Martin Brunovsky

Martin Brunovsky
National Institute of Mental Health | NUDZ · Applied Brain Electrophysiology (ABEP)

MD, PhD

About

175
Publications
23,349
Reads
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1,960
Citations
Additional affiliations
January 2015 - present
National Institute of Mental Health, Czech Republic
Position
  • Head of Department
November 2004 - present
Charles University in Prague, Third Faculty of Medicine
October 1999 - December 2014
Prague Psychiatric Center
Position
  • Head of EEG and Sleep laboratory

Publications

Publications (175)
Article
Full-text available
Psilocybin is a classical serotoninergic psychedelic that induces cognitive disruptions similar to psychosis. Gamma activity is affected in psychosis and is tightly related to cognitive processing. The 40 Hz auditory steady-state responses (ASSR) are frequently used as indicators to test the ability to generate gamma activity. Based on previous lit...
Article
Full-text available
Sleep disorders are diagnosed in sleep laboratories by polysomnography, a multi-parameter examination that monitors biological signals during sleep. The subsequent evaluation of the obtained records is very time-consuming. The goal of this study was to create an automatic system for evaluation of the airflow and SpO2 channels of polysomnography rec...
Article
Suicidal risk assessment is still a major challenge not only in psychiatric practice. Clinical investigation of suicidality can be significantly improved by using standardized scales for assessing suicide risk. The choice of a method for assessing suicidality also has significant implications for the search of valid available biomarker of suicidal...
Article
Several studies suggest that EEG parameters, reflecting top-down processes in the brain, may predict cognitive performance, e.g. short-term memory (STM) capacity. According to Lisman and Idart’s model, STM capacity is predicted by theta and gamma EEG waves and their ratio. This model suggests that the more periods of gamma band waves fit into one p...
Article
Full-text available
Objective Ketamine has been shown to be effective in treatment of episodes of major depressive disorder (MDD). This controlled study aimed to analyse the predictive and discriminative power of heart rate (HR) and heart rate variability (HRV) for ketamine treatment in MDD. Methods In 51 patients, HR and HRV were assessed at baseline before and duri...
Article
Full-text available
Functional magnetic resonance imaging (fMRI) techniques and electroencephalography (EEG) were used to investigate sleep with a focus on impaired arousal mechanisms in disorders of arousal (DOAs). With a prevalence of 2–4% in adults, DOAs are significant disorders that are currently gaining attention among physicians. The paper describes a simultane...
Article
Full-text available
Serotonergic agonist psilocybin is a psychedelic with antidepressant potential. Sleep may interact with psilocybin's antidepressant properties like other antidepressant drugs via induction of neuroplasticity. The main aim of the study was to evaluate the effect of psilocybin on sleep architecture on the night after psilocybin administration. Regard...
Article
The usage of EEG in the clinical diagnosis of psychiatric disorders has been a matter of debate for a long time (Williams, 1954). On one side, it has been argued that EEG recordings from psychiatric patients yield a relatively low abnormality detection rate, resulting in a neglectable value for diagnosis or impact on patient management (O’Sullivan...
Article
Full-text available
Explainable artificial intelligence holds a great promise for neuroscience and plays an important role in the hypothesis generation process. We follow-up a recent machine learning-oriented study that constructed a deep convolutional neural network to automatically identify biological sex from EEG recordings in healthy individuals and highlighted th...
Article
Introduction The global COVID-19 pandemic has affected the economy, daily life, and mental/physical health. The latter includes the use of electroencephalography (EEG) in clinical practice and research. We report a survey of the impact of COVID-19 on the use of clinical EEG in practice and research in several countries, and the recommendations of a...
Article
Full-text available
The rapid antidepressant effect of ketamine has become a breakthrough in the research and treatment of depression. Although predictive and modulating factors of the response to ketamine are broadly studied, little is known about optimal concurrent medication protocols. Concerning gamma-aminobutyric acid neurotransmission being a shared target for b...
Article
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depressive disorder, with outcomes approaching 45–55% response and 30–40% remission. Eligible predictors of treatment outcome, however, are still lacking. Few studies have investigated quantitative electroencephalography (QEEG) parameters as predictors of rTMS treatme...
Article
Full-text available
Simultaneous recordings of electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) are at the forefront of technologies of interest to physicians and scientists because they combine the benefits of both modalities—better time resolution (hdEEG) and space resolution (fMRI). However, EEG measurements in the scanner contain an elec...
Article
Full-text available
Objective: Transcranial direct-current stimulation (tDCS), a relatively new neuromodulation approach, provides some evidence of an antidepressant effect. This randomized, 4-week, double-blind study with 8-week, open-label, follow-up compared the efficacy and tolerability of left anodal tDCS with venlafaxine ER (VNF) in the treatment of depression...
Article
