Marta Marzotto

Marta Marzotto
University of Verona | UNIVR · Department of Pathology and Diagnostics

About

82
Publications
45,144
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2,187
Citations
Citations since 2016
24 Research Items
1073 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Introduction
Skills and Expertise

Publications

Publications (82)
Article
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Objective: We investigated the effects of three different homeopathic medicines in several dilutions/dynamizations on mice, using validated models which explore anxiety-like and emotional symptoms. Two complete series of investigations were performed in order to assess the activity of Gelsemium sempervirens; furthermore, we investigated Ignatia ama...
Article
Full-text available
As part of a rigorous investigation into the effects of Gelsemium sempervirens on laboratory mice, we performed two complete series of experiments and published three scientific papers. A recent commentary has, however, called into question the reproducibility and validity of these findings. In this article we discuss the major issues raised by thi...
Article
Full-text available
Background: Immunomodulatory properties are evoked by many highly diluted drugs and may be the base of complex systemic effects of the remedies in the organism. Monocyte/macrophages exert a pivotal role in innate immunity regulation and in inflammation. THP-1 cells have become one of most widely used cell lines to investigate the function and regul...
Article
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Background: A proinflammatory environment is a hallmark of several neurodegenerative diseases where astrocyte involvement is also well established. Astrocytes and microglia in central nervous system are mainly involved in the release of cytokines, oxygen free radicals and nitric oxide (NO). Several studies on C6 astroglioma cells, a widely used in...
Article
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Background: Nanoparticles (NP), because of their size (< 1μm) and high relative surface area, are highly reactive forms of their source material with biological, chemical, optical, electromagnetic, and thermal properties different from larger bulk forms of the same material. It has been speculated that NPs can occur in homeopathic products as a fu...
Article
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Homeopathy is often attacked with claims of not being evidence-based or for the implausible nature of its major principles of dilution/potentization and/or the similars (“similia similibus curentur”). However, these statements have already been falsified on the experimental ground, besides being incorrect on an epistemological level. Here we provid...
Article
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Drosera rotundifolia has been traditionally used for the treatment of respiratory diseases in phytotherapy and homeopathy. The mechanisms of action recognized so far are linked to the known effects of specific components, such as flavonoids, but are not completely understood. In this study, the biological functions of D. rotundifolia were explored...
Article
Background and Aim Arnica montana L. (Arnica m.) is a popular traditional medicine, used for its therapeutic properties in healing traumas, but little is known about its biological action on tissue formation and repair. This new work tested the effects of Arnica m. homeopathic dilutions on human macrophages, key cells in tissue defence and repair....
Article
In June 2019, the journal PLoS ONE retracted an original research article, published in 2016, which described the effects of homeopathic Arnica montana on interleukin-4 treated human macrophages. The results showed an increase in extracellular matrix gene expression, including the gene encoding fibronectin, which is one of the main proteins involve...
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Please note that the journal name is: “Journal of Alternative, Complementary and Integrative Medicine”. Introduction Homeopathy is a therapeutic natural medical alternative that is widely and increasing-ly being used, even for pediatric patients. Given this trend, it is essential that clinicians have the re-sources to advise their patients as to t...
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Gelsemium sempervirens L. (Gelsemium) is traditionally used for its anxiolytic-like properties and its action mechanism in laboratory models are under scrutiny. Evidence from rodent models was reported suggesting the existence of a high sensitivity of central nervous system to anxiolytic power of Gelsemium extracts and Homeopathic dilutions. In vit...
Article
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Arnica montana is a popular traditional remedy widely used in complementary and alternative medicine, in part for its wound-healing properties. The authors recently showed that this plant extract and several of its homeopathic dilutions are able to modify the expression of a series of genes involved in inflammation and connective tissue regeneratio...
Article
Zinc is an important metal in body homeostasis at different levels. Zinc in soluble form (Zn²⁺) and homeopathic Zincum metallicum were tested in macrophages and astrocytes in order to investigate its potential toxic or therapeutic effects. We evaluated cell viability (WST assay), cytokine production such as tumor necrosis factor alpha (TNF-α) and i...
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Objective: To test the effect of Arnica montana (Arnica m.) on human macrophages. Method: The human monocytic leukaemia cell line THP-1 was cultured and differentiated in mature macrophages with PMA and other differentiating agents. Macrophages were exposed to Arnica m. homeopathic dilutions (2c, 3c, 5c, 9c and 15c) or Control solvent. Total RNA wa...
