Mark Palmeri

Mark Palmeri
Duke University | DU · Department of Biomedical Engineering (BME)

M.D., Ph.D.

About

259
Publications
24,291
Reads
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8,333
Citations
Introduction
Acoustic radiation force imaging, shear wave elasticity imaging, multi-modality image registration, finite element method modeling, Linux and numerical analysis hacking, open source software
Additional affiliations
August 2008 - present
Duke University Medical Center
Position
  • Research Assistant
Description
  • Human Pharmacology Lab
May 2007 - April 2016
Duke University
Position
  • Research Assistant
Education
August 2002 - May 2005
Duke University
Field of study
  • Biomedical Engineering
August 2000 - May 2007
Duke University Medical Center
Field of study
  • Medicine
August 1996 - May 2000
Duke University
Field of study
  • Biomedical and Electrical Engineering

Publications

Publications (259)
Preprint
Full-text available
In ultrasound shear wave elasticity (SWE) imaging, a number of algorithms exist for estimating the shear wave speed (SWS) from spatiotemporal displacement data. However, no method provides a well-calibrated and practical uncertainty metric, hindering SWE's clinical adoption and utility in downstream decision-making. Here, we designed a deep learnin...
Article
Using a 3D rotational shear wave elasticity imaging (SWEI) setup, 3D shear wave data were acquired in the vastus lateralis of a healthy volunteer. The innate tilt between the transducer face and the muscle fibers results in the excitation of multiple shear wave modes, allowing for more complete characterization of muscle as an elastic, incompressib...
Article
Correctly calculating skin stiffness with ultrasound shear wave elastography techniques requires an accurate measurement of skin thickness. We developed and compared two algorithms, a thresholding method and a deep learning method, to measure skin thickness on ultrasound images. Here, we also present a framework for weakly annotating an unlabeled d...
Article
Transrectal ultrasound (TRUS) B-mode imaging provides insufficient sensitivity and specificity for prostate cancer (PCa) targeting when used for biopsy guidance. Shear wave elasticity imaging (SWEI) is an elasticity imaging technique that has been commercially implemented and is sensitive and specific for PCa. We have developed a SWEI system capabl...
Article
No PDF available ABSTRACT We will present a recent work on the development of an ultrasound system that provides co-registered 3-D acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), and B-mode imaging volumes to guide a targeted biopsy of prostate cancer.
Article
Ultrasound elasticity imaging in soft tissue with acoustic radiation force requires the estimation of displacements, typically on the order of several microns, from serially-acquired raw data A-lines. In this work, we implement a fully convolutional neural network (CNN) for ultrasound displacement estimation. We present a novel method for generatin...
Article
Full-text available
Shear wave dispersion (variation of phase velocity with frequency) occurs in tissues with layered and anisotropic microstructure and viscous components, such as the uterine cervix. This phenomenon, mostly overlooked in previous applications of cervical Shear Wave Elasticity Imaging (SWEI) for preterm birth risk assessment, is expected to change dra...
Article
Full-text available
Objectives To quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms. Methods Two elastic phantoms, representing healthy through fibrotic liver, were measured with 5 different ultrasound platfor...
Article
No PDF available ABSTRACT We present a method for model-based viscoelastic characterization using shear wave elastography. The shear wave displacement signal is differentiated to a series of fractional derivative orders, and the group speed of the signal at each derivative order is calculated. These speeds are compared to a look up table built from...
Article
Diagnosing prostate cancer through standard transrectal ultrasound (TRUS)-guided biopsy is challenging because of the sensitivity and specificity limitations of B-mode imaging. We used a linear support vector machine (SVM) to combine standard TRUS imaging data with acoustic radiation force impulse (ARFI) imaging data, shear wave elasticity imaging...
Chapter
Acoustic radiation force elasticity imaging (ARFI) methods have become a viable clinical option to noninvasively evaluate the stiffness of the liver to evaluate fibrosis stage. Unlike external vibration-based methods such as transient elastography, acoustic radiation force excitations can be focused directly in the tissue of interest, while also pr...
Article
Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a challenge for researchers looking to match current clinical-grade workflows. We introduce a de...
Article
Assessing material properties from observations of shear wave propagation following an acoustic radiation force impulse (ARFI) excitation is difficult in anisotropic materials because of the complex relations among the propagation direction, shear wave polarizations, and material symmetries. In this paper, we describe a method to calculate shear wa...
Article
No PDF available ABSTRACT This talk will present recent results from our multi-institutional effort to advance the application of Quantitative Ultrasound in obstetrics and in perinatal care. In the field of obstetrics, we are investigating the use of shear wave elasticity imaging (SWEI) to predict the risk of preterm birth based on assessing the vi...
Article
No PDF available ABSTRACT Prostate cancer (PCa) is conventionally diagnosed using transrectal ultrasound (TRUS) guided biopsy. B-mode ultrasound is used to direct the biopsy needle to regions of the prostate gland, but is not used to target cancer-suspicious regions due to its low specificity for PCa. We are developing multiparametric quantitative...
Article
While ultrasound shear wave elastography originally focused on tissue stiffness under the assumption of elasticity, recent work has investigated the higher order, viscoelastic properties of tissue. This paper presents a method to use group shear wave speeds at a series of derivative orders to characterize viscoelastic materials. This method uses a...
Preprint
Image post-processing is used in clinical-grade ultrasound scanners to improve image quality (e.g., reduce speckle noise and enhance contrast). These post-processing techniques vary across manufacturers and are generally kept proprietary, which presents a challenge for researchers looking to match current clinical-grade workflows. We introduce a de...
