Marlene Ågerstrand

Marlene Ågerstrand
Stockholm University | SU · Department of Environmental Science

PhD

About

60
Publications
31,231
Reads
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1,571
Citations
Introduction
My research focuses on understanding the science-policy interactions in risk assessment and management of chemicals. The overall aim of my work is to strengthen the protection of human health and the environment from hazardous chemicals. Together with colleagues at Stockholm University and Karolinska Institutet, I have developed the webtool SciRAP (www.scirap.org) which provides methods for the evaluation of toxicity and ecotoxicity studies for use in hazard and risk assessment of chemicals.
Additional affiliations
March 2019 - present
Stockholm University
Position
  • Professor (Assistant)
December 2014 - February 2019
Stockholm University
Position
  • Researcher
December 2012 - December 2014
Stockholm University
Position
  • PostDoc Position
Education
July 2007
Stockholm University
Field of study
  • Environmental Science

Publications

Publications (60)
Article
Full-text available
Interest in behavioural ecotoxicology is growing, partly due to technological and computational advances in recording behaviours but also because of improvements of detection capacity facilitating reporting effects at environmentally relevant concentrations. The peer-reviewed literature now contains studies investigating the effects of chemicals, i...
Article
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Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds. Below we report short extracts highlighting the main messages of the correspondences we received.
Article
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Highlights • 9 recommendations digest recent developments in regulatory environmental risk assessment. • Efforts are necessary to make the translation of ecotoxicology into regulatory decisions more open and transparent. • They require concerted and sustained action from a variety of sectors and stakeholders. • Better evidence will lead to bette...
Article
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The goal of identifying hazardous chemicals registered under the Registration, Evaluation, Authorization and restriction of CHemicals (REACH) Regulation and taking appropriate risk management measures relies on robust data registrations. However, the current procedures for European chemical manufacturers and importers to evaluate data under REACH n...
Article
Toxicity studies on chemicals registered under REACH are provided as summaries instead of submitting a full study report. Since the registration data are used by regulatory agencies to identify chemicals of concern, the study summaries must accurately reflect the information in studies. A “study summary” should include sufficient information on the...
Article
Full-text available
Antimicrobial substances are substances that have the ability to kill or slow down the growth of microorganisms such as bacteria, algae and fungi. Exposure of microorganisms to low concentrations of antimicrobial substances may lead to the development of antimicrobial resistance. To protect human health and the environment and to limit resistance,...
Article
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For decades, we have known that chemicals affect human and wildlife behavior. Moreover, due to recent technological and computational advances, scientists are now increasingly aware that a wide variety of contaminants and other environmental stressors adversely affect organismal behavior and subsequent ecological outcomes in terrestrial and aquatic...
Article
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The Society of Environmental Toxicology and Chemistry (SETAC) introduces recommendations for reporting ecotoxicity studies. The purpose of this is to facilitate the use of these studies in research as well as regulatory assessments. Compliance with these reporting recommendations will depend on individual researchers as well as scientific journals’...
Article
Full-text available
PurposeThe database Pharmaceuticals and Environment is a non-commercial, freely available web-based decision support presenting compiled environmental information for pharmaceutical substances. It was developed by Region Stockholm and launched in 2016 at janusinfo.se. The purpose of this paper is to present the database, report on its current use,...
Article
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The Partnership for Chemicals Risk Assessment (PARC) is currently under development as a joint research and innovation programme to strengthen the scientific basis for chemical risk assessment in the EU. The plan is to bring chemical risk assessors and managers together with scientists to accelerate method development and the production of necessar...
Article
Full-text available
Interest in behavioural ecotoxicology is growing, partly due to technological and computational advances in recording behaviours but also because of improvements of detection capacity facilitating reporting effects at environmentally relevant concentrations. The peer-reviewed literature now contains studies investigating the effects of chemicals, i...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Article
Regulatory authorities rely on risk and hazard assessments performed under REACH for identifying chemicals of concern and take action. Therefore, these assessments must be systematic and transparent. This study investigates how registrants evaluate and report data evaluations under REACH and the procedures established by the European Chemicals Agen...
Article
Societies worldwide are investing considerable resources into the safe development and use of nanomaterials. Although each of these protective efforts is crucial for governing the risks of nanomaterials, they are insufficient in isolation. What is missing is a more integrative governance approach that goes beyond legislation. Development of this ap...
