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Publications
Publications (65)
Background and aims:
As reported, hypertension (HTN) plays a leading role in explaining mortality worldwide, but it still has many confounding factors. This study explored whether the number of parity and age matters for HTN among couples from the Tehran Lipid and Glucose Study (TLGS).
Methods:
This study was conducted on 2851 couples from TLGS....
Background
Despite the many signs of progress in pharmacotherapies, metabolic syndrome (MetS) is one of the main public-health burdens worldwide. Our study aimed to compare the effect of breastfeeding (BF) in women with and without gestational diabetes mellitus (GDM) on MetS incidence.
Methods
Of females who participated in the Tehran Lipid and gl...
Objective:
Thyroid dysfunction and TPOAb positivity during pregnancy are associated with adverse pregnancy outcomes such as preterm delivery. The aim of this study was to predict preterm delivery based on identified risk factors, especially TPOAb levels.
Study design:
A secondary analysis was run on data collected in the Tehran Thyroid and Pregn...
PurposeDespite the beneficial effects of levothyroxine (LT4) therapy on pregnancy outcomes of women with subclinical hypothyroidism (SCH), its impact on the developmental status of offspring remains unclear. We aimed to assess the effects of LT4 therapy on the neurodevelopment of infants of SCH women in the first 3 years of life.MethodsA follow-up...
Objectives
There is considerable worldwide controversy regarding optimal screening and diagnostic approaches for GDM. This study aimed to compare the prevalence, maternal and neonatal outcomes of a One-step with a Two-step approach for the screening and diagnosis of GDM in a large community sample of pregnant women.
Methods
We conducted a secondar...
Despite solid evidence regarding the association of over-hypothyroidism with polycystic ovary syndrome (PCOS), the relationship between PCOS and subclinical hypothyroidism (SCH) is still a topic of debate. In the present population-based study, we aimed to assess if there is a difference between PCOS and the control group regarding the upper refere...
Background
Data is inconsistent and, for the most part, not sufficient to demonstrate the association between serum Prolactin (PRL) concentration within the physiologic range and the incidence rate of type 2 Diabetes Mellitus (DM) among men. Moreover, since both PRL and type 2 DM are associated with reproductive hormones, investigating these hormon...
Abstract Background C-peptide offers potential as a marker to indicate childhood metabolic outcomes. Measuring C-peptide concentration might have better future utility in the risk stratification of neonates born to overweight or diabetic mothers. Prior research has tried to bring this matter into the light; however, the clinical significance of the...
Background:
A limited number of studies have investigated the impact of idiopathic hirsutism (IH) on cardio-metabolic parameters with contradictory and inconclusive results. This study aimed to explore the effect of IH on metabolic outcomes.
Method:
In this population-based prospective study, 334 women with IH and 1226 women as healthy controls...
We aimed to compare the ovarian reserve of rats exposed to oral D‐galactose during prenatal and early life with rats exposed to D‐galactose only during the prenatal period. Fifteen female pregnant Wistar rats were randomly divided into three groups. The first and second groups were fed a D‐galactose enriched diet (35%) from the third day of pregnan...
Background
Unlike overt thyroid diseases, the impacts of subclinical thyroid dysfunction, especially subclinical hyperthyroidism (SH), on adverse pregnancy outcomes are inconclusive.
Objective
We aimed to investigate the effect of maternal SH on adverse maternal and neonatal outcomes based on urinary iodine concentration (UIC).
Methods
A secondar...
Background:
There is limited evidence regarding the impact of pregnancy loss on the subsequent risk of metabolic disorders. We aimed to investigate whether history of pregnancy loss is associated with the subsequent risk of prediabetes (pre-DM), diabetes (DM), and metabolic syndrome (METs) among couples.
Method:
In this population-based cohort s...
Background:
Embryonic life is critical for the formation of ovaries in mammals, and the intrauterine environment may affect ovarian reserve.
Objectives:
The present study aimed to investigate the impact of prenatal D-galactose exposure on ovarian reserve in female rat offspring in their later lives.
Methods:
Ten pregnant Wistar rats were rando...
Context
Although it is well documented that estrogen hormone is positively associated with bone mineral density and lower risk of fracture, there are limited studies on the association between duration of endogenous estrogen exposure (EEE) and fracture, especially by longitudinal design.
Objective
This study aimed to investigate the relationship b...
PurposeThere are conflicting results about the effects of maternal hypothyroidism (IMH) on adverse pregnancy outcomes. This study aimed to investigate the relationship between IMH identified in the first trimester of gestation and adverse pregnancy outcomes.Methods
In this prospective cohort study, we used data from the Tehran Thyroid and Pregnancy...
