Martin Korte

Martin Korte
Technische Universität Braunschweig · Zoological Institute

Prof. Dr.

About

200
Publications
31,903
Reads
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12,924
Citations
Introduction
The goal of our group is to understand the molecular and cellular mechanisms linking the functional changes to the structural modifications occurring during learning and memory processes and also to processes of forgetting. To this aim we use both in vitro and in vivo approaches to analyze the function as well as the morphology of neurons of the hippocampus. In addition we ask what role infections and the associated inflammatory reactions play for the progression of neurodegenerative diseases.
Additional affiliations
May 2012 - present
Helmholtz Centre for Infection Research
Position
  • Group Leader
September 2004 - present
Technische Universität Braunschweig
Position
  • Head of Department
September 1998 - August 2004
Max Planck Institute of Neurobiology
Position
  • Group Leader

Publications

Publications (200)
Article
Alzheimer's disease (AD) is histopathologically characterized by Aβ plaques and the accumulation of hyperphosphorylated Tau species, the latter also constituting key hallmarks of primary tauopathies. Whereas Aβ is produced by amyloidogenic APP processing, APP processing along the competing non-amyloidogenic pathway results in the secretion of neuro...
Article
Full-text available
Signaling of BDNF via its TrkB receptor is crucial in regulating several critical aspects of the architecture and function of neurons both during development and in the adult central nervous system. Indeed, several neurological conditions, such as neurodevelopmental and neurodegenerative disorders are associated with alterations both in the express...
Preprint
The anti-inflammatory cytokine interleukin-37 (IL-37) is a member of the IL-1 family but not expressed in mice. We used a human IL 37 (hIL-37tg) expressing mouse, which has been subjected to various models of local and systemic inflammation as well as immunological challenges. Those studies demonstrate an immune-modulatory role of IL-37 which can b...
Book
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You can download the fulltext via https://www.nomos-elibrary.de/10.5771/9783748927242-1/titelei-inhaltsverzeichnis?page=1
Article
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Influenza A virus (IAV) causes respiratory tract disease and is responsible for seasonal and reoccurring epidemics affecting all age groups. Next to typical disease symptoms, such as fever and fatigue, IAV infection has been associated with behavioral alterations presumably contributing to the development of major depression. Previous experiments u...
Article
Full-text available
Background Maturation is a process that allows synapses to acquire full functionality, optimizing their activity to diverse neural circuits, and defects in synaptic maturation may contribute to neurodevelopmental disorders. Neuroligin-1 (NL1) is a postsynaptic cell adhesion molecule essential for synapse maturation, a role typically attributed to b...
Article
Full-text available
A tight regulation of the balance between inhibitory and excitatory synaptic transmission is a prerequisite for synaptic plasticity in neuronal networks. In this context, the neurite growth inhibitor membrane protein Nogo-A modulates synaptic plasticity, strength, and neurotransmitter receptor dynamics. However, the molecular mechanisms underlying...
Preprint
Full-text available
Influenza A virus (IAV) causes respiratory tract disease and is responsible for seasonal and reoccurring epidemics affecting all age groups. Next to typical disease symptoms such as fever and fatigue, IAV infection has been associated with behavioral alterations presumably contributing to the development of major depression. Previous experiments us...
Article
Full-text available
Postsynaptic structures on excitatory neurons, dendritic spines, are actin-rich. It is well known that actin-binding proteins regulate actin dynamics and by this means orchestrate structural plasticity during the development of the brain, as well as synaptic plasticity mediating learning and memory processes. The actin-binding protein cortactin is...
Article
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Alterations in Ca ²⁺ homeostasis have been reported in several in vitro and in vivo studies using mice expressing the Alzheimer’s disease–associated transgenes, presenilin and the amyloid precursor protein (APP). While intense research focused on amyloid-β–mediated functions on neuronal Ca ²⁺ handling, the physiological role of APP and its close ho...
