Masakazu Kurita

Masakazu Kurita
The University of Tokyo | Todai · Department of Plastic, Reconstructive and Aesthetic Surgery

MD, PhD

About

103
Publications
21,429
Reads
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3,979
Citations
Citations since 2016
39 Research Items
2639 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Introduction
Development of therapeutics for plastic and reconstructive surgery patients
Additional affiliations
August 2018 - November 2019
The University of Tokyo
Position
  • Instructor
April 2015 - August 2018
Salk Institute for Biological Studies
Position
  • Research Associate
Description
  • JSPS postdoctoral fellowships for research abroad (2015-2016)
April 2005 - March 2015
Kyorin University
Position
  • Associate
Education
April 1997 - March 2003
The University of Tokyo
Field of study
  • Medicine

Publications

Publications (103)
Article
Although injective autologous fat transplantation is one of the most attractive options for soft-tissue augmentation, problems such as unpredictability and fibrosis resulting from fat necrosis limit its universal acceptance. Centrifugation is one of most common methods for overcoming these difficulties. This study was performed to investigate quant...
Article
Sclerotherapy is effective in the treatment of vascular malformations. However, in lesions with relatively high blood flow, its effect is not always adequate. We therefore developed a three-grade classification of vascular malformations to facilitate the selection of treatments according to vascular flow. We also developed the technique of embolosc...
Article
Full-text available
Large cutaneous ulcers are, in severe cases, life threatening1,2. As the global population ages, non-healing ulcers are becoming increasingly common1,2. Treatment currently requires the transplantation of pre-existing epithelial components, such as skin grafts, or therapy using cultured cells2. Here we develop alternative supplies of epidermal cove...
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Wearable sensors have seen remarkable recent technological developments, and their role in healthcare is expected to expand. Specifically, monitoring tissue circulation in patients who have undergone reconstructive surgery is critical because blood flow deficiencies must be rescued within hours or the transplant will fail due to thrombosis/haematom...
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Orbital cavernous venous malformation (OCVM) is a sporadic vascular anomaly of uncertain etiology characterized by abnormally dilated vascular channels. Here, we identify a somatic missense mutation, c.121G > T (p.Gly41Cys) in GJA4, which encodes a transmembrane protein that is a component of gap junctions and hemichannels in the vascular system, i...
Article
Background Pelvic lymphoceles are the most common complications after pelvic lymphadenectomy. Microsurgical procedures have attracted attention as an alternative treatment for lymphoceles. Here, we report six cases of refractory lymphoceles that were successfully treated using lymphovenous anastomosis (LVA). Methods Six patients underwent surgery...
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Full-text available
The classification of ultrasound (US) findings of pressure injury is important to select the appropriate treatment and care based on the state of the deep tissue, but it depends on the operator’s skill in image interpretation. Therefore, US for pressure injury is a procedure that can only be performed by a limited number of highly trained medical p...
Article
Background Lymphatic venous anastomosis (LVA) is a widely accepted surgical procedure for lymphedema. To obtain the best outcomes, surgeons should be well trained. A recent study introduced an LVA training model using pig trotters for their utility and structural similarity to human tissues. However, details regarding the utilization of anastomosis...
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Although the great toe plays important roles in walking, loading, and maintaining balance when compared with other toes, there are few reports on great toe reconstruction, including the reconstruction of distal phalanx. This report aims to describe the use of a superficial circumflex iliac artery perforator (SCIP)-osteocutaneous flap for reconstruc...
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Extracorporeal membrane oxygenation (ECMO) is a well-established mechanical circulatory support system used in patients with life-threatening cardiopulmonary conditions. However, severe complications associated with vascular access require consideration. We report a patient with fatal ventricular arrhythmia who was successfully resuscitated with EC...
Article
Background Lipoinjection is a promising treatment but has some problems, such as unpredictability and a low rate of graft survival due to partial necrosis.Methods To overcome the problems with lipoinjection, the authors developed a novel strategy known as cellassisted lipotransfer (CAL). In CAL, autologous adiposederived stem (stromal) cells (ASCs)...
Article
Aims Given the utility of ultrasonography in assessing pressure injury, some ultrasonographic findings have already been used as indicators of deep tissue pressure injury. Despite reports showing that a cloud-like ultrasonographic pattern reflected the presence of deep tissue necrosis, identifying cloud-like patterns was difficult given the presenc...
Article
The repair of a total lip defect and reconstruction of the vermilion border of the lip is challenging. Here, the authors report the successful functional and esthetic reconstruction of an injured upper lip using a free radial forearm flap and labia minora peripheral skin graft. A 43-year-old woman accidentally fell, resulting in a full-thickness wo...
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Full-text available
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence-based medicine (EBM) techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were de...
Article
Full-text available
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety and systematizing treatment, employing evidence‐based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQ) were decided ba...
Article
Full-text available
The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine (EBM) techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were de...
Article
