Masahiko Hara

Masahiko Hara
Shimane University · Center for Community-based Healthcare Research and Education

MD, PhD

About

107
Publications
9,300
Reads
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1,305
Citations
Citations since 2017
63 Research Items
998 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Additional affiliations
April 2019 - present
Shimane University
Position
  • Professor
December 2017 - present
Shimane University
Position
  • Professor
April 2016 - September 2016
Osaka University
Position
  • Specially Appointed Researcher

Publications

Publications (107)
Article
Full-text available
回復期リハビリテーション(回復期リハ)医療では急性期の専門的治療を終え病状が安定した患者に対して、多職種が協同して心身機能の回復や生活活動レベルの改善を図り、患者の社会、家庭への復帰を目的とした様々な取り組みが行われる。一方で超高齢社会の本邦においては回復期リハ医療の主たる対象疾患である脳血管障害等の患者が増加することは想像に難くなく、財政のひっ迫に対して医療費抑制政策をとらざるを得ない状況となっている。それに伴い2006年4月の診療報酬改定でこれまで無期限であった国民皆保険制度下でのリハビリテーション(リハビリ)に日数制限が設けられ、2016年の診療報酬改定では回復期リハ病棟入院料取得の施設基準として効果的かつ効率的な質の高いリハビリの実施が要件として加わった。施設基準要件は2年ごとの診療...
Article
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Background Persistent postural-perceptual dizziness (PPPD) is a newly defined disorder characterized by functional dizziness. Due to its recent discovery, definitive treatment for PPPD has not been established; therefore, this study aimed to assess the effectiveness of virtual reality (VR)-guided, dual-task, trunk balance training for the managemen...
Article
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OBJECTIVE Postoperative atrial fibrillation (POAF) after cardiac surgery is associated with increased mortality. The efficacy of landiolol hydrochloride for POAF prevention after coronary artery bypass grafting and valve surgery has been reported. However, little evidence is available on its role in POAF prevention after aortic root, ascending aort...
Article
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An aging population and declining birth rate have resulted in a significant increase in demand for healthcare and put additional burdens on healthcare professionals. Therefore, providing efficient healthcare through digital technology has become a priority. With the aim of improving treatment efficacy, we have developed the medical device, mediVR K...
Article
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Virtual reality (VR)-guided exercise therapy using mediVR KAGURA has been reported to improve gait function by extending the arm to spatial targets while sitting. We aimed to investigate toe and trunk–pelvic function and plantar sensation during gait in a postoperative patient with hallux valgus. A 60-year-old woman, whose foot deformities had impr...
Article
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Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curable treatment option for adolescent and young adult (AYA) patients with myelodysplastic syndrome (MDS). The study aim was to evaluate epidemiological data and identify prognostic factors for AYA patients with MDS undergoing allogeneic HSCT. Here, 645 patients were selected fr...
Preprint
Full-text available
Background Persistent postural-perceptual dizziness (PPPD) is a newly defined disorder of functional dizziness. Due to its recent discovery, definitive treatment for PPPD has not been established; therefore, this study aimed to measure the effectiveness of virtual reality (VR)-guided, dual-task, body trunk balance training using the mediVR KAGURA s...
Article
近年さまざまな医療分野でデジタル技術革新の事例がみられるようになっている.この流れはリハビリテーション(以下リハ)領域においても例外ではなく,特に仮想現実(virtual reality;VR)やその類似技術としての拡張現実(augmented reality;AR),混合現実(mixed reality;MR)技術に注目が集まっている.これらVR,AR,MR は,リハ領域ではヘッドマウントディスプレイ(HMD)等を用いて視覚および聴覚情報を提供する装置を指すことが多い.本稿では特に応用事例の多いVR に注目しつつ,筆者らが大阪大学との産学連携活動を通して開発したリハ用VR 医療機器「mediVR カグラ」の概要から適応および臨床効果,ならびに各種症状の改善機序等に関する理論根拠を示したい.
Article
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Fludarabine and a myeloablative dose of busulfan (Flu/Bu4) can improve prognosis after allogeneic hematopoietic stem cell transplantation (HSCT) with melphalan (Mel). We investigated the prognostic impact of adding Mel to Flu/Bu4 by comparing between Flu/Bu4/Mel and Flu/Bu4 groups. This study included 846 propensity score (PS)-matched patients who...