Context:
Although it is well-acknowledged that gestational diabetes mellitus (GDM) is associated with the increased risks of adverse pregnancy outcomes, the optimal strategy for screening and diagnosis of GDM are still a matter of debate.
Objective:
This study was conducted to demonstrate the non-inferiority of less strict GDM-screening criteria...
Purpose
Polycystic ovary syndrome (PCOS) and hyperprolactinemia are the most frequent endocrine disorders in women which share several common features. There are inconsistent results regarding the existence of a possible pathophysiological interplay between these endocrinopathies and the elevation of prolactin (PRL) in PCOS. The purpose of this stu...
Objectives
The aim of the present study was to evaluate the prevalence of polycystic ovary syndrome (PCOS), its phenotypical and cardio-metabolic features in a community sample of the Iranian population in comparison to healthy eumenorrheic, non-hirsute women without polycystic ovaries. The second aim was to assess the cardio-metabolic characterist...
Sir,
We read with interest the recent publication in Human Reproduction by Bell et al. (2021) on the substituting of serum anti-Müllerian hormone (AMH) levels instead of polycystic ovary morphology (PCOM) for making the diagnosis of polycystic ovary syndrome (PCOS). This study has a cross-sectional design with 163 participants aged 18–39 years, rec...
PurposeAdverse intrauterine environment may predispose offspring to cardio-metabolic dysfunction in later life. In this study, we aimed to investigate the effects of maternal hyperandrogenism (MH) on cardio-metabolic risk factors in female offspring in later life.Methods
This prospective population-based study included 211 female offspring with MH...
Background:
Pneumatic balloon dilation (PBD) is a first line treatment for idiopathic achalasia. Here we report the safety and efficacy of graded gradual PBD on short and long-term follow-up.
Methods:
We evaluated 1370 idiopathic achalasia patients over a period of 24 years (1994-2018), prospectively. 216 patients did not undergo PBD due to como...
Objective
This study was carried out to determine whether chronic diseases can influence age at natural menopause (ANM).
Study design and main outcome measures
This population-based prospective study recruited all eligible women from participants in the Tehran Lipid and Glucose Study (TLGS). The Cox proportional-hazards model (unadjusted and adjus...
Background
The existing data regarding the impact of Polycystic Ovary Syndrome (PCOS) on the risk of developing cardiovascular disease (CVD) are conflicting.
Aim
To explore the effect of PCOS status on the occurrence of silent coronary artery disease (CAD)/CVD.
Methods
A total of 1591 women without CVD at baseline, aged 18–45 years, including 356...
Background:
Following menopause, the risk of many diseases is increased, and this situation may be due to changes in anthropometric indices (AI), while the association between adiposity and age at natural menopause (ANM) is not clear yet.
Objectives:
This longitudinal study was conducted to investigate the ability of AI in predicting ANM.
Metho...
PurposeAging is associated with significant changes in fat distribution and menopause may alter this process. This study aimed to investigate the longitudinal effect of menopause on changes in adiposity indices (AI).MethodsA total number of 3876 non-menopausal women, aged > 20 years, who participated in the Tehran Lipid and Glucose study, were sele...
Cox model and traditional frailty models assume that all individuals will eventually experience the event of interest. This assumption is often overlooked, and situations will arise where it is not realistic. We introduce Compound Poisson frailty model for survival analysis to deal with populations in which some of the individuals will not experien...
Background
Preterm delivery (PTD) may predict the risk of long-term maternal complications. Little is known about the association between preterm delivery and maternal risk of chronic kidney disease (CKD).This study aimed to explore whether a history of preterm delivery is associated with the risk of maternal CKD.Methods
In this population-based co...
Background:
The actions of adipocytokines may be a connective factor between obesity and polycystic ovary syndrome (PCOS). It is suggested that irisin, as recently described cytokine secreted by skeletal muscles and glucose-dependent insulinotropic polypeptide (GIP) as an incretin hormone that induces cytokine expression, may play key roles in fav...
Background
The majority of available studies on the AMH thresholds were not age-specific and performed the receiver operating characteristic curve (ROC) analysis, based on variations in sensitivity and specificity rather than positive and negative predictive values (PPV and NPV, respectively), which are more clinically applicable. Moreover, all of...
Introduction:
Despite the evidence available on the adverse impact of gestational diabetes (GDM) and thyroid disorders on developing type 2 diabetes (T2DM), the concurrent influence of these disorders on the incidence of T2DM has not been reported yet.
Methods:
In this prospective study, 1894 non-diabetic women aged 20 to 60 years, with a histor...