For optimal wound bed preparation, wound debridement is essential to eliminate bacterial biofilms. However, it is challenging for clinicians to determine whether the biofilm is completely removed. A newly developed biofilm detection method based on wound blotting technology may be useful. Thus, we aimed to investigate the effect of biofilm eliminat...
Article
In vivo genome editing represents a powerful strategy for both understanding basic biology and treating inherited diseases. However, it remains a challenge to develop universal and efficient in vivo genome-editing tools for tissues that comprise diverse cell types in either a dividing or non-dividing state. Here, we describe a versatile in vivo gen...
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Full-text available
Cutaneous ulcers are a common cause of morbidity. We have developed a de novo epithelialization method for treating cutaneous ulcers by means of reprogramming wound-resident mesenchymal cells in vivo into cells able to form a stratified epithelium: induced stratified epithelial progenitors (iSEPs). Administration of 4 transcription factors (DNP63A,...
Article
A biofilm plays a crucial role in delaying wound healing. Sharp debridement, a possible effective method for eliminating biofilms, can only be applied to the wound with visible necrotic tissue; thus, no option has been available for eliminating biofilms that are not accompanied by necrotic tissue. Wound blotting was recently developed to visualize...
Article
We report a rare case of a 37-year-old man who presented with a huge arteriovenous malformation in the head and neck region. After resection, the 30 × 25 cm defect was reconstructed with a preexpanded musculocutaneous latissimus dorsi flap. The facial nerve had to be sacrificed during the resection, and smile reanimation was restored in a second op...
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Full-text available
A 13-month-old infant weighing 8.3 kg with a height of 72.3 cm visited our hospital for surgical resection of facial vascular malformation detected at birth. Because we anticipated the patient would have difficult airway management and massive perioperative bleeding, we postponed surgery to discuss the appropriate timing and general anesthesia appr...
Article
Background: The investigation of primary cells from a pathological lesion can elucidate the pathogenesis of diseases, but, for vascular malformations in humans, such basic research is still stagnant, because the isolation and culture of vascular endothelial cells (ECs) is very difficult. To obtain a sufficient amount of ECs from venous malformation...
Article
For the treatment of skull defect compensation after neurosurgery, a customized artificial bone is often employed owing to its toughness and the relative ease of producing cosmetically good result. However, implants are vulnerable to infection and removal of implant is sometimes necessary. Several other treatment options such as autologous bone gra...
Article
Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has not been directly demonstrated in vivo. Here, we report that partial reprogramming by short-term cyclic expression of Oct4, Sox2,...
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Full-text available
Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical applications. Despite rapid advances in the field, in vivo targeted transgene integration is still infeasible because current tools are inefficient, especially for non-dividing cells, which compose most adult tissues. This po...
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Background Fingertip replantation has become a standard operation for well-experienced microsurgeons, but naturally there are some unsuccessful cases. Furthermore, younger surgeons need experience with this procedure, as replantations are often an emergency operation and experts may not be available to attend. Therefore, we reviewed our cases to de...
Article
In lower eyelid reconstruction, several types of grafts from the nasal septum, ear cartilage, buccal mucosa, and hard palate mucosa have been used for an inner layer of the lower eyelid, but there have been no studies comparing these grafts. The authors retrospectively reviewed our cases of lower eyelid reconstruction, and compared chondromucosal g...
Article
The relationship between atrial fibrillation (AF) and flap survival has not been fully characterized. Therefore, the goal of this study was to investigate the effect of AF on survival areas of pedicled flap and survival rates of free flap in an experimental rat AF model.An aconitine-induced rat AF model was established without intubation anesthesia...
Article
Purpose: The purpose of this study was to perform continuous StO2 monitoring of rat island flaps during pedicle vessel occlusion using near-infrared spectroscopy (NIRS) in order to collect experimental data for StO2 flap monitoring under optimized conditions. Materials and methods: Twenty rats were used in this study. The 3 × 3 cm(2) epigastric...
Article
We reconstructed fingertip defects using the partial second toe pulp free flap technique as described by Lee et al, in 2008, with minor modifications. In all 8 cases, the flap remained viable with satisfactory cosmetic and/or functional outcomes. Callus formation with contraction was observed at the donor site in 2 cases. Although free flap transfe...
Article
Adiponectin has been shown to play a critical role in immunity. Recently, we reported that the adiponectin levels after allogeneic stem cell transplantation (SCT) were higher in recipients with chronic graft-versus-host disease (cGVHD). However, the effects of adiponectin on extracellular matrix (ECM) and regulatory factors in dermal fibroblasts re...
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To date, nerve stumps have been dissected at the proximal side of the donor muscle for reinnervation of the muscle in free neurovascular muscle transfer. Herein, we examined the use of the distal thoracodorsal nerve, dissected from the muscle belly at the distal side of the latissimus dorsi muscle, for the reinnervation of muscle. The rat right lat...
Article
Background: Although bleaching treatment using all-trans retinoic acid (RA) and hydroquinone (HQ) improves epidermal melanosis, the application of two medications and the irritant dermatitis induced by RA inconvenience patients. To overcome these problems, we developed a silicone sheet containing RA and HQ. Objective: To compare the efficacy of...
Article
