• Home
  • Martijn A Spruit
Martijn A Spruit

Martijn A Spruit
Ciro & Maastricht University

PhD

About

576
Publications
124,099
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
24,046
Citations

Publications

Publications (576)
Article
Full-text available
Background Fatigue is frequently reported in people with a non-communicable chronic disease. More insight in the nature of this symptom may enhance targeted treatment of fatigue. In this study, we aimed to gain more insight in the prevalence of different types of fatigue and in current prescribed treatment strategies to reduce fatigue in non-commun...
Article
Introduction: The chronic obstructive pulmonary disease (COPD) biomarker qualification consortium (CBQC) was formed under COPD Foundation management, with the goal of qualifying biomarkers and clinical outcome assessments through established regulatory processes. Within CBQC, a working group evaluated opportunities for qualification of an exercise...
Article
Background Hospital admissions are important contributors to the overall burden of chronic obstructive pulmonary disease (COPD). Understanding the patterns and causes of hospital admissions will help to identify targets for preventive interventions. This study aimed to determine the five-year all-cause hospital admission trajectories of patients wi...
Article
Full-text available
Background Inspiratory muscle training (IMT) improves inspiratory muscle strength, exercise capacity and health status in patients with chronic obstructive pulmonary disease (COPD). However, there is no additional effect on top of comprehensive pulmonary rehabilitation (PR). It is unclear whether patients with different baseline degrees of static h...
Article
Background: Beta-alanine (BA) supplementation increases muscle carnosine, an abundant endogenous antioxidant and pH buffer in skeletal muscle. Carnosine loading promotes exercise capacity in healthy older adults. As patients with chronic obstructive pulmonary disease (COPD) suffer from elevated exercise-induced muscle oxidative/carbonyl stress and...
Article
Background: There is high heterogeneity of outcomes and measures reported in the literature for pulmonary rehabilitation (PR), which might limit benchmarking and an effective evidence synthesis. A core outcome set (COS) can minimise this problem. It is however unclear which outcomes and measures are most important and suitable for different stakeho...
Article
Survivors of acute pulmonary embolism (PE) are at risk of developing persistent, sometimes disabling symptoms of dyspnea and/or functional limitations despite adequate anticoagulant treatment, fulfilling the criteria of the post-PE syndrome (PPES). PPES includes chronic thromboembolic pulmonary hypertension (CTEPH), chronic thromboembolic pulmonary...
Article
Full-text available
Background: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown. Methods: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, force...
Article
Introduction The 6-minute walking test (6MWT) is a widely used measure to assess functional status of people with chronic obstructive pulmonary disease (COPD). However, it requires a long hallway and might be time-consuming. Other simple measures might be useful as a first screening tool. We explored the predictive ability of the 1-minute sit-to-st...
Preprint
Background: Inspiratory muscle training (IMT) is a training method in patients with chronic obstructive pulmonary disease (COPD) to improve inspiratory muscle strength, exercise capacity and health status. It is unclear whether patients with different baseline degrees of static hyperinflation respond differentially to IMT as part of a pulmonary reh...
Article
Full-text available
PurposeObstructive sleep apnea (OSA) is a prevalent and multifaceted disease. To date, the presence and severity of objectively identified comorbidities and their association with specific OSA phenotypes, CPAP adherence, and survival remain to be elucidated. The aim of this study is to cluster patients with OSA based on 10 clinically important obje...
Article
Full-text available
Rationale: It is difficult to predict the effects of long-acting bronchodilators (LABD) on lung function, exercise capacity and physical activity in patients with chronic obstructive pulmonary disease (COPD). Therefore, the multidimensional response to LABD was profiled in COPD patients participating in the ACTIVATE study and randomized to LABD....
Article
Full-text available
Background: The psychological impact of COVID-19 can be substantial. However, knowledge about long-term psychological outcomes in patients with COVID-19 is scarce. Objective: In this longitudinal, observational study, we aimed to reveal symptoms of posttraumatic stress disorder (PTSD) and symptoms of anxiety and depression up to 6 months after t...
