Martina de Zwaan

Martina de Zwaan
Hannover Medical School | MHH

About

625
Publications
106,303
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18,444
Citations
Citations since 2016
209 Research Items
9153 Citations
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201620172018201920202021202205001,0001,500

Publications

Publications (625)
Article
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Background In individuals suffering from a rare disease the diagnostic process and the confirmation of a final diagnosis often extends over many years. Factors contributing to delayed diagnosis include health care professionals' limited knowledge of rare diseases and frequent (co-)occurrence of mental disorders that may complicate and delay the dia...
Article
Full-text available
Background The EQ-5D and the SF-6D are examples of commonly used generic preference-based instruments for assessing health-related quality of life (HRQoL). However, their suitability for mental disorders has been repeatedly questioned. Objective To assess the responsiveness and convergent validity of the EQ-5D-3L and SF-6D in patients with depress...
Article
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Introduction Misophonia refers to a phenomenon in which affected individuals have a selective intolerance to sounds of mostly oral or nasal origin. This intolerance is typically associated with strong emotional reactions such as anger, irritation, and disgust. The aim of this study was to conduct the first large epidemiological survey to determine...
Article
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Anorexia nervosa (AN), a psychiatric condition defined by low body weight for age and height, is associated with numerous dermatological conditions. Yet, clinical observations report that patients with AN do not suffer from infectious skin diseases like those associated with primary malnutrition. Cell-mediated immunity appears to be amplified in AN...
Article
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Zusammenfassung: Zielsetzung: Bei Personen vor Adipositaschirurgie wurden die Prävalenzen von Food Addiction (FA), alkoholbezogener Störung, Angst- und depressiven Störungen geschätzt. Zudem wurde untersucht, ob FA-Symptome mit Alkoholkonsum, Lebensqualität sowie Essstörungs-, Angst- und Depressionssymptomatik assoziiert sind und ob es Unterschiede...
Chapter
Die Adipositas wird als chronische Erkrankung mit hoher Rezidivneigung gesehen, weswegen den Betroffenen über die Phase der Gewichtsabnahme hinaus geeignete Maßnahmen zur langfristigen Gewichtsstabilisierung („extended care“) empfohlen werden sollten.
Chapter
Selbstbehandlungsansätze werden bereits seit längerer Zeit als Alternative zu bestehenden psychotherapeutischen und pharmakologischen Behandlungsansätzen diskutiert, u. a. im Rahmen von „Stepped-care-Modellen“ (Mitchell et al. 2011; Ramklint et al. 2012). Der überwiegende Teil basiert auf Therapiemanualen, die wesentliche Elemente der KVT-Ansätze e...
Chapter
Etwa die Hälfte der Teilnehmer eines konservativen Gewichtsreduktionsprogramms („Lifestyle“- Interventionen) reduziert ihr Gewicht um 5–10 %, was das Minimum an Gewichtsverlust im Hinblick auf eine klinisch signifikante Reduktion somatischer Risikoparameter darstellt. Neben der hohen Rate an Non-Respondern ist eine erneute Gewichtszunahme eher die...
Chapter
Bereits 1959 wurde von Albert Stunkard eine Untergruppe übergewichtiger Patientinnen und Patienten beschrieben, die durch wiederholte Episoden von Essanfällen ohne gegenregulatorische Maßnahmen gekennzeichnet war. In den Fokus des wissenschaftlichen Interesses gelangte diese Form der Essstörung jedoch erst, nachdem 1994 die Forschungskriterien für...
Chapter
Die Evidenz zur Pharmakotherapie der Anorexia nervosa (AN) ist insgesamt sowohl für Antidepressiva als auch für Antipsychotika unbefriedigend (AWMF 2018). Als primäres Zielkriterium galten in erster Linie Gewichtskriterien: Ausmaß des Gewichtszuwachses, Geschwindigkeit der Gewichtszunahme, Dauer der Behandlung bis zur Gewichtsrestitution und Anzahl...
Article
Objective: Patients suspected of having a rare (chronic) health condition have often gone a long way within the healthcare system. To date, little is known about the health-related quality of life of this group of patients. The study aims to describe the health-related quality of life and the perceived distress of patients suspected of having a ra...
Article
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Genetic factors are relevant for both eating disorders and body weight regulation. A recent genome-wide association study (GWAS) for anorexia nervosa (AN) detected eight genome-wide significant chromosomal loci. One of these loci, rs10747478, was also genome-wide and significantly associated with body mass index (BMI). The nearest coding gene is th...
