Martin Halle

• Chair at Technical University of Munich

Patients with diabetes mellitus exhibit an increased risk for the development of cardiovascular diseases and the presence of both comorbidities has a major impact not only on the prognosis but also the implementation of evidence-based treatment to reduce the cardiovascular risk. The new 2023 guidelines of the European Society of Cardiology (ESC) pr...

Aims To estimate the relation between physical exercise volume, type and intensity with all-cause mortality and recurrent vascular events in patients with cardiovascular disease (CVD), and to quantify to what extent traditional cardiovascular risk factors mediate these relations. Methods In the prospective UCC-SMART cohort (N=8,660), the associati...

Aims To develop and validate a recalibrated prediction model (SCORE2-Diabetes) to estimate the 10-year risk of cardiovascular disease (CVD) in individuals with type 2 diabetes in Europe. Methods and results SCORE2-Diabetes was developed by extending SCORE2 algorithms using individual-participant data from four large-scale datasets comprising 229 4...

Funding Acknowledgements Type of funding sources: None. Background Bicuspid aortic valve (BAV) is the most common congenital cardiac condition among the general population and competitive athletes. BAV could be associated with progressive aortic dilatation, stenosis and/or regurgitation. There are concerns about the possible detrimental effects of...

Background: The Mediterranean diet (MD) is an anti-inflammatory diet linked to improved health-related quality of life (HRQoL). Germline (g)BRCA1/2 mutation carriers have an increased risk of developing breast cancer and are often exposed to severe cancer treatments, thus the improvement of HRQoL is important. Little is known about the associations...

The German Centre for Cardiovascular Research (DZHK) is one of the German Centres for Health Research and aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics that impact the lives of people with cardiovascular disease. Therefore, DZHK members designed a collaboratively organised and integrated research plat...

Objective Post-COVID-19 syndrome presents a health and economic challenge affecting ~10% of patients recovering from COVID-19. Accurate assessment of patients with post-COVID-19 syndrome is complicated by health anxiety and coincident symptomatic autonomic dysfunction. We sought to determine whether either symptoms or objective cardiopulmonary exer...

Background: COVID-19 might pose a risk for adults with congenital heart disease (ACHD). However, data regarding the rate of infection as well as myocardial involvement in ACHD patients are currently lacking. Methods: During the study period from January to June 2021, all consecutive outpatients from our ACHD clinic were eligible to participate....

Reduced exercise tolerance and fatigue are hallmark features in both breast cancer (BC) and heart failure with preserved ejection fraction (HFpEF) and are associated with decreased physical function and quality of life. This brief review focuses on the mechanisms of exercise intolerance in women with BC across the survivorship continuum and highlig...

Familial hypercholesterolaemia (FH) is the most common inherited metabolic disorder characterized by high cholesterol and if left untreated leads to premature cardiovascular disease, such as heart attacks. Treatment that begins early in life, particularly in childhood, is highly efficacious in preventing cardiovascular disease and cost-effective, t...

Continuous glucose monitoring (CGM) use has several potential positive effects on diabetes management. These benefits are, e.g., increased time in range (TIR), optimized therapy, and developed documentation. Physical activity is a recommended intervention tool in diabetes management, especially for people with type 2 diabetes (T2D). The benefits of...

Background Post-COVID-19 syndrome presents a challenge when determining the occupational grading of symptomatic military personnel, and their ability to deploy. In particular, the accurate assessment of patients with post COVID-19 syndrome is complicated by health anxiety and coincident symptomatic autonomic dysfunction. We therefore sought to dete...

Familial hypercholesterolaemia (FH) is under-recognized and under-treated in Europe leading to significantly higher risk for premature heart disease in those affected. As treatment beginning early in life is highly effective in preventing heart disease and cost-effective in these patients, screening for FH is crucial. It has therefore now been reco...

Familial hypercholesterolaemia (FH) is under-recognized and under-treated in Europe leading to significantly higher risk for premature heart disease in those affected. As treatment beginning early in life is highly effective in preventing heart disease and cost-effective in these patients, screening for FH is crucial. It has therefore now been reco...

While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been shown to successfully reduce weight, would also improve HRQOL more effectively than a lifestyle inter...

Aims: Exercise training (ET) has been consistently shown to increase peak oxygen consumption (V̇O2 ) in patients with heart failure with preserved ejection fraction (HFpEF); however, inter-individual responses vary significantly. Because it is unlikely that ET-induced improvements in peak V̇O2 are significantly mediated by an increase in peak hear...

Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicen...

Background Cardiovascular disease (CVD) is an important cause of morbidity and mortality in breast cancer survivors. Effective screening modalities to identify CVD risk are lacking in this population. Adrenomedullin (ADM) has been suggested as a biomarker for subclinical cardiac dysfunction in the general population. Levels of ADM have been proven...

This review compares the primary prevention recommendations of the recent 2021 European Society of Cardiology (ESC) and 2019 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines on cardiovascular disease (CVD) prevention. Although the 2019 ACC/AHA guideline represents its inaugural version, the ESC guideline is an update...

Background: Modern personalised medicine requires patient-tailored decisions. This is particularly important when considering pharmacological cardioversion for the acute treatment of haemodynamically stable atrial fibrillation and atrial flutter in a shared decision-making process. We aimed to develop and validate a predictive model to estimate th...

Low-caloric formula diets can improve hemodynamic parameters of patients with type 2 diabetes. We, therefore, hypothesized that persons with overweight or obesity can benefit from a high-protein, low-glycemic but moderate-caloric formula diet. This post-hoc analysis of the Almased Concept against Overweight and Obesity and Related Health Risk- (ACO...

This article provides an overview of the recommendations of the Aviation and Occupational Cardiology Task Force of the European Association of Preventive Cardiology on returning individuals to work in high hazard occupations (such as flying, diving and workplaces that are remote from healthcare facilities) following symptomatic COVID-19 infection....

Physical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality. Therefore, we wanted to identify predictors of CPF (represented by peak oxygen uptake: VO 2peak ) in BRCA1/2 mutation carriers whose risk of developing BC is high. We use...

The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present position paper aims to provide practical evidence-based information to support the implementation of effective preventive measures. Aft...

The heart failure epidemic is growing and its prevention, in order to reduce associated hospital readmission rates and its clinical and economic burden, is a key issue in modern cardiovascular medicine. The present consensus document aims to provide practical evidence-based information to support the implementation of effective preventive measures....

This article summarizes the innovations and most important points of the recently published and updated ESC guidelines 2021 on the prevention of cardiovascular diseases. Developments in risk stratification and further developments with respect to targets and options for the treatment of risk factors necessitated an update of the guidelines from 201...

Background: The current gold standard biomarker for myocardial infarction (MI), cardiac troponin (cTn), is recognized for its high sensitivity and organ specificity; however, it lacks diagnostic specificity. Numerous studies have introduced circulating microRNAs as potential biomarkers for MI. This study investigates the MI-specificity of these se...

Work is beneficial for health, but many individuals develop cardiovascular disease (CVD) during their working lives. Occupational cardi-ology is an emerging field that combines traditional cardiology sub-specialisms with prevention and risk management unique to specific employment characteristics and conditions. In some occupational settings incapa...

Purpose Emerging evidence suggests that the progesterone-mediated receptor activator of nuclear factor κB (RANK)/soluble RANK ligand (sRANKL)/osteoprotegerin (OPG) pathway plays an important role in mammary carcinogenesis and is hyperactivated in germline (g) BRCA1/2 mutation carriers. We analyzed the effects of a 3-month intensive lifestyle interv...

For the first time guidelines on sports cardiology have been published by the European Society of Cardiology (ESC). The background is the need for recommendations regarding physical activity, exercise, training as well as options for amateur and elite sports in patients with heart diseases. These include recommendations for patients with cardiovasc...

Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model to estimate 5- and 10-year risk of cardiovascular disease (CVD) in individuals aged over 70 years in four geographical risk regions. Methods and results Sex-specific competing risk-adjusted models for estimating CVD risk (CVD mortality, myocardi...

Clinical estimation of the combined effect of several risk factors is unreliable and this resulted in the development of a number of risk estimation systems to guide clinical practice. Here, after defining general principles of risk estimation, the authors describe the evolution of the European Society of Cardiology’s (ESC) Systematic COronary Risk...

Funding Acknowledgements Type of funding sources: None. Background Deterioration of left ventricular function after acute myocardial infarction is common, particular in ST-elevation myocardial infarction (STEMI). This often leads to heart failure with reduced ejection fraction (HFrEF). Exercise training has shown to be beneficial in stable chronic...

