Markandeya Jois

Markandeya Jois
La Trobe University · School of Life Sciences

Doctor of Philosophy

About

95
Publications
12,669
Reads
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2,272
Citations
Citations since 2016
47 Research Items
1524 Citations
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2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Introduction
Skills and Expertise

Publications

Publications (95)
Article
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Purpose This study was conducted to explore doctors’ perceptions and understanding of the self-medication practices of people living with type 2 diabetes. Methods A qualitative research design incorporating 20 semi-structured, face-to-face interviews were conducted with doctors treating people with type 2 diabetes in Mysuru, India, between July 20...
Article
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Dietary interventions have gained much attention as alternative therapies in aging-associated diseases. Epidemiological studies suggest that polyphenols (PPs) play an important role in this regard. Cocoa is rich in PPs, greater in amount than in teas and red wine. This study aimed to characterize the age-associated and Aβ-induced changes in metabol...
Article
Context Monitoring the behaviour of animals can provide early warning signs of disease or indicate loss of appetite. Also, an understanding of the variation in behaviours among animals and their distributions is essential for meaningful statistical inference. Therefore, quantifying the variation of behaviours is of both biological and statistical i...
Article
Full-text available
Context Lamb loss and dyctocia are two major challenges in extensive farming systems. While visual observation can be impractical due to the large sizes of paddocks, number of animals and high labour cost, wearable sensors can be used to monitor the behaviour of ewes as there might be changes in their activities prior to lambing. This provides suff...
Preprint
Full-text available
Background: Self-medication practices are common among people living with type 2 diabetes. No studies conducted to understand doctors’ perception towards self-medication practices. Aim: To explore doctors’ perceptions and understanding of the self-medication practices of people living with type 2 diabetes in southwestern India. Methods: Semi-struct...
Article
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Background We previously showed that cocoa, a rich source of polyphenols improved the age-associated health and extended the lifespan in C. elegans when supplemented starting from L1 stage. Aim In this study, we aimed to find out the effects of timing of cocoa exposure on longevity improving effects and the mechanisms and pathways involved in life...
Article
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The use of many psychotropic drugs (PDs) is associated with increased caloric intake, significant weight gain, and metabolic disorders. The nematode Caenorhabditis elegans (C. elegans) has been used to study the effects of PDs on food intake. However, little is known about PDs effects on the body fat of C. elegans. In C. elegans, feeding behavior a...
Article
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The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be bioavailable in various organs, and in-turn exert phenotypic changes is highly debatable. Here, we isolate EVs from both raw and commercial bovine milk and characterize them by electron microscopy, nanoparticle tracking...
Article
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Background: Energy-dense diets have been implicated as a driving force in the global obesity crisis. Sucrose derived from sugar cane (Saccharum officinarum) is a carbohydrate source at the centre of this discussion. However, sugar cane is a complex plant containing a wide variety of phytochemicals that may have anti-obesity properties. The objectiv...
Article
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The aim of this article was to systematically review literature on clinical trials investigating the effects of culinary herbs and spices on obesity in adults. Relevant articles were searched through the electronic databases using predefined search terms. Thirty commonly used herbs and spices for weight loss were selected based on the literature. O...
Article
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Obesity is a growing health problem worldwide. The renin-angiotensin system (RAS) is present in adipose tissue, and evidence suggests that it is involved in both diet-induced obesity and the inflammation associated with obesity. The present experiments determined the effect of (1) different angiotensin-converting enzyme (ACE) inhibitors (captopril,...
Article
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BACKGROUND: Cocoa, a significant contributor of polyphenols to the western diet has been shown to be effective against Aβ induced toxicity in vitro. However, the effects of long-term cocoa supplementation on Aβ induced behavioural deficits, particularly on the short-term memory loss observed in human AD are not well defined. OBJECTIVE: This study c...
Article
Background: Increased intestinal permeability (IP) is associated with sepsis in the Intensive Care Unit (ICU). This study aimed to pilot a sensitive multi-sugar test to measure IP in critically ill patients in the non-fasted state. Methods: Critically ill mechanically ventilated adults were recruited from two ICUs in Australia. Measurements were...
Article
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Glycaemic index (GI) testing provides a useful point of comparison between carbohydrate sources. For this comparison to be meaningful, the methods used to determine GI values need to be rigorous and consistent between testing events. This requirement has led to increasing standardization of the GI methodology, with an international standard develop...
Article
