Martina Mosing

Martina Mosing
Murdoch University · College of Veterinary Medicine

Doctor of Veterinary Medicine

About

142
Publications
18,430
Reads
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1,256
Citations
Citations since 2017
37 Research Items
831 Citations
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2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Introduction
Martina Mosing currently works at the College of Veterinary Medicine, Murdoch University. Martina does research in Anaesthesia and Ventilation in Veterinary Medicine. Their current project is 'Regional ventilation monitoring by EIT for veterinary applications'.
Additional affiliations
August 2016 - present
Murdoch University
Position
  • Professor (Associate)
July 2010 - July 2016
University of Zurich
Position
  • Medical Professional
January 2007 - May 2010
University of Liverpool
Position
  • Professor (Associate)

Publications

Publications (142)
Article
Background: This study aimed to compare the distribution of ventilation measured by electrical impedance tomography (EIT), in foals under varying clinical conditions of sedation, postural changes, and continuous positive airway pressure (CPAP). To support the interpretation of EIT variables, specific spirometry data and F-shunt calculation were al...
Article
Background: Electrical impedance tomography (EIT) produces lung ventilation images via a thoracic electrode belt. Robust electrode design and material, providing low electrode skin contact impedance (SCI), is needed in veterinary medicine. The aim of this study was to compare three EIT electrode designs and materials. Methods: Simulations of cyl...
Article
Objective To describe some cardiorespiratory effects of an inspiratory-to-expiratory (IE) ratio of 1:1 compared with 1:3 in ventilated horses in dorsal recumbency. Study design Randomized crossover experimental study. Animals A total of eight anesthetized horses, median (range) 444 (330–485) kg body weight. Methods Horses were ventilated in dors...
Article
Full-text available
Electrical impedance tomography (EIT) is a non-invasive real-time non-ionising imaging modality that has many applications. Since the first recorded use in 1978, the technology has become more widely used especially in human adult and neonatal critical care monitoring. Recently, there has been an increase in research on thoracic EIT in veterinary m...
Article
Full-text available
Equine respiratory physiology might be influenced by the presence of an endotracheal tube (ETT). This experimental, randomized cross-over study aimed to compare breathing pattern (BrP) and ventilation distribution in anesthetized horses spontaneously breathing room air via ETT or facemask (MASK). Six healthy adult horses were anesthetized with tota...
Article
Objective: A linear relationship between impedance change (△Z) measured by thoracic electrical impedance tomography (EIT) and tidal volume (VT) has been demonstrated. This study evaluated the agreement between the displayed VT calculated by the EIT software (VTEIT) and spirometry (VTSPIRO) after an indirect two-point calibration. Approach: The E...
Article
Full-text available
The objective was to document the use of spirometry and ventilation settings in small animal anaesthesia and intensive care through a descriptive, open, online, anonymous survey. The survey was advertised on social media and via email. Participation was voluntary. The google forms platform was used. It consisted of eight sections in English: demogr...
Article
Full-text available
Several aspects of postnatal pulmonary adaption in the bovine neonate remain unclear, particularly the dynamics and regional ventilation of the lungs. We used electric impedance tomography (EIT) to measure changes in ventilation in the first 3 weeks of life in 20 non-sedated neonatal calves born without difficulty in sternal recumbency. Arterial bl...
Article
Full-text available
Background Equine asthma (EA) causes airflow impairment, which increases in severity with exercise. Electrical impedance tomography (EIT) is an imaging technique that can detect airflow changes in standing healthy horses during a histamine provocation test. Objectives To explore EIT-calculated flow variables before and after exercise in healthy ho...
Article
Full-text available
Background Left-sided cardiac volume overload (LCVO) can cause fluid accumulation in lung tissue changing the distribution of ventilation, which can be evaluated by electrical impedance tomography (EIT). Objectives To describe and compare EIT variables in horses with naturally occurring compensated and decompensated LCVO and compare them to a heal...
Article
Controlled mechanical ventilation (CMV) is routinely used in equine anaesthesia, with many different options available to facilitate the delivery of mechanical breaths. The complexity of equine respiratory pathophysiology and the wide range of devices available is described in the two parts of this scoping review. The second part of this review pro...