A 2-year-old girl presented to us with a bluish pigmented patch on her palm that had been present since she was 10 months old. She had no family history of pigmentary disorder. Histopathological examination revealed that elongated dendritic cells containing melanin granules were scattered in the dermis. We diagnosed the pigmentation as an aberrant...
Article
We experienced three patients with long-standing unilateral complete facial paralysis who previously underwent temporalis muscle transfer to the cheek for smile reconstruction. All patients complained of insufficient and uncomfortable buccal motion synchronised with masticatory movements and incomplete eyelid closure with ptotic eyebrow. To attain...
Article
Permanent make-up by tattooing on the face has become popular to save time and maintain a made-up face. However, according to the popularity of tattooing, the number of patients who want to remove their tattoos is also increasing because of disappointing tattoo designs or colors. To remove the original tattoo for permanent make-up, tattoo artists r...
Article
Among the various types of vascular malformations, arteriovenous malformations (AVMs) feature a wide range of clinical presentations and an unpredictable course. Surgical radical resection is supposed to be one of the most ideal therapeutic options ; however, it is often difficult due to the possibility of uncontrollable bleeding, functional distur...
Article
Complex regional pain syndrome (CRPS) is experienced as symptoms such as severe pain, swelling, articular contracture, and atrophic changes of the skin. The pathogenesis of the condition is not fully understood. Among the 74 cases of patients who underwent finger replantation and succeeded in fingers being salvaged, we experienced 3 cases of CPRS....
Article
Background: Neurovascular free muscle transfer is one of the main reconstructive options for established or long-standing facial paralysis. The two-stage gracilis muscle transfer combined with the cross-face nerve graft (two-stage method) has been supplanted by one-stage reconstruction using the latissimus dorsi muscle (LD) at our institution. Thi...
Article
Full-text available
The minimally-invasive nature of sclerotherapy makes it one of the first treatment options for venous malformations, although treatment-related complications, such as peripheral nerve paralysis, have been reported in some clinical cases. However, no studies of the aetiology of the detrimental effects of intraluminally-administered sclerotic agents...
Article
Sclerotherapy is useful for the treatment of arteriovenous vascular malformations. However, intravascular administration of sclerotic agents into small arteriovenous niduses is often difficult. Extravascular administration of sclerotic agents causes reduction of vascular flow on Doppler echo during clinical sclerotherapy. Therefore, we aimed to inv...
Article
Full-text available
Clinically, wounds on the face tend to heal with less scarring than those on the trunk, but the causes of this difference have not been clarified. Fibroblasts obtained from different parts of the body are known to show different properties. To investigate whether the characteristic properties of facial and trunk wound healing are caused by differen...
Article
: One issue in the adoption of autologous fat transfer to the breast is concern over mammographic changes that may obscure cancer detection. The authors compared mammographic changes following fat grafting to the breast with changes seen after breast reduction. : Twenty-seven women who had normal preoperative mammograms were treated with fat grafti...
Article
Dermal fibroblasts (DF) obtained from the superficial dermal layer and those from the deep dermal layer have different cellular functions. These differences are often associated with excessive scarring; they also influence early wound healing. We therefore investigated the differences between superficial and deep dermal fibroblasts with special emp...
Article
Percutaneous sclerotherapy is an effective therapeutic option for the treatment of venous malformations. Absolute ethanol is used as a sclerotic agent because of its effectiveness but is often avoided for treatment of superficial lesions because of the possible risk of cutaneous necrosis. A preclinical experimental study was performed to validate w...
Article
Between several therapeutic options, percutaneous sclerotherapy, an injection of sclerotic agents with a direct puncture of the lesion, is the preferred treatment for venous malformation because of its effectivenss and low invasiveness. However, sclerotherapy often has little effect on venous malformation located in the lip. We report two cases of...
Article
From the 1970's, microsurgery techniques have progressed remarkably and replanting an amputated finger is now a standard operation. The fundamental operative techniques and perioperative management are described in this article. Our original techniques are also reported, especially in finger tip replantation, which is still difficult. In replantati...
Article
Full-text available
The aim of this study was to investigate the possible pathological relation between mechanical stress and hyperpigmentation. We did this by investigating the influence of cyclic stretch on the expression of keratinocyte- and fibroblast-derived melanogenetic paracrine cytokines in vitro. Using primary human keratinocytes and fibroblasts, alterations...
Article
We present a case of a rapidly expanded hematoma in the thoracic region under the pectoral major muscle without previous specific bleeding disorders or injuries. The bleeding reappeared after the hospitalization and the vitals were influenced by sudden hemorrhage. After the re-bleeding, the symptoms, swelling and pain were well-retrieved with compr...
Article
Full-text available
Thread lifting has become popular as a minimally-invasive suspension procedure, but there is little basic and clinical evidence in the literature on the long-term effects. The authors investigate the effects of two types of lifting threads in a rat model over the course of seven months. The dorsal skin of 18 Wistar rats was implanted with a 20-mm f...
Article
We experienced severe post-inflammatory hyperpigmentation of groin flap that was transferred for the release of post-burn neck contracture. Inconsistency of the color between flap and recipient skin caused significant cosmetic problems. In order to improve the discoloration of the flap, combined therapy using Q-switched ruby (QSR) laser and bleachi...