Marlene Correia

University of Aveiro | UA

For the development of tissue-engineered bone grafts, an improved understanding of all metabolic adaptations associated with stem cell osteogenic differentiation process may be of help. Metabolomics has been an important tool in stem cell research, using both fingerprinting and footprinting strategies. In particular, a footprinting approach studies...

Mesenchymal stem cells (MSCs) have become the basis of numerous bioengineering studies due to their ability to differentiate into multiple cell lineages and secrete bioactive factors essential for tissue repair [1,2]. However, donor heterogeneity limits the clinical value of MSCs, triggering attempts to use data signatures as predictors of differen...

This paper describes, for the first time to our knowledge, a lipidome and exometabolome characterization of osteogenic differentiation for human adipose tissue stem cells (hAMSCs) using nuclear magnetic resonance (NMR) spectroscopy. The holistic nature of NMR enabled the timecourse evolution of cholesterol, mono- and polyunsaturated fatty acids (in...