for advanced pancreatic cancer is chemotherapy only with gemcitabine alone. Therefore, I wrote new combination chemotherapy regimen that is consistent with the complicated mechanism of pancreatic carcinogenesis. Chronic inflammation, long-standing more than 20-40 years (meta-inflammation), secondary to chronic in...
Preprint
Full-text available
Fibromyalgia (FM) is regulated by a variety of factors such as oxidative stress, diabetes mellitus, advanced glycation end products (AGE), and small intestinal bacterial overgrowth (SIBO). These factors activate NF-κB that drives the production of proinflammatory cytokines and pain. It has been reported that FM is not relevant to inflammatory resp...
Preprint
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Viral infections, inflammatory diseases and carcinoma are regulated by a variety of proinflammatory factors that could be effective therapeutic targets. Especially, Toll like receptors (TRLs) and transcriptional factors such as NF-κB play an important role in viral inflammation and cancer. Carcinoma is regulated by a variety of oncogenic factors t...
Preprint
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Cytokine storm and cancer initiation and of COVID-19 depend upon proinflammatory cytokines, only differing in amount and term. Cytokine production is controlled by NF-κB.Therefore, exacerbation of COVID-19 pneumonia is controlled by NF-κB. Patients with underlying diseases who had experienced COVID-19 infection-induced pulmonary fibrosis after sev...
Experiment Findings
Full-text available
Viral infections, inflammatory bowel diseases and carcinomas are regulated by a variety of proinflammatory factors that could be effective therapeutic targets. Especially, transcriptional factor NF-κB, and Toll like receptors (TRLs) play an important role in these diseases. Colorectal and lung epithelial cell injuries originate from oxidative stres...
Preprint
Full-text available
Viral infections, intractable diseases and carcinoma is regulated by a variety of proinflammatory factors that could be effective therapeutic targets. Especially, transcriptional factors such as NF-κB, Toll like receptors (TRLs) and ACE2 play an important role in viral inflammation. Lung cell injuries occur in human alveolar cells and bronchial epi...
Preprint
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炎症、難治性疾患や癌を発生、促進するタンパク(因子)はたくさんありますがそのうちでも強力な炎症惹起作用を持つものがNF-kB、HIF、COX-2です。これら3因子を発見した方々はすべてノーベル賞を受賞しています。この3因子を抑制することで効果的な癌治療を行うことができることを発表してきました。 コロナウイルス肺炎もこの因子特にNF-kB、COX-2を抑制することで効果的な肺炎治療ができます。ウイルスの刺激を受容しその刺激をNF-kBに伝える役をするのがトル様受容体です。肺損傷は肺胞、気管支上皮細胞やマクロファージなどの免疫細胞で起こっており重症な肺炎を引き起こす原因となっています。 活性化したNF-kBを抑制することでCOVID-19肺炎の重症化を防ぐことが可能です。現在のところこのNF-k...
Preprint
Full-text available
Viral infections, intractable diseases and carcinoma is regulated by a variety of proinflammatory factors that could be effective therapeutic targets. Especially, transcriptional factors such as NF-κB and Toll like receptors (TRLs) play an important role in viral inflammation. Lung cell injuries occur in human alveolar cells and bronchial epithelia...
Preprint
Full-text available
Carcinoma is regulated by a variety of oncogenic factors that could be effective therapeutic targets. Especially, angiogenic factors including VEGF, FGF and COX-2 play an important role in tumor initiation and proliferation. HIF activates NF-κB and induce angiogenic factors in the tumor microenvironment. It is possible to prevent carcinogenesis, pr...
Preprint
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Hemangioblastoma is regulated by a variety of various factors that are ideal targets for effective chemotherapy. Galectin-3 especially triggers the development of the tumor associated with angiogenesis. Furthermore, transcriptional factor NF-κB plays an important role in angiogenesis. Modulating irregulated or activated NF-κB prevents proliferation...
Preprint
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Endometrial Cancer is regulated by a variety of oncogenic factors and estrogen that are ideal targets for effective chemotherapy. Type II ECs, 10-20% of total EC cases, are responsible for EC death due to aggressive nature. Therefore, type II ECs are in need of new treatment options with molecular targeted therapies that target Toll-like receptors...
