Martin Lotze

Universität Greifswald · Functional Imaging Unit in the Institute of Diagnostic Radiology and Neuroradiology

There is still disagreement among studies with respect to the magnitude, location, and direction of sex differences of local gray matter volume (GMV) in the human brain. Here, we applied a state-of-the-art technique examining GMV in a well-powered sample (n = 2,838) validating effects in two independent general-population cohorts, age range 21–90 y...

Patients with complex regional pain syndrome suffer from chronic neuropathic pain, but also show a decrease in sensorimotor performance associated with characteristic central and peripheral neural system parameters. In the brain imaging domain these comprise altered functional sensorimotor representation for the affected hand side. With regard to n...

Background: The insula has important function in monitoring and integrating physiological responses to a personal experience of multimodal input. The experience of chills in response to auditory stimuli is an important example for a relevant arousing experience coupled with bodily response. A group study about altered chill experiences in patients...

The role of the human insula in facial emotion recognition is controversially discussed, especially in relation to lesion-location-dependent impairment following stroke. In addition, structural connectivity quantification of important white matter tracts, which links the insula to impairments in facial emotion recognition has not been investigated....

Background: Integrity of the corticospinal tract (CST) is an important biomarker for upper limb motor function following stroke. However, when structurally compromised, other tracts may become relevant for compensation or recovery of function. Methods: We used the ENIGMA Stroke Recovery data set, a multicenter, retrospective, and cross-sectional c...

BACKGROUND: Perivascular Spaces (PVS) are a marker of cerebral small vessel disease (CSVD) that are visible on brain imaging. Larger PVS has been associated with poor quality of life and cognitive impairment post-stroke. However, the association between PVS and post-stroke sensorimotor outcomes has not been investigated. METHODS: 602 individuals wi...

Background: Stroke leads to complex chronic structural and functional brain changes that specifically affect motor outcomes. The brain-predicted age difference (brain-PAD) has emerged as a sensitive biomarker. Our previous study showed higher global brain-PAD associated with poorer motor function post-stroke. However, the relationship between local...

In temporomandibular disorder (TMD), the effects of standard interventions such as using an occlusal splint and its impact on pain relief and pain catastrophizing are poorly understood. Earlier work pointed to a crucial role of insula activation with changes in pain relief by occlusal splint treatment. We performed a functional imaging study using...

The documentation of performance during functional imaging represents a standard procedure employed to control for compliance, sensorimotor, and cognitive demands. In the case of motor tasks, preciseness, force, and frequency have a significant impact on the magnitude of functional activation. Questionnaires are used in psychological investigations...

Anxiety disorders (AD) are associated with altered connectivity in large-scale intrinsic brain networks. It remains uncertain how much these signatures overlap across different phenotypes due to a lack of well-powered cross-disorder comparisons. We used resting-state functional magnetic resonance imaging (rsfMRI) to investigate differences in funct...

This study set out to investigate in a population-based longitudinal cohort, whether chronification of back pain (BP) is related to structural gray matter changes in corticolimbic brain structures. Gray matter volume (GMV) was measured in participants with chronic BP (CBP, n = 168) and controls without chronic pain (n = 323) at 2 time points with a...

Background and purpose Cognitive impairment (CI) in multiple sclerosis (MS) is associated with bidirectional changes in resting‐state centrality measures. However, practicable functional magnetic resonance imaging (fMRI) biomarkers of CI are still lacking. The aim of this study was to assess the graph‐theory‐based degree rank order disruption index...

Our comment emphasizes the multisensory guidance of mental training processes as pointed out by Krüger et al. 2022. Guided multisensory mental training can focus on different aspects of action performance and gradually increase the vividness of the mental construct. The authors previously described an interaction between neural representation, subj...

Emotionales Ansprechen und Motivation, hohe Repetitionsrate ohne Langeweile oder Habituation – das ist ein Repertoire, das die meisten konventionellen Therapien in diesem Ausmaß nicht abdecken können. Alle multidimensionalen Therapieansätze sind durch eine außergewöhnlich umfassende ZNS-Aktivität gekennzeichnet, was eine Nutzung im Bereich des Trai...

Insula damage results in substantial impairments in facial emotion recognition. In particular, left hemispheric damage appears to be associated with poorer recognition of aversively rated facial expressions. Functional imaging can provide information on differences in the processing of these stimuli in patients with insula lesions when compared to...

Objective: Specific phobia is a common anxiety disorder, but the literature on associated brain structure alterations exhibits substantial gaps. The ENIGMA Anxiety Working Group examined brain structure differences between individuals with specific phobias and healthy control subjects as well as between the animal and blood-injection-injury (BII) s...