Article
Full-text available
This study explores the application of electric impedance tomography (EIT) to estimate tidal volume (VT) by measuring impedance change per breath (∆Zbreath). Seventeen healthy horses were anaesthetised and mechanically ventilated for elective procedures requiring dorsal recumbency. Spirometric VT (VTSPIRO) and ∆Zbreath were recorded periodically; u...
Article
Full-text available
Background Electrical impedance tomography (EIT) generates images of the lungs based on impedance change and was able to detect changes in airflow after histamine challenge in horses. Objectives To confirm that EIT can detect histamine‐provoked changes in airflow and subsequent drug‐induced bronchodilatation. Novel EIT flow variables were develope...
Article
Electrical impedance tomography (EIT) provides clinically useful lung images; however, it would be an advantage to extract additional cardiovascular information from the data. The aim of this study was to evaluate if cardiac-related changes measured by EIT can be used to measure pulse rate (PR) under physiological as well as high and low blood pres...
Article
Controlled mechanical ventilation (CMV) is routinely used in equine anaesthesia, with many different options available to mechanically deliver breaths. The complexity of respiratory pathophysiology in anaesthetised horses and the wide range of devices available is described in this scoping review. The first part of the review outlines basic equine...
Article
Alpha2 receptor agonists (alpha2-agonists) are useful sedative and analgesic agents in sheep, but have adverse pulmonary effects, which are reportedly similar between different alpha2-agonists. This randomized crossover study compared pulmonary function after intravenous administration of an alpha2-agonist, either xylazine or an equipotent dose of...
Article
Full-text available
Electrical impedance tomography (EIT) is used in lung physiology monitoring. There is evidence that EIT is linearly associated with global tidal volume (VT) in clinically healthy patients where no positive end-expiratory pressure (PEEP) is applied. This linearity has not been challenged by altering lung conditions. The aim of this study was to dete...
Article
Full-text available
This study used electrical impedance tomography (EIT) measurements of regional ventilation and perfusion to elucidate the reasons for severe gas exchange impairment reported in rhinoceroses during opioid-induced immobilization. EIT values were compared to standard monitoring parameters to establish a new monitoring tool for conservational immobilis...
Article
Background: Electrical impedance tomography (EIT) generates thoracic impedance images of the lungs and has been used to assess ventilation in horses. This technique may have application in the detection of changes in airflow associated with equine asthma. Objectives: The objective was to determine if histamine-induced airflow changes observed wi...
Article
Objective: In EIT applications to the thorax,a single electrode plane has typically been used to reconstruct a transverse 2D "slice".However, such images can be misleading as EITis sensitive to contrasts above and below the electrodeplane, and ventilation and aeration inhomogeneitiescan be distributed in complex ways.Using two (or more) electrode...
Article
Background: Arterial hypoxaemia is common in anaesthetised horses, but little information exists regarding restoration of arterial oxygen tension (PaO2 ) during recovery from anaesthesia, or if intra-operative management factors exert any longer-term effect. Objectives: To evaluate PaO2 in horses recovering from general anaesthesia up to one hou...
Article
The objective of this study was to investigate the distribution pattern of two different volumes of a mepivacaine 2%/iopromide mixture along the infraorbital nerve using a controlled injection pressure. Infraorbital nerve blocks were performed at the infraorbital foramen with two different volumes (group 10: 10 mL or group 15: 15 mL) using a 22 gau...
Conference Paper
Full-text available
The aim of this study was to determine the influence of positive end-expiratory pressure (PEEP) on Tidal Volume (V T) estimation using electrical impedance tomography (EIT) technology, and spirometry (L/breath). Anaesthesia was induced in ten steers, volume controlled ventilation was initiated. An EIT belt was applied around the thorax. PEEP levels...
Article
Objective: Adenosine induces vasodilatation. The aim of this study was to investigate cardiovascular effects of two adenosine constant rate infusion (CRI) doses in dogs. Study design: Experimental, longitudinal repeated measure design. Animals: Ten healthy purpose-bred Beagle dogs. Methods: Each dog was sedated with butorphanol. Anaesthesia was ind...
Article
Objective: To assess changes in the distribution in pulmonary ventilation in anaesthetized ponies using electrical impedance tomography (EIT). Study design: Prospective experimental study. Animals: A group of eight adult pony geldings. Methods: General anaesthesia was induced and maintained using isoflurane in oxygen with volume-controlled ventilat...