Conference Paper
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The Avogadro constant seems a conceptual obstacle against which homeopathy collides, being often cited by those who assimilate homeopathy to placebo. That the homeopathic medicinal product is not a placebo is evident for most medicines on the marked, that are in low dilutions. For higher dilutions the problem can be addressed by physico-chemical an...
Article
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Arnica montana (Arnica m.) is used for its purported anti-inflammatory and tissue healing actions after trauma, bruises, or tissue injuries, but its cellular and molecular mechanisms are largely unknown. This work tested Arnica m. effects on gene expression using an in vitro model of macrophages polarized towards a "wound-healing" phenotype. The mo...
Data
Expression values (RPKM) and differential expression (Log2 Fold Change) of a series of extracellular matrix genes selected from the Reactome database as described in the text. The genes with FDR-adjusted p values > 0.05 and FDR unadjusted p values < 0.05 are here reported, while those with adjusted p values < 0.05 are reported in Table 1. Samples f...
Data
Expression values (RPKM) of Control and Arnica m.-treated cells and differential expression (Log2 Fold Change) of the series of genes reported in Table 1. IL-4-differentiated THP-1 macrophages were treated with Control solvent or with Arnica m. 2c, 3c, 5c, 9c and 15c dilutions. Samples from Control solvent and Arnica m. 2c were analysed by RNA-seq...
Article
Background Arnica montana is a popular traditional remedy widely used in complementary medicine, also for its wound healing properties. Despite its acknowledged action in clinical settings at various doses, the molecular aspects relating to how A. montana promotes wound healing remain to be elucidated. To fill this gap, we evaluated the whole plant...
Article
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Food safety is of critical public concern, and has drawn great attention in society. Consequently, developments of rapid, robust and accurate methods and techniques for food safety evaluation and control are required. As a nondestructive and convenient tool, near-infrared spectroscopy (NIRS) has been widely shown to be a promising technique for foo...
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Si tratta di una sintesi in italiano, pubblicata dalla rivista "Medicina Naturale" (Tecniche Nuove, Milano) di recenti lavori del nostro gruppo e di altri sul tema della natura fisico-chimica del medicinale omeopatico
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Cancer is the second leading cause of death in developed countries and poor diet and physical inactivity are major risk factors in cancer-related deaths. Therefore, interventions to reduce levels of smoking, improve diet, and increase physical activity must become much higher priorities in the general population's health and health care systems. Th...
Conference Paper
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Every medical approach comprises components that are "artistic", related to the practice, the skill, knowledge, intuition of the doctor, and components of "scientific" nature. Both are necessary. It is not always easy to distinguish these two dimensions of medical practice. What is classical Homeopathy is pretty clear, while there are considerable...
Conference Paper
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Homeopathy works by stimulating, modulating and directing the “life force” (homeodynamics in scientific terms) which is the actual protagonist of healing process. So, the outcome of the cure depends on the effective interaction between the well manufactured remedy, the patient’s life force and the method of prescription (individualization). This vi...
Conference Paper
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Here we survey the homeopathic basic principles (Similia and dilution/dynamization) with the aim of examining their consistency with modern scientific knowledge. Recognition of the function of enzymes, receptors and signal transduction and their dynamic interaction with drugs, makes it possible to look at homeopathy in a rational light. The corners...
Conference Paper
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Despite the major puzzling claims of homeopathy are far from to be clarified, there are several plausible hypotheses of the nature and action mechanism of homeopathic drugs, and some experimental evidence confirms their effects in rigorous laboratory models. This is a synthesis of the conference presentation of Paolo Bellavite at the World Homeopat...
Conference Paper
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While drugs at low dilutions work at molecular level exploiting high sensitivity of biological systems and amplification pathways, drugs at high dilutions require new models and new approaches. A major question is how these medicines may work in the body. The possible answers concern the identification of biological targets, the means of drug-recep...
Article
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It has been claimed that the homeopathic principle of 'similarity' (or 'similia') and the use of individualized remedies in extremely low doses conflicts with scientific laws, but this opinion can be disputed on the basis of recent scientific advances. Several mechanisms to explain the responsiveness of cells to ultra-low doses and the similarity a...
Article
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This commentary is a short response to criticisms to our work that appeared in a pharmacology journal. We hope that these clarifications will be welcomed in the interest of providing correct and truthful information to readers. In summary, we provided reliable evidence that Gelsemium sempervirens exerts a prevalently inhibitory effect on aseries of...