Article
Full-text available
Influenza viruses until today are a leading cause of worldwide severe pandemics and represent a major threat to human and animal health. Although the primary target of influenza viruses is the lung, infection may manifest with acute and even chronic neurological complications (e.g., status epilepticus, encephalopathies, and encephalitis) potentiall...
Article
The key role of APP for Alzheimer pathogenesis is well established. However, perinatal lethality of germline knockout mice lacking the entire APP family has so far precluded the analysis of its physiological functions for the developing and adult brain. Here, we generated conditional APP/APLP1/APLP2 triple KO (cTKO) mice lacking the APP family in e...
Article
Respiratory viruses as a major threat to human and animal health today are still a leading cause of worldwide severe pandemics. Although the primary target tissue of these viruses is the lung, they can induce immediate or delayed neuropathological manifestations in humans and animals. Already after the Spanish flu (1918/20) evidence accumulated tha...
Article
Full-text available
A Correction to this paper has been published: https://doi.org/10.1038/ni.3790
Article
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Numerous studies demonstrate that neuroinflammation is a key player in the progression of Alzheimer’s disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore a prime target for therapeutic options. The inactive IL-1β precursor requires processing by the the nucleotide-binding oligomerization domain-like receptor family, py...
Article
Full-text available
Dendritic spines are tiny membrane specialization forming the postsynaptic part of most excitatory synapses. They have been suggested to play a crucial role in regulating synaptic transmission during development and in adult learning processes. Changes in their number, size, and shape are correlated with processes of structural synaptic plasticity...
Article
Full-text available
Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer’s disease (AD) and is directly correlated with the cognitive decline typical of this pathology. The p75 neurotrophin receptor (p75NTR) binds amyloid-β oligomers in the nM range. While it was shown that µM concentrations of a...
Article
Neuroinflammation can be caused by various insults to the brain and represents an important pathological hallmark of neurodegenerative diseases including Alzheimer's disease. Infection-triggered acute systemic inflammation is able to induce neuroinflammation and may negatively affect neuronal morphology, synaptic plasticity and cognitive function....
Article
This overview will outline the current results of neuroscience research on the possible effects of digital media use on the human brain, cognition, and behavior. This is of importance due to the significant amount of time that individuals spend using digital media. Despite several positive aspects of digital media, which include the capability to e...
Article
Full-text available
Type I interferon receptor (IFNAR) signaling is a hallmark of viral control and host protection. Here, we show that, in the hippocampus of healthy IFNAR-deficient mice, synapse number and synaptic plasticity, as well as spatial learning, are impaired. This is also the case for IFN-β-deficient animals. Moreover, antibody-mediated IFNAR blocking acut...
Article
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The brain-derived neurotrophic factor (BDNF) plays crucial roles in both the developing and mature brain. Moreover, alterations in BDNF levels are correlated with the cognitive impairment observed in several neurological diseases. Among the different therapeutic strategies developed to improve endogenous BDNF levels is the administration of the BDN...
Article
Amyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological functions remain incompletely understood. Previous studies had indicated important synaptic functions of APP and the closely related homologue APLP2 in excitatory forebrain neurons for spine density, synaptic plasticity, and behavior. Here...
Chapter
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Organoids are developed from stem cells and serve as three-dimensional model systems for different organs. They have great potential for research and medicine, but also raise philosophical, ethical and legal questions which have rarely been discussed in Germany so far. This thematic study by the interdisciplinary research group (IAG) Gene Technolog...
Article
Full-text available
The Amyloid Precursor Protein (APP) is infamous for its proposed pivotal role in the pathogenesis of Alzheimer’s disease (AD). Much research on APP focusses on potential contributions to neurodegeneration, mostly based on mouse models with altered expression or mutated forms of APP. However, cumulative evidence from recent years indicates the indis...
Article
Full-text available
Precisely controlling the excitatory and inhibitory balance is crucial for the stability and information-processing ability of neuronal networks. However, the molecular mechanisms maintaining this balance during ongoing sensory experiences are largely unclear. We show that Nogo-A signaling reciprocally regulates excitatory and inhibitory transmissi...