Background Individuals with anxiety disorders (ADs) often display hypervigilance to threat information, although this response may be less pronounced following psychotherapy. This study aims to investigate the unconscious recognition performance of facial expressions in patients with panic disorder (PD) post-treatment, shedding light on alterations...

Objective: Specific phobia is a common anxiety disorder, but the literature on associated brain structure alterations exhibits substantial gaps. The ENIGMA Anxiety Working Group examined brain structure differences between individuals with specific phobias and healthy control subjects as well as between the animal and blood-injection-injury (BII)...

Objective The role of ipsilateral descending motor pathways in voluntary movement of humans is still a matter of debate, with partly contradictory results. The aim of our study therefore was to examine the excitability of ipsilateral motor evoked potentials (iMEPs) regarding site and the specificity for unilateral and bilateral elbow flexion extens...

Chronische Schmerzen sind für Therapeutinnen und Therapeuten eine große Herausforderung. Am liebsten würden wir den Schmerz rasch lindern, was jedoch unmöglich ist. Die gemeinsame Arbeit mit chronisch von Schmerz betroffenen Patienten und Patientinnen kann deshalb leicht zu Frustration auf beiden Seiten führen. Für einen Therapieerfolg ist es gut,...

Excitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are synthesized by the enzyme autotaxin (ATX) at cortical synapses and modulate glutamatergic transmission, and eventually alter E/I balance of cortical networks. Here, we analyzed functional consequences of altere...

Background and Objectives: The aim of this secondary data analysis was to determine whether multiple sclerosis (MS) is associated with changes in global degree rank order disruption index (kD), a graph theory-based functional connectivity measure representing shift in overall distribution of nodal degree centrality. Additionally, we tested the rela...

Background: Longitudinal intervention studies on treatment options in temporomandibular dysfunction (TMD) including self reports and salivary biomarkers of stress are rare and the exact therapeutic function of occlusal splints widely unknown. Methods: We examined the therapeutic effects of a Michigan splint with occlusal relevance in patients wi...

Background: Longitudinal intervention studies on treatment options in temporoman- dibular dysfunction (TMD) including self reports and salivary biomarkers of stress are rare and the exact therapeutic function of occlusal splints widely unknown. Methods: We examined the therapeutic effects of a Michigan splint with occlusal relevance in patients wit...

Functional imaging has helped to understand the role of the human insula as a major processing network for integrating input with the current state of the body. However, these studies remain at a correlative level. Studies that have examined insula damage show lesion-specific performance deficits. Case reports have provided anecdotal evidence for d...

Anxiety disorders (AD) are associated with altered connectivity in large-scale intrinsic brain networks. The extent to which these signatures are shared across different phenotypes remains unclear, as well-powered transdiagnostic comparisons are still largely missing. We used resting-state functional magnetic resonance imaging (rsfMRI) to investiga...

Wir können nur dann Höchstleistungen bringen, wenn wir optimal motiviert sind. Doch was bedeutet das eigentlich, und wie können wir Patienten in der Neurorehabilitation so motivieren, dass unsere Therapie besonders effektiv umgesetzt wird?

Mentales Training beinhaltet den systematischen Einsatz von Bewegungsvorstellungen mit dem Ziel der Verbesserung von Lernen und Leistung bei Bewegungshandlungen. Welche Erkenntnisse gibt es dazu im Sport und wie lassen sie sich in die Neuroreha intergrieren?

Sex differences in the size of specific brain structures have been extensively studied, but careful and reproducible statistical hypothesis testing to identify them produced overall small effect sizes and differences in brains of males and females. On the other hand, multivariate statistical or machine learning methods that analyze MR images of the...

The execution of voluntary movements is primarily governed by the cerebral hemisphere contralateral to the moving limb. Previous research indicates that the ipsilateral motor network, comprising the primary motor cortex (M1), supplementary motor area (SMA), and premotor cortex (PM), plays a crucial role in the planning and execution of limb movemen...

(1) Background: BPD is characterized by affect dysregulation, interpersonal problems, and disturbances in attachment, but neuroimaging studies investigating attachment representations in BPD are rare. No study has examined longitudinal neural changes associated with interventions targeting these impairments. (2) Methods: We aimed to address this ga...

Background: Chronic pain of different aetiologies and localization has been associated with less grey matter volume (GMV) in several cortical and subcortical brain areas. Recent meta-analyses reported low reproducibility of GMV alterations between studies and pain syndromes. Methods: To investigate GMV in common chronic pain conditions defined b...

Background and objectives: Functional outcomes after stroke are strongly related to focal injury measures. However, the role of global brain health is less clear. Here, we examined the impact of brain age, a measure of neurobiological aging derived from whole brain structural neuroimaging, on post-stroke outcomes, with a focus on sensorimotor perf...