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The human vagina is a complex and dynamic ecosystem containing an abundance of microorganisms. In women of childbearing age, this system is dominated by Lactobacillus spp. In the present work, seventeen newly isolated vaginal strains were identified by 16S rDNA sequencing and were investigated for their antimicrobial properties. Twelve of the isola...
Conference Paper
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Conferenza tenuta su invito in un Convegno organizzato da Fondazione Belladonna. Tre capitoli: 1. L e regole della Natura e la complessità fondamentale della vita; 2. Modello a rete: omeodinamica, omeopatologia, omeoterapia; 3. Il Simile nello studio sperimentale
Article
Ethnopharmacological relevance: Gelsemium sempervirens L. is a traditional medicinal plant mainly distributed in the southeastern of the United States, employed in phytotheraphy and homeopathy as nervous system relaxant to treat various types of anxiety, pain, headache and other ailments. Although animal models showed its effectiveness, the mechan...
Article
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Gelsemium sempervirens L. (Gelsemium s.) is a traditional medicinal plant, employed as an anxiolytic at ultra-low doses and animal models recently confirmed this activity. However the mechanisms by which it might operate on the nervous system are largely unknown. This work investigates the gene expression of a human neurocyte cell line treated with...
Article
In September 2013 issue of Int. J. Clin. Pract., a lengthy letter concerned “bias and adverse effects in homeopathy”. The letter apparently raised “scientific criticism”, actually was dedicated to throw mud on researchers who deal with homeopathy issues. As group of scientists working in the University of Verona, here we defend the integrity and re...
Article
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Recent studies conducted in human/animal cells have suggested that homeopathic remedies may have an effect on the gene regulation, initiating a cascade of gene actions to correct the disorder or disease at a cellular level. We have focused our attention on the possible gene modulation effect of Gelsemium sempervirens, a traditional medicinal plant...
Article
Several lines of evidence suggest that homeopathic high dilutions (HDs) can effectively have a pharmacological action, and so cannot be considered merely placebos. However, until now there has been no unified explanation for these observations within the dominant paradigm of the dose-response effect. Here the possible scenarios for the physicochemi...
Article
The pharmacodynamics aspects of homeopathic remedies are appraised by laboratory studies on the biological effects at various levels (cellular, molecular and systemic). The major question is how these medicines may work in the body. The possible answers concern the identification of biological targets, the means of drug-receptor interactions, the m...
Article
ABSTRACT The bacteriocin-producing Streptococcus thermophilus strains that can dominate in natural dairy ecosystems, may also enhance safety in products obtained from natural cultures. In this study, we sought to identify bacteriocin production and bacteriocin genes in 75 strains of dairy and plant origin. The strains were tested for antimicrobial...
Article
This report summarises the latest research developments in the field of high dilutions and homeopathy, as presented at the GIRI symposium of the leading international organisation of scientists in this field, in Florence, Italy in September 2012. The scientific community's early scepticism concerning the possible biological and pharmacological acti...
Conference Paper
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Questa comunicazione riassume i recenti avanzamenti della ricerca nel campo delle alte diluizioni e dell’omeopatia, partendo dalle relazioni presentate ad un convegno della principale organizzazione internazionale di scienziati che lavorano in questo campo. L’iniziale scetticismo nel mondo scientifico a riguardo della possibile azione biologica e f...
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Background: Gelsemium s. preparations contain a complex mixture of active compounds and is traditionally used in homeopathy and phytomedicine as remedy against anxiety, neuralgias and inflammation. As previously reported (Florence 2012, Barcelona 2013), we are currently assessing the genetic responsiveness of neuronal cells to low and high dilution...
Article
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Background: Gelsemium sempervirens (Gelsemium s.) is a highly toxic plant but is employed at low doses and/or high dilutions as an anxiolytic and antidepressant. Previous investigations in our laboratory [1,2] have shown a significant anxiolytic-like activity of Gelsemium s., using emotional response models in laboratory mice. Although there is som...
Article
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Two previous investigations were performed to assess the activity of Gelsemium sempervirens (Gelsemium s.) in mice, using emotional response models. These two series are pooled and analysed here. Gelsemium s. in various homeopathic centesimal dilutions/dynamizations (4C, 5C, 7C, 9C, and 30C), a placebo (solvent vehicle), and the reference drugs dia...