Article
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Objective Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients. Design Observational study. Setting This study included patients with AS from a Japanese multicentre registry who...
Article
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Background Prediction of atrioventricular block (AVB) resolution after steroid therapy in patients with cardiac sarcoidosis (CS) is difficult. Methods We identified 24 patients with CS and complete or advanced AVB receiving steroid therapy. AVB resolution was assessed by reviewing surface electrocardiogram and the percentage of ventricular pacing...
Article
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◎ 仮想現実(VR)技術の医療応用は30 年以上の歴史があるものの,その効果はきわめて限定的であった. ◎ われわれは大学での産学連携活動を通して,まったく新しいアプローチのVR リハビリテーション用医療機器の開発に成功した. ◎ このVR 機器「mediVR カグラ Ⓡ」は歩行(姿勢)・上肢・認知・内耳機能障害および疼痛の改善手段として応用が進んでいる. ◎ 近年では病院などでのリハビリテーションにおける新型コロナウイルス感染症対策としても注目されており,また遠隔リハビリテーション機器としての応用も進められている.
Article
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Objectives Patients with haemoptysis often experience daily physical and mental impairment. Bronchial artery embolisation is among the first-line treatment options used worldwide; however, no evidence exists regarding the health-related quality of life (HRQoL) after bronchial artery embolisation. Therefore, this study aimed to evaluate the effects...
Article
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The 4-Fr catheter system is not recommended for invasive functional assessment of coronary artery stenosis, because it tends to distort the aortic waveform. This study aimed to identify the incidence of aortic waveform distortion and a feasible method for correct diagnosis of coronary artery stenosis with a 4-Fr catheter. We retrospectively investi...
Article
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Background Delirium is associated with high mortality after cardiac surgery. However, evidence on the epidemiology of delirium in patients with acute decompensated heart failure (ADHF) is limited. This study aimed to assess the incidence and prognostic impact of delirium in patients with ADHF. Methods This single-center prospective observational s...
Article
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Background/purpose: Hamstring tendon autografts are commonly used for double-bundle anterior cruciate ligament reconstruction (DB-ACLR). If the volume of the semitendinosus (ST) tendon is insufficient, the gracilis (G) tendon is also harvested. Additional harvesting of the G autograft can affect patients' short-term postoperative outcome, such as...
Article
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Aims: Acute decompensated heart failure (ADHF) can occur early after transcatheter aortic valve implantation (TAVI), but the risk factors or mechanisms associated with it have not been fully determined. This hypothesis-generating study aimed to investigate the clinical indices associated with the development of ADHF within 72 hours after TAVI and t...
Article
Background: Fractional flow reserve (FFR) derived from coronary CT angiography (FFRCT) values were recently recommended to be measured 1-2 cm distal to the stenosis for clinical decision making given potential overestimation of ischemia by FFRCT values at far-distal segments, though supporting data is lacking. Objective: This study evaluated the di...
Article
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仮想現実(virtual reality, VR)技術は医療現場ではヘッドマウントディスプレイ(head mounted display, HMD)を装着することで視覚及び聴覚情報を置き換える装置を指すことが多い(図1)。近年, リハビリテーション領域におけるVR技術の応用事例に関する報告が増えている。本邦においても, 大阪大学における産学連携活動によって生まれたリハビリテーション用VR医療機器(mediVRカグラ🄬, 株式会社mediVR, 豊中市, 日本)の販売が2019年3月から開始となる等, 今後益々VR技術の医療現場における応用が進むことが期待される。本コラムでは, VR技術の慢性疼痛患者に期待される効果を中心にその医学的理論根拠を解説する。
Article
株式会社mediVR では仮想現実技術を用いたリハビリテーション支援用医療機器の開発及び製造販売を行っている。本特集ではニーズの掘り起こしから開発理論,上市から臨床効果に至るまでの弊社の取り組みを紹介することによって,読者が医療機器開発の一連の流れを理解し,医工連携活動を行う際の一助となるような情報提供を行いたい。
Article
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Background:The Japanese Ministry of Health, Labour and Welfare has tried to promote telemedicine since 2018, but faces difficulties in increasing the use of telemedicine partly due to a lack of clinical evidence. This study investigated the disease control status and safety of telemedicine, which, in Japan, is provided under the National Health Ins...