Background: The study evaluated the effectiveness of EEG alpha 1, alpha 2 and theta power, along with prefrontal theta cordance (PFC), frontal and occipital alpha 1, alpha 2 asymmetry (FAA1/2, OAA1/2) at baseline and their changes at week 1 in predicting response to antidepressants. Method: Resting-state EEG data were recorded from 103 depressiv...
Article
Full-text available
Objective Previous studies have demonstrated the efficacy of reduction of prefrontal theta cordance (RC) after 1week of treatment in the prediction of antidepressant response. Our study aimed to compare the ability of RC in the prediction of response to various treatments. Methods In total, 167 inpatients with MDD were treated with various antidep...
Chapter
The time-domain independent component analysis (ICA) is commonly used technique for neural and noise signal separation in electroencephalographic (EEG) data. Nevertheless, the estimated independent sources have to be further classified by an expert using predefined or learned features. Automatic algorithms on market suffer from unsatisfactory sensi...
Article
Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains unclear, the traditional model focused on alternations in the serotonin system. Selective serotonin reuptake inhibitors provide the most effective treatment; however, as much as...
Article
Full-text available
Background The underlying symptomatology of obsessive–compulsive disorder (OCD) can be viewed as an impairment in both cognitive and behavioral inhibition, regarding difficult inhibition of obsessions and behavioral compulsions. Converging results from neuroimaging and electroencephalographic (EEG) studies have identified changes in activities thro...
Article
Objectives: Although schizencephaly belongs to the class of neurodevelopmental disorders, which are a well-known predisposing factor for psychosis, there is a lack of relevant studies and diagnostic guidelines on this relationship. Method: A case report of first-episode psychosis with persistent negative symptoms associated with schizencephaly i...
Article
Objective Time-course of ketamine effect was assessed in depressive patients by QEEG to elucidate changes associated with treatment and to assess potential predictors of response. Methods The analysis was completed from data of two double-blind, cross-over, placebo-controlled studies, assessing the effect of ketamine infusion (0.54 mg/kg) in 51 in...
Article
Full-text available
Rationale: Disruption of auditory event-related evoked potentials (ERPs) P300 and mismatch negativity (MMN), electrophysiological markers of attentive and pre-attentive cognitive processing, is repeatedly described in psychosis and schizophrenia. Similar findings were observed in a glutamatergic model of psychosis, but the role of serotonergic 5-H...
Conference Paper
Full-text available
Introduction.-Studies in adults show that approximately 30-60% of individuals diagnosed with bipolar disorder (BD) retrospectively report the onset of their illness in childhood. Objectives.-To determine psychopathology, cognitive functions and identify early markers in EEG cortical sources, cortical connec-tivity and event-related potentials (ERPs...
Article
Introduction: Mirror neurons are specific association neurons that are active both during a certain movement and during the observation of such movement. It can be assumed that mirror neurons play an important role in the ability to imitate and are an important condition for the rehabilitation of the locomotor system. Methods: The aim of our work w...
Article
Introduction and objectives Previous studies demonstrated efficacy of reduction of QEEG prefrontal theta cordance (RC) after the first week of treatment in the prediction of antidepressant response. Aims The study aimed to compare the ability of RC in the prediction of response to various antidepressant classes. Methods All patients (n = 142) wer...
Article
The study examines the occurrence of alpha activity andtheir intracerebral sources in sLORETA imaging duringChinese health exercise. The experiment was conductedwith five participants (three male and two females aged27-52) who carried out simple, repetitive, symmetricalmovements with their upper limbs. The duration of theexercise was 10 minutes wit...
Poster
Full-text available
OBJECTIVES The serotonergic hallucinogen psilocybin, has profound effects on the human mind, which can be characterized by alteration in perception, thinking disorder and strong emotional salience. The character of the altered state of consciousness induced by hallucinogens is hardly predictable; while an important role has the environment in which...
Poster
Full-text available
Patients suffering from schizophrenia have been shown to exhibit impaired P50 ERP amplitude-reduction to the second (S2) relative to the first (S1) of identical brief auditory stimuli. This reduction is often mentioned in connection with the inability to filter redundant sensory stimuli typically manifested as inability to gate neuronal responses r...
Conference Paper
Full-text available
Patients suffering from schizophrenia have been shown to ex- hibit impaired P50 ERP amplitude-reduction to the second (S2) relative to the first (S1) of identical brief auditory stimuli. This reduction is often mentioned in connection with the inability to filter redundant sensory stimuli typically manifested as in- ability to gate neuronal respons...
Article
The substantial non-response rate in depressive patients indicates a continuing need to identify predictors of treatment outcome. The aim of this 6-week, open-label study was (1) to compare the efficacy of a priori defined predictors: ≥20% reduction in MADRS score at week 1, ≥20% reduction in MADRS score at week 2 (RM ≥ 20% W2), decrease of cordanc...