PurposeTo compare the effects of oral contraceptives (OCs) with different progestins, including Levonorgestrel (LNG), Desogestrel (DSG), Cyproterone Acetate (CPA), and Drospirenone (DRSP) on adipokines levels and adiposity indices in women with polycystic ovary syndrome (PCOS).Methods
In this parallel randomized clinical trial, 120 women with PCOS...
Introduction: Despite the evidence available on the adverse effects of gestational diabetes (GDM) and thyroid disorders on developing type 2 diabetes (T2DM), the concurrent effect of these disorders on the incidence of T2DM has not been reported yet.
Methods: At the initiation of the Tehran Thyroid Study (TTS) non-diabetic women aged 20 to 60 years...
Introduction: Despite the evidence available on the adverse impact of gestational diabetes (GDM) and thyroid disorders on developing type 2 diabetes (T2DM), the concurrent influence of these disorders on the incidence of T2DM has not been reported yet. Methods: In this prospective study, 1894 non-diabetic women aged 20 to 60 years, with a history o...
Introduction: Despite the evidence available on the adverse impact of gestational diabetes (GDM) and thyroid disorders on developing type 2 diabetes (T2DM), the concurrent influence of these disorders on the incidence of T2DM has not been reported yet.
Methods: In this prospective study, 1894 non-diabetic women aged 20 to 60 years, with a history o...
The recurrent event data are encountered in many longitudinal studies. In many situations, there are a non‐susceptible fraction of subjects without any recurrent events, manifesting heterogeneity in risk among study participants. The frailty models have been widely used to account for this heterogeneity that does not rely on self‐reported survival...
Background:
Although preeclampsia (PE), as an endothelial disorder can lead to renal dysfunction during pregnancy, results of studies focusing on the potential long-term potential effects of PE on renal function are insufficient and those available are controversial. This study investigated the incidence rate and risk of chronic kidney disease (CK...
Objective:
To investigate whether trends of adiposity and glucose metabolism parameters in women with low ovarian reserve status based on their anti-Mullerian hormone (AMH) levels differ from those with high ovarian reserve.
Methods:
In this population-based prospective study, eligible women, aged 20 to 50 years, were selected from among partici...
PurposeTo define reference values for various insulin sensitivity (IS) indices in healthy women in a population-based study of the five provinces in IranMethods
In this cross-sectional study, 250 normal-weighted women without hypertension, diabetes, polycystic ovary syndrome, hormonal disorders, pregnancy, or menopause were evaluated in this study....
Background: This study was conducted to evaluate the success rate of male infertility treatment and the factors affecting its outcome.
Methods: In a historical cohort study, from Mar 2013 to Mar 2014, 323 couples with male factor were investigated. Couples had treated with IUI or/and ICSI were included randomly. Assisted re-production technology (A...
Background and aims:
Today, human beings are exposed to the ELF magnetic field of electrical equipment and power lines, which can damage Leydig cells and alter the secretion of reproductive hormones. The purpose of this study was to investigate the relationship between exposure to ELF magnetic field and the level of some reproductive hormones in m...
Background and Aims: Today, human beings are exposed to the ELF magnetic
Background:
The risk of cardiovascular disease in women increases after menopause. It has been shown that women with lower pre-menopausal ovarian reserve may experience increased cardiovascular risk. We sought to determine whether there is any association between ovarian reserve, as assessed by Anti-Mullerian hormone (AMH), and preeclampsia (PE)....
Background
The risk of cardiovascular disease in women increases after menopause. It has been shown that women with lower pre-menopausal ovarian reserve may experience increased cardiovascular risk. We sought to determine whether there is any association between ovarian reserve, as assessed by Anti-Mullerian hormone (AMH), and preeclampsia (PE).
Me...
Background:
Despite existing evidence regarding the role of testosterone as a protective factor for the kidney function in male adults, there are conflicting and inconclusive results on the influence of testosterone deficiency on developing chronic kidney disease (CKD).
Objective:
This study aimed to investigate the incidence and hazard ratio of...
Background The risk of cardiovascular disease in women increases after menopause. It has been shown that women with lower pre-menopausal ovarian reserve may experience increased cardiovascular risk. We sought to determine whether there is any association between ovarian reserve, as assessed by Anti-Mullerian hormone (AMH), and preeclampsia (PE).Met...
Background The risk of cardiovascular disease in women increases after menopause. It has been shown that women with lower pre-menopausal ovarian reserve may experience increased cardiovascular risk. We sought to determine whether there is any association between ovarian reserve, as assessed by Anti-Mullerian hormone (AMH), and preeclampsia (PE).
Me...
Background:
Obese women with polycystic ovary syndrome (PCOS) may face additional barriers in achieving weight loss. We aimed to compare the effects of the hypocaloric low glycemic index (LGI) diet on anthropometric variables and insulin resistance in women with and without PCOS and investigate the effect of this diet on the clinical and hormonal...