Article
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理学療法士の未来が変わる.そんなことを感じさせる医療機器が登場した.仮想現実(virtual reality:VR)技術を応用して歩行に必要な姿勢バランスと二重課題型の認知処理能力を定量的に可視化し,セラピストがより適切に治療介入を行えるようにしたリハビリテーション用医療機器「mediVRカグラ」の導入施設が増えている. mediVRカグラは,座位で行うトレーニングで歩行機能が改善することが最大の特徴で,一見するとごく一般的なVRゲームのようにしか見えないが,その開発に神経内科医や理学療法士,作業療法士が深く関与している点が既存のVR製品とは明確に異なる.その結果はまさに目を見張る効果であり,姿勢バランス制御系の脳内モデルの再構築だけでなく,これまで改善が難しかった注意障害を中心とした認知機...
Article
Introduction Fludarabine and a myeloablative dose of intravenous busulfan with or without total body irradiation (Flu/Bu4) is a widely accepted myeloablative conditioning regimen with reduced toxicity for allogeneic hematopoietic stem cell transplantation (HSCT) that has been able to expand the indications for allogeneic HSCT while maintaining the...
Article
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Hangovers are associated with negative economic consequences due to decreased job performance or frequent visits to physicians. Thus, a new strategy for the alleviation of hangover-related symptoms is needed to avoid this detriment to the society. The purpose of this nationwide randomised, double-blind, placebo-controlled physicians’ trial was to e...
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Herein, we report two cases of erratic coil migration from the bronchial artery to the bronchus after bronchial artery embolization (BAE). Neither patient exhibited haemoptysis recurrence, but chest radiographs revealed that part of the coil had disappeared. In Case 1, the patient coughed up the coil 4.5 years after BAE. We performed repeat BAE to...
Article
Pre-procedural valvuloarterial impedance (Zva) is considered as a useful predictor of mortality in patients diagnosed as having severe aortic stenosis (AS) who undergo transcatheter aortic valve implantation (TAVI). However, the prognostic significance of post-procedural Zva remains unclear. We aimed to evaluate the prognostic significance of Zva a...
Article
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Background: Virtual reality (VR) technology has been recently introduced in a variety of clinical settings, such as physical, occupational, cognitive, and psychological rehabilitation or training. However, the clinical efficacy of VR rehabilitation compared with traditional training techniques remains to be elucidated. Case: A 90-year-old man un...
Article
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Background Reduced muscle strength and physical performance are prevalent in patients of maintenance hemodialysis (MHD), and deleterious changes in these parameters are associated with increased mortality. Methods This retrospective observational study included 306 patients, who received a 6-month resistance exercise program during hemodialysis, t...
Article
Objectives In this study, we sought to investigate the association between revolution speed of rotational atherectomy (RA) and debulking area assessed by frequency domain‐optical coherence tomography (FD‐OCT). Background The number of patients with severe calcified coronary artery disease requiring treatment with calcium ablation, such as RA, is i...
Preprint
Though second allogenic haematopoietic stem cell transplantation (HSCT) is considered a curative treatment option after myelodysplastic syndrome (MDS) relapse, scant epidemiological data are available. We investigated the outcomes and prognostic factors of second allogenic HSCT in 99 patients with MDS who relapsed after the first HSCT. The median a...
Article
Objectives The objective was to evaluate the safety, feasibility, and accuracy of the jailed‐pressure wire technique using a durable optical fiber‐based pressure wire with high‐pressure dilatation using a non‐compliant balloon after main vessel stenting. Background Fractional flow reserve (FFR) information can help interventionists determine wheth...
Article
Background: Little evidence is available regarding the risk of peri-procedural stroke detected by diffusion-weighted magnetic resonance imaging (DW-MRI) after transcatheter aortic valve replacement (TAVR). Our purpose was to evaluate stroke risk after TAVR using DW-MRI by enrolling consecutive patients who underwent transfemoral TAVR and post-proc...
Article
nts Introduction Myelodysplastic syndrome (MDS) is clinically and biologically heterogeneous. Although the pathobiology of MDS is complex and not fully understood, the development of MDS involves a series of genetic changes, which influence hematopoietic growth and differentiation, resulting in the accumulation of abnormal cells and the impairment...
Article
Introduction Myelodysplastic syndrome (MDS) represent a group of clonal myeloid stem cell disorder with a heterogeneous spectrum of presentation. Although allogeneic hematopoietic stem cell transplantation (HSCT) was the well-studied and only curative treatment option for patients with MDS, relapse remains a major drawback like other hematological...