Chapter
Der Kern von Lernen durch Lehren ist, dass Studierende der MINT-Fächer an der Technischen Universität Braunschweig durch einen Perspektivenwechsel – von der Rolle des passiv Lernenden in die des aktiv Lehrenden – den Lernstoff noch einmal unter neuen Aspekten durchdenken und durchdringen und so das Gelernte verfestigen, besser verstehen und vor all...
Article
Multiple variants of intellectual disability, e.g., the Fragile X Syndrome are associated with alterations in dendritic spine morphology, thereby pointing to dysregulated actin dynamics during development and processes of synaptic plasticity. Surprisingly, although the necessity of spine actin remodeling was demonstrated repeatedly, the importance...
Article
Full-text available
Purkinje cells (PCs) are primarily affected in neurodegenerative spinocerebellar ataxias (SCAs). For generating animal models for SCAs, genetic regulatory elements specifically targeting PCs are required, thereby linking pathological molecular effects with impaired function and organismic behavior. Because cerebellar anatomy and function are evolut...
Article
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Prenatal stress (PS) has long-term sequelae for the morphological and functional status of the central nervous system of the progeny. A PS-induced proinflammatory status of the organism may result in an impairment of both hippocampal synaptic plasticity and hippocampus-dependent memory formation in adults. We addressed here the question of how PS-i...
Article
Full-text available
Neurotrophins mediate neuronal growth, differentiation, and survival via tropomyosin receptor kinase (Trk) or p75 neurotrophin receptor (p75NTR) signaling. The p75NTR is not exclusively expressed by neurons but also by certain immune cells, implying a role for neurotrophin signaling in the immune system. In this study, we investigated the effect of...
Article
Full-text available
Brain-derived neurotrophin factor (BDNF) has been implicated in neuronal survival, differentiation and activity-dependent synaptic plasticity in the central nervous system. It was suggested that during postnatal development BDNF regulates neuronal architecture and spine morphology of neurons within certain brain areas but not others. Particularly s...
Article
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Neural stem cells (NSCs) in the adult mouse hippocampus occur in a specific neurogenic niche, where a multitude of extracellular signaling molecules converges to regulate NSC proliferation as well as fate and functional integration. However, the underlying mechanisms how NSCs react to extrinsic signals and convert them to intracellular responses st...
Chapter
Belohnung fördert die Motivation. Dieser Grundsatz erscheint jedem einleuchtend und vollkommen nachvollziehbar, aber manchmal muss man als Wissenschaftler auch das Offensichtliche belegen. Um die Allgemeingültigkeit zu überprüfen, beobachteten Psychologen in einer Studie die freiwilligen und belohnten Tätigkeiten von Vorschulkindern. Dafür wurden e...
Article
Increasing evidence suggests that synaptic functions of the amyloid precursor protein (APP), which is key to Alzheimer pathogenesis, may be carried out by its secreted ectodomain (APPs). The specific roles of APPsα and APPsβ fragments, generated by non-amyloidogenic or amyloidogenic APP processing, respectively, remain however unclear. Here, we exp...
Article
Acute influenza infection has been reported to be associated with neurological symptoms. However, the long-term consequences of an infection with neurotropic and non-neurotropic influenza A virus (IAV) variants for the CNS remain elusive. We can show that spine loss in the hippocampus after infection with neurotropic H7N7 (rSC35M) and non-neurotrop...
Preprint
Maturation is a process that allows synapses to acquire full functionality; failures in synaptic maturation may contribute to neurodevelopmental disorders. Neuroligins are postsynaptic cell-adhesion molecules essential for synapse maturation, but the underlying pathways are incompletely understood. Here, we show that maturational increases in activ...
Article
Our experiences and memories define who we are and evidence accumulates that memory formation is dependent on functional and structural adaptations of synaptic structures in our brain. Especially dendritic spines, the postsynaptic compartments of synapses, show a strong structure-to-function relationship and a high degree of structural plasticity....
Article
Full-text available
Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally befor...
Article
Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.
