Maruoka Hiroshi

• Saitama Prefectural University

Objectives: Long-term exposure to heat-not-burn cigarette smoke can serve as a risk factor for smoking-related diseases such as chronic obstructive pulmonary disease (COPD), similar to the exposure to conventional cigarettes. In this study, we evaluated the effects of heat-not-burn cigarettes on the alveoli and the cytokine expression in COPD muscl...

[Purpose] Patients with interstitial lung disease (ILD) tend to be bedridden due to dyspnea, and consequently muscle atrophy becomes a concern. For the treatment of such patients, there has been interest in neuromuscular electrical stimulation (NMES). Since the effect of NMES on ILD patients has not been established, we examined the effect of NMES...

[Purpose] It has been reported that exercise affects skeletal muscle in the chronic obstructive pulmonary disease (COPD) disease model. In this study, we examined the effects of neuromuscular electrical stimulation (NMES) in skeletal muscle on alveoli and cytokines. [Materials and Methods] We used twenty wild-type mice, randomly divided into three...

[Purpose] It is thought that quadriceps muscle strength of patients with respiratory diseases is related to their daily living activities (ADL). However, quadriceps force (QF) requires patient effort and often cannot be measured. This study examined the relationship between quadriceps muscle thickness and ADL. [Participants and Methods] The study i...

The number of heart failure patients is increasing rapidly in Japan because of its large elderly population. As age increases, arterial stiffness and physical dysfunction progress. This study aimed to evaluate the association between the physical function and arterial stiffness in elderly heart failure patients. This retrospective, observational st...

[Purpose] To examine the effects of ankle plantar- and dorsiflexion on hemodynamics and autonomic nervous system activity as a basis for the effective management of orthostatic hypotension. [Subjects and Methods] Eight healthy males (age: 28.8 ± 5.3) performed a motor task based on the following protocol: maintaining a resting sitting position for...

[Purpose] Hormone replacement therapy has been reported to be effective for alleviating menopausal symptoms, its side effects have been a concern. Therefore, it is necessary to investigate methods that could alleviate menopausal symptoms but with fewer side effects. Few previous reports have investigated the effects of simplified, viable manual lym...

[Purpose] This study examined how exercise capacity and the oxidative stress regulation system are affected by different amounts of dietary Ubiquinol (reduced form of coenzyme Q10, H2CoQ10: QH) over the long term. [Subjects and Methods] Twenty-three senescence-accelerated mouse P1 (SAMP1) mice were randomly divided into two groups: one consuming a...

[Purpose] This study examined how exercise capacity and the oxidative stress regulation system are affected by different amounts of dietary Ubiquinol (reduced form of coenzyme Q10, H(2)CoQ10: QH) over the long term. [Subjects and Methods] Twenty-three senescence-accelerated mouse P1 (SAMP1) mice were randomly divided into two groups: one consuming...

Background: Cardiac autonomic dysfunction and anxiety-depression is prognostic factors after acute myocardial infarction (AMI). Cardiac rehabilitation (CR) is an effective treatment for cardiac autonomic dysfunction and anxiety-depression. Also β-blocker can be expected to have the effect of improving the prognosis of heart disease. Purpose: This s...

In this study with 30 nurses as study subjects, we examined how 12 weeks of a study treatment affected body measurements, blood biochemistry, and the oxidative stress regulatory system. Subjects were randomly divided into two groups: one that received licorice flavonoid oil (LFO) capsules and l-carnitine capsules (supplement group n = 15), and anot...

In this study with 30 nurses as study subjects, we examined how 12 weeks of a study treatment affected body measurements, blood biochemistry, and the oxidative stress regulatory system. Subjects were randomly divided into two groups: one that received licorice flavonoid oil (LFO) capsules and L-carnitine capsules (supplement group n = 15), and anot...

