Mark D. Peterson

Mark D. Peterson
University of Michigan | U-M · Department of Physical Medicine and Rehabilitation

Ph.D., M.S., CSCS*D, FACSM

About

228
Publications
214,873
Reads
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7,277
Citations
Introduction
My specific research interests have been devoted to physical activity epidemiology and behavioral interventions for the treatment/prevention of obesity and related cardiometabolic diseases, frailty, functional motor declines, cognitive health, and early mortality. This includes research efforts directed at understanding and identifying precision strategies to prevent metabolic dysregulation and secondary musculoskeletal pathology among children and adults with neuromuscular impairments as well as a variety of frailty syndromes, and research to better understand health disparities among individuals with physical and intellectual disabilities from the context of access to preventive care and community wellness.
Additional affiliations
January 2009 - present
University of Michigan
August 2001 - December 2008

Publications

Publications (228)
Article
Full-text available
Background Pain is the most common symptom of cerebral palsy and spina bifida (CP/SB). The objective of this study was to compare the opioid prescription patterns for differing pain types and overlapping pain among adults living with and without CP/SB. Methods Privately-insured beneficiaries were included if they had CP/SB (n = 22,647). Adults wit...
Article
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The huge burden and vulnerability imposed by non-communicable diseases (NCDs) during the COVID-19 pandemic highlighted how healthy lifestyle behaviors and the well-being of people living with NCDs need to be prioritized. The aim of our study is to better understand the impact of the COVID-19 pandemic on healthy lifestyle behaviors and perceived men...
Article
Objective: This study aims to determine the perceived impact of the coronavirus pandemic on physical and mental health and healthy lifestyle behaviors in community-dwelling persons with disabilities, as compared to those without disabilities. Design: A prospective cross-sectional study was conducted with a web-based global survey. Results: Ove...
Article
Objective To compare the prevalence and incidence of, and adjusted hazards for comorbidities among adults with traumatic spinal cord injuries (TSCIs) across insurance types (private vs governmental insurance) in the United States. Patients and Methods Privately insured (N=9081) and Medicare (N=7645) beneficiaries with a diagnosis of TSCI were incl...
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Background: The coronavirus disease 2019 (COVID-19) pandemic has disrupted the lives of people around the world since 2020. This study aims to reveal perceived impact of the coronavirus pandemic on physical and mental health and eating behaviors among people with disabilities and without disabilities in South Korea, as compared to other countries....
Article
Objective To examine the risk of PPHs for adults (18 and older) with TSCI to identify the most common types of preventable hospitalizations and their associative risk factors. Design Cohort study Setting Using 2007-2017 U.S. claims data from the Optum Clinformatics Data Mart, we identified adults (18+) with diagnosis of TSCI (n=5,380). Adults wit...
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Objective: To compare the incidence of and adjusted hazard ratios for common cardiometabolic diseases, musculoskeletal disorders, and psychological morbidities among adults with and without multiple sclerosis (MS). Patients and methods: Beneficiaries were included if they had an International Classification of Diseases, Ninth Revision, Clinical...
Article
Aim: To: (1) investigate the importance of outcome measurement instruments (OMIs) within a core outcome set (COS) for multimorbidity (at least two chronic health conditions) risk in individuals with cerebral palsy (CP); (2) investigate the feasibility of OMIs within the COS in international clinical research settings in adolescents and adults with...
Article
Study design: Longitudinal cohort study of privately insured beneficiaries with and without traumatic spinal cord injury (SCI). Objectives: Compare the incidence of and adjusted hazards for psychological morbidities among adults with and without traumatic SCI, and examine the effect of chronic centralized and neuropathic pain on outcomes. Setti...
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Objective Adults with congenital (cerebral palsy or spina bifida (CP/SB)) or acquired disabilities (spinal cord injury (SCI) or multiple sclerosis (MS)) have higher incidence of age-related health conditions. There is a gap in the literature about the risk of dementia among adults living with these disabilities. This study aimed to examine time to...
