Marna E Ericson

Marna E Ericson
The Hormel Institute

Doctor of Philosophy

About

90
Publications
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2,196
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Publications

Publications (90)
Article
Full-text available
The diagnostic tests available to identify vector-borne pathogens have major limitations. Clinicians must consider an assortment of often diverse symptoms to decide what pathogen or pathogens to suspect and test for. Even then, there are limitations to the currently available indirect detection methods, such as serology, or direct detection methods...
Article
Full-text available
The COVID-19 pandemic revealed a need for new understanding of the mechanisms regulating host–pathogen interactions during viral infection. Transfer RNA-derived RNAs (tDRs), previously called transfer RNA fragments (tRFs), have recently emerged as potential regulators of viral pathogenesis. Many predictive studies using bioinformatic approaches hav...
Article
Full-text available
Bartonella bacilliformis (B. bacilliformis), Bartonella henselae (B. henselae), and Bartonella quin-tana (B. quintana) are bacteria known to cause verruga peruana or bacillary angiomatosis, vascular endothelial growth factor (VEGF)-dependent cutaneous lesions in humans. Given the bacteria's association with the dermal niche and clinical suspicion o...
Article
Background: Allergic contact dermatitis to tattoo ink may last from weeks to years. Formaldehyde is a strong sensitizer that may be present in predispersed tattoo inks. Objectives: The aim of this study was to evaluate the presence of formaldehyde in predispersed tattoo inks using the chromotropic acid method. Methods: Tattoo inks from 39 comp...
Article
Full-text available
Bartonella spp. are re-emerging and neglected bacterial pathogens. The natural reservoirs for several species of this genus are domestic animals such as cats and dogs, the most common pets in the USA and Brazil. Some cat studies suggest that the infection is more prevalent in tropical and poverty-stricken areas. These bacteria were associated with...
Article
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We demonstrate Bartonella spp are abundant in skin lesions resembling striae distensae. These striae distensae‐like lesions, coincidental with sudden onset of neuropsychiatric symptoms, indicate testing for suspected Bartonella spp. infection.
Article
Background: The inherent characteristics of the sickle cell disease (SCD), the most common genetic hematological disorder, increase the propensity of infections. Bartonella spp. are emerging and neglected bacteria. A large spectrum of clinical manifestations has been linked to bartonella bloodstream infection in the last two decades that can cause...
Article
Neuropeptide inflammation seems to play a role in the pathogenesis of lichen planopilaris and frontal fibrosing alopecia
Article
Background: Nail polish is known to contain potentially hazardous chemicals that have been linked to adverse health effects after overexposure. Formaldehyde is used as an antimicrobial, preservative, and nail hardener in select nail products, yet it is a recognized carcinogen and potent allergen in allergic contact dermatitis. Objective: The aim...
Article
Background: Formaldehyde resins may be used in textiles. Objective: The aim of the study was to investigate the presence of formaldehyde in textiles using the chromotropic acid method. Method: Clothing scraps (from local department store tailors, n = 77) and upholstery fabric cuttings (from a furniture reupholstery store, n = 22) were collecte...
Article
Background: Formaldehyde is a common preservative and strong sensitizer. Objective: The aim of the study was to evaluate the release of formaldehyde from baby/toddler wet wipes using the chromotropic acid method (CAM). Methods: An online search of best-selling baby wipes was conducted. None declared formaldehyde or formaldehyde-releasing prese...
Article
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Innate immune complement activation may contribute to sickle cell disease (SCD) pathogenesis. Ischemia‐reperfusion physiology is a key component of the inflammatory and vaso‐occlusive milieu in SCD and is associated with complement activation. C5a is an anaphylatoxin, a potent pro‐inflammatory mediator that can activate leukocytes, platelets, and e...
Article
Background: Preservatives such as formaldehyde and formaldehyde releasers (F/FRs) are found in personal care products. Studies from Europe and Israel have indicated that products with undeclared F/FRs on product labels may have detectable levels of formaldehyde. Objective: The aim of the study was to determine the presence of formaldehyde in sam...