Article
Full-text available
Background Clusters of COPD patients have been reported in order to individualize the treatment program. Neither co-morbidity clusters, nor integrated respiratory physiomics clusters contributed to a better prediction of outcomes. Based on a thoroughly assessed set of pulmonary and extra-pulmonary traits at the start of a pulmonary rehabilitation (...
Article
Full-text available
Patients with pulmonary hypertension present limited tolerance to exercise and aerobic capacity, which is reflected in the reduction in peak oxygen consumption and functional performance. This intolerance to exercise has traditionally been attributed to cardiac and respiratory dysfunction. However, as it happens in other chronic diseases, lower-lim...
Article
Background and aim Patients with early-onset severe COPD are often female and characterized by severe emphysema. Extrapulmonary disease manifestations have not yet been investigated in this clinical phenotype. Therefore, this study aimed to study the physical and mental health profile of patients with early-onset severe COPD. Methods This is a cro...
Article
Full-text available
The 6 min walking test (6MWT) has been largely studied. Less is, however, known about responders and non-responders to pulmonary rehabilitation (PR) in other meaningful activities. We explored responders and non-responders and the predictors of response to PR in the 1 min sit-to-stand test (1 min STS) and the 6MWT and compared both measures in clas...
Article
Background Physical capacity (‘can do’) and physical activity (‘do do’) are prognostic indicators in COPD and can be used to subdivide COPD patients into four exclusive subgroups (the so-called “can do, do do” quadrants). This concept might be useful to better understand the impact of physical capacity and physical activity on all-cause mortality i...
Article
Long COVID is seen in a growing group of patients who experience a large number of symptoms after previous infection with SARS-CoV-2. The symptoms persist and are accompanied by impaired functioning without a sufficient pathophysiological explanation. While the condition is more commonly seen in patients who have been critically ill, predictive fac...
Article
Full-text available
Background Little is known regarding treatment of urinary incontinence (UI) in women with chronic obstructive pulmonary disease (COPD). The aim of the study was to explore the efficacy of pelvic floor muscle training (PFMT) or cough-suppression techniques (CST) on UI in women with COPD. Methods A three-armed, two-centred, single-blinded, randomise...
Article
Full-text available
Aims It is increasingly recognized that the presence of comorbidities substantially contributes to the disease burden in patients with heart failure (HF). Several reports have suggested that clustering of comorbidities can lead to improved characterization of the disease phenotypes, which may influence management of the individual patient. Therefor...
Article
Full-text available
Background Falls risk is elevated in chronic obstructive pulmonary disease (COPD). However, there is a lack of evidence regarding the contributing factors. Here, we examined the feasibility of, and initial responses to, large walking perturbations in COPD, as well as the adaptation potential of people with COPD to repeated walking perturbations tha...
Article
Full-text available
Introduction Bioelectrical impedance analysis (BIA) can be used to estimate Fat-Free Mass Index (FFMI). However, the use of directly measured BIA variables, such as phase angle (PhA), has gained attention. The frequency of low FFMI and PhA and its associations with exercise capacity and health-related quality of life (HRQL) in patients with idiopat...
Article
Full-text available
Introduction: The coronavirus disease (COVID-19) continues to affect many countries globally, with the long-term impact of the disease now being recognized. According to the latest research, some of the affected individuals continue to experience functional limitations, reduced physical performance and impaired health-related quality of life (HRQo...
Article
Full-text available
(1) To evaluate the prevalence of severe and chronic fatigue in subjects with and without chronic disease; (2) to assess to which extent multi-morbidity contributes to severe and chronic fatigue; and (3) to identify predisposing and associated factors for severe and chronic fatigue and whether these are disease-specific, trans-diagnostic, or generi...