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There is a large body of evidence linking muscular weakness, as determined by low grip strength, to a host of negative aging-related health outcomes. Given these links, grip strength has been labeled a “biomarker of aging”; and yet, this metric provides no biological plausibility. The objective of this study was to determine the association between...
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Introduction Cerebral palsy (CP) and spina bifida (SB) are congenital disabilities. Due to life-long disability, adults with CP/SB are with greater needs for preventative care. Little is known about racial/ethnic disparities in use of preventative services in this population. Our objective was to examine racial/ethnic disparities in use of preventa...
Article
Background : Alzheimer's disease and related dementia (ADRD) and multiple sclerosis (MS) are two neurodegenerative diseases with some shared pathophysiological characteristics. While the salient attribute of ADRD is a progressive decline in cognitive function, MS is mainly known for causing physical weakness, vision loss, and muscle stiffness. Prog...
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As individuals with cerebral palsy (CP) age, they face unique challenges which complicate their ability to access and receive appropriate health care. These problems exist at the level of the health care system, the clinician, and the individual. At the system level, there is an inadequate number of professionals who are informed of and interested...
Article
Aim To examine the risk of Alzheimer disease and related dementia (ADRD) among adults with cerebral palsy (CP). Method Using administrative insurance claims data for 2007 to 2017 in the USA, we identified adults (45y or older) with a diagnosis of CP (n=5176). Adults without a diagnosis of CP were included as a typically developing comparison group...
Article
Purpose: To compare the incidence and hazard of neuropsychiatric, musculoskeletal, and cardiometabolic conditions among adults with and without vision impairment (VI). Design: Retrospective cohort study. Methods: SETTING: Enrollees in a large private health insurance provider in the U.S. Study population: 24,657 adults age ≥18 years with VI...
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Background: The objective of this study was to use nationally-representative data on Americans greater than 50 years of age to determine the association between grip strength and inflammation as independent predictors of incident disability, chronic multimorbidity and dementia. Methods: Middle age and older adults (n = 12,618) from the 2006-2008...
Article
Objective To identify pain phenotypes among adults living with cerebral palsy (CP), and compare phenotypes in terms of pain intensity, anxiety and depressive symptoms, and self-reported perceived stress. Method Seventy-one adults with CP who presented to the University of Michigan (mean age = 39.3±16.2; 43 females, 28 males). The median of 6 on th...
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Objectives: This systematic review and meta-analysis was designed to determine the overall mean blood pressure and prevalence of hypertension among a representative sample of adults living with cerebral palsy by combining individual participant data. Additional objectives included estimating variations between subgroups and investigating potential...
Chapter
The age‐related changes in morphological and functional characteristics of skeletal muscle are often accompanied by other comorbid conditions which may cluster and serve to worsen the severity of sarcopenia, risk for frailty, and disability. The contribution of age‐related sarcopenia to functional decline is mediated largely by reductions in muscle...
Article
Background: Individuals living with cerebral palsy (CP) or spina bifida (SB) are at heightened risk for a number of chronic health conditions such as secondary comorbidities, that may develop or be influenced by the disability, the presence of impairment, and/or the process of aging. However, very little is known about the prevalence and/or risk o...
Article
Background Context Individuals living with a spinal cord injury (SCI) are at heightened risk for a number of chronic health conditions such as secondary comorbidities that may develop or be influenced by the injury, the presence of impairment, and/or the process of aging. Purpose The objective of this study was to compare the incidence of and adju...
Article
Background Musculoskeletal (MSK) disorder in adults with cerebral palsy (CP) is higher than in the general population. Evidence lacks about physical therapy (PT) and occupational therapy (OT) service utilization among older adults (65> years) living with CP. Objective We compared the presence of comorbidities and patterns of PT and OT use among ol...
Article
Introduction Despite the greater risk of an array of morbidities, little is known about when morbidities occur for adults with cerebral palsy. The objective of this study is to determine the timecourse of morbidity risk/development for adults with cerebral palsy and the effect by patient-level factors. Methods Cross-sectional data from 2016 were u...