Funding Acknowledgements Type of funding sources: None. Background. Although structured exercise training is strongly recommended in cardiac patients, uncertainties exist about the methods for determining exercise intensity (EI) and their correspondence with effective EI obtained by ventilatory thresholds. We aimed to determine the first (VT1) and...

Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and obesity. Since insulin is the key weight regulator, we hypothesised that the addition of meal replacement to a lifestyle intervention reduces insulin levels more effectively than lifestyle intervention alone. In the internationa...

As formula diets have demonstrated to be effective in reducing weight, we hypothesised that in patients with overweight or obesity and accompanied cardiovascular risk factors, combining a liquid formula diet with a lifestyle intervention is superior in reducing weight and improving cardiovascular risk factors than lifestyle intervention alone. In t...

Background Germline BRCA1/2 mutation carriers (gBMC) face increased cancer risks that are modulated via non-genetic lifestyle factors whose underlying molecular mechanisms are unknown. The peptides Neurotensin (NT) and Enkephalin (ENK)—involved in tumorigenesis and obesity-related diseases—are of interest. We wanted to know whether these biomarkers...

Although meal replacement can lead to weight reduction, there is uncertainty whether this dietary approach implemented into a lifestyle programme can improve long-term dietary intake. In this subanalysis of the Almased Concept against Overweight and Obesity and Related Health Risk (ACOORH) study (n = 463), participants with metabolic risk factors w...

The guidelines for sports cardiology have recently been published for the first time by the European Society of Cardiology (ESC). They address recommendations for leisure time exercise and competitive sports in athletes with cardiovascular diseases. The spectrum ranges from women during pregnancy, athletes with increased cardiovascular risk and ris...

Phase III outpatient cardiac rehabilitation groups (cardiac rehab groups) are crucial for effective cardiovascular prevention and rehabilitation. The need to increase the number of these groups is limited by the decreasing availability of physicians as it has been mandated that all cardiac rehab groups have to be supervised by physicians. Study dat...

Heart failure patients (HF-rEF, HF-pEF or in combination) represent a relevant proportion of patients in cardiological rehabilitation facilities. They require a multimodal therapy concept due to the impaired systolic and/or diastolic ventricular function, the risk of malignant arrhythmias and the cardiac implantable electrical devices (CIED). In ad...

Background Physical activity has beneficial effects on depression, as well as on other mental and somatic diseases. The amount of recommended exercise is still under discussion. We investigated whether marathon runners (MA) exhibit less or more depressive symptoms and negative affects compared to sedentary controls (SC) and how their mood changes i...

Physical activity (PA) and exercise training (ET) are highly effective in the prevention of cardiovascular disease (CVD) via improvement of cardiovascular risk factors (CV RFs), such as blood pressure (BP), lipid profile, glycaemic control, body fat mass, and inflammation. In the first part of this chapter, we describe the currently observed effect...

Lifestyle interventions have been shown to reverse hyperglycemia to normoglycemia. However, these effects are not long-lasting and are accompanied with high dropout rates. As formula diets have been shown to be simple in usage and effective in improving glycemic control, we hypothesised that adding a low-carbohydrate and energy deficit formula diet...

Heart failure (HF) is a clinical syndrome defined by clinical symptoms and functional or structural cardiac abnormalities. Based on left ventricular ejection fraction, HF can be classified as reduced ejection fraction (HFrEF), mid-range ejection fraction (HFmrEF), or preserved ejection fraction (HFpEF). A hallmark feature of all of these forms of H...

Cardiovascular diseases are the leading cause of death worldwide. Adherence to a healthy lifestyle lifelong is capable of significantly reducing the cardiovascular risk by up to 70% and is therefore a key component in primary prevention of cardiovascular disease. According to the European and American guidelines lifestyle interventions include not...

Objective: Existing literature has shown heart rate recovery one minute (HRR1) after exercise termination in cardiopulmonary exercise testing (CPET) to correlate with performance, although no data exist on HRR3 and 5 in a population without manifest cardiovascular disease. We aimed to analyze whether HRR3 and 5 correlate with relative oxygen uptake...