Article
Objectives Novel automated computed tomography (CT) software (Valve ASSIST 2) has been developed for transcatheter aortic valve implantation (TAVI), which not only provides three‐dimensional (3D) reconstruction of multidetector (MD) CT images, but also enables intraprocedural real‐time fusion of fluoroscopic and MDCT images. We aimed to clarify the...
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Objective: The ability to walk is one of the most important basic functional activities of daily living, and the number of patients with walking disability who need rehabilitation is increasing worldwide. The purpose of this first-in-man study was to evaluate the safety and feasibility of an off-label, tailor-made, dual-task rehabilitation program...
Article
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Objectives The aim of this study was to investigate the 2-year prognostic impact of N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at discharge following transcatheter aortic valve implantation (TAVI). Design Multicentre prospective observational study. Settings Seven institutions from multicentre, observational registry of symptoma...
Article
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Objectives: In recognition of the significant impairment caused by haemoptysis on a patient's quality of life, bronchial artery embolisation has been introduced worldwide as one of the first-line treatment options. Since little evidence is available on the mechanisms of recurrent haemoptysis after super-selective bronchial artery coil embolisation...
Article
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Primary graft failure can be a cause of early morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT), as it leads to a high risk of severe infections and bleeding. Splenomegaly is associated with primary graft failure in patients of myelofibrosis, but the association between splenomegaly and outcomes after HSCT in p...
Article
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The representation of women in Japanese academic medicine is not evident. We aimed to assess trends related to the proportion of female first authors in Japanese cardiovascular journals. We reviewed original research articles in 6 journals published in English by Japanese societies between 2006 and 2015 related to cardiovascular fields. We conducte...
Article
Goals: The purpose of this study was to investigate and summarize our experience of a standardized strategy using computed tomography (CT) followed by colonoscopy for the assessment of colonic diverticular hemorrhage with focus on a comparison of CT and colonoscopy findings in patients with colonic diverticular hemorrhage. Background: Colonic di...
Article
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Background Six risk factors for screw cutout after internal fixation of intertrochanteric fractures have been reported. The purpose of the present study was to evaluate and compare the impact of the 6 risk factors of screw cutout to clarify the most important one. Methods We enrolled 8 consecutive patients who had screw cutout and 48 random contro...
Article
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Background Even with abundant evidence for osmotic demyelination in patients with hyponatremia, the risk factors for overcorrection have not been fully investigated. Therefore the purpose of this study is to clarify the risks for overcorrection during the treatment of chronic profound hyponatremia. Methods This is a single-center retrospective obs...
Article
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Objective: There is no detailed information available about trend in the morphological change after conservative medical treatment in patients with symptomatic spontaneous isolated superior mesenteric artery dissection (SISMAD). Methods: We enrolled 27 consecutive patients with symptomatic SISMAD who underwent conservative medical treatment betw...
Article
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Background The International Liaison Committee on Resuscitation (ILCOR) periodically updates the consensus recommendations for cardiopulmonary resuscitation to improve the outcomes of out‐of‐hospital cardiac arrest (OHCA). However, little is known about the differences in outcomes of witnessed OHCA following the publication of the ILCOR 2010 and th...
Article
Background Little is known about the recent proportion and trends of randomised controlled trials (RCTs) published in Japanese cardiovascular journals. Methods and results This study retrospectively reviewed all original research articles published between 2006 and 2015 in six English-language journals issued by societies related to cardiovascular...
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Background: Idiopathic spinal subarachnoid hemorrhage (IS-SAH), defined as spinal SAH without apparent cause, is extremely rare. The objective of the present study was to establish a consensus on the diagnosis and management of IS-SAH. Methods: We enrolled 5 consecutive cases of IS-SAH at our institution, and we enrolled 19 previously published...
Article
There are very few epidemiological studies on Japanese patients with deep vein thrombosis (DVT). In particular, mortality rate differences in Japanese DVT patients with and without malignancy have rarely been evaluated. To elucidate these differences, we enrolled 211 patients who had been diagnosed with de-novo acute DVT of the pelvis or lower extr...
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Background In this study, we sought to investigate the 2‐year prognostic impact of B‐type natriuretic peptide (BNP) levels at discharge, following transcatheter aortic valve replacement. Methods and Results We enrolled 1094 consecutive patients who underwent transcatheter aortic valve replacement between 2013 and 2016. Study patients were stratifi...