Article
Aims: Pica and rumination disorder are known as feeding disorder diagnoses in childhood, but little is known about their occurrence in adulthood. This study aimed to assess prevalence rates of one-time and recurrent pica and rumination behaviours (PB and RB) in adults, including sociodemographic subgroups, and to examine associations with other ea...
Article
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Zusammenfassung Hintergrund Patienten mit unklarer Diagnose und Verdacht auf eine Seltene Erkrankung stellen unter anderem Ärzte vor besondere Herausforderungen. Ziel der Arbeit (Fragestellung) Das ZSE-DUO-Projekt will herausfinden, ob die gemeinsame Patientenbetreuung durch einen somatischen Arzt und einen Arzt für Psychiatrie und Psychotherapie...
Article
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Objective Previous research suggests that patients with anorexia nervosa (AN) show an impaired capacity to mentalize (reflective functioning, RF). RF is discussed as a possible predictor of outcome in psychotherapeutic processes. The study aimed to explore RF in sessions of patients with AN and its association with outcome and type of treatment. M...
Article
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Background: Compulsive buying-shopping disorder (CBSD) is associated with high materialistic values endorsement and excessive purchasing of consumer goods. A subgroup of individuals with CBSD engage in socially unacceptable behaviors to continue shopping despite negative consequences. This investigation aimed at exploring possible links between eg...
Article
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Background Chronic kidney disease (CKD) has emerged as a risk factor for cognitive impairment. Living kidney donation results in reduction of the donors’ renal function. This is considered acceptable in general but possible associations with cognitive function have not yet been studied. Methods Sixty living kidney donors (LKD), who had donated bet...
Article
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In patients after kidney transplantation (KTx) an increased rate of affective and anxiety disorders has been observed. Repeatedly, a relationship between mental health issues and increased morbidity and mortality in KTx recipients has been reported. However, information on the prevalence of mental disorders in KTx patients is scarce. As part of the...
Article
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Background: Metabolic syndrome (MetS) is associated with an increased risk for cardiovascular events and high socioeconomic costs. Despite lifestyle interventions focusing on exercise are effective strategies to improve parameters of the above aspects, many programs fail to show sustained effects in the long-term. Methods: At visit 2 (V2) 129 co...
Article
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Disturbances of HPA axis functioning as represented by cortisol awakening reaction (CAR) belong to the mediating pathways linking psychosocial distress and cardiovascular risk. Both depression and anxiety have been confirmed as independent risk factors for coronary artery disease (CAD). However, data on anxiety and cortisol output in CAD patients a...
Article
Zusammenfassung. Zielsetzung: Der Beitrag stellt die deutsche Übersetzung der Diagnosekriterien für die Kauf-Shopping-Störung vor, die im Rahmen einer internationalen Delphi-Studie entwickelt wurden. Methodik: In einem iterativen Prozess wurden die vorgeschlagenen englischen Diagnosekriterien aus der Originalveröffentlichung ins Deutsche übersetzt...
Article
Introduction A hyper-coagulant state is a biological mechanism that triggers cardiac events in patients with coronary artery disease (CAD). Depressive symptoms and anxiety predict an unfavourable course of CAD. The SPIRR-CAD-RCT examined the effects of a psychological intervention and provided the opportunity to explore cross-sectional associations...
Preprint
Full-text available
Background In individuals suffering from a rare disease the diagnostic process and the confirmation of a final diagnosis often extends over many years. Factors contributing to delayed diagnosis include health care professionals' limited knowledge of rare diseases and frequent (co-)occurrence of mental disorders that may complicate and delay the dia...
Article
Full-text available
Background Genetics and biology may influence the age at onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to AN age at onset and to investigate the genetic associations between age at onset of AN and age at menarche. Methods A secondary analysis of the Psychiatric Genomics Consor...
Conference Paper
Auch wenn das Studienziel nicht erreicht wurde, so zeigte sich erste positive Tendenzen sowie eine hohe Adhärenz zur Studienteilnahme. Es bleibt zu diskutieren, inwieweit die Covid-19-Pandemie und die damit verbundenen Einschränkungen Einfluss auf das Studienoutcome genommen haben. Zudem gilt es zu prüfen, inwieweit für zukünftige Studien noch stär...
Article
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Objective The aim of the present study was to investigate whether the remission of preoperative food addiction is associated with increases or new onset of other addictions within the first year following bariatric surgery. Methods One hundred and twenty-five bariatric surgery patients were assessed before surgery (t1) and at 6 months (t2) and 1 y...
Article
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Objectives: It has been recommended that all candidates for lung transplantation undergo pre-transplant psychosocial evaluation for risk assessment. However, psychosocial issues are only important if they correlate with outcomes after transplantation. Methods: In this prospective study patients who were referred for lung transplantation from 2016 t...