Article
Chronic pain is the most commonly reported physical symptomology of cerebral palsy (CP) and spina bifida (SB) throughout the lifespan, and yet, pain is perhaps the least understood comorbidity in these populations. The objective of this study was to compare the prevalence and types of pain diagnosed among adults living with and without CP or SB. In...
Article
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Objectives Determine the risk of incident dementia in adults with cerebral palsy (CP) compared with age, sex and general practice (GP) matched controls. Design Retrospective cohort study. Setting UK GPs linked into the Clinical Practice Research Datalink (CPRD). Participants CPRD data were used to identify adults aged 18 or older with a diagnosi...
Article
Objective Traumatic spinal cord injury (TSCI) is a life altering event most often causing permanent physical disability. Little is known about the risk of developing Alzheimer’s disease and related dementia (ADRD) among middle-aged and older adults living with TSCI. Time to diagnosis of and adjusted hazard for ADRD was assessed. Design Cohort Stud...
Article
Objective To evaluate the influence of vitamin D supplementation with a multimodal exercise program on postural balance and muscle strength in older women with low bone mineral density (BMD) and vitamin D insufficiency. Methods 12-week, randomized, double-blind, placebo-controlled clinical trial. Total of 422 subjects were screened for participati...
Article
Background People living with spinal cord injuries (SCIs) experience motor, sensory and autonomic impairments that cause musculoskeletal disorders following the injury and that progress throughout lifetime. The range and severity of issues are largely dependent on level and completeness of the injury and preserved function. Objective High risk of...
Article
The benefits of physical activity (PA) for health have been extensively studied; however, people with disabilities (PWDs) are more likely to be inactive compared to the general population. The topic of barriers and facilitators to PA for PWDs has been studied, but most reviews have focused on specific impairments, institution-based exercise program...
Article
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Purpose: The COVID-19 pandemic has drastically impacted every aspect of life, including how people exercise and access fitness resources. Prior to COVID-19, the global burden of disease attributable to sedentary behavior disproportionately affected the health of people with disabilities (PWD). This pre-existing gap has only widened during COVID-19...
Article
Introdução: Idosos tem maior risco de instabilidade postural e quedas, que piora quando se associa a carência de vitamina D e hipotrofia muscular. Objetivo: Avaliar a influência da suplementação de vitamina D com um programa de exercícios multimodais no equilíbrio postural e força muscular em mulheres idosas com baixa densidade mineral óssea (DMO)...
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Background Individuals with cerebral palsy (CP) manifest skeletal fragility problems early in life, are vulnerable to non-trauma fracture (NTFx), and have a high burden of premature mortality. No studies have examined the contribution of NTFx to mortality among adults with CP. The purpose of this study was to determine if NTFx is a risk factor for...
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Background: Individuals with cerebral palsy (CP) are vulnerable to non-trauma fracture (NTFx) and premature mortality due to respiratory disease (RD); however, very little is known about the contribution of NTFx to RD risk among adults with CP. The purpose of this study was to determine if NTFx is a risk factor for incident RD and if NTFx exacerba...
Article
Background: Adults with cerebral palsy (CP) have increased risk for developing various secondary chronic diseases, especially when they have other neurodevelopmental disabilities (NDDs). Multiple medications are likely prescribed to manage the greater morbidity-related burden for adults with CP; however, because health care delivery and care coord...
Article
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Objective: To determine physical activity, sleep, and nutrition patterns in individuals with cerebral palsy (CP) and investigate the association of Gross Motor Function Classification System (GMFCS) and age with these health behaviors. Methods: A cross-sectional study was conducted in an outpatient setting. Participants included adolescents and...
Article
Background Very little is known about the risk of developing psychological morbidities among adults living with cerebral palsy (CP) or spina bifida (SB). The objective of this study was to compare the incidence of and adjusted hazards for psychological morbidities among adults with and without CP or SB. Methods Privately insured beneficiaries were...