Preprint
Full-text available
Larsson and coworkers recently presented a study in Food and Chemical Toxicology on the cumulative risks to the Danish population from dietary exposure to pesticide residues. They base their analysis on food monitoring data, spray journals, controlled field trials and food consumption data in the Danish population. A cumulative hazard-index (HI) ap...
Preprint
Larsson and coworkers recently presented a study in Food and Chemical Toxicology on the cumulative risks to the Danish population from dietary exposure to pesticide residues. They base their analysis on food monitoring data, spray journals, controlled field trials and food consumption data in the Danish population. A cumulative hazard-index (HI) ap...
Article
Full-text available
This is a call for action to scientific journals to introduce reporting requirements for toxicity and ecotoxicity studies. Such reporting requirements will support the use of peer-reviewed research studies in regulatory decision-making. Moreover, this could improve the reliability and reproducibility of published studies in general and make better...
Article
Full-text available
Regulatory hazard and risk assessments of chemical substances have to include all reliable and relevant data to be credible and complete. However, screening the literature for appropriate studies and extracting data is burdensome. Therefore, reducing impediments by making data easily and readily accessible to risk assessors could result in more com...
Article
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Evaluation of the reliability and relevance of toxicity and ecotoxicity studies is an integral step in the assessment of the hazards and risks of chemicals. This evaluation is inherently reliant on expert judgment, which often leads to differences between experts’ conclusions regarding how individual studies can contribute to the body of evidence....
Article
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The interactions between academic research and regulatory assessment of chemicals may in theory seem straightforward: researchers perform studies, and these studies are used by regulators for decision-making. However, in practice the situation is more complex, and many factors decide a research study’s regulatory use. According to several EU chemic...
Article
Environmental hazard and risk assessment serve as the basis for regulatory decisions to protect the environment from unintentional adverse effects of chemical substances including nanomaterials. This process requires reliable and relevant environmental hazard data upon which classification and labelling can be based and Predicted No-Effect Concentr...
Article
Water is a vital resource for natural ecosystems and human life, and assuring a high quality of water and protecting it from chemical contamination is a major societal goal in the European Union. The Water Framework Directive (WFD) and its daughter directives are the major body of legislation for the protection and sustainable use of Euro- pean fre...
Article
Water is a vital resource for natural ecosystems and human life, and assuring a high quality of water and protecting it from chemical contamination is a major societal goal in the European Union. The Water Framework Directive (WFD) and its daughter directives are the major body of legislation for the protection and sustainable use of European fresh...
Article
The REACH regulation requires EU manufacturers and importers of substances to register information on the hazard and risk of their substances with the European Chemicals Agency (ECHA). Risk management of the substances is based on the provided information. It is known that conclusions on hazard and risk are influenced by expert judgements as well a...
Article
Full-text available
Regulatory policies in many parts of the world either recognize the utility of, or mandate, that all available studies be considered in Environmental/Ecological Hazard and Risk Assessment (ERA) of chemicals, including studies from the peer-reviewed literature. Consequently, a vast array of different studies and data types need to be considered. The...
Article
Different tools have been developed that facilitate systematic and transparent evaluation and handling of toxicity data in the risk assessment process. The present paper sets out to explore the combined use of two web-based tools for study evaluation and identification of reliable data relevant to health risk assessment. For this purpose, a case st...
Article
There is increasing awareness that the value of peer-reviewed scientific literature is not consistent, resulting in a growing desire to improve the practice and reporting of studies. This is especially important in the field of ecotoxicology, where regulatory decisions can be partly based on data from the peer-reviewed literature, with wide-reachin...
Article
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Background: The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health...
Article
As a response to the need for a more robust and complete reporting of ecotoxicity studies, reporting recommendations have been developed in a collaboration between the Dutch National Institute for Public Health and the Environment, the Swiss Centre for Applied Ecotoxicology, the Swiss Federal Institute of Aquatic Science and Technology, and Stockho...
Article
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From the lectures presented at the 2nd International Workshop on Obesity and Environmental Contaminants, which was held in Uppsala, Sweden, on 8–9 October 2015, it became evident that the findings from numerous animal and epidemiological studies are consistent with the hypothesis that environmental contaminants could contribute to the global obesit...
Article
