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PhD candidate at Werner Siemens Imaging Center. My main research interest focuses on Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) combined with others imaging modalities. Projects: -"Quantitative MRI for non-invasive hypoxia mapping to guide tumor therapy" within the iFIT cluster of excellence -"Diagnosis and therapy of hepatocellular carcinoma (HCC) including multiparametric imaging and methods of system modeling" -"MRS for metabolic diseases''
Cerebral hypoperfusion and vascular dysfunction are closely related to common risk factors for ischemic stroke such as hypertension, dyslipidemia, diabetes, and smoking. The role of inhibitory G protein-dependent receptor (G i PCR) signaling in regulating cerebrovascular functions remains largely elusive. We examined the importance of G i PCR signa...
Pancreatic Cancer (PC) has a poor prognosis, with a 5-year survival rate of only 9%. Even after radical surgical procedures, PC patients have poor survival rates, with a high chance of relapse (70–80%). Imaging is involved in all aspects of the clinical management of PC, including detection and characterization of primary tumors and their resectabi...
Background: To investigate the correlation between 18F-labeled fluoroazomycinarabinoside (18F-FAZA) PET data and hypoxia immunohistochemical markers in patients with high-grade glioma (HGG). Patients and methods: Prospective study including 20 patients with brain MRI suggestive for HGG and undergoing 18F-FAZA PET/CT before treatment for hypoxia...
Pertussis toxin (PTX) is a potent virulence factor in patients suffering from whooping cough, but in its detoxified version, it is applied for vaccination. It is thought to contribute to the pathology of the disease including various CNS malfunctions. Based on its enzymatic activity, PTX disrupts GPCR-dependent signaling by modifying the α-subunit...
PurposeThe aim of the present systematic review was to provide an overview on the different positron emission tomography (PET) hypoxia radiotracers in the clinical setting of lung cancer. Methods We performed a comprehensive literature review on the role of PET hypoxia imaging in lung cancer using the electronic databases PubMed and Scopus to selec...
Hypoxia can influence response to chemo and radiotherapy in different tumours, including non-small cell lung cancer (NSCLC) and high-grade gliomas (HGG). PET/CT can non-invasively investigate hypoxia and ¹⁸F-FAZA seems to be the most promising radiotracer. However, there are still controversial issues related to image analysis and data interpretati...