Martin ŠrejberPalacký University Olomouc · Department of Physical Chemistry
Martin Šrejber
Master of Science
About
11
Publications
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126
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Citations since 2017
Introduction
Publications
Publications (11)
RNA-based therapies have shown promise in a wide range of applications, from cancer therapy, treatment of inherited diseases to vaccination. Encapsulation of RNA into ionizable lipid (IL) containing lipid nanoparticles (LNPs) has enabled its safe and targeted delivery. We present here the simulations of the self-assembly process of pH-sensitive RNA...
Graphene derivatives are an emerging and important class of promising materials because they can bear a wide variety of functional groups, rendering them suitable for a plethora of applications, ranging from energy storage to sensorics. Further functionalisation of these materials requires a thorough understanding of their reactivity at the molecul...
Recent advances in RNA-based medicine have provided new opportunities for the global current challenge, i.e., the COVID-19 pandemic. Novel vaccines are based on a messenger RNA (mRNA) motif with a lipid nanoparticle (LNP) vector, consisting of high content of unique pH-sensitive ionizable lipids (ILs). Here we provide molecular insights into the ro...
Emerging experimental evidence suggests tau pathology spreads between neuroanatomically connected brain regions in a prion‐like manner in Alzheimer's disease (AD). Tau seeding, the ability of prion‐like tau to recruit and misfold naïve tau to generate new seeds, is detected early in human AD brains before the development of major tau pathology. Man...
Liposomal formulations can be advantageous in a number of scenarios such as targeted delivery to reduce the systemic toxicity of highly potent Active Pharmaceutical Ingredients (APIs), to increase drug bioavailability by prolonging systemic circulation, to protect labile APIs from degradation in the gastrointestinal tract, or to improve skin permea...
Liposomal formulations can be advantageous in a number of scenarios such as targeted delivery to reduce the systemic toxicity of highly potent Active Pharmaceutical Ingredients (APIs), to increase drug bioavailability by prolonging systemic circulation, to protect labile APIs from degradation in the gastrointestinal tract, or to improve skin permea...
Biological membranes act as barriers or reservoirs for many compounds within the human body. As such, they play an important role in pharmacokinetics and pharmacodynamics of drugs and other molecular species. Until now, most membrane/drug interactions have been inferred from simple partitioning between octanol and water phases. However, the observe...
Biological membranes act as barriers or reservoirs for many compounds within the human body. As such, they play an important role in pharmacokinetics and pharmacodynamics of drugs and other molecular species. Until now, most membrane/drug interactions have been inferred from simple partitioning between octanol and water phases. However, the observe...
Mammalian cytochromes P450 (CYPs) are an important class of enzymes involved in the biotransformation of many endo- and exogenous compounds. CYP isoforms are attached to the membrane of the endoplasmic reticulum or mitochondria, and their catalytic domains move along the membrane surface while being partially immersed in the membrane environment. T...
Projects
Projects (2)
Drug-membrane crossing events play a key role in pharmacodynamics and pharmacokinetics. A particular attention is paid to the passive (unassisted) permeation of drug; for which the experimental elucidation of permeability coefficients is that is still a challenging task. Biased MD simulations appear a relevant tool to i) assess and predict permeation and ii) provide an atomistic resolution of this event.