Article
Full-text available
Background: Fatigue is the most commonly reported symptom in patients with persistent complaints following COVID-19 (ie, long COVID). Longitudinal studies examining the intensity of fatigue and differentiating between physical and mental fatigue are lacking. Objective: The objectives of this study were to (1) assess the severity of fatigue over tim...
Preprint
BACKGROUND The psychological impact of COVID-19 can be substantial. However, knowledge about long-term psychological outcomes in patients with COVID-19 is scarce. OBJECTIVE In this longitudinal, observational study, we aimed to reveal symptoms of posttraumatic stress disorder (PTSD) and symptoms of anxiety and depression up to 6 months after the o...
Article
Patients with chronic respiratory diseases typically experience dyspnea, fatigue, exercise intolerance, difficulty performing daily activities, and impaired quality of life (QOL), despite optimal medical therapies.¹ Extrapulmonary manifestations, including limb muscle weakness, nutritional disturbances, anxiety, depression, cardiovascular deconditi...
Conference Paper
Full-text available
The magnitude of response to pulmonary rehabilitation (PR) is influenced by the selection of outcomes and measures. Outcome and measure selection depends on various factors which can lead to high heterogeneity of reported outcomes/measures in the literature, hindering bench marking between and within PR centers and an effective evidence synthesis....
Article
Background Regular exercise positively affects cardiovascular physiology, translating into the adequate capacity of microvascular blood vessels to dilate in response to acute bouts of exercise. However, this remains unstudied in patients with chronic obstructive pulmonary disease (COPD), who often suffer from cardiovascular comorbidity. Therefore,...
Article
Full-text available
Revathy Munuswamy,1,* Jana De Brandt,2,* Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,* Luc Michiels1,* 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium; 2Faculty of Rehabilitation Sciences, Rehabilitation Research Center REVAL, Biomedical Research Institute BIOME...
Article
Background: Self-management is considered important in the management of patients with idiopathic pulmonary fibrosis (IPF) or sarcoidosis. However, data about the degree of activation for self-management is lacking. Objectives: The aim of the study was to determine the degree of activation for self-management in patients with IPF or sarcoidosis...
Article
Physical activity (PA) is of key importance for health among healthy persons and individuals with COPD. PA has multiple dimensions that can be assessed and quantified objectively using activity monitors. Moreover, as shown in the published literature, variable methodologies have been used to date to quantify PA among individuals with COPD, precludi...
Preprint
Full-text available
Background Little is known regarding treatment of urinary incontinence (UI) in women with chronic obstructive pulmonary disease (COPD). The aim of the study was to explore the efficacy of pelvic floor muscle training (PFMT) or cough-suppression techniques (CST) on UI in women with COPD. Methods A three armed, two centred, single blinded, randomised...
Article
Full-text available
Pulmonary rehabilitation is based on a thorough patient assessment, including peripheral oxygen saturation (SpO 2 ) and heart rate (HR) at rest and on exertion. To understand whether exercise-field tests identify patients who desaturate (SpO 2 < 90%) during physical activities, this study compared the six-minute walk test (6MWT) and daily-life tele...
Article
Full-text available
Hyaluronic acid (HA) is a key component of the extracellular matrix. HA and its metabolism are suggested to be altered in the lungs of patients with chronic obstructive pulmonary disease (COPD). The present study explored systemic HA, and its metabolic regulators, in patients with clinically stable COPD and smoking and non-smoking controls. Further...
Article
Full-text available
Introduction: The understanding of whether and to what extent employment status affects readmission and mortality is limited in patients with COPD. Aim: To explore how employment status affects readmission and mortality after first admission to the hospital with acute exacerbation of COPD (AECOPD). Methods: This study used Danish national regi...
Article
Full-text available
Background The Post-Pulmonary Embolism Syndrome (PPES) comprises heterogeneous entities, including chronic thromboembolic disease with/without pulmonary hypertension (CTEPH/CTEPD), and deconditioning. Objectives To assess underlying physiological determinants of PPES, and efficacy and safety of rehabilitation training in these patients. Methods 5...