Background:
Ovarian reserve, vital for reproductive function, can be adversely affected by thyroid diseases. Despite alternations of thyroid hormones with ageing, data on interactions between the overtime trend of thyroid functions and ovarian reserve status has rarely been reported. We aimed to examine the overtime trend of thyroid hormones, thyr...
Objectives:
To estimate the incidence of hypertension and the trend of systolic and diastolic blood pressure changes and relating factors influencing women with and without prior preeclampsia (PE).
Study design:
This prospective population based study included a total of 3022 eligible women (355 with PE and 2667 non-PE) recruited from participan...
Abstract Background Data of studies focusing on the trends of adiposity indices among women with prior gestational diabetes mellitus (GDM), are limited and controversial. The aim of this study was to compare overtime trends of adiposity indices in women with and without history of GDM, using data of the long term longitudinal population-based Tehra...
Background
The association between low testosterone concentration and increased risk of hyperglycemia in men has been demonstrated in observational and interventional studies. However, considering a variety of confounding factors, limited population‐based studies have so far been conducted. Also, no information is available regarding the effect of...
Introduction: Thyroid peroxidase antibody (TPOAb) is the main risk factor for thyroid dysfunction during pregnancy and can be a marker of these disorders during pregnancy. This study was performed with aim to evaluate the frequency of positive thyroid peroxidase antibody and its related factors during pregnancy.
Methods: This study is a secondary a...
Background:
Currently, various clinical and laboratory diagnostic methods are used to detect overt hypothyroidism during pregnancy. The Billewicz scoring index, as a clinical scale for detection of hypothyroidism, has been applied in general populations; however, its application during pregnancy remains a controversial subject of ongoing research....
Objective:
Physiological gestational changes are associated with alterations in thyroid function which require different biochemical interpretation from that of non-pregnant women and necessitate established pregnancy-specific reference ranges. We aimed to identify the trimester-specific ranges of thyroid markers in a healthy population of pregnan...
Objective: Considering the role of anti-Müllerian hormone (AMH) in female fertility and its high levels in women with polycystic ovary syndrome (PCOS), the longer reproductive span of these women is in doubt. In the present study, we aimed to improve earlier predictions using a non-linear model to substantiate the question as to whether PCOS women...
Context
Currently, there is no consensus on universal thyroid screening and Levothyroxine (LT4) treatment of subclinical hypothyroid pregnant women who are negative for thyroid peroxidase antibody (SCH-TPOAb⁻).
Objective
We aimed to evaluate the benefits of LT4 treatment on pregnancy outcomes in SCH-TPOAb⁻ women.
Design
This study was conducted w...
Purpose:
Evidence shows that patients with gestational diabetes mellitus (GDM) may exhibit features of dyslipidemic phenotype later in life. We aimed to examine and compare dyslipidemia incidence rate and the trend of lipid changes over a 15-years follow-up between the women with the history of GDM and their healthy peers.
Methods:
This longitud...
Aim:
Very few extensive follow-up investigations evaluating patients with history of gestational diabetes mellitus (GDM) have been documented. We conducted this longitudinal study to estimate the incidence of diabetes and its predictors in women with and without GDM.
Method:
A total of 2458 eligible women, aged 20-50years (476 with GDM and 1982...
Objectives:
Schizophrenia patients often experience relapses once and even more with no limit on number of relapses. The time among relapses are rarely considered in studies. The aim of this study was to identify some risk factors of time to elapses in schizophrenic patients with recurrent events model in survival analysis.
Methods:
In a retrosp...
Introduction: Schizophrenia is a severe mental disorder and one of its important features is repetition of relapses over time. The aim of this study was to identify some risk factors of relapse time in schizophrenia patients using Weibull parametric accelerated failure time frailty model in survival analysis with Bayesian approach. Materials and Me...
Projects
Projects (3)
C-peptide offers potential as an alternative marker to indicate fetomaternal metabolic outcomes. C-peptide concentration might indicate a more accurate prognosis of pregnancy complications and an improved risk stratification in neonates born to overweight or diabetic mothers. Prior research has tried to bring this matter into the light, however, the clinical significance of these associations is still far from reach. Here we sought to investigate the associations between umbilical cord blood C-peptide concentration and fetomaternal metabolic outcomes.
Although cross-sectional studies have reported a significant association between higher quartiles of serum Prolactin (PRL) concentration within the physiologic range and lower risk of type 2 Diabetes Mellitus (DM) in both sexes, and longitudinal studies have demonstrated this association among women, data is inconsistent and for the most part not sufficient to demonstrate this association among men.