Mark Rawle

Mark Rawle
University College London | UCL · Institute of Epidemiology and Health Care

MB ChB(hons) MSc MRCP AKC

About

18
Publications
1,397
Reads
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368
Citations
Citations since 2017
15 Research Items
358 Citations
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Introduction
Mark Rawle currently works at the Institute of Epidemiology and Health Care, University College London. His research focuses on the epidemiology of both polypharmacy in older populations and cognitive impairment (including Alzheimer's disease). He is a consultant geriatrician, working in Whipps Cross University Hospital (Bart's Health).
Additional affiliations
September 2016 - October 2019
University College London
Position
  • Fellow
Description
  • Epidemiological research with longitudinal modelling of cognitive outcomes over the life course using the National Survey for Health and Development. Work on the effects of polypharmacy composition on cognitive and functional outcomes in later life.
August 2013 - present
North East Thames NHS Deanery, UCLP
Position
  • Registrar in Geriatric and General Medicine
Description
  • Clinical work with special interest in memory services. Employing trusts have included: Royal London Hospital, Homerton University Hospital, Whipps Cross Hospital and University College Hospital.
Education
October 2015 - August 2017
King's College London
Field of study
  • Philosophy and Theology
September 2015 - August 2016
King's College London
Field of study
  • Gerontology
January 2012 - April 2013
Royal College of Physicians
Field of study
  • General Medicine

Publications

Publications (18)
Article
Full-text available
We tested the association between APOE-ε4 and processing speed and memory between ages 43 and 69 in a population-based birth cohort. Analyses of processing speed (using a timed letter search task) and episodic memory (a 15-item word learning test) were conducted at ages 43, 53, 60–64 and 69 years using linear and multivariable regression, adjusting...
Article
Full-text available
Objectives To investigate longitudinal associations between polypharmacy and cognitive and physical capability and to determine whether these associations differ with cumulative exposure to polypharmacy. Design Prospective birth cohort study. Setting England, Scotland, and Wales. Participants An eligible sample of men and women from the Medical...
Article
Full-text available
Background: To describe the development of polypharmacy and its components in a British birth cohort in its seventh decade and to investigate socioeconomic and gender differences independent of disease burden. Methods: Data from the MRC National Survey for Health and Development were analysed to determine the prevalence and composition of polyph...
Article
Full-text available
Objectives The life course determinants of midlife and later life cognitive function have been studied using longitudinal population-based cohort data, but far less is known about whether the pattern of these pathways is similar or distinct for clinically relevant cognitive state. We investigated this for Addenbrooke’s Cognitive Examination third e...
Article
Full-text available
Background: Cardiovascular disease remains the most common cause of death in industrialized countries. The use of beta-blockers is well established as a secondary prevention of myocardial infarction. However, little is known about the benefits of beta-blockers for people living with dementia. Objective: To evaluate the use of beta-blockers in pe...
Article
Full-text available
Background Anticholinergic burden (ACB) is associated with an increased risk of delirium in the older population outside of the acute hospital setting. In acute settings, delirium is associated with increased mortality, and this association is greater with full syndromal delirium (FSD) than with subsyndromal delirium (SSD). Little is known about th...
Article
Full-text available
Background Atypical presentations of COVID‐19 pose difficulties for early isolation and treatment, particularly in institutional care settings. We aimed to characterize the presenting symptoms and associated mortality of COVID‐19 in older adults, focusing on care home residents admitted to secondary care. Methods A retrospective cohort study of 13...
Preprint
Full-text available
Background: The United Kingdom (UK) care home population has experienced high mortality during the COVID-19 pandemic. Atypical presentations of COVID-19 are being reported in older adults and may pose difficulties for early isolation and treatment, particularly in institutional care settings. We aimed to characterise the presenting symptoms and ass...
Article
Full-text available
Objective Medication adherence is a major challenge in the treatment of older patients; however, they are under‐represented in research. We undertook a systematic review focused on older patients to assess the reasons underlying non‐adherence in this population. Methods We searched multiple electronic databases for studies reporting reasons for no...
Data
Table S1. Standardized Cross‐sectional Associations of Polypharmacy with Cognitive and Physical Capability at Age 69 (Data for Figure 1) Table S2. Standardized Longitudinal Associations of Polypharmacy with Cognitive and Physical Capability (Data for Figure 2) Table S3. Sensitivity Analyses for Cross‐sectional Associations of Polypharmacy with Co...
Preprint
Full-text available
We tested the association between APOE-ε4 and processing speed and memory between ages 43 and 69 in a population-based birth cohort. Analyses of processing speed (using a timed letter search task) and episodic memory (a 15-item word learning test) were conducted at ages 43, 53, 60-64 and 69 years using linear and multivariable regression, adjusting...
Conference Paper
Background Polypharmacy, a growing phenomenon within the British population, has been linked with increased falls, reduced functional status and higher all-cause mortality in later life. However the risk profile for individual medications is not universal, with cardiovascular medications in particular posing a high risk. Prior research has found th...
Conference Paper
Objective To report the diagnostic accuracy of AD8, a brief informant screening questionnaire for the detection of dementia and cognitive impairment. Methods Prospective observational study, Cognitive Function Clinic. Results Of 153 consecutive patients seen between July-December 2013, 100 (M:F=55:45; age range 16–92 years, median 63 years) attende...
Article
Objective To report derivation of subscores from the Montreal Cognitive Assessment (MoCA) analogous to those derived from MMSE (MoCA Ala score) and Addenbrooke's Cognitive Examination (MoCA VLOM ratio) and examine their utility in differential diagnosis of Alzheimer's disease (AD) from dementia with Lewy bodies (DLB) and frontotemporal lobar degene...
Article
Full-text available
One member of a pedigree with NARP syndrome (neurogenic weakness, ataxia, and retinitis pigmentosa), a mitochondrial disorder due to a point mutation at position 8993 in the mitochondrial genome ATPase 6 gene, was reevaluated some 20 years after first being reported in the medical literature. Initially assessed at age 39 years, she had retinitis pi...

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Project (1)