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8
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Introduction
Skills and Expertise
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December 2015 - December 2019
Publications
Publications (8)
Traditional Transwell inserts with track‐etched 10 μm thick polymer membranes have been intensively used for studying cellular barriers. However, their thickness hampers direct cell‐cell interaction between the adjacent cells which has been shown to critically influence the barrier formation. Therefore, here the effect of reduced distance between t...
Current organ-on-chip devices suffer from lack of throughput. A multiplexed two-layer device with transparent, through-hole polydimethylsiloxane (PDMS) membrane was developed. This device allows individually addressable cell cultures in a single chip without cross-talk between them. By co-culturing human cerebral microvascular endothelial hCMEC/D3...
In bottom-up tissue engineering, small modular units of cells and biomaterials are assembled toward larger and more complex ones. In conjunction with a new implementation of this approach, a novel method to fabricate microscale objects from biopolymers by thermal imprinting on water-soluble sacrificial layers is presented. By this means, geometrica...
Free-standing polydimethylsiloxane (PDMS) through-hole membranes have been studied extensively in recent years for chemical and biomedical applications. However, robust fabrication of such membranes with sub-μm through-holes, and at a sub-μm thickness over large-areas is challenging. In this paper, we report a robust and simple method for large-sca...
Organ-on-chip systems promise to be useful tools for disease modeling and drug testing. These systems focus on the separation of the parenchymal tissue from endothelial cells, which form the vasculature. Previous organ-on-chip models make use of artificial membranes to separate two fluidic channels representing the parenchymal and the endothelial s...
Photo-crosslinked networks were prepared from fumaric acid monoethyl ester-functionalized poly(D,L-lactic acid) oligomers and N-vinyl-2-pyrrolidone. Two model proteins, lysozyme and albumin, were incorporated into the network films as solid particles and their release behavior was studied. By varying the NVP content and macromer molecular weight th...