Article
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Background and aims: Consensus in acknowledging compulsive buying-shopping disorder (CBSD) as a distinct diagnosis has been lacking. Before research in this area can be advanced, it is necessary to establish diagnostic criteria in order to facilitate field trials. Methods: The study consisted of the following phases: (1) operationalization of a...
Article
Electronic medication monitoring devices (EMD) have been used as a gold standard for assessing medication adherence. We used a wireless EMD (SimpleMed+), assessed its usability in patients after kidney transplantation (KTx), evaluated adherence, and analyzed concordance with other adherence measures. Fifty-five patients (53% female, mean age 46 yea...
Article
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Introduction: While identity problems and materialistic value endorsement have been described as predisposing factors for buying-shopping disorder (BSD) in the literature, little empirical data are available on the role of socially undesirable personality features that may contribute to financial misconduct and manipulative interpersonal behaviors...
Article
Objective Organ transplantation is the treatment of choice for patients with end-stage organ disease. From early on, the psychological perspective on integrating the organ has been of interest. As quantitative studies on organ integration are scarce, we aimed at evaluating this aspect in a large sample of kidney transplant (KTx) recipients. Method...
Article
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Introduction: DNA methylation constitutes one important epigenetic mechanism that regulates gene expression in human cells. With regard to obesity, bariatric surgery-induced weight loss has been associated with promoter methylation changes in several genes. Hyperleptinemia is a characteristic feature of obesity. The underlying regulating mechanism...
Article
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Abstract Background and objectives Internet-based technologies play an increasingly important role in the management and outcome of patients with chronic kidney disease (CKD). The healthcare system is currently flooded with digital innovations and internet-based technologies as a consequence of the coronavirus disease 2019 (COVID-19) pandemic. Howe...
Article
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Background: Evidence shows that anxiety and depressive disorders play an important role in eating disorder behavior. However, given the epidemiology of eating disorders, there is a need to investigate potentially gender-specific connections. Method: This study tested the associations of anxiety and depression symptoms with eating disorder symptoms...
Article
Hintergrund: Kaufsucht geht mit einer hohen psychischen Komorbidität einher. Bislang haben nur wenige Studien untersucht, ob sich Patient*innen mit Kaufsucht hinsichtlich der komorbiden Psychopathologie von Patient*innen mit anderen psychischen Störungen unterscheiden. Ziel der Arbeit: Die Arbeit untersuchte die Häufigkeit von Angst-, Depressions-...
Article
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Clinical observations show that patients with anorexia nervosa (AN) are surprisingly free from infectious diseases. There is evidence from studies in Drosophila melanogaster that starvation leads to an increased expression of antimicrobial peptides (AMPs). AMPs are part of the innate immune system and protect human surfaces from colonization with p...
Article
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Background Coronary heart disease (CHD) is the leading cause of death and years of life lost worldwide. While effective treatments are available for both acute and chronic disease stages there are unmet needs for effective interventions to support patients in health behaviors required for secondary prevention. Psychosocial distress is a common como...
Article
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Guidelines recommend a healthy lifestyle and regularly physical activity (PA) after kidney transplantation (KTx). The KTx360° program is a multicenter, multisectoral, multimodal, telemedicine-based follow-up care program. Effects of the first COVID-19 wave restrictions on health-related quality of life and PA of supervised KTx360° patients were eva...
Article
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Background: The diagnosis and treatment of cancer are associated with psychological distress that often leads to a significant reduction in emotional and physical well-being and quality of life. Early detection of psychological distress is therefore important. This study aims to assess the psychological distress of inpatient cancer patients using...
Article
Aim: The aim of the study was to evaluate the psychometric properties of the 13-item Pathological Buying Screener (PBS, [1]) in a clinical sample. Method: The PBS was administered to a total sample of 413 treatment-seeking patients (buying-shopping disorder n=151, gambling disorder n=59, alcohol dependency n=60, other mental disorders [anxiety,...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Zusammenfassung Ziel: Personen mit schwerer Adipositas profitieren von adipositaschirurgischen Maßnahmen bezüglich Gewichtsabnahme und Reduktion körperlicher Komorbiditäten. Der Artikel fokussiert auf postoperative Depression und Suizidalität/Suizid und stellt eine narrative Überblicksarbeit von rezenten Metaanalysen und kontrollierten Studien dar....
Article
Buying disorder is defined by an extreme preoccupation with buying/shopping, by overpowering urges to buy, and by recurrent loss of control resulting in buying/shopping episodes in which the person purchases more than he or she can safely afford. The harmful spending behavior results in indebtedness, disruption of family life and personal relations...