Exaggerated blood pressure response during exercise is a risk factor for cardiovascular disease, but is inhomogeneously defined in the literature. We used a novel approach by taking into account both workload and blood pressure to define exercise hypertension (systolic values > 200 mmHg at 100W). We examined medically controlled hypertensives (n =...

https://www.sabcs.org/Program/Poster-Sessions/Poster-Session-6 P6-10-16 High circulating levels of adrenomedullin are associated with metabolic syndrome and low cardiorespiratory fitness in BRCA1 and BRCA2 mutation carriers https://www.abstractsonline.com/pp8/#!/7946/session/43

BACKGROUND: Risk factors for cardiovascular disease (CVD) and breast cancer overlap substantially. Identification of the underlying mechanisms associated with this co-occurrence is of great public health importance. Adrenomedullin (AM) is an almost ubiquitously expressed peptide with vasodilator and natriuretic properties. Previous studies have obs...

Purpose: Cardiorespiratory fitness (CRF) is a predictor of lower mortality in patients with coronary artery disease (CAD) and cancer patients. Whether cancer survivors with preserved ejection fraction (EF) have a higher fitness level than patients with stable CAD and heart failure with preserved EF (HFpEF) is unknown. Methods: We enrolled 61 cancer...

Background & aims: Evidence-based concepts to prevent breast cancer in women with BRCA1/2 mutations are limited. Adherence to a Mediterranean diet (MedD) has been associated with a lower risk for breast cancer, possibly due to a favorable fatty acid (FA) intake. Here, we studied in an at-risk population the effect of a lifestyle intervention that...

Background: Aortic root ectasia might induce hemostatic disorders in patients with Marfan syndrome (MFS) via altered blood flow and rheology. The aim of this study was to explore the hemostasis in patients with MFS compared with healthy controls. Methods: In this cross-sectional case-control study we included patients with verified MFS (n=51) an...

Eine Sporttherapie ist als unterstützende Maßnahme in der onkologischen Behandlung zu sehen, ist jedoch leider immer noch kein etablierter integraler Bestandteil für alle Patienten. Tumorpatienten profitieren von einer Sporttherapie, weil sie die Belastbarkeit, eine Fatigue-Symptomatik und die Lebensqualität verbessert und einer Sarkopenie entgegen...

Regular moderate physical activity (PA) has been linked to beneficial adaptations in various somatic diseases (e.g. cancer, endocrinological disorders) and a reduction in all-cause mortality from several cardiovascular and neuropsychiatric diseases. This study was designed to investigate acute and prolonged exercise-induced cardio- and neurophysiol...

Erratum zu: Kardiologe 2019 10.1007/s12181-019-0299-0 Im Abschnitt „Übergangsregelung“ des Beitrags wird als Voraussetzung für alle Stufen fälschlicherweise die Zusatzbezeichnung Sportmedizin gefordert. Diese ist jedoch lediglich für die Anerkennung der Stufe 3 Voraussetzung. Wir …

Lifestyle interventions have shown to reverse hyperglycemia to normoglycemia. However, most interventions are cost-intensive. Formula diets have shown to improve glycemic control and be cost-effective. We, therefore, hypothesized that adding a low-carbohydrate formula diet to a low-intense lifestyle intervention is superior in reversing prediabetes...

Eine Sporttherapie sollte ein fester Bestandteil der onkologischen Therapie sein, da sie zu einer Verbesserung der Belastbarkeit, der Fatigue-Symptomatik sowie der Lebensqualität führt und bei einigen Tumorentitäten ggf. auch Einfluss auf die Prognose der Erkrankung hat. Wichtig ist es, die Sporttherapie an den klinischen Status des Patienten anzup...

Myocardial involvement during viral infection is underestimated (∼5%). Most infections are not perceived and resolve spontaneously. Symptoms may be non-specific, but include new onset of angina in a young athlete, chest pain, increased resting and exercise heart rate, increased dyspnoea, palpitations, syncope, and impairment of exercise capacity. P...

Die Bedeutung der körperlichen Aktivität in der Primär- und Sekundärprävention kardialer Erkrankungen ist seit Langem bekannt. Regelmäßiges und strukturiertes Training ist ein unverzichtbarer Bestandteil der Behandlung kardial erkrankter Patienten. Zunehmend wird darüber hinaus von Freizeit- und Leistungssportlern eine kardiologische Diagnostik gew...

Ein gesunder Lebensstil kann das Tumorrisiko deutlich senken. Neben Alkohol, Rauchen und Ernährungsfaktoren ist Inaktivität als eigenständiger Risikofaktor für Tumorerkrankungen zu sehen. Hohe Evidenz von körperlicher Aktivität als protektiver Faktor gibt es für das Mamma‑, Kolon- und Endometriumkarzinom. Eine Risikoreduktion durch körperliche Akti...