Markus Gantert

Markus Gantert
Maastricht University | UM · MHeNS School for Mental Health and Neuroscience

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56
Publications
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Introduction

Publications

Publications (56)
Article
Full-text available
Objective To evaluate the impact on cesarean section (CS) rate with of a program of multiple non-clinical interventions targeted at health-care professional within a hospital maternity ward. Materials and methods Retrospective quasi-experimental pre-post intervention study with an historical control group conducted in a second-level teaching hospi...
Article
Aim To evaluate low back pain (LBP) incidence and impact throughout pregnancy in terms of women’s well-being and delivery outcomes. Material and methods Cross-sectional prospective study conducted on singleton pregnancies at ≥37th gestational age admitted for delivery. Localization of LBP, intensity and frequency as well as derived functional disab...
Article
Full-text available
Efforts to use traditional native tissue strategies and reduce the use of meshes have been made in several countries. Combining native tissue repair with sufficient mesh applied apical repair might provide a means of effective treatment. The study group did perform and publish a randomized trial focusing on the combination of traditional native tis...
Article
The technique of laparoscopic pectopexy was published in 2010. A subsequent randomized trial focused on pectopexy versus sacropexy revealed no new risks for patients and significant advantages in terms of operating time and de novo defecation disorders compared to sacrocolpopexy. The present international multicenter trial was performed to evaluate...
Article
Full-text available
Infections during pregnancy can adversely affect the development of the fetal brain. This may contribute to disease processes such as schizophrenia in later life. Changes in the (cyto-) architecture of the anterior cingulate cortex (ACC), particularly in GABA-ergic interneurons, play a role in the pathogenesis of schizophrenia. We hypothesized that...
Article
Full-text available
Chorioamnionitis is a major risk factor for preterm birth in multifetal pregnancies. However, there is little clinical data whether chorioamnionitis is restricted to one amniotic compartment in multifetal pregnancies. To explore whether chorioamnionitis is confined to the exposed compartment and does not cross to the unaffected fetus in twin pregna...
Article
Full-text available
Chorioamnionitis is an important problem in perinatology today, leading to brain injury and neurological handicaps. However, there are almost no data available regarding chorioamnionitis and a specific damage of the cerebellum. Therefore, this study aimed at determining if chorioamnionitis causes cerebellar morphological alterations. Chorioamnionit...
Article
Exposure of the fetus to antenatal inflammation can occur from chorioamnionitis, which may progress to a fetal inflammatory response syndrome (FIRS) and to fetal sepsis. We tested whether the fetal myocardium responded to systemic Gram-negative endotoxinaemia. We hypothesized that the myocardium would respond to inflammation by changes in hypoxia-i...
Article
Full-text available
The bacterial infection of chorion and amnion is a common finding in premature delivery and is referred to as chorioamnionitis. As the mother rarely shows symptoms of a systemic inflammation, the course of chorioamnionitis is frequently asymptomatic and chronic. In contrast, the fetal inflammatory response syndrome represents a separate phenomenon,...
Article
We evaluated the impact of chorioamnionitis on the intrapartal EEG delta frequency in the non-anesthetized preterm sheep. 10 mg intra-amniotic LPS or saline were given 2 or 14 days before preterm birth at gestational day 125. Lambs were delivered by Caesarean section under local anesthesia. A 5-minute EEG depicted delta activity and amplitude, and...
Article
Full-text available
We quantified the impact of chorioamnionitis on both the white and gray matter structures of the preterm ovine central nervous system (CNS). The CNS was studied at 125 days of gestation, either 2 or 14 days after the intraamniotic administration of 10 mg of lipopolysaccharide (LPS) (Escherichia coli) or saline. Apoptotic cells and cell types were a...
Article
Antenatal pulmonary inflammation is associated with reduced risk for respiratory distress syndrome but with an increased risk for bronchopulmonary dysplasia (BPD) with impaired alveogenesis. We hypothesized that fetal systemic inflammation induced by intravenous (IV) lipopolysaccharide (LPS) would affect lung development in utero. Twenty-one fetal...
Article
Full-text available
Chorioamnionitis is the most significant source of prenatal inflammation and preterm delivery. Prematurity and prenatal inflammation are associated with compromised postnatal developmental outcomes, of the intestinal immune defence, gut barrier function and the vascular system. We developed a sheep model to study how the antenatal development of th...
Article
Full-text available
Antenatal infections are associated with an increased risk of perinatal morbidity and mortality. Systemic application of endotoxins to the fetus results in an increase in placental vascular resistance and chronic reduction in umbilical blood flow. We studied morphological alterations of the placenta in response to fetal inflammation in the preterm...
Article
In the treatment of breast cancer there is a change of the paradigms. Meanwhile sentinel lymph node biopsy (Sn-LNB) has become established for many indications. Network from surgeons, gynecologists, nuclear medicine doctors and pathologists is necessary to guarantee a successful use of the method. Unifocal breast cancer ≤ 2 cm combined with clinica...
Chapter
Full-text available
Die Diskussionen über die sog.Wunschsectio hat ihren Ursprung in Großbritannien und im deutschsprachigen Ausland [1, 3, 14].Diese „importierte Diskussion“ hat zu einer großen Verunsicherung bei Eltern und Ärzten geführt. Es ist das Verdienst des Präsidenten unserer Gesellschaft, durch Aufnahme dieser Pro- und Kontradebatte in das Kongressprogramm,...
Article
The sheep placenta is an often used model in placental research. Uterine epithelium and trophoblast of this synepitheliochorial placenta form a complex, intensely interdigitating epithelial barrier separating maternal and fetal organisms. The close topographical relation and additionally the presence of hybrid syncytia formed by focal fusion of bot...
Article
Fragestellung: Intrauterine Infektionen sind mit einer hohen perinatalen Morbiditat und Mortalitat assoziiert. Klinische und experimentelle Untersuchungen weisen auf eine inflammatorische Schadigung der weisen Hirnsubstanz hin. Biochemische Indikatoren fur die Entwicklung einer Hirnschadigung bzw. einer neurologischen Auffalligkeit liegen nicht vor...
Article
Full-text available
Brain damage around birth may cause lifelong neurodevelopmental deficits. We examined the therapeutic potential of human umbilical cord blood-derived mononuclear cells containing multipotent stem cells to facilitate motor recovery after cerebral hypoxic-ischemic damage in neonatal rats. Left carotid artery ligation followed by 8% O(2) inhalation fo...
Conference Paper
Full-text available
Hypoxic-ischemic cerebral damage is an important contributor to perinatal mortality and morbidity. Experimental evidence has shown that neuroprotective strategies using pharmacologic agents can alleviate perinatal brain damage. However, so far no convincing strategies are available for the regeneration of damaged structures of the perinatal nervous...
Article
Full-text available
Klinische und epidemiologische Studien weisen auf eine wichtige Rolle perinataler Infektionen in der Genese fetaler und neonataler Schädigungen hin. Eine Chorioamnionitis ist nicht nur von wesentlicher Bedeutung für die Entwicklung einer Frühgeburt, sondern erhöht auch das Risiko perinataler Hirnschäden. Im Vordergrund stehen neben der peri- und in...
Chapter
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Conference Paper
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Presentation
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Gefahren der Wunschsectio für Mutter, Kind, Geburtshelfer, Hebammen, Berufsbild, Fach, Ausbildung und Haftpflicht
Article
Axillary lymph node metastases in breast cancer patients are one of the most important prognostic factors. Many previous studies have shown that in the detection of occult micrometastases immunohistochemical methods are superior when compared to routine hematoxylin-eosin staining. The aim of the study was to document the rate of missed occult micro...

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