Article
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Background/purpose: The efficacy of low-dose trimethoprim-sulfamethoxazole (TMP-SMX) may be acceptable for the treatment of pneumocystis pneumonia (PCP) in non-human immunodeficiency virus (HIV)-infected patients, with a low incidence of adverse reactions. This study is aimed to evaluate the efficacy and safety of such a regimen for the treatment...
Article
Predicting severe acute GvHD (aGvHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is challenging but critical. Mild aGvHD may have a favorable impact on relapse, whereas severe aGvHD is associated with poor outcomes. The aim of this study was to evaluate whether elevated eosinophil count in the bone marrow (BM) at 1 month after H...
Article
Objectives: The aim of this study was to compare the ability of conventional versus computed tomography angiography (CTA) to predict procedural success and 30-min wire crossing rates in percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) lesions. Background: Coronary CTA can be used to assess the morphology of CTO lesions....
Article
Allogeneic stem cell transplantation (SCT) from an HLA-matched sibling donor (MSD) is a post-remission treatment that offers a potential cure for adults with cytogenetically normal acute myeloid leukemia in their first complete remission (CN-AML/CR1). However, the best alternative in the absence of an MSD remains unclear. The aim of this study was...
Article
Using a novel combined angiography-computed tomography (CT) system, we evaluated the impact of the intra-aortic root position of a right coronary artery (RCA) catheter on its coaxiality. We retrospectively enrolled 19 patients who underwent CT scans during bilaterally engaged percutaneous coronary intervention (PCI). Coaxiality was defined as the a...
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Objectives: Evidence on the safety and long-term efficacy of super-selective bronchial artery embolization (ssBAE) using platinum coils in patients with hemoptysis is insufficient. The objective of the present study was to evaluate the safety and the 3-year post-procedure hemoptysis-free survival rate of de-novo elective ssBAE using platinum coils...
Article
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Background: Balloon aortic valvuloplasty (BAV) is resurging as a bridge treatment in patients with severe aortic stenosis (AS) with a dissemination of transcatheter aortic valve implantation. However, the significantly high periprocedural mortality and complication rates still limit the indications of BAV. Further efforts are needed to improve the...
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Aims To evaluate and compare outcomes and impacts of delay of time to cardiovascular resuscitation (CPR) by type of first documented rhythm in pediatric patients with out-of-hospital cardiac arrest (OHCA). Methods and Results We enrolled 3,968 pediatric (aged<18 years) OHCA patients whose events were witnessed between 2005 and 2012 from a prospect...
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Objectives: To evaluate the short-term and long-term prognostic impacts of acute phase coronary collaterals to occluded infarct-related arteries (IRA) after ST-elevation myocardial infarction (STEMI) in the percutaneous coronary intervention (PCI) era. Design: A prospective observational study. Setting: Osaka Acute Coronary Insufficiency Study (OAC...
Article
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Background: There is no definite consensus regarding the management of symptomatic isolated celiac artery dissection (ICAD), and the effect of conservative medical treatment has never been evaluated. Methods and Results: We enrolled 13 consecutive symptomatic ICAD patients without signs of arterial rupture between 2006 and 2015. All patients receiv...
Article
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Although allogeneic hematopoietic stem cell transplantation from an HLA-matched sibling donor (MSD) is a potentially curative post-remission treatment for adults with acute myeloid leukemia (AML) in their first CR, transplant-related morbidity and mortality remains a major drawback. We retrospectively compared the outcomes of patients who underwent...
Article
Background: Previous studies indicated that the three-dimensional features of the mitral valve (MV) have a significant impact on MV disease. However, quantification of MV with manual tracing software was too time-consuming for routine clinical practice. This study was performed to investigate the efficacy and accuracy of MV quantification with a n...
Article
Background: It is unclear whether risk factors for bleeding and discontinuation are different between dabigatran and rivaroxaban. Methods and results: We enrolled consecutive patients with atrial fibrillation who received dabigatran or rivaroxaban, had a CHADS2 score >1 and creatinine clearance >30ml/min. During this period, only dabigatran and...
Article
Background: It is unclear whether serum high-sensitive troponin T (hs-TnT) levels at the convalescent stage of ST-elevation myocardial infarction (STEMI) are associated with long-term mortality. Methods: This study enrolled a total of 2944 consecutive STEMI patients who were registered in the Osaka Acute Coronary Insufficiency Study between 2000 an...