Maryam Iman

The percutaneous bioavailability of naproxen is low and several technologies have been utilized to overcome the problem. Although, some studies have reported the permeation‐enhancing properties of natural essential oils, no research has reflected the effectiveness of Lavandula angustifolia essential oil (LAEO) on increasing the percutaneous absorpt...

Polyethylene terephthalate (PET) is widely used as a raw material in the manufacture of beverage bottles, packaging industries, and only after one use becomes waste. Since these types of wastes are decomposed in long term and cause environmental hazards, the issue of recycling and their reuse in the concrete industry could be accounted as a solutio...

Sulfur mustard is one of the chemical warfare agent. It rapidly reacts with the cutaneous tissues and other tissues, leading to various devastating long-term effects on human health. Mustard-exposed veterans suffer from its chronic skin problems, including itching, burning sensation, and eczema. We aimed to evaluate the protective effects of Myrtus...

Objectives: The neem (Azadirachta indica) have been used in herbal medicine for the treatment of multiple diseases, particularly cancer. The mechanism of anti-cancer properties of neem are far from clear. However, it is well accepted that anti-cancer effects of neem is mediated via its hepatic anti-oxidant activity. In the present review, we are g...

Objectives: Resveratrol as a natural polyphenolic agent can alleviate neuropathic pain symptoms. The mechanism of analgesic activity of resveratrol is far from clear. The current study examine whether analgesic activity of resveratrol is mediated by its neuroprotective and anti-oxidant activity in the neuropathic pain. We further examine whether a...

In this study, the compressive strength, ultrasonic pulse velocity (UPV), impact resistance, gamma-ray radiation shielding properties, and investigation of microstructure by scanning electron microscope (SEM) analysis of concrete specimens produced from magnetite aggregate Fe3O4 containing 0.6% of polypropylene fiber (PPF) and various percentages o...

Western blot (WB) or immunoblot is a workhorse method. It is commonly used by biologists for study of different aspects of protein biomolecules. In addition, it has been widely used in disease diagnosis. Despite some limitations such as long time, different applications of WB have not been limited. In the present review, we have summarized scientif...

The fly ash-based geopolymer concrete is composed of alkali-activated aluminosilicate and aggregates. The removal of cement from concrete plays a significant role in reducing greenhouse gases. The industrial disposal of recycled tires is an environmental issue, and using them in concrete, while maintaining its mechanical properties and employing st...

The naproxen bioavailability via percutaneous route is low, and several technologies have been used to overcome the problem. Although the permeation enhancer properties of natural essential oils have been reported, there is no study to show the effectiveness of Lavandula angustifolia essential oil on the percutaneous absorption of naproxen sodium f...

Background: To formulate a nanoemulsion (NE) from cold pressed neem oil and to compare its repellant activity with normal cold pressed oil and N,N-Diethyl-meta-toluamide (DEET) as a standard chemical compound and to improve efficacy of repellency against Anopheles stephensi, through NE formulations. Methods: In this study, complete protection time...

This paper illustrates the results of an experimental investigation on fracture characteristics and ductility of normal concrete (NC) and rubberized concrete (RC), involving the tests of 128 three-point bending specimens with different polyethylene terephthalate (PET) aggregate volumes. Generally, the parameters were analyzed by the size effect met...

In this study, the effect of various temperatures at 25, 200, 400, and 600 °C, on the mechanical and gamma ray shielding properties of heavy-weight concrete (HC) with various content of Nano Bismuth Oxide (NB) at levels of 0, 2, 4 and 6% were determined. Evaluation of gamma-ray attenuation was measured three different gamma rays energies at 662, 11...

This paper is an experimental study of the shielding performance of heavy concrete (HC) containing magnetite aggregates and different content 0%, 2%, 4% and 6% of nanoscale particles of titanium dioxide (NT), replaced by weight of cement in various temperatures cycles of 25, 200, 400 and 600 °C. Weight loss, ultrasonic pulse velocity (UPV), compres...