Article
Repetitive transcranial magnetic stimulation (rTMS) has been demonstrated to have efficacy in the treatment of unipolar depression but limited research has explored the efficacy of rTMS in bipolar depression. Therefore, we conducted a comparative clinical trial evaluating clinical responses to prefrontal bilateral and unilateral rTMS in patients su...
Article
Full-text available
Background: Obsessive-compulsive disorder (OCD) is associated with cognitive dysfunction. Although there are several studies focused on the neurobiology of OCD, little is known about the biological correlates of the cognitive deficit linked to this disorder. The aim of our study was to examine the association between cognitive impairment and curre...
Article
Object The aim of our study was to monitor the intracerebral localization of brain electric activity during qi gong practice with open and closed eyes. Methods Five volunteers were tested. They performed exercise for eight minutes with open eyes and subsequently for eight minutes with closed eyes. Simultaneously, electroencephalographic activity w...
Article
The elucidation of the brain circuitry underlying neural bases of mood and emotion represents the essential aim of modern neuroscience and psychiatric research. The aims of the study was to identify QEEG correlates of autobiographically induced emotionally neutral and emotionally negative situation (sadness) using the QEEG methods sLORETA (standard...
Article
Introduction The substantial non-response rate in depressive patients indicates a need to identify predictors of treatment outcome. Objective and aims The aim of the open-label, 6-week study was: – to compare efficacy of a priori defined predictors: ≥ 20% reduction in MADRS score at week 1, ≥ 20% reduction in MADRS score at week 2 (RM ≥ 20% W2), d...
Article
Full-text available
The loudness dependence of the auditory evoked potential (LDAEP) is an easily accessible and non-invasive electrophysiological method of assessing neuromodulatory effects of monoamines, specifically serotonin, on central nervous system. Previous studies showed that the LDAEP can be a useful tool in clinical practice in predicting the therapeutic ef...
Article
Schizophrenic disorders are often associated with impaired sensory inhibition - sensory gating. This process prevents sensory system from overloading with stimuli going in quick succesion that do not carry any new information. The impairment (deficit) can be revealed by measurement of P50. Evoked potential P50 is characterized by neurophysiological...
Article
Full-text available
Comorbidities associated with depression have been researched in a number of contexts. However, the epidemiological situation in clinical practice is understudied, especially in the post-Communist Central and Eastern Europe region. The aim of this study was to assess physical comorbidities in depression, and to identify whether there are increased...
Article
Full-text available
Background: Approximately 30%-60% of adults diagnosed with bipolar disorder (BD) report onset between the ages 15 and 19 years; however, a correct diagnosis is often delayed by several years. Therefore, investigations of the early features of BD are important for adequately understanding the prodromal stages of the illness. Methods: A complete r...
Article
Pharmacological models of psychosis bring a unique tool for studying brain disconnection in humans as well as in animals. Even though several electrophysiological biomarkers have been already described in schizophrenia, little is known about EEG biomarkers in pharmacological models of psychosis and about the translational validity of these data. St...
Article
Full-text available
Aberrant amygdala reactivity to affective stimuli represents a candidate factor predisposing patients with bipolar disorder (BD) to relapse, but it is unclear to what extent amygdala reactivity is state-dependent. We evaluated the modulatory influence of mood on amygdala reactivity and functional connectivity in patients with remitted BD and health...
Article
In the present study we investigated the potential antipsychotic effects of the mGlu2/3 agonist LY379268 on changes in EEG power spectra and coherence in the ketamine model of psychosis. In order to use behaviorally active drug doses, experiments detecting changes in locomotor activity and sensorimotor gating were also conducted. In EEG experiments...
Article
Full-text available
Current studies suggest that an early improvement of depressive symptoms and the reduction of prefrontal theta cordance value predict the subsequent response to antidepressants. The aim of our study was (1) to compare the predictive abilities of early clinical improvement defined as ≥20 % reduction in Montgomery and Åsberg Depression Rating Scale (...
Article
Background Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) directed to the left temporo-parietal region is a promising effective treatment for auditory hallucinations (AHs) in patients who do not respond to antipsychotic medication. However, little is known about the electrophysiological effect on regional functional activity a...
Article
Full-text available
The aims of this double-blind study were to assess and compare the efficacy of quantitative electroencephalographic (QEEG) prefrontal theta band cordance in the prediction of response to 4-week, right, prefrontal, 1-Hz repetitive transcranial magnetic stimulation (rTMS) or venlafaxine ER in patients with major depressive disorder (MDD). Prefrontal...
Article
Full-text available
The effectiveness of prefrontal theta cordance and early reduction of depressive symptoms in the prediction of antidepressant treatment outcome in patients with resistant depression: analysis of naturalistic data