Article
Background Electrical impedance tomography (EIT) is a method to measure regional impedance changes within the thorax. The total tidal impedance variation has been used to measure changes in tidal volumes in pigs, dogs and humans. Objectives To assess the ability of EIT to quantify changes in tidal volume in anaesthetised mechanically ventilated ho...
Article
Full-text available
Objective: To describe the cardiorespiratory effects of a change in table position in anaesthetized horses. Study design: Prospective, crossover, randomized, experimental study. Animals: Six adult horses (mean body weight 621 ± 59 kg, aged 13 ± 4 years). Methods: The horses were anaesthetized twice in dorsal recumbency. They were either plac...
Article
Full-text available
Objective To determine the agreement of invasive blood pressure measured in the facial, metatarsal and carotid arteries, and evaluate the effects of two haemodynamic conditions on agreement. Study design Prospective randomized study. Animals A group of eight horses aged 7 (4–23) years with a body weight of 493 ± 33 kg. Methods Horses were anaest...
Article
Full-text available
The arterial to end-tidal CO2 difference (P(a-ET)CO2) and alveolar dead space fraction (VDalvfrac = P(a-ET)CO2/PaCO2), are used to estimate Enghoff’s “pulmonary dead space” (V/QEng), a factor which is also influenced by venous admixture and other pulmonary perfusion abnormalities and thus is not just a measure of dead space as the name suggests. Th...
Article
Full-text available
In the first edition of this journal Barbara Weaver wrote a review titled ‘Equine Anaesthesia’ [1], stating, that, at that time it was quickly becoming accepted practice that many horses were being anaesthetised “by essentially similar procedures, i.e. premedication, induction and then maintenance by controlled inhalation”. Her review focussed upon...
Article
Full-text available
Objective: To compare the efficacy of three continuous positive airway pressure (CPAP) interfaces in dogs on gas exchange, lung volumes, amount of leak during CPAP and rebreathing in case of equipment failure or disconnection. Study design: Randomized, prospective, crossover, experimental trial. Animals: Ten purpose-bred Beagle dogs. Methods:...
Conference Paper
Full-text available
Objective: Aim of this study was to measure the dynamic changes of lung ventilation in new born calves over the first 3 weeks of their life using electrical impedance tomography (EIT). Methods: EIT parameters were recorded for at least 21 breaths at 0, 0.25, 0.5, 0.75, 1, 2, 4, 6, 8, 12 and 24 hours and at day 2, 3, 4, 5, 6, 7, 9, 11, 13, 15, 17, 1...
Article
Objective: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) on regional distribution of ventilation and dead space in anaesthetized horses. Study design: Randomized, experimental, crossover study. Animals: A total of eight healthy adult horses. Methods: Horses were anaesthetized twice with isoflu...
Article
Full-text available
Objective: To evaluate three routinely used tidal volumes (VT; 10, 12 and 15 mL kg(-1)) for controlled mechanical ventilation (CMV) in lung-healthy anaesthetized dogs by assessing alveolar ventilation (VTalv) and dead space (DS). Study design: Prospective, randomized clinical trial. Animals: A total of 36 client-owned dogs. Methods: Dogs wer...
Article
Full-text available
Objective: To compare airway management during induction of anaesthesia, spontaneous ventilation (SV) and controlled mechanical ventilation (CMV), using an endotracheal tube (ETT), laryngeal mask (LM), rabbit-specific supraglottic airway device (v-gel) or facemask (FM). Study design: Prospective randomized crossover experiment. Animals: Ten Ne...
Article
Objective: To evaluate the regional distribution of ventilation in horses during spontaneous breathing and controlled mechanical ventilation (CMV) using electrical impedance tomography (EIT). Study design: Prospective, experimental case series. Animals: Four anaesthetized experimental horses. Methods: Horses were anaesthetized with isofluran...
Article
Full-text available
This study evaluated the breathing pattern and distribution of ventilation in horses prior to and following recovery from general anaesthesia using electrical impedance tomography (EIT). Six horses were anaesthetised for 6 hours in dorsal recumbency. Arterial blood gas and EIT measurements were performed 24 hours before (baseline) and 1, 2, 3, 4, 5...
