Martha Luna

• Reproductive Medicine Associates of New York

To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds. This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with pre...

Objective: Although chromosomal heteromorphisms are commonly found in the general population, some researchers have suggested a correlation with higher rates of embryo aneuploidy. This study aimed to assess the rates of embryo aneuploidy in couples who carry a chromosome heteromorphism. Methods: The study included couples who had G-banding karyo...

Objective PGT-A with NGS is broadly utilized by reproductive specialists at modern ART treatment centers to improve embryo transfer selection. However, there are technical limitations to PGT which might prevent formal designation of the embryo as euploid or aneuploid. While re-biopsy of the embryo is possible, some studies suggesting that the selec...

OBJECTIVE: To compare obstetrical and neonatal outcomes following single embryo transfer (SET) versus (vs.) multiple embryo transfer (MET) from frozen-thawed embryo transfer cycles (FET) of autologous pre-implan-tation genetic tested for aneuploidy (PGT-A) embryos. DESIGN: Retrospective cohort study from the SART CORS national database. MATERIALS A...

(Abstracted from Hum Reprod 2020;35:1889–1899) Although the physiologic mechanism remains unclear, late follicular phase progesterone elevation (LFPE) commonly occurs during controlled ovarian hyperstimulation (COH) for assisted-reproductive technology (ART) such as in vitro fertilization (IVF). Late follicular phase progesterone elevation has been...

Los índices elevados de fragmentación del ADN espermático no se asocian con escasa blastulación o aumento de aneuploidía embrionaria en tratamientos de fertilización in vitro Resumen OBJETIVO: Analizar la relación entre el índice de fragmentación del ADN espermático y el desarrollo embrionario; además, las tasas de euploidía embrionaria en una pobl...

Study question: What is the impact of a late follicular phase progesterone elevation (LFPE) during controlled ovarian hyperstimulation (COH) on embryonic competence and reproductive potential in thaw cycles of preimplantation genetic testing for aneuploidy (PGT-A) screened embryos? Summary answer: Our study findings suggest that LFPE, utilizing...

Study question: Does hysteroscopic endometrial peeling improve reproductive outcomes in women with implantation failure? Summary answer: Women with implantation failure may benefit from intraoperative endometrial peeling prior to a frozen embryo transfer (FET). What is known already: Trials on endometrial scratching with pipelle and diagnostic h...

Study question: Does endometrial receptivity analysis (ERA) test offer clinical utility in patients with recurrent pregnancy loss (RPL)? Summary answer: Women with RPL may benefit from a personalized adjustment in timing of frozen embryo transfer. What is known already: Successful embryo implantation requires an appropriate embryonic development...

Objective: Genetic carrier screening has the potential to identify couples at risk of having a child affected with an autosomal recessive or X-linked disorder. However, the current prevalence of carrier status for these conditions in developing countries is not well defined. This study assesses the prevalence of carrier status of selected genetic...

OBJETIVO: Revisar la bibliografía de la prevalencia, factores de riesgo, síntomas, diagnósticos y tratamiento de las pacientes con istmocele. MÉTODO: Búsqueda electrónica en las bases de datos: PubMed, EMBASE y Google Scholar. Se utilizaron los siguientes términos, palabras y sus combinaciones: “Cesarean section defect, uterine niche, isthmocele,...

Efecto del tabaquismo en la fertilidad femenina y masculina Resumen El tabaquismo tiene un efecto nocivo en la salud causando daño multisistémico y aumentando el riesgo de distintas enfermedades. La fertilidad es una de las funciones biológicas que puede verse afectada; sin embargo, los mecanismos subyacentes de este problema siguen sin estar claro...

Study question: Does endometrial biopsy (EMB) and chronic endometritis (CE) screening offer clinical utility in patients following euploid embryo implantation failure? Summary answer: Patients, regardless of endometrial biopsy findings, have similar IVF outcomes on a subsequent treatment cycle as compared with patients who do not undergo endometria...

A higher frequency of polymorphic variants in chromosomes have been described in the infertile population, as genes involved with fertility and viability are thought to reside in heterochromatin. Recent studies have been able to describe a deleterious effect of variant karyotypes on reproductive outcome, However, the reproductive potential of affec...

Objective Oral contraceptives pills (OCPs) have been a long-standing adjuvant used for multiple purposes during ART treatment. Despite a widespread adoption of OCPs in many clinical settings, some studies have suggested that OCP utilization might exhibit a deleterious effect on IVF outcomes. Opponents have proposed the progesterone compound of OCPs...