Preprint
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Carcinoma is regulated by a variety of oncogenic factors that are ideal targets for effective chemotherapy. Immune system is significantly relevant to gut microbiota, which is also associated with gut-organs axis in tumor microenvironment (TME). NF-κB plays an important role in gut-organs axis and tumor cells in TME. It might be possible to prevent...
Preprint
Full-text available
Carcinoma is regulated by a variety of oncogenic factors that are effective therapeutic targets for targeted chemotherapies. Immune system is significantly relevant to gut microbiota, which is also associated with gut-organs axis in tumor microenvironment (TME). NF-κB plays pivotal role in gut-organs axis and tumor cells in TME. It might be possibl...
Preprint
Full-text available
The current chemotherapeutic option for advanced colorectal cancer is chemotherapy with molecular targeted and cytotoxic agents. So I wrote combination chemotherapy regimen that is consistent with the mechanism of colorectal carcinogenesis. Long-standing chronic inflammation more than 20-40 years, secondary to chronic infection predisposes to cance...
Preprint
Full-text available
The current chemotherapeutic option for advanced pancreatic cancer is chemotherapy only with gemcitabine alone. So I wrote combination chemotherapy regimen that is consistent with the mechanism of pancreatic carcinogenesis. Chronic inflammation, long-standing more than 20-40 years, secondary to chronic infection predisposes to cancer. Toll-like rec...
Preprint
Full-text available
To the patients with bladder cancer in Japan, especially those who have had first or second line chemotherapy at Shizuoka Cancer Shizuoka Cancer Center situated in Nagaizumi, Japan, is said to have the best equipment in Japan. In addition to the splendid facilities, staff is also gentle. However, the medical level and activities of the Center is n...
Preprint
Full-text available
I have treated many patients with ovarian cancer since the 2000s. We could prolong overall survival with the combination of thalidomide, celecoxib and cytotoxic agent gemcitabine or irinotecan. We submitted this regimen as clinical trial (Chiken in Japanese) to Ministry of Health, Labor and Welfare in Japan. However this clinical trial was rejected...
Preprint
Full-text available
I have treated meny patients with pleural effusion and ascites since the 2000s.We could prolong overall survival with the combination of thalidomide, celecoxib and cytotoxic agent gemcitabine or irinotecan. We submitted this regimen as clinical trial (Chiken in Japanese) to Ministry of Health, Labor and Welfare in Japan. However this clinical trial...
Preprint
Full-text available
The day was the 17th day since we began the chemotherapy, I was so surprised to find the patient laughing and enjoying TV program with clear consciousness at the morning round. I heard the brook chirping in the hospital room. That was the sound of urine stream from urination tube. The combination of thalidomide, celecoxib, valproic acid or/and low...
Preprint
Full-text available
I synthesized highly purified thalidomide in 1999 and treated more than 600 cancer patients with excellent outcome since 2000. But we are ordered to recall every capsule and clinical trial was rejected due to the toxicity of thalidomide and celecoxib by the Ministry of Health, Labor and Welfare in Japan. The combination of thalidomide, celecoxib,...
Preprint
Full-text available
I would like let researchers in the world know that Japanese patients with intractable or malignant diseases are spending miserable life with low-grade medical care due to poor intelligent bureaucrats.
Preprint
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A number of diseases including autoimmune diseases and malignancies including breast cancer are supposed to be caused by imbalance of microbiota "dysbiosis". Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) identifying pathogen-associated molecular patterns (PAMPs) including lipopolysaccharide (LPS) 1 Dendritic cells are main ant...
Preprint
Full-text available
Behçet's disease (BD) is a rare inflammatory disorder with four major symptoms consisting of oral aphthous ulcers, ocular lesions, skin lesions, and genital ulcerations. 1 Gut Microbiota is a potential regulator of immune function of articular, gastrointestinal, cardiopulmonary, neurologic, and vascular system. 2 The pathogenesis of BD is close rel...
Preprint
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Herpes zoster (HZ) is caused by reactivation of herpesvirus, varicella zoster virus (VZV). One of the most common and debilitating sequelae is herpetic neuralgia. After primary infection with varicella, when cellular immunity to VZV decreases with age or because of immunosuppression, the virus reactivates and travels along the sensory nerves to the...
