Martina Klünemann

Martina Klünemann
European Molecular Biology Laboratory | EMBL · Structural and Computational Biology Unit (Heidelberg)

PhD

About

12
Publications
2,787
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
425
Citations
Introduction
Martina Klünemann currently works at the Structural and Computational Biology Unit (Heidelberg), European Molecular Biology Laboratory. Martina does research in Systems Biology, Microbiology and Bioinformatics. Their most recent publication is 'Perturbation-response genes reveal signaling footprints in cancer gene expression'.
Additional affiliations
January 2013 - present
European Molecular Biology Laboratory
Position
  • PhD Student

Publications

Publications (12)
Article
Full-text available
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently¹ and the main underlying mechanism proposed is the chemical transformation of drugs by microorganisms (biotransformation). Here we investigated the depletion of...
Article
Full-text available
Extracting signalling pathway activities from transcriptome data is important to infer mechanistic origins of transcriptomic dysregulation, for example in disease. A popular method to do so is by enrichment analysis of signature genes in e.g. differentially regulated genes. Previously, we derived signatures for signalling pathways by integrating pu...
Article
Full-text available
Bacterial metabolism plays a fundamental role in gut microbiota ecology and host-microbiome interactions. Yet the metabolic capabilities of most gut bacteria have remained unknown. Here we report growth characteristics of 96 phylogenetically diverse gut bacterial strains across 4 rich and 15 defined media. The vast majority of strains (76) grow in...
Article
Full-text available
Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug research. A common approach is to infer signaling activity of pathways from gene expression. However, mapping gene expression to pathway components disregards the effect of post-translational modifications, and downstream signatures represent very specific expe...
Thesis
Studies as early as in the 70s showed that the gut and its intrinsic gut microbiota is a possible site of drug modification and later studies confirmed that human microbiota metabolism with its diverse set of genes can be a cause for drug side effects. Yet, our knowledge of the biochemical capabilities of gut bacteria to interact with or metabolize...
Article
Full-text available
Numerous pathway methods have been developed to quantify the signaling state of a cell from gene expression data, usually from the abundance of transcripts of pathway members, and are hence unable to take into account post-translational control of signal transduction. Gene expression signatures of pathway perturbations can capture this, but they ar...
Article
The gut microbiota is increasingly being recognized as a key site of metabolism for drugs and other xenobiotic compounds that are relevant to human health. The molecular complexity of the gut microbiota revealed by recent metagenomics studies has highlighted the need as well as the challenges for system-level modeling of xenobiotic metabolism in th...

Network

Cited By

Projects