To determine whether ovarian stimulation outcome and success rates are equivalent between GnRH agonist and GnRH antagonist regimens when all other variables are held constant. Retrospective analysis. Infertile patients (n = 1,277) < 35 years of age, with normal ovarian reserve, undergoing their first in vitro fertilization cycle with a GnRH antagon...

Oocyte cryopreservation has recently emerged as an option for women to preserve their fertility for medi-cal (e.g. treatable malignancy) or elective indications (e.g. advancing age). This report describes an IRB-approved study of over 200 oocyte cryopreservation cycles at one center. Patients presenting for oocyte cryopreservation (January 2005 to...

To determine if patients with a low response to controlled ovarian hyperstimulation during IVF benefit from intracytoplasmic sperm injection (ICSI) METHODS: Retrospective analysis of 350 IVF cycles in which four or fewer oocytes were retrieved. Severe male factor cases were excluded from analysis. Conventional insemination (CI) and ICSI were compar...

To analyze the outcomes and particular characteristics of monozygotic (MZ) pregnancies conceived by in vitro fertilization (IVF). Retrospective data analysis. Large private-academic fertility center. IVF-conceived MZ pregnancies. Statistical analysis of MZ pregnancy outcomes depending on fetal order and pregnancy reductions status. Spontaneous preg...

To define the prevalence of low-level sex chromosome mosaicism in a cohort of infertile men. Prospective cohort study of infertile men. Tertiary university infertility center. One hundred one consecutive men who presented with primary infertility for evaluation. Fluorescent in situ hybridization for X and Y was performed on 200 cells, and if an abe...

As the incidence and awareness of infertility have increased in the last decades, reproductive endocrinologists and scientists have striven to improve the therapeutic options being offered to patients. One of the most advanced and efficient technologies currently being offered is assisted reproductive technology. Among the various techniques that a...

This study suggests that paternal age may be inversely associated with reproductive outcome, as demonstrated by a decline in fertilization, blastocyst formation, implantation and cryopreservation rates with advancing age.

To determine if elevated body mass index in young women with normal ovarian reserve was associated with poorer ovarian response, difficulty at embryo transfer, and lower clinical pregnancy rates. Retrospective study of 417 first, fresh in vitro fertilization cycles performed between October 2004 and December 2006. All women were under the age of 35...

To evaluate developmental potential of fast cleaving day 3 embryos. Retrospective analysis. Academic reproductive center. Three thousand five hundred twenty-nine embryos. Day 3 embryos were classified according to cell number: slow cleaving: <or=6 cells, intermediate cleaving: 7-9 cells, and fast cleaving: >or=10 cells, and further evaluated on day...

To investigate sperm morphology on the day of fresh testicular sperm extraction (TESE) with intracytoplasmic sperm injection (ICSI), and its effect on fertilization and pregnancy rates, as TESE in conjunction with ICSI results in high fertilization and pregnancy rates in most patients, but to our knowledge only one small study has assessed the morp...

To evaluate how the ranking of IVF programs changes if high-order multiple pregnancies (HOMPs) are considered negative outcomes. Retrospective analysis. The 2004 Society for Assisted Reproductive Technology Clinic Outcome Reporting System. Two hundred seven programs that performed >50 IVF cycles were analyzed, and only patients <or=35 years of age...

To evaluate and compare IVF outcomes of patients within different age categories who had a normal basal FSH level with outcomes of patients with an elevated day 3 FSH level. Retrospective analysis. Large, private IVF center. We analyzed 2,708 patients. Of these, 2,477 had normal basal FSH levels, and 231 had elevated basal FSH levels (> or =13.03 I...

To evaluate the sex ratio of offspring born after blastocyst transfers. Retrospective data analysis. A large assisted reproductive technology center. We included 1,284 offspring from 937 deliveries during the period August 2003-August 2005. Tabulation and statistical analysis of all births resulting from fresh IVF cycles. The sex of resulting offsp...

To determine the clinical potential of donor-oocyte cryopreservation and thaw techniques for recipient patients. Institutional review board-approved prospective study of donor oocyte cryopreservation. A large, private infertility center. Four anonymous oocyte donors underwent ovarian hyperstimulation for the purpose of oocyte retrieval and cryopres...

To evaluate and compare the inflammatory response and mediators in the endometrium of patients with hydrosalpinges compared with normal controls. Retrospective case-control study. Urban medical center. PATIENT(S) AND INTERVENTION(S): Hysterectomy samples were identified as being affected by hydrosalpinx or salpingitis (n = 30) and were age-matched...