Data
S1.File.avi. Baseline impedance changes with respiratory cycle. Regions of higher impedance, consistent with increasing gas content of lung tissue are denoted by paler colouration during the respiratory cycle. (AVI)
Data
S2.File.avi. Impedance changes with respiratory cycle after recovery from anaesthesia. Note the increase in duration of increased intrathoracic impedance consistent with the breath holding phenomenon and also the change in distribution of impedance within the thorax during the breath holding period. (AVI)
Conference Paper
Full-text available
Finite element (FE) models are used to reconstruct electrical impedance tomography (EIT) images from surface voltage measurements. The main objective of this abstract was to calculate
Conference Paper
Full-text available
Finite element (FE) models are used to reconstruct electrical impedance tomography (EIT) images from boundary voltage measurements. Usually, these models are created by segmenting computer tomography (CT) scans of individual subjects and by building respective FE models from these segments. While for humans several pre-complied modes have become pu...
Article
Full-text available
Objective: To evaluate the effects of continuous positive airway pressure (CPAP) on intrapulmonary shunt, cardiac output and oxygen delivery in horses subjected to a 6 hour period of general anaesthesia. Study design: Randomized, experimental, crossover study. Animals: Ten healthy adult horses. Methods: Following medetomidine, diazepam and k...
Article
Full-text available
Objective: To assess the effects of 3 contrast medium injection techniques on attenuation values for canine adrenal glands during contrast-enhanced CT. Animals: 9 healthy Beagles. Procedures: 3 protocols were evaluated in a randomized cross-over design study: 700 mg of iodine/kg at a constant injection rate over 20 seconds (full-dose constant...
Article
Full-text available
The intestinal microbiota is important for health and disease. Factors that disturb the equine intestinal microbiota need further investigation. To determine the effects of transport, fasting and anaesthesia on the faecal microbiota of healthy adult horses using next generation sequencing. Experimental trial. Faecal samples were taken from 8 horses...
Article
To review the evidence regarding the reversal of neuromuscular block (NMB) in companion animals with emphasis on the development and use of newer agents. Data sources include scientific reviews and original research publications in both human and veterinary literature using Pubmed and Scopus as search data bases. Unpublished and locally published d...
Article
Full-text available
To compare airway management during induction of anaesthesia, in spontaneous ventilation and controlled mechanical ventilation (CMV), using a cat-specific supraglottic airway device (the v-gel), a classical laryngeal mask (LM) or an endotracheal tube (ETT). Prospective, randomized clinical trial. Forty-five healthy cats. After premedication, cats w...
Article
In critically ill patients with significant pulmonary hypertension (PH), close perioperative cardiovascular monitoring is mandatory, considering the increased morbidity and mortality in this patient group. Although the pulmonary artery catheter is still the standard for the diagnosis of PH, its use to monitor cardiac output (CO) in patients with PH...
Article
Dieser Artikel beschreibt die adäquate Anwendung von Kristalloiden und Kolloiden beim Kleintier. Dabei werden praktische Überlegungen für die Wahl der korrekten Infusionslösung, die Verabreichungsart und die Infusionsrate diskutiert.
Article
Full-text available
Objective To compare the effects of propofol and alfaxalone on respiration in cats.Study designRandomized, ‘blinded’, prospective clinical trial.AnimalsTwenty cats undergoing ovariohysterectomy.Methods After premedication with medetomidine 0.01 mg kg−1 intramuscularly and meloxicam 0.3 mg kg−1 subcutaneously, the cats were assigned randomly into tw...
Conference Paper
Full-text available
The aim of the study was to evaluate the center of ventilation (CoV) and percentage of total tidal variation per region of interest (ROI) in horses during spontaneous and controlled mechanical ventilation (CMV) using electrical impedance tomography (EIT).
Conference Paper
Full-text available
The aims of this study were to evaluate the breathing pattern of horses after recovery from anaesthesia using electrical impedance tomography (EIT) and assess the effects on arterial blood gases.
Article
Full-text available
The aim of this study was to test the effect of cardiac output (CO) and pulmonary artery hypertension (PHT) on volumetric capnography (VCap) derived-variables. Nine pigs were mechanically ventilated using fixed ventilatory settings. Two steps of PHT were induced by IV infusion of a thromboxane analogue: PHT25 [mean pulmonary arterial pressure (MPAP...