[Purpose] In this study, combined training with breathing resistance and sustained physical exertion was carried out to evaluate its physiological effects and its effect on improve endurance capacity. [Subjects and Methods] The subjects were nine healthy adults (mean age 20.4, SD ± 1.7 years). The combined training group (n = 5) carried out 6 weeks...

[Purpose] Balance training lowers the risk of falling in the elderly, but it is not known which specific muscles should be strengthened. The purpose of this study was to determine associations between fatigue of individual muscle groups in the lower limbs and balance. [Subjects and Methods] We tested 42 lower limbs of 21 healthy young adults with n...

[Purpose] The effects of exercise and food consumption on the oxidative stress regulation system were studied using 45 male ICR mice. [Subjects and Methods] The mice were randomly divided into two groups: a control group (CO group) and a group consuming a reduced form of coenzyme Q10 (H2CoQ10: QH) (QH group). Both groups were made to run on a tread...

目的：マウスにおける食品摂取と運動トレーニング (EX) が酸化ストレス防御系や運動能力へおよぼす影響について検討した． 方法：対象は雄性マウス 46 匹とし，無作為に還元型コエンザイム Q10 (H2CoQ10: QH) 摂取群，QH 摂取＋EX 群，EX 群，コントロール群の 4 群に区分した．全群は研究開始時と研究開始 3 ヶ月，6 ヶ月，9 ヶ月の各時点においてラット用トレッドミルにて限界走行させ運動能力（走行時間）を測定した．酸化ストレス防御系は活性酸素・フリーラジカル分析装置を使用し，研究開始時と 6 ヶ月の時点で酸化ストレス度 (d-ROM test) と抗酸化力 (BAP test) を測定し，d-ROM/BAP 比を算出した．また，9 ヶ月の時点では速反応性／遅反応性抗酸化...

The purpose of this study was to examine the effect on oxidative stress (OS) of muscle stress caused by different training sets. Twenty-five healthy volunteers (22.0 +/- 2.6 years old) with no past history of medication were recruited for this study. A free radical analytical system was used to measure OS (hydroperoxide consistency), and blood spec...

In order to identify the group of muscles related to deterioration of balance function in the elderly, an exploratory experiment was conducted to analyze and study the influence of lower limb muscular fatigue on balance disturbance in the stable upright position. A stabilometer and a multipurpose muscle function testing and training system were use...

The relationship between muscle stress (MS) or exercise stress (ES) was examined in 20 healthy young volunteers (all male, 22.9 ± 4.8 years old, mean ± SD) through cardiopulmonary exercise testing and coronary flow velocity (CFV). A heart lung function measuring system was used to conduct expiration gas analysis through isokinetic testing, a traini...

The relation between VE-VCO2 slope and left ventricular function was examined in 38 patients (37 male and 1 female; mean age 55.1 ± 7.3 years) with acute myocardial infarction (AMI). Left ventricular function was measured with electrocardiogram gated single photon emission computed tomography in the acute phase (4.0 ± 2.4 days after onset) and the...

In order to accurately estimate the muscle fiber conduction velocity (MFCV), the normalized peak-averaging technique (NPAT) has been proposed. Electromyograms (EMGs) were recorded using surface array electrodes during the isometric contractions of biceps brachii muscles of ten healthy volunteers. The EMGs recorded from the vicinity of endplates, we...

The purpose of this study was to compare the ventilation-carbon dioxide production slope (VE-VCO2 Slope) of a field walking test, comprising of a six minute walk test (6M) and self-paced walking (SP), with the exercise capacity or VE-VCO2 Slope obtained by cardiopulmonary exercise testing (CPX). Expiration gas was measured during exercise loading i...

The relationship between exercise capacity and left ventricular function has been evaluated in 35 patients with acute myocardial infarction (34 males and 1 female; mean age 55.5 ± 7.1 years). Single photon emission computed tomography (SPECT) was used to measure left ventricular function in the acute phase (4.9 ± 2.2 days after onset) and the chron...