Marta A. Fik

Marta A. Fik
Adam Mickiewicz University | UAM · Department of Bioinorganic Chemistry

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18
Publications
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Introduction

Publications

Publications (18)
Article
Full-text available
Generation of well-defined potential metallotherapeutics for cancer treatment, one of the most population-threatening diseases, is challenging and an active area of modern research in view of their unique properties and thus multiple possible pathways of action in cells. Specifically, Schiff base ligands were recognized as very promising building b...
Article
Full-text available
Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine (LaPA complex). A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. We found that, differ...
Article
The understanding and the application of reversible covalent reactions and coordination chemistry together with the proper design of the molecular frameworks, allow to achieve not only well-defined output architectures but also different grades of complex behavior. In this work, the dynamic nature of the helical systems offers an additional level o...
Article
The aim of the reported research is to evaluate the significance and potential role of the thiophene moiety in potential DNA and BSA targeting drugs. For this purpose a Thiophene-BenzoThiazole tandem molecule (TBT) and its mononuclear silver(I) complex [Ag(TBT)2]⁺ was synthesized. The research was carried out using spectroscopic techniques such as...
Article
Full-text available
Herein, we described the synthesis of two l-phenylalanines α-derivatized with a terminal alkyne moiety whose structures differed by phenyl ring halogen substitution (two o-Cl in 1 vs. one p-Br in 2) and investigated their effect on biological macromolecules and living cells. We explored their interaction with quadruplex DNA (G4 DNA), using tel26 an...
Article
Generation of well-defined organic-inorganic hybrid materials with controllable size and morphology is challenging and active area of modern research in view of their unique properties and thus multifunctional applications. Specifically polyoxometalates (POMs) were recognized as a very promising group for the construction of those systems, nonethel...
Article
Herein, we present a spectroscopic (CD and UV) and SEM study of a phenylalanine derivative carrying a terminal alkyne moiety and indicated by us CF3IIIPhe, with particular attention to its interaction with Cu(II) cation and some biological macromolecules, as well as a preliminary evaluation of its effect on cancerous cells. CD spectroscopy evidence...
Article
Full-text available
The problem of pollution in the current world is growing, however people’s awareness of environmental protection and ecology is also increasing. The aim of the study is to present three new Schiff base compounds with Co(II/III) ions and to assess their photocatalytic activity. The study was supported by cyclic voltammetry technique. In due course t...
Article
Glycol nucleic acids (GNA) are synthetic genetic-like polymers with an acyclic three-carbon propylene glycol phosphodiester backbone. Here, the synthesis, luminescence properties, circular dichroism (CD) spectra, and confocal microscopy speciation study in HeLa cells of (R,S) and (S,R) pyrenyl-GNA (pyr-GNA) nucleosides are reported. Enantiomericall...
Article
This paper presents a report of the synthesis and chemical transformations of anthracene-thymine and 4-thiothymine derivatives. In a reaction of 1-(anthracen-9-yl)-1-hydroxy-3-(N1-thyminyl)-propane with ethylene glycol either an elimination or substitution product is preferentially formed depending on reaction conditions. In the presence of Yb(OTf)...
Article
Herein, we present synthesis and characterization of new ligand with N2O‐donor moiety based on benzothiazole unit and its two complexes with Cu(II) cations. X‐ray diffraction measurements revealed solid state structures of presented compounds as mono‐ and dinuclear entities. Both complexes appeared to be highly effective catalysts in oxidation proc...
Article
Six complexes of various Mn(II) salts: MnBr2·4H2O (1), Mn(NO3)2·4H2O (2), MnCl2·4H2O (3) with 2-(1-methyl-2-(pyridin-2-ylmethylene)hydrazinyl)benzo[d]oxazole LA (complexes 1A–3A) and 2-(2-((1H-imidazol-4-yl)methylene)-1-methylhydrazinyl)benzo[d]oxazole HLB (complexes 1B–3B) have been synthesized. All complexes were obtained in 1:1 stoichiometry. Th...
Article
Herein, we present the efficient synthesis of two new supramolecular complexes according to reaction conditions. Mononuclear iron (III) and tetranuclear iron(II) complexes with a new N2O-donor Schiff base ligand HL which self-organises into thermally stable (up to 250 °C). The second one self-organises in non-covalent organic framework stabilised b...
Article
Much attention has been focused recently on the improvement of the photocatalytic efficiency of already known degradation catalysts and design of the new ones. Since silver(I) compounds are of high interest in the field of photodegradation processes due to their good optical and electron properties concerning HOMO-LUMO band gaps we have designed tw...
Article
The self-assembly of 6,6′′′′-dimethyl-2,2′;6′,2′′;6′′,2′′′-quaterpyridine L with tetrahedral ions of silver(i) and copper(i) leads to the formation of dinuclear double stranded helicates 1-4. ¹H NMR studies confirm the stability of each helicate both in 2% aqueous DMSO solution, which plays the role of a medium in biological studies, and in the cel...
Article
Reactions of 6,6″-dimethyl-2,2′:6′,2″-terpyridine ligand L and VX3 (X = Cl, Br) in aerobic conditions result in formation of two new mononuclear coordination compounds: [VOLCl2] 1 and [VO2L]2Br2·3H2O 2, as revealed by means of single crystal X-ray analyses. The final form of vanadium complex in the solid state, either oxido (V(IV)) or dioxido (V(V)...
Article
Full-text available
6,6″-Dimethyl-2,2':6',2″-terpyridine ligand (L) reacts in equimolar ratio with Ag(I) ions what results in formation of dinuclear double helicates, which differ in terms of framework and complexity in accordance to counterions and solvent applied. Obtained complexes were thoroughly studied in terms of their biological activity, with the positive ant...

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Projects

Projects (2)
Project
The goal of the project is to shed light into understanding of structural prerequisites that must be fulfilled in metal complexes, so that acquisition of antiproliferative effect toward cancerous cell lines is observed.
Project
The goal of the project is to enhance our understanding of the factors that govern the design and successful synthesis of materials (usually coordination compounds) with preprogrammed properties.