Preprint
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Schizophrenia is a chronic and debilitating psychotic disorder characterized by disturbed behavior, thinking, emotions, and perceptions. Acute psychotic episodes of schizophrenia are delusions, hallucinations, illogical thinking, and incoherent speech. There is accumulating evidence that there exists relationship between the pathological processes...
Preprint
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Malignant ascites is frequently associated with various malignant tumors including breast, ovarian, endometrial, gastrointestinal, or pancreatic cancer. It is now widely accepted that despite overall improvements in oncological care in the palliative setting, symptomatic malignant ascites remains a severe clinical problem and to be widely resistant...
Preprint
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Bladder cancer is highly chemosensitive. In metastatic setting, chemotherapy treatment remains the only therapeutic option and the standard treatment is based on cisplatin chemotherapy regimens. Despite the promising results obtained by standard chemotherapy based on gemcitabine and cisplatin, the majority of patients die of metastatic disease. The...
Preprint
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Biliary tract cancers (BTC) arise from the epithelium of the biliary tree and are anatomically classified into cholangiocarcinomas(CCAs) of the intrahepatic and extrahepatic cholangiocarcinoma and gallbladder cancer (1.2). Surgical resection is the standard treatment in early stage. But unfortunately the majority of patients are diagnosed with meta...
Preprint
Full-text available
Amyloid precursor protein (APP) is a type I transmembrane protein that includes several human isoforms due to alternative splicing. 1 In the brain, β-APP(Aβ) is a key player in the molecular pathogenesis of Alzheimer's disease(AD).2 It is important to elucidate the mechanism of APP expression and the proteolytic process of APP to the generation of...
Article
Full-text available
Gallbladder cancer is an asymptomatic disease in the early stage and no therapeutic measure is available except surgical intervention. The prognosis for patients with advanced,i.e., unresectable or metastatic disease is dismal, with median survival usually being less than 6 months if not treated with chemotherapy. To date, chemotherapy for gallblad...
Article
Full-text available
Chemotherapy for the treatment of brain metastases arising from non-small cell lung cancer (NSCLC) has been limited by poor efficacy and high toxicity. Especially in heavily pretreated patients with brain metastases, further chemotherapy is known to be extraordinarily difficult. Expression of vascular endothelial growth factor is necessary but not...
Article
Full-text available
Malignant mesothelioma (MM) is a rare neoplasm that is commonly fatal within 12-17 months after diagnosis. There are no widely accepted curative approaches. It recurs even after the most aggressive surgical resection. MM is resistant to chemotherapy and radiation. Most of the chemotherapeutics have been evaluated in MM, however, no drugs have a res...
Article
Full-text available
The prognosis of pancreatic cancer with metastases or recurrence is quite poor. Chemotherapy has not resulted in a significant survival benefit; median survival is 3-6 months. Various chemotherapeutic agents have been evaluated and the standard chemotherapy of pancreatic cancer is gemcitabine. The response rate, however, is low at 13%. Thalidomide...
Article
Full-text available
Advanced human pancreatic cancer is considered a chemoresistant disease. To date, no treatments have had a significant efficacy on the disease. Patients with pancreatic cancer, however, experienced an improvement in the related symptoms with gemcitabine. Thalidomide has been shown to have antiangiogenic and immunomodulatory effects, including the i...
Preprint
Full-text available
I have treated over 40 patients with pancreatic cancer since the 2000s.We could prolong overall survival with the combination of thalidomide, celecoxib and cytotoxic agent gemcitabine or irinotecan. We submitted this regimen as clinical trial (Chiken in Japanese) to Ministry of Health, Labor and Welfare in Japan. However this clinical trial was rej...
Article
Full-text available
Malignant pleural effusion (PE) and ascites are associated with highly symptomatic, advanced-stage cancers. These fluid accumulations cause severe symptoms such as abdominal distention, shortness of breath, cachexia, anorexia, and fatigue. Malignant PE and ascites have consistently been shown to indicate a poor prognosis in advanced-stage cancer pa...

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Projects (12)
Project
To see researchers achievements on Research Gate.
Project
To enhance contemporary research issues, using a broad spectrum of research methods from the humanities to the social and hard sciences.
Project
Multiculturalismo, Interculturalismo, Cristianismo, Judaísmo e Islam