Article
Full-text available
Background: Fatigue is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF) or sarcoidosis. However, the difference in fatigue perceptions for these patients is unknown and this may be important to better understand what fatigue means to the individual patient. Methods: This cross-sectional quantitative study aims to determine t...
Article
Background: Oxidative/carbonyl stress is elevated in lower-limb muscles of patients with Chronic Obstructive Pulmonary Disease (COPD). Carnosine is a skeletal muscle antioxidant particularly present in fast-twitch fibers. Aims: To compare muscle carnosine, oxidative/carbonyl stress, antioxidants and fiber characteristics between patients with CO...
Article
Background: The magnitude of response to pulmonary rehabilitation (PR) is influenced by the selection of outcomes and measures. Objectives: This systematic review aimed to review all outcomes and measures used in clinical trials of PR for individuals with chronic obstructive pulmonary disease (COPD). Methods: The review involved a search of Sc...
Article
Full-text available
OBJECTIVE: Asthma is frequently accompanied by dysfunctional breathing of which hyperventilation has been recognized as a subtype. The prevalence of hyperventilation in stable asthma has been scantily studied using blood gas analysis. Hence, a reliable estimate of its prevalence is lacking. It is unknown whether the Nijmegen Questionnaire (NQ) is a...
Article
Background: Reduced physical activity is common in COPD and is associated with poor outcomes. Physical activity is therefore a worthy target for intervention in clinical trials, however, trials evaluating physical activity have used heterogeneous methodologies. Research question: What is the available evidence on the efficacy and/or effectivenes...
Article
Full-text available
Background Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD. Methods Pubmed, PsycINFO, EMBASE, Cochrane and...
Article
Purpose To determine the association between quadriceps muscle strength (QMS) and endurance (QME) and exercise capacity in COPD patients after stratification for sex and resting lung function (LF). Methods Data were collected in 3246 COPD patients (60% men, 64±9 years), including measures of exercise capacity (peak aerobic capacity (peakVO 2 )), si...
Article
Full-text available
Background and objective Low fat-free mass (FFM) is common in patients with chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality. Few studies have evaluated longitudinal changes in body composition in patients with COPD compared with non-COPD controls. This study aimed to compare longitudinal changes in total and...
Article
Full-text available
Background: A subgroup of patients recovering from COVID-19 experience persistent symptoms, decreased quality of life, increased dependency on others for personal care and impaired performance of activities of daily living. However, the long-term effects of COVID-19 on physical activity (PA) in this subgroup of patients with persistent symptoms rem...
Article
Full-text available
Purpose: Not all patients with chronic obstructive pulmonary disease (COPD) experience similar benefits following pulmonary rehabilitation (PR). This pre-post PR study used a large sample of patients with COPD to determine whether PR-induced changes of oxygen uptake (VO2) kinetics and exercise responses of VO2, carbon dioxide output (VCO2), minute...
Article
Full-text available
Objective: To determine the response to a pulmonary rehabilitation (PR) program and minimal important differences (MIDs) for the Short Physical Performance Battery (SPPB) subtests and SPPB summary score in patients with Chronic Obstructive Pulmonary Disease (COPD). Design: Retrospective analysis using distribution- and anchor-based methods. Set...
Article
Full-text available
Previous studies of associations of forced expiratory lung volume in one second (FEV 1 ) with peak oxygen uptake (VO 2peak ) in chronic obstructive pulmonary disease (COPD) have not taken sex, age and height related variance of dynamic lung volumes into account. Nor have such demographic spread of spirometric measures been considered in studies com...
Article
Full-text available
Introduction Patients with COPD are vulnerable to workforce detachment. Better knowledge of features associated with paid work loss might be of help to design and select appropriate interventions. Method This cross-sectional study aimed to explore the presence of treatable traits in COPD patients without paid work. Patients with COPD below 65 year...