Marton Toth

Marton Toth
Nemalife Inc.

PhD
Rethinking in vivo/ in vitro/ molecular characterization R&D

About

25
Publications
5,218
Reads
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1,312
Citations
Introduction
Safety and efficacy testing, Longevity screening, Whole-organism-whole-life assays
Additional affiliations
February 2009 - present
Rutgers, The State University of New Jersey
Position
  • Research Associate

Publications

Publications (25)
Article
Full-text available
Introduction: Cannabigerol (CBG) is becoming widely available despite little being known about its potential toxicity or long-term effects. Materials and Methods: The present investigation involved two distinct studies. The first study explored acute and long-term effects of CBG on toxicity, lifespan, and aging in adult Caenorhabditis elegans (C....
Article
Full-text available
Introduction: Despite widespread use of cannabidiol (CBD), no lifelong toxicity study has been published to date. Caenorhabditis elegans is often used in preclinical lifelong toxicity studies, due to an estimated 60–80% of their genes having a human ortholog, and their short lifespan of ∼2–3 weeks. In this study, we examined both acute and long-ter...
Article
Full-text available
Transcriptome-based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age-related disease. We hypothesized that, by mimicking the transcriptional signature of the highly conserved longevity intervention of FOXO3 (daf-16 in worms) overexpression, we could identify and repurpose compounds with similar...
Article
Full-text available
The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional neuronal decline and neurodegenerative disease1, 2. Accordingly, neurons invest considerable cellular resources in chaperones, protein degradation, autophagy and mitophagy to maintain proteostasis and mitochondrial quality3, 4...
Chapter
Full-text available
In this section, we present two applications of microfluidic flow for 3D microscopy. The first method uses a microfluidic channel that is tilted along the optical axis. We record several progressively defocused images of the flowing sample as it passes across the focal plane. The resulting focal stack is then processed using a Wiener deconvolution...
Article
Full-text available
Understanding cellular outcomes, such as neuronal remodeling, that are common to both healthy and diseased aging brains is essential to the development of successful brain aging strategies. Here, we used Caenorhabdits elegans to investigate how the expression of proteotoxic triggers, such as polyglutamine (polyQ)-expanded huntingtin and silencing o...
Article
Full-text available
We present a 3D tomography technique for in-vivo observation of microscopic samples. The method combines flow in a microfluidic channel, illumination through a slit aperture, and a Fourier lens for simultaneous acquisition of multiple perspective angles in the phase-space domain. The technique is non-invasive and naturally robust to parasitic sampl...
Conference Paper
We combine a microfluidic channel and hybrid space-angle measurement to observe live biomaterial in motion. We experimentally demonstrate the technique by co-registering 3D absorption and 3D differential-phase-contrast images on live, freely swimming C.elegans nematodes.
Article
Full-text available
Caenorhabditis elegans is a powerful model for analysis of the conserved mechanisms that modulate healthy aging. In the aging nematode nervous system, neuronal death and/or detectable loss of processes are not readily apparent, but because dendrite restructuring and loss of synaptic integrity are hypothesized to contribute to human brain decline an...
Article
Full-text available
Cell growth-the primary determinant of cell size-has an intimate relationship with proliferation; cells divide only after they reach a critical size. Despite its developmental and medical significance, little is known about cellular pathways that mediate the growth of cells. Accumulating evidence demonstrates a role for autophagy-a mechanism of euk...
Article
Full-text available
Aging is a multifactorial process with many mechanisms contributing to the decline. Mutations decreasing insulin/IGF-1 (insulin-like growth factor-1) or TOR (target of rapamycin) kinase-mediated signaling, mitochondrial activity and food intake each extend life span in divergent animal phyla. Understanding how these genetically distinct mechanisms...
Article
Full-text available
Autophagy (cellular self-eating) is a highly regulated, lysosome-mediated catabolic process of eukaryotic cells to segregate by a special membrane and subsequently degrade their own constituents during development or starvation. Electron microscopy analysis reveals autophagic elements in various cell types of the nematode Caenorhabditis elegans, wh...
Article
Autophagy (cellular self‐eating) is a highly regulated, lysosome‐mediated catabolic process of eukaryotic cells to segregate by a special membrane and subsequently degrade their own constituents during development or starvation. Electron microscopy analysis reveals autophagic elements in various cell types of the nematode Caenorhabditis elegans, wh...
Article
Full-text available
Here we show that in the nematode Caenorhabditis elegans mutational inactivation of two autophagy genes unc-51/atg1 and bec-1/atg6/beclin1 results in small body size without affecting cell number. Furthermore, loss-of-function mutations in unc-51 and bec-1 suppress the giant phenotype of mutant animals with aberrant insulin-like growth factor-1 (in...
Article
Full-text available
Autophagy is a highly regulated cellular pathway used by eukaryotic cells to consume parts of their constituents during development or starvation. It is associated with extensive rearrangements of intracellular membranes, and involves the cooperation of many gene products in the regulation and execution phase by largely unknown mechanisms. Recent r...
Article
Full-text available
Necrotic cell death is a common feature in numerous human neurodegenerative disorders. In the nematode Caenorhabditis elegans, gain-of-function mutations in genes that encode specific ion channel subunits such as the degenerins DEG-1 and MEC-4, and the acetylcholine receptor subunit DEG-3 lead to necrotic-like degeneration of a subset of neurons. N...

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