Dieser Überblick soll als Einführung in die Repräsentation neuropsychologischer Funktionen dienen. Ein Großteil des Wissens zur Repräsentation der Funktionen ist durch Testung an Patientinnen mit umschriebenen Schädigungen, an Gruppenstudien zu Patienten mit unterschiedlichen Schädigungsorten (Stichwort „lesion mapping“) oder durch funktionelle Rep...

Background A bidirectional functional link between vestibular and fear-related disorders has been previously suggested. Objective To test a potential overlap of vestibular and fear systems with regard to their brain imaging representation maps. Methods By use of voxel-based mapping permutation of subject images, we conducted a meta-analysis of ea...

In post-stroke spasticity (PSS), effective treatment with botulinum neurotoxin (BoNT) is associated with transient decrease in activation of the ipsilesional superior parietal lobule (SPL) and intraparietal sulcus (IPS). We hypothesized that this would be reflected in changes in resting-state functional connectivity (rsFC) of the SPL/IPS. Our aim w...

Neuroinflammatory mechanisms and maladaptive neuroplasticity underlie the progression of complex regional pain syndrome (CRPS), which is prototypical of central neuropathic pain conditions. While cortical maladaptive alterations are well described, little is known about the contribution of the brainstem to the pathophysiology. This study investigat...

Background The Symbol Digit Modalities Test (SDMT) is most frequently used to test processing speed in patients with multiple sclerosis (MS). Functional imaging studies emphasize the importance of frontal and parietal areas for task performance, but the influence of frontoparietal tracts has not been thoroughly studied. We were interested in tract-...

Chills are emotional peaks especially in response toward acoustic stimuli. In the present study, we examined facial expressions associated with pleasant and unpleasant chill experiences during music and harsh sounds by measuring electromyographic activity from facial corrugator and zygomatic muscles. A rubber bulb could be pressed by the participan...

Who has not experienced that sensation of losing the power of speech owing to an involuntary bout of laughter? An investigation of this phenomenon affords an insight into the neuronal processes that underlie laughter. In our functional magnetic resonance imaging study, participants were made to laugh by tickling in a first condition; in a second on...

It is hypothesized that the ability to discriminate between threat and safety is impaired in individuals with high dispositional negativity, resulting in maladaptive behavior. A large body of research investigated differential learning during fear conditioning and extinction protocols depending on individual differences in intolerance of uncertaint...

It is hypothesized that the ability to discriminate between threat and safety is impaired in individuals with high dispositional negativity, resulting in maladaptive behavior. A large body of research investigated differential learning during fear conditioning and extinction protocols depending on individual differences in intolerance of uncertaint...

We, here, provide a personal review article on the development of a functional MRI in the radiology departments of two German university medicine units. Although the international community for human brain mapping has met since 1995, the researchers fascinated by human brain function are still young and innovative. However, the impact of functional...

Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification of lesion burden and accurate image processing. Current automated lesion segmentation methods for T1-weighted (T1w) MRIs, commonly used in stroke research, lack accuracy and reliability. Manual segmentation remains the gold standard, but it is time-con...

rsFC fMRI Seed-based analysis of distinct pattern of anxiety diagnoses.

Emotionales Ansprechen und Motivation, hohe Repetitionsrate ohne Langeweile oder Habituation – das ist ein Repertoire, das die meisten konventionellen Therapien in diesem Ausmaß nicht abdecken können. Alle multidimensionalen Therapieansätze sind durch eine außergewöhnlich umfassende ZNS-Aktivität gekennzeichnet, was eine Nutzung im Bereich des Trai...

Sensorimotor representations of swallowing in pre- and postcentral gyri of both cerebral hemispheres are interconnected by callosal tracts. We were interested in (1) the callosal location of fibers interconnecting the precentral gyri (with the primary motor cortex; M1) and the postcentral gyri (with the primary somatosensory cortex; S1) relevant fo...

Background Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper‐limb sensorimotor impairment. We investigated associations between non‐l...

Introduction: The complex regional pain syndrome (CRPS) is a chronic pain condition which frequently results in sensorimotor dysfunction of the affected limb. With respect to pathophysiology an impaired interaction in sensorimotor cortex has been hypothesized¹. Sensorimotor interactions can be assessed through transcranial magnetic stimulation (TMS...

Introduction: The complex regional pain syndrome (CRPS) is a chronic pain condition, which can follow limb trauma and is accompanied with sensorimotor dysfunction¹. Current pathophysiological concepts assume local inflammatory processes that lead to peripheral and central sensitization of the nociceptive system². Secondary maladaptive alterations o...

