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Introduction
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Publications
Publications (25)
Almost nothing is known about the condition of the knee joints of multistage ultra-marathon (MSUM) runner. This is first image-based investigation of the femoropatellar joint (FPJ) using a mobile 1.5T MRI accompanying the MSUM TransEurope Foot-Race (TEFR) 64 stages over 4486 km. Twenty-two (20 male) subjects got a knee MRI-protocol at defined measu...
Purpose:
Indicating lumbar disc herniation via magnetic resonance imaging (MRI) T2 mapping in the posterior annulus fibrosus (AF).
Methods:
Sagittal T2 maps of 313 lumbar discs of 64 patients with low back pain were acquired at 3.0 Tesla (3T). The discs were rated according to disc herniation and bulging. Region of interest (ROI) analysis was pe...
Background
The treatment of larger osteochondral lesions of the talus remains an operative challenge. In addition to micro fracturing and osteochondral transplantation one promising strategy could be the operative repair with a cell-free multilayered nano-composite scaffold with the potential to regenerate bone and cartilage in one treatment.
Meth...
Aims and Objectives:
Surgical repair of osteochondral lesions ranging from 2 or more cm2 still is a clinical challenge. Using MaioRegen® a biocomposite allograft consisting of magnesium hydroxyapatite and equine collagen could be a promising treatment option.
Materials and Methods:
8 consecutive patients suffering from a single osteochondral lesio...
Introduction
The treatment of larger osteochondral lesions in the knee is still a clinical challenge. One promising strategy to overcome this problem could be surgical repair by using a cell-free multilayered nano-composite scaffold.
Method
In this prospective cohort study eight consecutive patients which suffered from a single osteochondral lesion...
In times of declining immunization rates among children in many countries and an increasing threat of potentially vaccine-preventable diseases, there is a strong need for new strategies to improve trust in vaccinations and acceptance of recommendations, especially in parents of infants and children. A survey to evaluate vaccination acceptance has b...
The goal of cartilage repair techniques such as microfracture (MFX) or matrix-associated autologous chondrocyte transplantation (MACT) is to produce repair tissue (RT) with sufficient glycosaminoglycan (GAG) content. Sodium magnetic resonance imaging (MRI) offers a direct and noninvasive evaluation of the GAG content in native cartilage and RT. In...
All surgical cartilage repair techniques require valid, reproducible, and widely applied diagnostics, which provide a basis for staging and for follow-up of the cartilage repair tissue as well as the adjacent cartilage.
Background:
Matrix-associated autologous chondrocyte transplantation (MACT) has become an established articular cartilage repair technique. It provides good short-term and midterm results; however, long-term results are lacking.
Purpose:
To prospectively assess the clinical outcome after MACT in the knee to report long-term results.
Study desig...
Autologous Chondrocyte Transplantation introduced cell therapy in the treatment of pathologic condition in the locomotors stem, particularly in cartilage repair. The use biomaterials as scaffolds for transplantation assured cell delivery and supported cell behaviour towards the condrocytic phenotype to provide chondrogenic potential to regenerate a...
Chemical exchange saturation transfer (CEST) is a technique that allows generating a contrast in magnetic resonance images based on chemical exchange of free water protons and protons of solute molecules. From the many exogenous and endogenous molecules that have been introduced as CEST contrast agents, CEST contrast mediated by glycosaminoglycans...
Target audience Musculoskeletal radiologists, physicists developing sequences for imaging of fast relaxing tissues, OA specialists Purpose The integrity of the calcified cartilage as well as tidemark (calcified cartilage front) is one of the signs of osteoarthritis (OA) progressing. In the later OA stages tidemark duplicates or multiplies, is compr...
PURPOSE
Validation of glycosaminoglycan-dependent chemical exchange saturation transfer (gagCEST) imaging as a tool for monitoring of cartilage glycosaminoglycan (GAG) content at 3 Tesla.
METHOD AND MATERIALS
Intact ankles from 10 human cadavers were first examined by MRI and subsequently analysed histobiochemically. Morphological MRI and gagCEST...
PURPOSE
To compare the sodium signal-to-noise ratio (SNR), suggestive of glycosaminoglycan (GAG) content, between native cartilage and cartilage repair tissue in the ankle joint of patients treated by microfracturing (MFX) or matrix-associated autologous chondrocyte transplantation (MACT).
METHOD AND MATERIALS
Institutional Review Board approval a...
Purpose:
The aim of this study was to assess the stability of the glycosaminoglycan (GAG) content in the long term after matrix-associated autologous chondrocyte transplantation (MACT) with Hyalograft C in the knee over a follow-up period of one year.
Methods:
In this cross-sectional evaluation, 11 patients after MACT of the knee consented to de...
Articular cartilage damage is challenging to treat. The patient has to deal with pain, functional impairment and compromized quality of life. Ultimately, he has to face the risk of early total joint replacement. A variety of treatment options is available to improve the situation for the patient. Mosaicplasty, bone marrow-stimulating techniques and...
