Marlies Oostland

University of Amsterdam | UVA · Swammerdam Institute for Life Sciences

The serotonin 5-HT(3) receptor is the only ligand-gated ion channel activated by serotonin and is expressed by GABAergic interneurons in many brain regions, including the cortex, amygdala and hippocampus. Furthermore, 5-HT(3) receptors are expressed by glutamatergic Cajal-Retzius cells in the cerebral cortex. We used 5-HT(3A)/enhanced green fluores...

Functional 5-HT(3) receptors are transiently expressed by cerebellar granule cells during early postnatal development, where they modulate short-term synaptic plasticity at the parallel fibre - Purkinje cell synapse. Here, we show that serotonin controls maturation of Purkinje cells in the mouse cerebellum. Serotonin 3 (5-HT(3)) receptors regulate...

Serotonin plays an important role of controlling the physiology of the cerebellum. However, serotonin receptor expression has not been fully studied in the developing cerebellum. We have recently shown that cerebellar granule cells transiently express 5-HT3 receptors. In the present study, we investigate expression of 5-HT1 and 5-HT2 receptors in t...

Cerebellar climbing-fiber-mediated complex spikes originate from neurons in the inferior olive (IO), are critical for motor coordination, and are central to theories of cerebellar learning. Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels expressed by IO neurons have been considered as pacemaker currents important for oscillatory...

To make successful evidence-based decisions, the brain must rapidly and accurately transform sensory inputs into specific goal-directed behaviors. Most experimental work on this subject has focused on forebrain mechanisms. Using a novel evidence-accumulation task for mice, we performed recording and perturbation studies of crus I of the lateral pos...

Cannibalism in the animal kingdom is widespread and well characterized, whereas the occurrence of human cannibalism has been controversial. Evidence points to cannibalism in aboriginal societies, prehistory, and the closely related chimpanzees. We assembled a non-comprehensive list (121 offenders, ~631 victims) of cannibalistic homicides in modern...

Molecular mechanisms that configure neuronal responses to synaptic input are critical for coordinated behavior. Evidence from mice with global deletion of the HCN1 gene, which encodes hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with rapid kinetics, suggests that this channel is important for synaptic integration underlying le...

Document S1. Supplemental Experimental Procedures, Figures S1–S6, and Tables S1 and S2

The cerebellum is richly innervated by serotonin: serotonergic fibres are the third main afferent fibres into the cerebellum. There is a great diversity in serotonin receptors, of which serotonin 1 - 2 and 4 - 7 receptors are all G protein coupled receptors. The serotonin 3 (5-HT 3 ) receptor is the only ligand-gated ion channel for serotonin. Thes...

The cerebellum is richly innervated by serotonin: serotonergic fibres are the third main afferent fibres into the cerebellum. There is a great diversity in serotonin receptors, of which serotonin 1 - 2 and 4 - 7 receptors are all G protein coupled receptors. The serotonin 3 (5-HT 3 ) receptor is the only ligand-gated ion channel for serotonin. Thes...

The work described in this thesis gives insights in the mechanism behind the serotonergic control of the cerebellum during postnatal development. The findings present a powerful role for serotonin in the physiology of the developing cerebellum. The effects of the serotonergic control extend both spatially and temporally, while it is able to keep up...

In adult animals, the cerebellum is richly innervated by serotonin: serotonergic fibres are the third main afferent fibres into the cerebellum. However, the physiology of the serotonergic system and its functional significance are not fully known during development in the cerebellum. In this review we will focus on the serotonergic regulation of th...