Sensorimotor performance after stroke is strongly related to focal injury measures such as corticospinal tract lesion load. However, the role of global brain health is less clear. Here, we examined the impact of brain age, a measure of neurobiological aging derived from whole brain structural neuroimaging, on sensorimotor outcomes. We hypothesized...

Sex differences in the size of specific brain structures have been extensively studied but careful and reproducible statistical hypothesis testing to identify them produced overall small effect sizes and differences brains of males and females. On the other hand, multivariate statistical or machine learning methods that analyse MR images of the who...

Movement limitation is a common characteristic of chronic pain such that pain prevents the very movement and activity that is most likely to promote recovery. This is particularly the case for pathological pain states such as complex regional pain syndrome (CRPS). One clinical approach to CRPS that has growing evidence of efficacy involves progress...

Background Fear of abandonment and aloneness play a key role in the clinical understanding interpersonal and attachment-specific problems in patients with borderline personality disorder (BPD) and has been investigated in previous functional Magnet Resonance Imaging (fMRI) studies. The aim of the present study was to examine how different aspects o...

The Study of Health in Pomerania (SHIP), a population-based study from a rural state in northeastern Germany with a relatively poor life expectancy, supplemented its comprehensive examination program in 2008 with whole-body MR imaging at 1.5 T (SHIP-MR). We reviewed more than 100 publications that used the SHIP-MR data and analyzed which sequences...

Objective The role of ipsilateral descending motor pathways in voluntary movement of humans is still a matter of debate. Few studies have examined the task dependent modulation of ipsilateral motor evoked potentials (iMEPs). Here, we determined the location of upper limb biceps brachii (BB) representation within the ipsilateral primary motor cortex...

Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification of lesion burden and accurate image processing. Current automated lesion segmentation methods for T1-weighted (T1w) MRIs, commonly used in rehabilitation research, lack accuracy and reliability. Manual segmentation remains the gold standard, but it is...

Motives motivate human behavior. Most behaviors are driven by more than one motive, yet it is unclear how different motives interact and how such motive combinations affect the neural computation of the behaviors they drive. To answer this question, we induced two prosocial motives simultaneously (multi-motive condition) and separately (single moti...

Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is involved in sensorimotor behavior but has not been widely studied within the context of post-stroke upper limb sensorimotor impairment. The hippocampus is vulnerable to secondary degeneration after stroke, and damage to this region could furth...

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of sp...

Results on gray matter alterations in complex regional pain syndrome (CRPS) showed heterogeneous findings. Since CRPS is a rare disease, most studies included only small and heterogeneous samples resulting in a low reliability of findings between studies. We investigated 24 CRPS patients with right upper limb affection in the chronic stage of disea...

Introduction. Transcranial magnetic stimulation (TMS) induced ipsilateral silent periods (iSP) provide information on interhemispheric inhibitory drive, but varying methodological approaches in equipment, measurement, and data analysis hamper the comparability and overall reproducibility. Even though it is generally agreed that only pulses above re...

Background. In patients with multiple sclerosis (MS) lesions of the corpus callosum can be found even at early disease stages. With transcranial magnetic stimulation (TMS) the transcallosal interhemispheric inhibition can be investigated using the ipsilateral silent period (ISP). Various studies revealed differences in the duration of ISP in MS-pat...

Zunehmendes Alter, Stress und Immobilisation führen zu einem Abbau der grauen Substanz. Kann Bewegungstraining diesen Prozess aufhalten oder verzögern?

Insgesamt dient die Rehabilitation von älteren Menschen dem Erhalt der selbstbestimmten Teilhabe und trägt nachweislich zur Minderung der Pflegebedürftigkeit bei. In einigen Bereichen wurden vergleichbare Therapiefortschritte durch die Rehabilitation wie bei jüngeren Patienten nachgewiesen. Die Komplikationsrate ist allerdings erhöht, und das Team...

Single case studies about patients with unilateral insular lesions reported deficits in emotion recognition from facial expressions. However, there is no consensus about both the actual extent of impairments and the role of lesion lateralization. To investigate associations of brain lesions and impairments in a facial emotion recognition task, we u...

Motor imagery practice is a current trend, but there is a need for a systematic integration of neuroscientific advances in the field. In this review, we describe the technique of motor imagery practice and its neural representation, considering different fields of application. The current practice of individualized motor imagery practice schemes of...

Cigarette smoking increases the likelihood of developing anxiety disorders, among them panic disorder (PD). While brain structures altered by smoking partly overlap with morphological changes identified in PD, the modulating impact of smoking as a potential confounder on structural alterations in PD has not yet been addressed. In total, 143 PD pati...