Article
Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic scarring alopecias affecting primarily the scalp. Although both diseases may share some clinical and histopathological features, in the last decade, FFA has become an “epidemic” particularly in Europe, North and South America with unique clinical manifestations compared...
Article
Background: Bartonella henselae, a Gram-negative, zoonotic, alpha-proteobacteria has been previously implicated in association with cutaneous vasoproliferative lesions (bacillary angiomatosis), nodular panniculitis and multifocal erythema (erythema multiforme) in dogs. Objective: Describe clinical, microbiological and histological lesions in a d...
Article
Background: Sickle cell disease (SCD) is the most prevalent hematologic genetic disorder. Acute vaso-occlusive painful crisis is the hallmark of the disease and may be related to subclinical infections. Bartonellosis, a rare and neglected infection, is caused by Bartonella spp., which can be found in donated blood. These bacteria cause intraerythr...
Article
Full-text available
Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice...
Poster
Full-text available
Bartonella spp. are blood-borne, Gram-negative vector-transmitted bacteria capable of causing prolonged infection in humans and a diverse spectrum of visceral and cutaneous manifestations. Previously, we reported immunoreactive (IR) B. henselae associated with dermal collagen in non-lesional skin of a patient with persistent Bartonellosis (Abst.563...
Article
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Background The genus Bartonella is comprised of a rapidly increasing number of pathogenic species that induce a seemingly diverse spectrum of neurological symptoms. During the 12 year period that followed the initial onset of neurological and gastrointestinal symptoms, an 11 year-old girl experienced a spectrum of neurological complaints including...
Article
Dermatomyositis (DM) is commonly associated with scalp pruritus that can be severe. In addition, significant crawling and burning sensations have been reported in these cases. The etiology of these scalp sensations in the context of dermatomyositis is not fully understood. We report a 42-year old female with treatment-resistant dermatomyositis and...
Article
Full-text available
Bartonella henselae is a causative agent of anemia, cat scratch disease, bacillary angiomatosis, recurrent fever, hepatitis, endocarditis, chronic lymphadenopathy, joint and neurological disorders. B. henselae are intra-erythrocytic bacteria. The goal of this study was to visualize the B. henselae invasion into enucleated human red blood cells in r...
Article
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Background: Bartonella spp. are neglected fastidious Gram-negative bacilli. We isolated Bartonella henselae from 1.2% of 500 studied blood donors and demonstrated that the bacteria remain viable in red blood cell units after 35 days of experimental infection. Now, we aim to evaluate the possibility of B. henselae transmission by blood transfusion...
Article
Bartonella henselae is a causative agent of anemia, cat scratch disease, bacillary angiomatosis, recurrent fever, hepatitis, endocarditis, chronic lymphadenopathy, joint and neurological disorders. B. henselae are intra-erythrocytic bacteria. The goal of this study was to visualize the B. henselae invasion into enucleated human red blood cells in r...
Article
Full-text available
Bartonella henselae Biofilm Detected on Catheter of Patient with Persistent Bartonellosis - Volume 21 Issue S3 - Melissa Weber-Sanders, Paulo ENF Velho, Gislaine Vieira-Damiani, Marilene Neves da Silva, Vitor B. Pelegati, Carlos Lenz Cesar, Marna Ericson
Article
Obtaining digital images of color brightfield microscopy is an important aspect of biomedical research and the clinical practice of diagnostic pathology. Although the field of digital pathology has had tremendous advances in whole-slide imaging systems, little effort has been directed toward standardizing color brightfield digital imaging to mainta...
Article
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Background Topically applied opioids promote angiogenesis and healing of ischemic wounds in rats. We examined if topical fentanyl stimulates wound healing in diabetic rats by stimulating growth-promoting signaling, angiogenesis, lymphangiogenesis and nerve regeneration.Methods We used Zucker diabetic fatty rats that develop obesity and diabetes on...
Article
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Bartonella henselae is increasingly associated with a variety of pathological entities, which are often similar in dogs and human patients. Following an acute flea infestation, a dog developed an unusual clinical presentation for canine bartonellosis. Comprehensive medical, microbiological, and surgical interventions were required for diagnosis and...