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Background The regulatory evaluation of ecotoxicity studies for environmental risk and/or hazard assessment of chemicals is often performed using the method established by Klimisch and colleagues in 1997. The method was, at that time, an important step toward improved evaluation of study reliability, but lately it has been criticized for lack of d...
Article
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Systematic review (SR) is a rigorous, protocol-driven approach designed to minimise error and bias when summarising the body of research evidence relevant to a specific scientific question. Taking as a comparator the use of SR in synthesising research in healthcare, we argue that SR methods could also pave the way for a “step change” in the transpa...
Presentation
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The regulatory awareness, i.e. the understanding of environmental legislation, data requirements and risk assessment processes, is low among environmental scientists. This creates a barrier between academia and regulatory agencies that may prevent collaboration and regulatory use of peer-reviewed studies. Three European initiatives aiming at simpli...
Article
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Predicted No Effect Concentrations (PNECs) or Environmental Quality Standards (EQSs), are derived in a large number of legal frameworks worldwide. When deriving these safe concentrations, it is necessary to evaluate the reliability and relevance of ecotoxicity studies. This evaluation is often subject to expert judgment, which may introduce bias an...
Article
Full-text available
This paper presents ten recommendations for improving the European Medicines Agency's guidance for environmental risk assessment of human pharmaceutical products. The recommendations are based on up-to-date, available science in combination with experiences from other chemical frameworks such as the REACH-legislation for industrial chemicals. The r...
Article
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(Eco)toxicity studies conducted according to internationally standardized test guidelines are often considered reliable by default and preferred as key evidence in regulatory risk assessment. At the same time regulatory agencies emphasize the use of all relevant (eco)toxicity data in the risk assessment process, including non-standard studies. Howe...
Article
Full-text available
In this study we assess the applicability of a set of reliability criteria proposed by Ågerstrand et al. This was done by evaluating the reliability of 12 non-standard peer-reviewed ecotoxicity and toxicity studies for Bisphenol A. There was an overall agreement between the evaluator and the authors of the papers regarding the result of the evaluat...
Chapter
In this chapter, we argue that data evaluation is a crucial step in the risk assessment process and that the data inclusion criteria employed will have fundamental effects on the outcome of any risk assessment. Therefore, evaluation methods and data inclusion criteria need, as a minimum, to be transparent, unbiased, and systematic. To improve the c...
Thesis
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A complex process like risk assessment and the subsequent risk management decision makingshould be regularly evaluated, in order to assess the need to improve its workings. In this thesisthree related matters are addressed: evaluation of environmental risk management strategies,evaluation of environmental risk assessments, and how ecotoxicity data...
Article
Ecotoxicity data with high reliability and relevance are needed to guarantee the scientific quality of environmental risk assessments of pharmaceuticals. The main advantages of a more structured approach to data evaluation include increased transparency and predictability of the risk assessment process, and the possibility to use non-standard data....
Article
Full-text available
Standard test data are still preferred and recommended for regulatory environmental risk assessments of pharmaceuticals even though data generated by non-standard tests could improve the scientific basis of risk assessments by providing relevant and more sensitive endpoints. The aim of this study was to investigate if non-standard ecotoxicity data...
Article
The Swedish environmental and classification system for pharmaceuticals is a voluntary, industry-owned system with the purpose to provide environmental information about active pharmaceutical ingredients in the Swedish market. In this paper we report the results from a detailed evaluation of the accuracy and consistency of the risk assessments cond...
Article
A significant number of Active Pharmaceutical Ingredients (APIs) have been identified in the environment and in surface waters. Data on the environmental hazards associated with these substances are emerging but are still scarce. We have compiled publicly available ecotoxicity data for APIs into a database called WikiPharma. The use of the database...
Article
In 2005 the Swedish Association of the Pharmaceutical Industry (LIF) initiated a national environmental classification and information system for pharmaceuticals. This investigation reports the results from a survey, conducted among the persons involved in the start-up process. The aim of this study is to generate knowledge contributing to the clar...
Conference Paper
The Swedish environmental information and classification scheme for pharmaceuticals - An empirical investigation of the motivations, intentions and expectations underlying its development and implementation

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Projects

Projects (2)
Project
EDC-MixRisk focuses on the effects of mixtures of endocrine disruptive chemicals on children by developing methods for risk assessment. The aim is to promote use of safer chemicals for the next generations. Webpage: edcmixrisk.ki.se/