Marlies Oostland

Marlies Oostland
University of Amsterdam | UVA · Swammerdam Institute for Life Sciences

PhD

About

14
Publications
2,130
Reads
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145
Citations
Citations since 2016
9 Research Items
121 Citations
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2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
Introduction
Assistant Professor in Cellular and Circuit Neuroscience, with the Cellular and Computational Neuroscience Group of Helmut Kessels at the University of Amsterdam.
Additional affiliations
September 2021 - August 2022
University College London
Position
  • PostDoc Position
January 2018 - August 2021
Princeton University
Position
  • PhD Student
January 2015 - December 2017
The University of Edinburgh
Position
  • Fellow
Description
  • I investigate the computational mechanisms in the brain during spatial navigation. To study this I make single-unit extracellular recordings in vivo using multichannel silicon probes from awake behaving mice in a virtual reality setup.
Education
January 2008 - July 2008
University of Cambridge
Field of study
  • Neuroscience
September 2006 - August 2008
University of Amsterdam
Field of study
  • Biomedical Sciences, track Neurobiology
September 2003 - August 2006
University of Amsterdam
Field of study
  • Psychobiology

Publications

Publications (14)
Article
The serotonin 5-HT(3) receptor is the only ligand-gated ion channel activated by serotonin and is expressed by GABAergic interneurons in many brain regions, including the cortex, amygdala and hippocampus. Furthermore, 5-HT(3) receptors are expressed by glutamatergic Cajal-Retzius cells in the cerebral cortex. We used 5-HT(3A)/enhanced green fluores...
Article
Full-text available
Functional 5-HT(3) receptors are transiently expressed by cerebellar granule cells during early postnatal development, where they modulate short-term synaptic plasticity at the parallel fibre - Purkinje cell synapse. Here, we show that serotonin controls maturation of Purkinje cells in the mouse cerebellum. Serotonin 3 (5-HT(3)) receptors regulate...
Article
Full-text available
Serotonin plays an important role of controlling the physiology of the cerebellum. However, serotonin receptor expression has not been fully studied in the developing cerebellum. We have recently shown that cerebellar granule cells transiently express 5-HT3 receptors. In the present study, we investigate expression of 5-HT1 and 5-HT2 receptors in t...
Article
Full-text available
Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO), are critical for motor coordination, and are central to theories of cerebellar learning. Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels expressed by IO neurons have been considered as pacemaker currents important for oscillatory...
Article
Full-text available
To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral pos...
Article
Full-text available
Cannibalism in the animal kingdom is widespread and well characterized, whereas the occurrence of human cannibalism has been controversial. Evidence points to cannibalism in aboriginal societies, prehistory, and the closely related chimpanzees. We assembled a non-comprehensive list (121 offenders, ~631 victims) of cannibalistic homicides in modern...
Article
Molecular mechanisms that configure neuronal responses to synaptic input are critical for coordinated behavior. Evidence from mice with global deletion of the HCN1 gene, which encodes hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with rapid kinetics, suggests that this channel is important for synaptic integration underlying le...
Data
Document S1. Supplemental Experimental Procedures, Figures S1–S6, and Tables S1 and S2
Chapter
The cerebellum is richly innervated by serotonin: serotonergic fibres are the third main afferent fibres into the cerebellum. There is a great diversity in serotonin receptors, of which serotonin 1 - 2 and 4 - 7 receptors are all G protein coupled receptors. The serotonin 3 (5-HT 3 ) receptor is the only ligand-gated ion channel for serotonin. Thes...
Chapter
The cerebellum is richly innervated by serotonin: serotonergic fibres are the third main afferent fibres into the cerebellum. There is a great diversity in serotonin receptors, of which serotonin 1 - 2 and 4 - 7 receptors are all G protein coupled receptors. The serotonin 3 (5-HT 3 ) receptor is the only ligand-gated ion channel for serotonin. Thes...
Thesis
Full-text available
The work described in this thesis gives insights in the mechanism behind the serotonergic control of the cerebellum during postnatal development. The findings present a powerful role for serotonin in the physiology of the developing cerebellum. The effects of the serotonergic control extend both spatially and temporally, while it is able to keep up...
Article
Full-text available
In adult animals, the cerebellum is richly innervated by serotonin: serotonergic fibres are the third main afferent fibres into the cerebellum. However, the physiology of the serotonergic system and its functional significance are not fully known during development in the cerebellum. In this review we will focus on the serotonergic regulation of th...

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