Article
This is an exciting era in the development and cross-disciplinary use of new imaging technologies, including single-photon and multiphoton laser scanning microscopy; second-and third-harmonic generation imaging; coherent anti-Raman stokes imaging (CARS); and live-cell, whole-mouse, hyperspectral, and super-resolution microscopy. These imaging techn...
Article
The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease.
Article
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Key Points Inhibition of mast cells with cromolyn or imatinib results in reduced systemic inflammation and neurogenic inflammation in sickle mice. Pharmacological inhibition or genetic depletion of mast cells in sickle mice ameliorates chronic and hypoxia/reoxygenation-induced pain.
Article
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Background Bartonella henselae is a zoonotic, alpha Proteobacterium, historically associated with cat scratch disease (CSD), but more recently associated with persistent bacteremia, fever of unknown origin, arthritic and neurological disorders, and bacillary angiomatosis, and peliosis hepatis in immunocompromised patients. A family from the Netherl...
Article
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Lapatinib, an oral, small-molecule, reversible inhibitor of both EGFR and HER2, is highly active in HER2 positive breast cancer as a single agent and in combination with other therapeutics. However, resistance against lapatinib is an unresolved problem in clinical oncology. Recently, interest in the use of natural compounds to prevent or treat canc...
Article
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Osteosarcoma is the most common malignant bone tumor found in children and adolescents and is associated with many complications including cancer pain and metastasis. While cancer patients often seek complementary and alternative medicine (CAM) approaches to treat cancer pain and fatigue or the side effects of chemotherapy and treatment, there is l...
Article
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Objectives: Intranasal delivery has been shown to target peptide therapeutics to the central nervous system (CNS) of animal models and induce specific neurological responses. In an investigation into the pathways by which intranasal administration delivers insulin to the CNS, this study has focused on the direct delivery of insulin from the olfact...
Article
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374 Sickle cell disease (SCD) is associated with inflammation, endothelial dysfunction and pain. We observed increased immunoreactivity (ir) of pro-inflammatory and vasoactive neuropeptides, substance P (SP) and calcitonin-gene related peptide (CGRP) accompanied by decreased mu opioid receptor (MOR)-ir in the skin of sickle as compared to control m...
Article
Full-text available
Sickle cell disease is the most common hereditary hematologic disorder in the world. Painful vaso-occlusive crises are the hallmark of the disease and it is difficult to treat. Chronic infection is related to a higher painful crisis rate in these patients. Bartonella spp. are fastidious bacteria of zoonotic transmission. They can cause human asympt...
Article
Background: Lapatinib, an oral, small-molecule, reversible inhibitor of both EGFR and HER2, is highly active in HER2 positive breast cancer as a single agent and in combination with other therapeutics. However, resistance against lapatinib is an unresolved problem in clinical oncology. Recently, interest in the use of natural compounds to prevent o...
Article
Scalp pruritus is a common complaint that is considered a diagnostically and therapeutically challenging situation. Scalp skin has a unique neural structure that contains densely innervated hair follicles and dermal vasculature. In spite of the recent advances in our understanding of itch pathophysiology, scalp itching has not been studied as yet....
Article
2118 Painful non-healing leg ulcers in sickle cell disease (SCD) pose major treatment challenges for which there is no satisfactory therapy. We observed that the vascular and nerve architecture are abnormal, and mu opioid receptor (MOR) expression is decreased in the skin of BERK mice expressing sickle hemoglobin, as compared to HbA-BERK mice expre...
Conference Paper
Sickle cell disease (SCD) is accompanied by chronic inflammation and severe pain for which available therapies are unsatisfactory. We found that pain was accompanied by increased peripheral expression of pro-inflammatory and vasoactive neuropeptides, substance P (SP) and calcitonin gene related peptide (CGRP), and decreased expression of mu opioid...
Article
Full-text available
Activation of receptor tyrosine kinases (RTK) plays a key role in the prognosis of mammary cancer. Lapatinib is a small molecule dual RTK inhibitor that targets epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). Identifying the protein targets involved in the effects of lapatinib and other RTK inhibitors mi...
