Marwa Sharaky

Marwa Sharaky
National Cancer Institute Egypt | NCI · Department of Cancer Biology

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6
Publications
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25
Citations

Publications

Publications (6)
Article
A molecular hybridization approach was used to construct and develop a variety of new bis-thiazoles coupled to benzofuran or benzothiazole moieties as anticancer drugs. The target compounds 6a-f and 7a-f were synthesized by reacting the respective bis-thiosemicarbazones 5a–f with bromoacetylbenzofuran or bromoacetybenzothiazole. Several analytical...
Preprint
Purpose : Androgen receptor (AR) is often expressed in breast cancer, but its role in estrogen receptor positive (ER+) type is controversial. Although AR and its splicing variant 7 (ARV7) play a role in the pathobiology of breast cancer, the precise mechanisms are not fully understood. Therefore, the aim of the current study is to determine the inf...
Article
Full-text available
Breast cancer (BC) and endocrine resistance to chemotherapy are challenging problems where angiogenesis plays fundamental roles. Thus, targeting of VEGFR-2 signalling pathway has been an attractive approach. In this study, we synthesised a new sorafenib analogue, thieno[2,3-d]pyrimidine based urea derivative, KM6. It showed 65% inhibition of VEGF2...
Article
Background & objective: Glycosyl heterocycles, being as nucleoside analogs with modified glycon and hybrid heterocycle motifs, are of considerable interest and thus the targeted compounds were synthesized via convenient and efficient approach. Methods: New indolyl-thiadiazolyl thioglycosides scaffolds were synthesized starting with the reaction...
Article
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A series of a novel 2, 3'-bipyrrole derivatives was synthesized via the reaction of chalcone, (E)-1-(furan-2-yl)-3-(1H-pyrrol-2-yl) prop-2-en-one, with different amino acids in an alkaline medium. The reaction proceeds throughout the condensation of the amino acids with chalcone to give imine intermediate consequent by decarboxylation, and then int...
Article
Full-text available
A new series of thiazolidinone (5a-g), thiazinone (9a-g) and dithiazepinone (9a-g) heterocycles bearing a benzenesulfonamide scaffold was synthesized. Cytotoxicity of these derivatives was assessed against MCF-7, HepG2, HCT-116 and A549 cancer cell lines and activity was compared to the known cytotoxic agents doxorubicin and 5-FU where the most act...

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