Objective(s) Azole antifungal agents, which are widely used as antifungal antibiotics, inhibit cytochrome P450 sterol 14α-demethylase (CYP51). Nearly all azole antifungal agents are N-substituted azoles. In addition, an azolylphenalkyl pharmacophore is uniquely shared by all azole antifungals. Due to importance of nitrogen atom of azoles (N-3 of im...

Hydrogels are among the drug delivery systems that are used to modify drug release by the oral route. Inclusion of porous nanoparticles and cellulose nanofibers (CNF) in a hydrogel matrix structure improves the mechanical strength of the hydrogel and modifies drug release. CNF have been widely used for the preparation of biomedical systems because...

Malaria is a parasitic disease mainly caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale and rarely by animal plasmodium such as Plasmodium knowlesi. Despite the worldwide endorsement of eradicating malaria, the mortality and morbidity of malaria is still high, especially in children of resource‐poor region...

In the present study, the dual function of interleukin-23 (IL-23) Aptamer to suppress brain inflammation via attachment to macrophage stimulating 1 (MST1) kinase and IL-23, was introduced. Also, the anti-inflammatory property of IL-23 Aptamer has been investigated. This study showed that IL-23 Aptamer could reduce the clinical development of brain...

Background and Aim: According to the latest estimate published by the World Health Organization in 2017, there are 219 million malaria cases and 435,000 deaths. With the emergence of drug-resistant strains in malaria, there is a need for new drug targets every time. In this study, the design and docking study of the pyrimidine derivatives for inhib...

BACKGROUND: Candida species are the most common opportunistic fungal infections. Today, cinnamon plants have been considered for anti-Candida properties. AIM: This study aimed to investigate the effectiveness of cinnamaldehyde extract (from cinnamon derivatives) on Candida albicans and Candida glabrata species and comparison with nystatin. MATERI...

Exposure to high doses of acetaminophen is the most common cause of drug induced liver injury. We investigated the protective effects of Hedera helix extract against acetaminophen induced oxidative stress and hepatotoxicity using a mouse model. We used two control groups: group A was given 0.9% NaCl, group B was an acetaminophen control that was gi...

Ketamine has been extensively used as an anesthetic drug. Chiral auxiliaries such as tert-butanesulfinamide (TBSA) can be used for the asymmetric synthesis of (S)-ketamine. Condensation of TBSA with ketones provides tert-butanesulfinylimines in consistently high yields. The tert-butanesulfinyl group actuates the imine for nucleophilic addition, is...

Introduction: The aim of the study was to evaluate the protective effect of Hedera helix (ivy) leaf extract on paracetamol-induced oxidative stress and renal toxicity in mouse model. Methods: Sixty male Swiss albino mice were randomly divided into six equal groups. Group A: as the control group, received NaCl 0.9%. Group B: received a single (i.p.)...

The purpose of this study was to evaluate the anti-inflammatory property of gelatin hydrogel containing cerium oxide nanoparticles coated with interleukin-17 Aptemer ([[email protected]]). Here, the brain inflammation model was induced by both proteolipid protein (PLP) and parathion. Then, the expression of some inflammatory genes and the serum lev...

Introduction: In this study, we aimed to evaluate the protective effects of Descurainia sophia seed extract on paracetamol-induced oxidative stress and acute liver injury in mice. Methods: Sixty male Swiss albino mice were divided into 6 groups, group I: as control group received NaCl 9%. Group II: as paracetamol group received paracetamol intraper...

Unfortunately, the original publication of the article contained an error in the affiliation section. The correct affiliation for author Maryam Iman should be Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

We present a novel asymmetric synthesis route for synthesis of (S)-ketamine using a chiral reagent according to the strategy (Scheme 1), with good enantioselectivity (85% ee) and yield. In this procedure, the (S)-tert-butanesulfinamide (TBSA) acts as a chiral auxiliary reagent to generate (S)-ketamine. A series of new intermediates were synthesized...

A different molecular mechanism underlying human papilloma virus (HPV)‐negative and HPV‐active pathogenesis is responsible for better response to therapies in HPV‐associated oropharyngeal squamous cell carcinoma (OPSCC). In this study, we aim to provide an insight into molecular basis underlying this distinction and introduce possible targeted ther...

Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our present research we report some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures. A series of novel 4-flurophthalimides designed using bioisosteric replacement were synth...

Background and Aim: In this study, a group of nitron-based oximes involving a pyridinium moiety were assessed as novel drug candidates in the reactivation of inhibited AChE in a docking study. Methods: The chemical structures of novel reactivators were built using the HyperChem program and conformational studies were performed using a semi-experime...

It has been determined that high-intensity exercise training is associated with the production of oxidative stress factors leading to a reduction in the efficiency and physical functioning of rapid reaction forces. Conversely, high levels of physical activity and coping with oxidative stress factors (using supplements) are highly suggested for rapi...

Background: Hydroxyurea (HU) is used to treat cancer., HU has a short half-life due to its small molecular weight and high polarity, therefore a high dosage of the drug should be used which introduces side effects and more rapid development of resistance. Objective: The objective of the current study is to design a new lipophilic analogues of hy...

A B S T R A C T The aim of this study was to introduce a prodigiosin-conjugated aptamer to attach to surface of brain cancer cells. Crystal structure of glutamate receptor and 106 nucleotide aptamers were separately interacted in NVT ensemble for duration of 50,000 ps at 310 K by Ascalaph designer software. Finally, delta intermolecular energy (ΔIN...

Background: P-glycoprotein (P-gp) causes the efflux of cancer chemotherapy drugs from tumor cells, so it's inhibition can be one target for design and synthesis of new anticancer drugs. Objective: In this study new compounds of 1,4-dihydropyridine (DHP) were recommended as inhibitors of P-gp. Methods: We synthesized new symmetrical DHP with 36...

The main objective of this study is to introduce a novel numerical approach, based on Artificial Neural Network (ANN), to predict the shear strength of Perfobond rib shear connector (PRSC). For this purpose, 90 records were extracted from the literature and were used to develop a number of Bayesian neural network models for predicting the shear str...

Expanded polystyrene (EPS) concrete is known as a lightweight and environmentally-friendly material with suitable properties for energy absorption which is made by partial or full replacement of the natural stone materials with man-made non-absorbent grains. In recent years, depending on the concrete density and strength requirements, EPS concrete...

Calpeptin analogues represent anti-cancer properties with inhibition of calpain. In this research, we applied a quantitative structure-activity relationship (QSAR) model on 34 calpeptin derivatives to select the most appropriate compound. QSAR was employed to generate models and predict the more significant compound through a series of calpeptin de...

Introduction: Sulfur mustard (SM) is an extremely toxic gas used in chemical warfare to cause massive lung injury and death. Victims exposed to SM gas acutely present with inhalational lung injury, but among those who survive, some develop obstructive airway diseases referred to as SM-lung syndrome. Pathophysiologically, SM-lung shares many charact...

Objective: To determine the effects of chitosan-zinc oxide nanocomposite conduit on transected sciatic nerve in animal model of rat. Methods: Sixty male White Wistar rats were used in this study. A 10-mm sciatic nerve defect was bridged using a chitosan-zinc oxide nanocomposite conduit (CZON) filled with phosphate buffered saline. In chitosan gr...

Microbial remediation of nitroaromatic compounds (NACs) is a promising environmentally friendly and cost-effective approach to the removal of these life-threating agents. Escherichia coli (E. coli) has shown remarkable capability for the biotransformation of 2,4,6-trinitro-toluene (TNT). Efforts to develop E. coli as an efficient TNT degrading bioc...

Acetylcholinesterase has important role in synaptic cleft. It breaks down the acetylcholineat cholinergic synapsesand terminates the cholinergic effects. Some chemical agents like organophosphorus compounds (OPCs) including nerve agents and pesticides react with acetylcholinesteraseirreversibly. They inhibit normal biological enzyme action and resu...

Distigmasterylhemisuccinoyl- sn -glycero-3- phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Our previous study revealed that a liposome-intercalated Amphotericin B prepared from DSHemsPC (DSHemsPC-Lip-AmB) possess excell...