Conference Paper
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Riassunto Sono riportati i principali esperimenti svolti nel nostro laboratorio, mediante metodi rigorosi, attendibili e riproducibili, i cui risultati dimostrano che Istamina inibisce l'attivazione dei basofili umani e Gelsemium e Ignatia hanno effetti ansiolitici su modelli murini di comportamento. Tali sostanze agiscono in diluizioni/dinamizzazi...
Article
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Quali sono i meccanismi con cui le sostanze alimentari ci proteggono dallo sviluppo dei tumori? e Quali sono i principi attivi più importanti? le risposte della scienza e i consigli degli esperti su come integrare gli approcci naturali nell'oncologia moderna. Introduzione Recenti sviluppi in oncologia Alterazioni cellulari e bersagli molecolari...
Article
Ignatia amara (Ignatia), a remedy made from the Strychnos ignatii seeds, is used for anxiety-related symptoms, but consistent evidence of its activity in reproducible experimental models is lacking. An investigation was performed in order to assess on mice, by means of emotional response models, the activity of homeopathic Ignatia dilutions/dynamiz...
Article
Full-text available
As part of a rigorous investigation into the effects of Gelsemium sempervirens on laboratory mice, we performed two complete series of experiments and published three scientific papers. A recent commentary has, however, called into question the reproducibility and validity of these findings. In this article we discuss the major issues raised by thi...
Article
Full-text available
As a result of a challenging and pioneering work on this medicinal plant, we published three papers that do nothing more than report and discuss the experimental findings, as these were consecutively obtained. These papers contain all the necessary explanations, so that an unbiased perusal of them should be enough to confirm the overall validity of...
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The present paper reviews the clinical research carried out over the past three decades to evaluate the effectiveness of homeopathy for the treatment of respiratory allergies, common upper respiratory tract infections, otorhinolaryngologic complaints, and rheumatic diseases. We include in the analysis both randomised and non-randomised trials, assi...
Conference Paper
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Il gruppo di ricerca sull"omeopatia e la medicina integrata presso l"università di Verona è sorto nel 1990, il primo lavoro sull"omeopatia fu pubblicato dall"Istituto Superiore di Sanità in quell"anno (Bellavite 1990): anche noi facciamo il ventennale, anzi, lo abbiamo appena fatto! L"omeopatia vive del progresso della scienza e lo promuove. Ciò si...
Article
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Flavonoids, a large group of polyphenolic metabolites derived from plants have received a great deal of attention over the last several decades for their properties in inflammation and allergy. Quercetin, the most abundant of plant flavonoids, exerts a modulatory action at nanomolar concentrations on human basophils. As this mechanism needs to be e...
Article
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This study was designed to investigate the putative anxiolytic-like activity of ultra-low doses of Gelsemium sempervirens (G. sempervirens), produced according to the homeopathic pharmacopeia. Five different centesimal (C) dilutions of G. sempervirens (4C, 5C, 7C, 9C and 30C), the drug buspirone (5 mg/kg) and solvent vehicle were delivered intraper...
Article
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Homeopathy is an ancient and complex therapeutic method that is rediscovering its scientific foundations. Hormesis is a frequently observed phenomenon that has been rigorously reported with precise dose-response curves. The therapeutic method based on the principle of 'like cures like' should not be confused with hormesis, which has several differe...
Article
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Flavonoids, such as quercetin, were reported to inhibit histamine release and cytokine production by basophils, but there is no evidence describing their action on membrane markers and intracellular biochemical pathways. The aim of the study was to examine the effect of several quercetin doses on an in vitro human basophil activation system that ev...
Article
The first part of this paper reviews the effects of homeopathic remedies on several models of anxiety-like behaviours developed and described in rodents. The existing literature in this field comprises some fifteen exploratory studies, often published in non-indexed and non-peer-reviewed journals. Only a few results have been confirmed by multiple...
Article
The bacterial populations of raw milk employed for the production of Fontina cheese in alpine farms located in different valleys and altitudes (from 700 to 2246 m above sea level) were investigated by culture independent techniques. Total microbial DNA was isolated from milk and curd samples and used as template in Polymerase Chain Reaction (PCR) t...
Conference Paper
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L’homéopathie est d’abord apparue sous la forme d’une discipline expérimentale, comme le confirme l’énorme quantité de données cliniques réunies sur plus de deux siècles. Cependant, la tradition médicale de l’homéopathie a été séparée de celle de la science conventionnelle pendant longtemps. Aujourd’hui, un processus osmotique entre les disciplines...