Martha Baydoun

Martha Baydoun
Institut Pasteur de Lille

PhD

About

14
Publications
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190
Citations

Publications

Publications (14)
Article
Full-text available
The number of cancers attributable to infectious agents represents over 20% of the global cancer burden. The apicomplexan intracellular parasite Cryptosporidium is currently considered one of the major causes of mild and severe diarrhea worldwide. However, less attention has been paid to its tumorigenic potential despite the high exposure of humans...
Article
Full-text available
Often discovered at an advanced stage, ovarian cancer progresses to peritoneal carcinoma, which corresponds to the invasion of the serosa by multiple tumor implants. The current treatment is based on the combination of chemotherapy and tumor cytoreduction surgery. Despite the progress and standardization of surgical techniques combined with effecti...
Article
Full-text available
Blastocystis is frequently identified in humans and animal hosts and exhibits a large genetic diversity with the identification of 17 subtypes (STs). Despite its zoonotic potential, its prevalence and ST distribution in edible marine fish and marine mammals remain unknown. A large-scale survey was thus conducted by screening 345 fish caught in Atla...
Article
Surgical management of peritoneal metastases raises the problem of the theoretical spread of the entire peritoneal surface. Intraperitoneal photodynamic therapy (IntraPDT) has been limited by the lack of specificity of photosensitizers (PS) and difficulties to bring light into the abdominal cavity. Recent data in ovarian cancer may give development...
Article
Full-text available
Ex vivo explant culture models offer unique properties to study complex mechanisms underlying tissue growth, renewal, and disease. A major weakness is the short viability depending on the biopsy origin and preparation protocol. We describe an interphase microfluidic culture system to cultivate full thickness murine colon explants which keeps morpho...
Article
Full-text available
To date, pancreatic adenocarcinoma (ADKP) is a devastating disease for which the incidence rate is close to the mortality rate. The survival rate has evolved only 2–5% in 45 years, highlighting the failure of current therapies. Otherwise, the use of photodynamic therapy (PDT), based on the use of an adapted photosensitizer (PS) has already proved i...
Article
Full-text available
Blastocystis sp. is an enteric protozoan that frequently colonizes humans and many animals. Despite impacting on human health, data on the prevalence and subtype (ST) distribution of Blastocystis sp. remain sparse in Africa. Accordingly, we performed the first multicenter and largest epidemiological survey ever conducted on Blastocystis sp. for thi...
Article
Blastocystis sp. is frequently identified in a wide range of animal hosts, including bovids. Because of its burden and zoonotic potential, this parasite has been sought in domestic cattle from various countries, since this livestock may also represent a possible reservoir of human infection. However, epidemiological data regarding the prevalence an...
Article
Full-text available
Background The association between Cryptosporidium and human colon cancer has been reported in different populations. However, this association has not been well studied. In order to add new strong arguments for a probable link between cryptosporidiosis and colon human cancer, the aim of this study was to determine prevalence and to identify specie...
Article
Full-text available
Cryptosporidium parvum is a major cause of diarrheal illness and was recently potentially associated with digestive carcinogenesis. Despite its impact on human health, Cryptosporidium pathogenesis remains poorly known, mainly due to the lack of a long-term culture method for this parasite. Thus, the aim of the present study was to develop a three-d...

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Projects

Projects (2)
Project
This project is a PhD and starts in October 2019 for 3 years. The aim of the project is to develop a device to illuminate homogeneously and reproductively the peritoneal cavity in order to destroy all metastasis with photodynamic therapy.
Project
The enteric parasites Cryptosporidium and Blastocystis currently represent major socioeconomic and public health issues. These infectious agents are responsible for gastrointestinal infections that can be severe and sometimes fatal in immunocompromised patients. However they remain usually neglected by health authorities. Consequently basic knowledge on the biodiversity, circulation, and pathophysiology of these parasites is urgently required especially since few or no efficient treatments are available against these infections. Because they exhibit a large genetic diversity and can be found in numerous hosts, these microorganisms also represent invaluable models to address a major biological question in the field of Ecology of Parasitism: what is the nature of the genetic diversity of these parasites and its impact on the circulation and pathogenicity of different species and genotypes or subtypes? The research activities of my team optimally combine skills and methodological tools applicable to each of our models in i) epidemiology and phylogeny, ii) cellular and molecular biology, iii) comparative OMICs and metagenomics and iii) development of in vivo and ex vivo models.