Article
There is an urgent need for unbiased evaluations of potential therapeutic treatments. An early indicator of treatment efficacy might allow for a more individualized and effective therapeutic regimen. In the present study we employed the MNU model of ER+ mammary tumors to address this question. Rats were treated with MNU at 50 days of age. When an a...
Article
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL EGFR is a validated therapeutic target; but unfortunately, only a small percentage of patients with EGFR-overexpressing tumors respond to therapy, and resistance develops even in responsive patients. Gefitinib (Iressa) is a small molecule tyrosine kinase inhibitor that suppre...
Article
Background: Activation of tyrosine kinase receptors, including EGFR, HER2, HER3 and HER4, plays a key role in the prognosis of mammary cancer. EGFR is a validated therapeutic target; but unfortunately, only a small percentage of patients with EGFR-overexpressing tumors respond to therapy, and resistance develops even in responsive patients. Iressa...
Article
s: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Nov 7-10, 2010; Philadelphia, PA Activation of receptor tyrosine kinases (RTKs) plays a key role in the prognosis of mammary cancer. EGFR and HER2 are validated therapeutic targets. Lapatinib is a small molecule dual RTK inhibitor that targets EGFR and HER2. Identifying...
Conference Paper
The mechanisms underlying non-healing leg ulcers in sickle cell disease (SCD) remain unknown and their treatment is difficult. We hypothesized that leg ulcers in SCD cause injury to nerve fibers leading to neurogenic inflammation, and peripheral and central sensitization resulting in chronic pain and impairment of wound healing. We examined our hyp...
Article
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC We have developed a one-day imaging acquisition and analysis protocol to quantify orientation of the collagen fibrils at the boundary of a mammary tumor lobule in a tissue biopsy. We reported that the degree of radially-aligned collagen fibrils in the tumor-stromal inter...
Article
Full-text available
Sickle cell disease causes severe pain. We examined pain-related behaviors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transgenic mice expressing human sickle hemoglobin (HbS). Paw withdrawal threshold and withdrawal latency (to mechanical and thermal stimuli, respectively) and grip force were lower in...
Article
822 Neural mechanisms underlying severe pain in sickle cell disease (SCD) remain unknown. Opioids, the primary medications for pain in SCD, are frequently associated with development of tolerance and side effects. We used transgenic heterozygous BERK mice expressing human sickle hemoglobin (hBERK) and age/sex matched mice of similar genetic backgro...
Article
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Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 is a widely expressed protein whose function might be critical in various nonneuronal physiologic conditions. The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is overe...
Article
The receptor tyrosine kinase inhibitor, SU11248, was added to localised radiation to evaluate the response of bone metastases and to define the basic mechanism of radiosensitisation. Treatment with SU11248 and radiation was assessed in vitro using cultured 4T1 breast cancer cells and in vivo using an orthotopic 4T1 murine mammary tumour model of br...
Article
Although pain was previously not considered an important element of multiple sclerosis (MS), recent evidence indicates that over 50% of MS patients suffer from chronic pain. In the present study, we utilized the Theiler's murine encephalomyelitis virus (TMEV) model of MS to examine whether changes in nociception occur during disease progression and...
Article
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The ability of the epidermal growth factor receptor inhibitor gefitinib (Iressa) to prevent/treat methylnitrosourea (MNU)-induced mammary cancers and to modulate biomarkers in female Sprague-Dawley rats was examined. Rats were given a single dose of MNU (75 mg/kg body weight) at 50 days of age. In the prevention studies, continual treatment with Ir...
Article
Radiation therapy is a widely used treatment for metastatic bone cancer, but the rapid onset of tumor radioresistance is a major problem. We investigated the radiosensitizing effect of enzastaurin, a protein kinase Cbeta (PKCbeta) inhibitor, on bone tumor growth and tumor-related pain. We found that enzastaurin enhanced the effect of ionizing radia...