Article
Objective To compare the incidence of and adjusted hazards for cardiometabolic morbidities among adults with and without cerebral palsy or spina bifida. Methods Privately-insured beneficiaries were included if they had an ICD-9-CM diagnostic code for cerebral palsy or spina bifida (n=15,302). Adults without cerebral palsy or spina bifida were also...
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The reliability of lipidomics, an approach to identify the presence and interactions of lipids, to analyze the bone marrow lipid composition among pediatric populations with bone fragility is unknown. The objective of this study was to assess the test-retest reliability, standard error of measurement (SEM), and the minimal detectable change (MDC) o...
Article
Aim To determine if pain is associated with 12‐month incidence of mood affective disorders (MAD) in adults with cerebral palsy (CP). Method Data from Optum Clinformatics® Data Mart (2013–2016) were used for this retrospective cohort study. Diagnostic codes were used to identify adults (≥18y) with CP, incident cases of MAD, and covariates (other ne...
Article
Objective To compare the longitudinal incidence of psychological morbidities and multimorbidity and estimates of chronic diseases among adults with spinal cord injuries (SCIs) as compared with adults without SCIs. Methods Privately insured beneficiaries who had medical coverage at any time between January 1, 2001, and December 31, 2017 were includ...
Article
https://deepblue.lib.umich.edu/bitstream/2027.42/153554/1/dmcn14440_am.pdf
Article
Objective: This study examined the environmental barriers and facilitators that hinder or promote participation among adults aging with physical disabilities. Method: Data come from an ongoing study of 1,331 individuals aging with long-term physical disability ( M = 65 years). Linear regression examined the association between individual and socioe...
Article
Objective: To determine the prevalence of major noncommunicable diseases among young adults with pediatric-onset disabilities (PoDs) compared with young adults without PoDs. Patients and methods: Data were obtained from the Optum Clinformatics Data Mart, a de-identified nationwide claims database of beneficiaries from a single private payer in t...
Article
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Aim: To compare the rate of falls between adults with and without cerebral palsy (CP). Method: We used primary care data on 1705 adults with CP and 5115 adults without CP matched for age, sex, and general practice attended. We compared odds of experiencing a fall between adults with and without CP using conditional logistic regression. We compar...
Article
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Background: The objective of this study was to use nationally-representative data on Americans age 50+ to determine the association between grip strength and inflammation as independent predictors of incident disability, chronic multimorbidity and dementia. Methods: Older adults (n=12,618) from the 2006-2008 waves of the Health and Retirement Study...
Article
Full-text available
Despite evidence suggesting race and ethnicity are important factors in responses to environmental exposures, drug therapies, and disease risk, few studies focus on the health needs of racially- and ethnically-diverse aging adults.The objective of this study was to determine the burden of 10 health conditions across race and ethnicity for a nationa...
Article
Context: Cancer-related fatigue (CRF) is one of the most common symptoms experienced by cancer patients following hematopoietic cell transplantation (HCT). Yoga is an approach with supportive evidence to improve CRF in different cancer populations, but to our knowledge, has not been tested in an adult HCT population. Objectives: The aim of this...
Article
Objectives: Quantifying the association between muscle weakness and mortality with carefully matched cohorts will help to better establish the impact of weakness on premature death. We used a matched cohort analysis in a national sample of older Americans to determine if those who were weak had a higher risk for mortality compared with control gro...
Article
Background: Fracture is a high-burden condition that accelerates unhealthful aging and represents a considerable economic burden. Adults with neurodevelopmental disabilities (NDDs) may be susceptible for fracture at younger ages compared to adults without NDDs; and yet, very little is known about the burden of fracture for these underserved popula...
Article
Objective: To determine individual and aggregated associations of cerebral palsy (CP)-related symptoms and the effect of comorbid neurodevelopmental conditions on mood (affective) disorders among adults with CP. Methods: Cross-sectional data from 2016 were extracted from a random 20% sample of the Medicare fee-for-service database. International...