Objective(s) Phthalimide-based derivatives have anticonvulsant activity like as phenytoin by inhibition of sodium channel. In our previously research we mentioned about some phthalimide derivatives as potent anticonvulsant agents. Materials and Methods Fourteen analogs of 2-substituted phthalimide pharmacophore were synthesized and then were evalu...

A series of compounds related to ameltolide were studied for anticonvulsant potential in the subcutaneous pentylenetetrazol (sc Ptz) test in mice. These compounds were synthesized and characterized by TLC followed by IR and H¹NMR. In-vivo screening data acquired indicate that most of analogs have the ability to protect against PTZ-induced seizure....

Background: The multidrug resistance (MDR) of cancer cells has become a great barrier to the success of chemotherapy. Objective: In this study quantitative structure activity relationship (QSAR) modeling was applied to 461,4-dihydropyridine structures (DHPs),and some selected compounds were docked. Methods: QSAR was used to generate models and...

Background and Aim: Fungal infections, especially candida species, are the most common opportunistic fungal infections and the treatments with chemical drugs have many side effects. Melissa Officinalis has antimicrobial effects that has caused it to be considered in many microbial treatments. In this study, it has been tried to compare this herbal...

Abstract: Background: Recent studies have shown that the high mortality of patients with colorectal cancer (CRC) is related to its ability to spread the surrounding tissues, thus there is a need for design- ing and developing new drugs. Objective: In this study some of the recent patents also reviewed, we proposed a combinational therapy, an inhibi...

Background: High doses of Cisplatin (CP) can disrupt the normal function of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia. Objective: In this study, the defensive effect of Melissa officinalis and vitamin E against testicular injuries caused by CP in male ra...

Current researches have showed that N3, N5-diaryl-2, 6-dimethyl -1, 4-dihydropyrine-3, 5- dicarboxamide analogues demonstrate notable anti-tubercular activity. In this study, Hantzsch condensation was used to design and synthesize new analogues of dihydropyridine (DHP). Different diary carboxamides were inserted at positions 3 and 5 of the DHP ring...

Background: Ribonucleotide Reductase (RNR) is an important anticancer chemotherapy target. It has main key role in DNA synthesis and cell growth. Therefore several RNR inhibitors, such as Hydroxyurea, have entered the clinical trials. Based on our proposed mechanism, radical site of RNR protein reacts with Hydroxyurea in which hydroxyurea is conve...

Intravenous administration of Taxotere® (a commercial form of docetaxel, DTX) leads to many problems such as hypersensitivity, hemolysis, cutaneous allergy, and patient refusal due to its prolonged injection. The oral absorption of DTX is very low due to its hydrophobic nature. The purpose of this study was to prepare and carry out an in vitro eval...

Background: Selenocyanate derivatives have been recently presented as potent anti-leishmanial agents. Objective: In this research, thirty five selenocyanate and diselenide compounds were subjected to docking studies and compared to Edelfosine and Miltefosine as reference drugs and then molecular dynamics (MD) simulation analysis. Methods: Desi...

Background: Fenobam is a non-competitive mGluR5 antagonist as an anxiolytic agent. Objective: In this research a new series of fenobam analogues containing thiazole moiety instead of imidazole ring were designed and synthesized. Methods: The ureido-substituted products were synthesized from reaction of amino thiazole derivatives and isocyanate...

Curcumin is a polyphenolic natural compound with multiple targets that used for the prophylaxis and treatment of some type of cancers like cervical and pancreatic cancers. Objective: In this study, ten new curcumin derivatives were designed and synthesized and their cytostatic activity evaluated against the Hela and Panc cell lines that some of the...

Phthalimide and hydrazine pharmacophores have been demonstrated to be inhibitors of cyclooxygenases (COX) and lipoxygenases (LOX) and to possess a marked analgesic and anti-inflammatory activity. A new group of hybrid analogs of phthalimide and hydrazine (2-(arylmethylideneamino) isoindolines), possessing a variety of substituents (OMe, OH, NO2, Cl...