Article
Skeletal metastases are a major source of morbidity for cancer patients. The purpose of this study was to evaluate the effects of megavoltage irradiation and antiangiogenic therapy on metastatic bone cancer. A tumor xenograft model was prepared in C3H/Scid mice using 4T1 murine breast carcinoma cells. Twenty-eight mice bearing tumors were treated w...
Article
• Advances in immunohistochemical techniques and the development of antibodies specific for nerves, neuropeptides, lymphatics and endothelial cells have given investigators the opportunity to visualize all cutaneous nerves endothelial and endothelial- derived cells. • The use of confocal laser scanning microscopy offers additional sensitivity and t...
Article
Pain in sickle cell disease (SCD) is characterized by chronic vasculopathy. Characterization of pain and vasculature may be critical to improve the analgesic ability of opioids in treating pain in SCD. Therefore, we examined the association between vasculature, innervation and pain in a transgenic mouse model of SCD (BERK) and control mice (HbABERK...
Article
Full-text available
The skin as a barrier and immune organ is exposed to omnipresent environmental challenges such as irradiation or chemical and biologic hazards. Neuropeptides released from cutaneous nerves or skin and immune cells in response to noxious stimuli are mandatory for a fine-tuned regulation of cutaneous immune responses and tissue maintenance and repair...
Article
Ixodes scapularis ticks transmit Anaplasma phagocytophilum (Ap), agent of human granulocytic anaplasmosis (HGA). Invasion of neutrophil granulocytes (PMN) by Ap is the hallmark of the disease, but these short-lived phagocytes are not likely the sole cell type required for productive infection. We analyzed infection of microvascular endothelial cell...
Article
A protective role for the lion's mane has long been assumed but this assumption has never been tested. We compared patterns of injury, mane development and adult mane morphology in a population of African lions and found no compelling evidence that the mane conferred effective protection against wounding. The mane area was not a specific target of...
Article
Full-text available
This study demonstrates the feasibility and efficacy of using flow cytometric analysis with intracellular cytokine staining for characterization of T-cell phenotype and functional status in extensive alopecia areata (EAA) scalp skin. Cell suspensions were made from scalp punch biopsies taken from 12 patients with long-standing EAA (average disease...
Article
Chronic non-healing and painful leg ulcers are a serious manifestation of sickle cell disease (SCD). We hypothesized that structurally and functionally aberrant interdependent triad of angiogenesis, neurogenesis and lymphangiogenesis leads to localized ischemic insult, pain and edema, respectively, resulting in non-healing, painful and ulcerative w...
Article
Full-text available
Functional and anatomical relationships among primary afferent fibers, blood vessels, and cancers are poorly understood. However, recent evidence suggests that physical and biochemical interactions between these peripheral components are important to both tumor biology and cancer-associated pain. To determine the role of these peripheral components...
Article
Full-text available
To determine the mechanisms by which adoptive immunotherapy could reduce lethality to acute myelogenous leukemia (AML), a novel technique was developed to track both leukemic blasts and adoptively transferred cytotoxic T cells (CTLs) independently and simultaneously in mice. To follow the fate of ex vivo generated anti-AML-reactive CTLs, splenocyte...
Article
Strong direct and indirect evidence supports an autoimmune etiology for alopecia areata. T lymphocytes that have been shown to be oligoclonal and autoreactive are predominantly present in the peribulbar inflammatory infiltrate. Alopecia areata frequently occurs in association with other autoimmune diseases, such as thyroiditis and vitiligo, and aut...
Article
The damage from rapid high energy impacts to cartilage may contribute to the development of osteoarthritis (OA). Understanding how and when cells are damaged during and after the impact may provide insight into how these lesions progress. Mature bovine articular cartilage on the intact patella was impacted with a flat impacter to 53 MPa in 250 ms....
Article
Full-text available
The hair pluck procedure alters the anatomy of the anagen hair bulb. Hemorrhage can occur in the mesenchymal sheath and breaks at the proximal epithelium, above or around the upper third of the dermal papilla, have been reported. We hypothesized that innervation, as identified with protein gene product 9.5 (PGP 9.5), and expression of the neuropept...