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Objective Individuals with paediatric-onset disabilities (PoDs) have complex healthcare needs and are susceptible to adverse health outcomes, which may impose a higher strain on healthcare resources. The burden of healthcare resource utilisation and costs attributed to the population of adults with PoDs is not clearly established. The objective her...
Article
Background: Persons with cerebral palsy (CP) have an increased risk for secondary chronic conditions during childhood, including mental health disorders. However, little is known about how these disorders affect adults with CP. Objective: To determine the prevalence of mental health disorders among adults with CP compared with those without CP....
Article
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Objective: To compare the incidence of noncommunicable diseases between adults with and without cerebral palsy (CP). Methods: A cohort study was conducted using primary care data from the Clinical Practice Research Datalink. Cox models, stratified by matched set and adjusted for potential confounders, were fitted to compare the risk of any nonco...
Article
Fragala, MS, Cadore, EL, Dorgo, S, Izquierdo, M, Kraemer, WJ, Peterson, MD, and Ryan, ED. Resistance training for older adults: position statement from the national strength and conditioning association. J Strength Cond Res XX(X): 000-000, 2019-Aging, even in the absence of chronic disease, is associated with a variety of biological changes that ca...
Article
In Reply We thank Gao and Adesman for their insightful comments regarding our Research Letter.¹ In their Letter to the Editor, they brought up 4 points that could enhance interpretation of findings from our analysis of the 2016 National Survey of Children’s Health (NSCH) and stated that “a more nuanced analysis and discussion would have been helpfu...
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Purpose: Individuals with cerebral palsy (CP) are susceptible to early development of high-burden medical conditions, which may place a considerable strain on health care resources. However, little is known about the prevalence of high-burden medical conditions or health care resource utilization among adults with CP. The purpose of this study was...
Article
The purpose of our scoping review was to determine if children and young people with cerebral palsy (CP) have elevated total or regional body fat compared to children and young people without CP. Databases (Ovid MEDLINE, Embase Ovid, CINHAL and Scopus) were systematically searched from 1 January 1993 to 7 December 2018 in order to identify articles...
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The aims of this study are to i) examine a clustered metabolic syndrome composite score (MetScore) and fatness among college students across body mass index (BMI) categories, and ii) determine whether fit individuals have lower MetScores, fewer individual metabolic syndrome components, and lower fatness than unfit individuals across BMI categories....
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Background: People with cerebral palsy (CP) may be at increased risk of musculoskeletal conditions due to various factors including malnutrition and abnormal levels of skeletal loading. This study aimed to compare the incidence of osteoporosis, osteoarthritis and inflammatory musculoskeletal diseases between adults with and without CP. Methods:...
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Objective: To identify existing outcome measurement instruments (OMIs) assessing risk factors for cardiometabolic disease in adolescents and adults with cerebral palsy (CP) reported on in the literature or used in the field. Data sources: The COnsensus-based Standards for the selection of health Measurement Instruments database of systematic rev...
Article
Background: Individuals living with a spinal cord injury (SCI) are at heightened risk for a number of chronic health conditions such as secondary comorbidities that may develop or be influenced by the injury, the presence of impairment, and/or the process of aging. However, very little is known about the development of secondary comorbidities amon...
Article
Full-text available
Background Many adults are living longer with health conditions in the United States. Understanding the disability-adjusted life years (DALYs) for such health conditions may help to inform healthcare providers and their patients, guide health interventions, reduce healthcare costs, improve quality of life, and increase longevity for aging Americans...
Article
Background: Despite extensive research on falls among individuals with stroke, little is known regarding the impact of neurological conditions with comorbid diagnoses and motor functional capacity on the risk of falls in these individuals. Hence, the purpose of this study was to determine the fall risk and the contribution of reduced motor functio...
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Background Estimates of multimorbidity, defined as the presence of at least two chronic conditions, some of which attributable to modifiable behaviours, are high in adults with cerebral palsy (CP). An assessment protocol evaluating multimorbidity risk is needed in order to develop and evaluate effective interventions to optimize lifelong health in...