Background The antidepressant mianserin has been shown to extend the lifespan of Caenorhabditis elegans (C. elegans), a well-established model organism used in aging research. The extension of lifespan in C. elegans was shown to be dependent on increased expression of the scaffolding protein (ANK3/unc-44). In contrast, antidepressant use in humans...
Article
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BACKGROUND: Cocoa, one of the richest dietary sources of polyphenols has been studied for its health promoting effects, but how long-term consumption of cocoa affects age-associated health and lifespan is not well defined. OBJECTIVE: The objective of this study was to determine the effects of long-term cocoa consumption on age-associated health and...
Article
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Self-medication practices of type 2 diabetes in India include the use of both traditional and western medications. It is important to understand the factors influencing self-medication. A total of 3257 studies were screened and nine studies (six quantitative and three qualitative) were included. The Hawker tool and Joanna Briggs Institute Critical...
Article
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Obesity have become significant health concern globally.This review aims to evaluate some herbs and spice on body weight. A comprehensive review on herbs and spices and its effect on body weight currently not available. Some herbs and spice have the potential to reduce body weight.
Article
The association between intestinal permeability (IP) and body composition remains unclear. The gold standard differential sugar-absorption test is arduous to complete, with zonulin being increasingly used as an independent biomarker of IP. This pilot study aimed to explore the association between small IP, zonulin concentrations and body compositio...
Conference Paper
Mental illness is a major cause of healthcare burden worldwide. Treatment of mental disorders mainly relies on psychotherapy or prescribed medications (psychotropic medication). The use of these medications has rapidly increased in the last few decades and has been linked to overweight, obesity and metabolic disorders. The present study aims to exa...
Conference Paper
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most common cause of dementia worldwide. Amyloid-β (Aβ) induced oxidative stress and toxicity are believed to be behind the pathogenesis of AD. Currently there is no pharmaceutical intervention that has been shown to cure or treat AD. Polyphenol rich food are of great i...
Article
Applying toxicity testing of chemicals in higher order organisms, such as mice or rats, is time-consuming and expensive, due to their long lifespan and maintenance issues. On the contrary, the nematode Caenorhabditis elegans (C. elegans) has advantages to make it an ideal choice for toxicity testing: a short lifespan, easy cultivation, and efficien...
Article
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: Hypertension is a major risk factor for cardiovascular disease, affecting 1 billion people worldwide. Literature suggests some herbs and spices have cardiovascular benefits, such as decreasing blood pressure; yet evidence is inconsistent. This article reviewed randomized controlled trials investigating effects of herbs and spices on blood pressur...
Article
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Myostatin is a negative regulator of skeletal muscle growth. Muscle tissue is the largest tissue in the body and influences body growth. Commercial Avian broiler chickens are selected for high growth rate and muscularity. Daweishan mini chickens are a slow growing small-sized chicken breed. We investigated the relations between muscle (breast and l...
Article
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Animal models of B12 deficiency have proven to be difficult due to storage of substantial amounts in the liver and the length of time required to maintain animals on a B12 deficient diet to induce deficiency. Caenorhabditis elegans (C. elegans), due to its short lifespan, has recently emerged as an alternate model to investigate vitamin B12 (B12) d...
Article
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Background: Traditional toxicological studies have relied heavily on various animal models to understand the effect of various compounds in a biological context. Considering the great cost, complexity and time involved in experiments using higher order organisms. Researchers have been exploring alternative models that avoid these disadvantages. On...
Article
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Caenorhabditis elegans are typically cultured in a monoxenic medium consisting of live bacteria. However, this introduces a secondary organism to experiments and restricts the manipulation of the nutritional environment. Due to the intricate link between genes and environment, greater control and understanding of nutritional factors are required to...
Article
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Exosomes are extracellular vesicles secreted by multiple cell types into the extracellular space. They contain cell-state specific cargos which often reflects the (patho)physiological condition of the cells/organism. Milk contains high amounts of exosomes and it is unclear whether their cargo is altered based on the lactation stage of the organism....
Article
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The objectives of this study were to validate the application of Bluetooth technology to determine maternal pedigree and to determine ewe-lamb spatial relationships in extensive farming systems. A total of 35 first-cross Merino ewes (Merino × Border Leicester and East Friesian) and 23 of their lambs aged 1 to 3 wk were fitted with activity monitors...
Article
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Background: Quinoa (Chenopodium quinoa) is a pseudo-cereal originally cultivated in the Andean region. The popularity of its seeds has increased in recent years due to the claims of health benefits and superfood qualities. Studies to date on the health benefits of quinoa have been restricted to animal models, and the results provide weak to moderat...