Two benzimidazole derivatives and one nitroimidazole derivative were designed using molecular hybridization approach. The designed compounds were synthesized and their in vitro antifungal activities were tested against Candida albicans and Saccharomyces cerevisiae strains. Based on the antifungal activity data, compound 9 containing 2-methyl-5-nitr...

Graphene modified glassy carbon electrodes have been developed for the determination of calcium dobesilate in pharmaceutical formulations. The prepared graphene and CNTs were used as a conductive substrate for electrochemical study of calcium dobesilate. The direct electrochemistry of calcium dobesilate showed a reversible cyclic voltammogram with...

Recent studies have indicated that 1, 4-dihydropyridine-3, 5-dicarboxamide derivatives show significant anti-tubercular activity. In this research, new derivatives of 1, 4-dihydropyridine were designed and synthesized using Hantzsch condensation in which dicyclohexyl and different dicyclohexylcarbamoyl were substituted at C-3 and C-5 positions of t...

Malaria is a parasitic disease caused by five different species of Plasmodium. More than 40% of the world's population is at risk and malaria annual incidence is estimated to be more than two hundred million, malaria is one of the most important public health problems especially in children of the poorest parts of the world, annual mortality is abo...

Aims: In this research, a group of triazole derivatives with CYP51 inhibitory activity was subjected to a docking study followed by a quantitative structure-activity relationship (QSAR) analyses. Methods: Desired azoles were built using the HyperChem program and conformational studies were performed through a semi-empirical method. A docking study...

Background: In recent years, apple cider vinegar has been singled out as an especially helpful health remedy. It has been widely used in various dosage forms in alternative medicine for several conditions such as diabetes and obesity. In this study, the effect of apple cider vinegar on blood glucose level has been evaluated. Methods: Intraperitonea...

Fifteen compounds related to ameltolide with sodium channel inhibitory activity were subjected to a molecular docking study. The chemical structures of all compounds were built using the program HyperChem and conformational studies were performed with a semiempirical method followed by the PM3 method. A docking study was performed using the program...

Azole antifungal agents, which are widely used as antifungal antibiotics, inhibit cytochrome P450 sterol 14α demethylase (CYP51). In this research, a group of 1-methylimidazole derivatives were synthesized for evaluation as antibacterial and antifungal agents. Antimicrobial evaluation revealed that some of these compounds exhibited significant anti...

Introduction: RNA interference is a sequence-specific gene silencing phenomenon in which small interfering RNAs (siRNAs) can trigger gene transcriptional and post-transcriptional silencing. This phenomenon represents an emerging therapeutic approach for in vivo studies by efficient delivery of specific synthetic siRNAs against diseases. Therefore,...

Quantitative structure activity relationship analyses were used to identify the ideal physicochemical characteristics of potential chalcone derivatives as anti-Leishmania agents. The HyperChem program was used to build chalcone structures and to perform conformational analyses through the semiempirical method followed by the PM3 force field. Dragon...

Candida albicans is one of the most common causes of invasive fungal infections. Azole antifungal agents are widely used as fungal antibiotics which inhibit the cytochrome P450 sterol 14α-demethylase (CYP51). This study describes the homology modeling and three-dimensional model of CYP51 from C. albicans SC5314. Dope score, GA341 of Modeller, PROCH...

Antiepileptic drugs are used to prevent or reduce the occurrence of epileptic seizures, but up to 30 % of patients are resistant to the available medical therapies. Ten new analogs of 2-aryl substituent of isoindoline-1,3-dione have been synthesized and evaluated for their anticonvulsant activities. The in vivo screening data acquired indicate that...

Experimental data of selenocyanate derivatives show that they are potent inhibitors of Leishmania growth. In the current study, a series of selenocyanate derivatives were subjected to quantitative structure activity relationship and quantitative structure toxicity relationship analyses to identify the ideal physicochemical characteristics of potent...

In the treatment of leishmaniasis, chemotherapy is expensive and has various side effects. The major side effects are due to multiple injections that are required over a course of several weeks and non-selectivity of the drugs. In addition, there is no fully effective drug available against the cutaneous form of the disease. Experimental data of py...