Article
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Objectives: The study examines body image of male cancer patients and their female partners as well as factors influencing body image. Methods: N = 73 heterosexual couples in which the male partner was diagnosed with prostate (PC; n = 52) or laryngeal cancer (LC; n = 21) completed questionnaires on body image acceptance (Self Image Scale), relation...
Article
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Background and aims: In addition to craving responses to salient food cues, the anticipation of short-term rewarding consumption of palatable food may overrun the anticipation of long-term negative consequences of obesity. The present investigation addressed the potential interplay of food cravings and decision-making abilities in individuals with...
Article
Zusammenfassung Ziel Analyse des derzeitigen Wissens zur Bedeutung der SARS-CoV-2-Pandemie für Menschen mit Adipositas. Formulierung von Gesundheitsempfehlungen der Deutschen Adipositas-Gesellschaft. Methodik Selektive Literatursuche in PubMed und Internetrecherche. Ergebnisse Derzeit gibt es keine belastbaren Hinweise, dass Menschen mit Adipositas...
Article
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Purpose: After organ transplantation, adherence to immunosuppressive medication (ISM) is crucial to prevent organ rejection. To enable adherence, patients need to be well informed about the different aspects associated with their ISM. However, literature suggests that knowledge regarding ISM is often inadequate. Patients and Methods: In a cross-se...
Article
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Genetic variations affecting the course of depressive symptoms in patients with coronary artery disease (CAD) have not yet been well studied. Therefore, we set out to investigate whether distinct haplotypes of the two insertion/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (5-HTTLPR) and the angiotensin I-converting...
Article
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Patients with dystonia experience unusual postures and disfigurement. The aim of the study was to examine changes in the body concept in relation to quality of life and severity of dystonia. Our cohort consisted of 20 patients with idiopathic dystonia resistant to medical therapy who were planned for pallidal deep brain stimulation. The results wer...
Article
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Introduction: Network approaches to psychopathology posit that mental disorders emerge from interrelated symptoms, and thus connectivity among symptoms are assumed to negatively predict the treatment response and decrease with efficacious treatment. Objective: This study uniquely sought to elucidate the network structure, its change, and its pre...
Article
Purpose: Although fear of cancer recurrence (FoR) is one of the major concerns in cancer patients and their partners with approximately 49% reporting moderate to high FoR, few studies investigated predictors and sex-role-specific differences. The aim of the current study was to investigate FoR in couples with different types of cancer and to gain a...
Article
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Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying...
Article
Liebe Kolleginnen und Kollegen, Nun sind wir seit mehr als einem Monat mit einer Pandemie konfrontiert und wahrscheinlich hat niemand von uns so etwas schon einmal in seinem Leben erlebt. Der ein oder andere von uns muss schon sehr weit in seinem Leben zurückschauen, wo er den Hauch einer universellen Bedrohung mitbekam, 1960 die Kuba-Krise. Die El...
Article
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Objective There is solid evidence that kidney transplant (KTx) patients are susceptible to weight gain after transplantation. Post-transplantation obesity [body mass index (BMI) ≥ 30 kg/m2] seems to be associated with higher risks of hypertension, dyslipidemia, diabetes mellitus, and cardiovascular events, while there are contradicting findings reg...
Article
Zusammenfassung Die langfristige Gewichtsabnahme stellt die größte Herausforderung bei der Therapie von Übergewicht und Adipositas dar. Dabei gilt das restriktive Essverhalten, im Sinne individueller Strategien der kognitiven Kontrolle über die Nahrungszufuhr, als ein unabdingbarer Bestandteil von Interventionen zur gesundheitsförderlichen Verhalte...
Article
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The aim of the study was to investigate the prevalence of, and attitudes toward, vegetarianism and veganism. We also assessed the association between vegetarianism/veganism and eating disorder, depressive, and somatic symptoms. A cross-sectional questionnaire survey in adults in Germany that was representative in terms of age, gender, and education...
Article
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Objective It is well known that the occurrence of mental disorders is more common in lung transplant candidates compared to the general population. After transplantation mental disorders may negatively affect quality of life, adherence to immunosuppressive medication, as well as overall survival. Therefore, the identification of patients at risk is...
Article
Full-text available
Background: It is an important condition for adequate weight loss and prevention of adverse events that bariatric surgery (BS) candidates possess good specific health knowledge. There is a paucity of standardized instruments to evaluate the specific health knowledge of patients before and after BS. Therefore, we developed a 32-item multiple-choice...