Article
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Dynamic regulation of plasticity thresholds in a neuronal population is critical for the formation of long-term plasticity and memory and is achieved by mechanisms such as metaplasticity. Metaplasticity tunes the synapses to undergo changes that are necessary prerequisites for memory storage under physiological and pathological conditions. Here we...
Article
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The amyloid precursor protein (APP), a key player in Alzheimer’s disease, belongs to the family of synaptic adhesion molecules (SAMs) due to its impact on synapse formation and synaptic plasticity. These functions are mediated by both the secreted APP ectodomain that acts as a neurotrophic factor and full-length APP forming trans-cellular dimers. T...
Article
Amyloid precursor protein (APP) gives rise to the amyloid-? peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful lo...
Article
Full-text available
The amyloid precursor protein (APP) is well known to be involved in the pathophysiology of Alzheimer’s disease via its cleavage product amyloid ß (Aß). However, the physiological role of APP, its various proteolytic products and the amyloid precursor-like proteins 1 and 2 (APLP1/2) are still not fully clarified. Interestingly, it has been shown tha...
Article
The Fragile X syndrome (FXS) as the most common monogenetic cause of cognitive impairment and autism indicates how tightly the dysregulation of synapse development is linked to cognitive deficits. Symptoms of FXS include excessive adherence to patterns that point to compromised hippocampal network formation. Surprisingly, one of the most complex hi...
Article
Full-text available
Interleukin-2 (IL-2)-deficient mice have cytoarchitectural hippocampal modifications and impaired learning and memory ability reminiscent of Alzheimer's disease. IL-2 stimulates regulatory T cells whose role is to control inflammation. As neuroinflammation contributes to neurodegeneration, we investigated IL-2 in Alzheimer's disease. Therefore, we...
Article
Full-text available
Dieser Beitrag widmet sich dem Stand in der Aus- und Weiterbildung zur Medienkompetenz mit besonderem Fokus auf interaktive digitale Medien. Wir gehen dabei davon aus, dass die Nutzung digitaler Medien zwar eine Reihe positiver Entwicklungen, sowohl in der Lehre als auch im Lernprozess, initiieren und freisetzen kann, dass aber Technikeinsatz allei...
Data
Major GO terms and KEGG pathways, revealed by ChIP-Enrich bioinformatics tool, found to be enriched among the genes having Satb2 peaks within their promoters.DOI: http://dx.doi.org/10.7554/eLife.17361.012
Data
Differentially expressed genes between Satb2 cKO mice and Satb2flox/flox littermate controls in the CA1 region as assessed by RNA-seq.Shown are the genomic coordinates of the identified Satb2 binding sites and the distance to the TSS of the corresponding gene.DOI: http://dx.doi.org/10.7554/eLife.17361.018
Data
List of miRNAs predicted to target mouse Arc 3’UTR by the bioinformatics tools TargetScan, PITA and miRanda.The miRNAs identified as up-regulated in the CA1 region of Satb2 cKO vs. control mice are shown in red.DOI: http://dx.doi.org/10.7554/eLife.17361.026
Data
No major significant differences in splicing were observed between the CA1 region of Satb2 cKO mice (n = 9) and littermate controls (n = 9).Only one gene showed differential exon usage at FDR corrected p-value significance level 0.01 and 12 genes at FDR 0.1 (based on DEXSeq R-package with default parameters).DOI: http://dx.doi.org/10.7554/eLife.173...
Data
List of differentially expressed miRNAs between Satb2 cKO mice and littermate controls (Satb2flox/floxmice) in the CA1 region as assessed by small RNA-seq analysis (base mean above 10 counts, 1.5-fold change, and adjusted p < 0.05).DOI: http://dx.doi.org/10.7554/eLife.17361.020
Data
List of differentially expressed miRNAs in the CA1 region of Satb2 cKO mice vs. littermate controls that contain Satb2 peak(s) within their promoter.DOI: http://dx.doi.org/10.7554/eLife.17361.021
Data
List of primers used in RT-qPCR and ChIP-qPCR analyses. DOI: http://dx.doi.org/10.7554/eLife.17361.027