Article
Image segmentation is a key process in analyzing biological images. However, it is difficult to detect the differences between foreground and background when the image is unevenly illuminated. The unambiguous segmenting of multi-well plate microscopy images with various uneven illuminations is a challenging problem. Currently, no publicly available...
Article
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The bush coconut is used as a source of food by several Australian Aboriginal communities. It is actually a scale insect gall. Originally all bush coconut insects were given the same species name, but now there are at least three species in Australia. The bloodwood trees at Kiwirrkurra (Western Australia), Corymbia opaca, had bush coconuts built by...
Article
Chicken skeletal muscle satellite cells are located between the basement membrane and the sarcolemma of mature muscle fibers. Avian broilers have been genetically selected based on their high growth velocity and large muscle mass. The Wuding chicken is a famous local chicken in Yunnan Province that undergoes non-selection breeding and is slow growi...
Article
Exosomes are membranous vesicles that are released by a variety of cells into the extracellular microenvironment and are implicated in intercellular communication. As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Here, we describe ExoCarta (http://www.exocarta.org), a m...
Article
Introduction: Fenugreek has a wide array of therapeutic actions (i.e. hypoglycaemic, hypocholesterolaemic and antibacterial); however, the adverse effects of its consumption are not as widely reported. Numerous studies have investigated the use of fenugreek in a plethora of different formats (i.e. whole seed, crushed seed, oil extract, methanol ext...
Article
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Dietary deficiency of ω3 fatty acid during development leads to impaired cognitive function. However, the effects of multiple generations of ω3 fatty-acid deficiency on cognitive impairment remain unclear. In addition, we sought to test the hypothesis that the cognitive impairments of ω3 fatty-acid-deficient mice are mediated through the arachidoni...
Article
There are a myriad of proteins responsible for modulation of expenditure of energy. Angiotensin II (Ang II) is a vital component of renin-angiotensin system that affects blood pressure and also linked to both cachexia and obesity via fat and muscle metabolism. Previous research suggests that the direct action of Ang II is on the brain, via angioten...
Article
Modern China, similar to most developing nations, has seen a rise in the prevalence of both obesity and diesel exhaust based air pollution. The cause of obesity is multi-factorial encompassing diet, lifestyle and social factors. Also there has been a reduction in the consumption of fruit, vegetables, and traditional medicinal foods such as polyphen...
Article
Most of the fat oxidation effects of green tea have been observed in a beverage form. This study explored the use of green tea as feed formation in obese mice to protect against diet-induced obesity. Forty-eight adult C57BL/6J mice were randomised to either a control diet with 36.1 % w/w sucrose or a standard diet, except for the replacement of 2 %...
Article
There is evidence that an atypical adrenoreceptor subtype is involved in mediating some of the physiological effects of catecholamines, particularly in some adipose tissue sites. Therefore, a study was conducted to determine the effect of the β3-agonist BRL35135A on growth performance and body composition in ruminant lambs. Twenty-two second cross...
Article
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Angiotensin-converting enzyme (ACE) inhibition can reduce the body weight of mice maintained on a high-fat diet. The current study examined the effect of the ACE inhibitor, captopril (CAP), on the reversal of diet-induced obesity (DIO), insulin resistance and inflammation in mice. DIO was produced in C57BL/6J male mice (n=30) by maintaining animals...
Article
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There is evidence that an atypical adrenoreceptor subtype is involved in mediating some of the physiological effects of catecholamines, particularly in some adipose tissue sites. Therefore, three experiments were conducted to determine the metabolic and energetic responses to oral administration of the purported beta(3)-agonist BRL35135A in ruminan...
Article
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Omega-3 polyunsaturated fatty acid deficiency, particularly during the prenatal period, can cause hypertension in later life. This study examined the effect of different sources of alpha-linolenic acid (canola oil or flaxseed oil) in the prevention of hypertension and other metabolic symptoms induced by an omega-3 fatty acid-deficient diet. Dams we...
Article
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Dietary omega-3 fatty acid deficiency can lead to hypertension in later life; however, hypertension is affected by numerous other dietary factors. We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in omega-3 fatty acids. Female rats were placed on one of four experimental diets 1 week...
Article
The mechanisms of how tea and epigallocatechin-3-gallate (EGCG) lower body fat are not completely understood. This study investigated long-term administration of green tea (GT), black tea (BT), or isolated EGCG (1 mg/kg per day) on body composition, glucose tolerance, and gene expression related to energy metabolism and lipid homeostasis; it was hy...
Article
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In addition to its role as an energy store, adipose tissue also acts as an endocrine organ, synthesizing and secreting hormones and cytokines. This review discusses angiotensin II (Ang-II), the biologically active component of the renin-angiotensin system (RAS). Evidence suggests that a functioning RAS is present in adipose tissue. Animal studies h...