Article
Full-text available
Ziel der Studie war es, den Effekt von zwei Ringer-Laktat-Lösungen (Fresenius®=RLF, Bichsel®=RLB) auf Elektrolytund Laktatkonzentration sowie Säure-Basen-Status beim Pferd während einer 6-stündigen Allgemeinanästhesie zu untersuchen. Zehn Pferde wurden mit 10ml/kg/h RLF oder RLB während der Allgemeinanästhesie infundiert. Natrium (Na), Kalium (K),...
Article
To describe bispectral index (BIS) findings and compare them with cardiovascular and respiratory trends during cardiac arrest and successful CPR in a propofol-anesthetized calf. A 3-month-old calf was anesthetized as part of a research project. A thromboxane analog drug (U46619) was administered IV to induce pulmonary hypertension. Within 10 minute...
Article
The aim of this study was to compare the effect of two Ringer-Lactate solutions (Fresenius®= RLF, Bichsel® = RLB) on electrolyte and lactate concentrations as well as acid-base status of horses undergoing 6 h of general anaesthesia. Ten horses were allocated to receive either RLF or RLB at 10ml/kg/hour during anaesthesia. Na, K, Cl, ionized Ca, lac...
Article
History: Two cats were presented for orthopaedic surgery. Physical Examination: With the exception of the orthopaedic injuries found, clinical examination showed no abnormality. Management: As part of anaesthetic management, one cat received intrathecal morphine, the other epidural morphine. Following recovery, intense grooming was observed. After...
Article
Full-text available
To compare acid-base balance and incidence of hyperchloraemic metabolic acidosis following administration of three crystalloid solutions to dogs undergoing anaesthesia for orthopaedic surgery. Prospective, randomised, clinical study. Sixty dogs. During a non-standardised anaesthetic, 0.9% saline (S), Hartmann's solution (H) or a polyionic glucose-f...
Article
Objective The aim of this study was to investigate normal values for the dynamic compliance of the respiratory system (Crs) and respiratory system resistance (Rrs) in mechanically ventilated anaesthetized dogs. Study design Prospective clinical study. Animals Forty healthy dogs undergoing elective orthopaedic surgery. Body weight was (mean ± SD) 26...
Article
Reasons for performing study: Hypoxaemia is a common problem during equine anaesthesia. Continuous positive airway pressure (CPAP) is a ventilation mode routinely employed in man to overcome hypoxaemia but has not been objectively assessed in horses. Objectives: To test the effects of CPAP on oxygenation and its indices in anaesthetised horses i...
Article
Full-text available
During epidural needle placement in a 32-kg dog the subarachnoid space was punctured and half the intended dose of lidocaine, bupivacaine, and morphine was injected. After recovery from anesthesia the dog showed signs of severe pruritus of the tail base and limbs and myoclonus of the tail and hind limbs. Methadone, acepromazine, ketamine, buprenorp...
Poster
A 3 year 9 month old female neutered Chinchilla cat, body mass 2.45kg (BCS 3/5) was presented with chronic vomiting. Clinical examination revealed a heart rate of 220 beats/minute, with no cardiac murmur audible. The rhythm was irregularly irregular. Peripheral pulses were strong, with no pulse deficits. Respiratory rate was 30 breaths/minute with...
Article
This study investigated volumetric capnography (VC) in detecting airway responsiveness following airway challenge using carbachol in seven sedated dogs via face mask. Nebulised saline was administered, followed by increasing concentrations of nebulised carbachol until airflow limitation occurred (EP). Dead space (DS) variables and shape indices of...
Article
Full-text available
This case series is the first report of the use of CPAP (continuous positive airway pressure) ventilation in adult horses. Two horses and 3 ponies anesthetized for orthopedic procedures in lateral recumbency received 10 cm H(2)O CPAP. During anesthesia, arterial oxygen partial pressure tended to increase and arterial carbon dioxide pressure tended...
Article
Full-text available
This paper documents use of an endobronchial blocker (EBB) to achieve selective lung ventilation (SLV) for the purpose of lung lobectomy with thoracoscopy. A 3-year-old female neutered Labrador Retriever, body mass of 18.5 kg, was presented for exploratory thoracoscopy. Acepromazine and methadone were administered as premedication, and anaesthesia...