Article: Intermittent dosing in melanoma
- Huntsman Cancer Institute & Dept. of DermatologySalt Lake City, Utah, United States
Dr. McMahon’s lab works on mechanisms underlying the development and treatment of metastatic melanoma, lung and thyroid cancer. His lab described the generation of BRaf(CA) mice which allow for conditional expression of oncogenic BRAF(V600E) in any target tissue. This mouse has been used widely in his lab and in the research community at-large to study tumor initiation, cancer progression and response to pathway-targeted pharmacological or immunologically based therapies.