Conference Paper
Our long-term goal is to quantify changes in the viscoelastic behavior of the uterine cervix during pregnancy using Shear Wave Elasticity Imaging. In this study we compared the sensitivity of two quantitative imaging biomarkers of viscosity extracted from either a time-domain or a frequency-domain analysis of shear wave dispersion. The time-domain...
Article
Transrectal ultrasound (TRUS) imaging is routinely performed to guide core-needle biopsies for the definitive diagnosis of prostate cancer (PCa). Needles are rigidly attached to the transducer and randomly sample the prostate yielding a high rate of false negative determinations. This study investigated the combined use of acoustic radiation force...
Article
Acoustic Radiation Force Impulse (ARFI) and Shear Wave Elasticity Imaging (SWEI) have been shown to have value in quantifying the stiffness of skin in sclerotic disease processes, such as morphea and Graph-Versus-Host-Disease (GVHD). Quantifying the stiffness of sclerotic skin can have clinical value in longitudinal monitoring of disease progress a...
Article
Commercial shear elasticity systems have been available to clinicians for several years for characterizing liver stiffness. The Radiological Society of North America (RSNA) established a Quantitative Imaging Biomarker Alliance (QIBA) committee on Ultrasound Shear Wave Speed to help achieve better consistency between the shear wave speed and elastic...
Article
Current prostate cancer screening methods involve non-targeted needle biopsies and the detection of clinically-insignificant lesions that receive excessive treatments, exposing patients to unnecessary adverse side effects and placing a burden on our health care systems. There is a strong clinical need for improved prostate imaging methods that are...
Article
In the original publication of this paper [1] , equation (3) contained sign errors for the amplitude of the third and fourth Heaviside functions. The corrected equation is shown in the following: \begin{align*}&\hspace {-1.8pc}\frac {d^{2}}{dt^{2}}u( t )+\omega ^{2}\tau \frac {d}{dt}u( t )+\omega ^{2}u( t ) \\=&S\omega ^{2}( H( t )-H( t-t_{\mat...
Article
Recent investigations of viscoelastic properties of materials have been performed by observing shear wave propagation following localized, impulsive excitations, and Fourier decomposing the shear wave signal to parameterize the frequency-dependent phase velocity using a material model. This paper describes a new method to characterize viscoelastic...
Article
Abnormal parturition, e.g. pre- or post-term birth, is associated with maternal and neonatal morbidity and increased economic burden. This could potentially be prevented by accurate detection of abnormal softening of the uterine cervix. Shear Wave Elasticity Imaging (SWEI) techniques that quantify tissue softness, such as shear wave speed (SWS) mea...
Article
Shear wave elasticity imaging (SWEI) characterizes the mechanical properties of human tissues to differentiate healthy from diseased tissue. Commercial scanners tend to reconstruct shear wave speeds for a region of interest using time-of-flight methods reporting a single shear wave speed (or elastic modulus) to the end user under the assumptions th...
Article
The aim of this study was to assess the ability of shear wave elasticity imaging (SWEI) to detect changes in cervical softness between early and late pregnancy. Using a cross-sectional study design, shear wave speed (SWS) measurements were obtained from women in the first trimester (5-14 wk of gestation) and compared with estimates from a previous...
Article
Harmonic imaging techniques have been applied in ultrasonic elasticity imaging to obtain higher-quality tissue motion tracking data. However, harmonic tracking can be signal-to-noise ratio and penetration depth limited during clinical imaging, resulting in decreased yield of successful shear wave speed measurements. A logical approach is to increas...
Article
Recent measurements of shear wave propagation in viscoelastic materials have been analyzed by constructing the 2-D Fourier transform (2DFT) of the shear wave signal and measuring the phase velocity c(ω) and attenuation α(ω) from the peak location and full width at half-maximum (FWHM) of the 2DFT signal at discrete frequencies. However, when the she...
Article
Tissue harmonic imaging has been widely used in abdominal imaging because of its significant reduction in acoustic noise compared with fundamental imaging. However, tissue harmonic imaging can be limited by both signal-to-noise ratio and penetration depth during clinical imaging, resulting in decreased diagnostic utility. A logical approach would b...
Chapter
Acoustic radiation force impulse (ARFI) imaging is a novel, ultrasonic elasticity imaging modality that has been developed to improve ultrasonic imaging performance to delineate clinically significant prostate cancer (PCa). Overly aggressive PCa treatment can have negative outcomes for patients and places an excessive burden on our healthcare syste...
Article
Shear wave elasticity imaging has shown promise in evaluation of the pregnant cervix. Changes in shear wave group velocity have been attributed exclusively to changes in stiffness. This assumes homogeneity within the region of interest and purely elastic tissue behavior. However, the cervix is structurally/microstructurally heterogeneous and viscoe...
Article
Ultrasound shear wave elastography is emerging as an important imaging modality for evaluating tissue material properties. In its practice, some systematic biases have been associated with ultrasound frequencies, focal depths and configuration, transducer types (linear versus curvilinear), along with displacement estimation and shear wave speed est...
Article
Ultrasound elasticity imaging has been developed over the last decade to estimate tissue stiffness. Shear wave elasticity imaging (SWEI) quantifies tissue stiffness by measuring the speed of propagating shear waves following acoustic radiation force excitation. This work presents the sequencing and data processing protocols of SWEI using a Verasoni...
Article
We are developing methods to objectively describe the acoustic and viscoelastic properties of the in vivo cervix to monitor the structural changes that occur during pregnancy. Clinicians commonly use digital palpation to subjectively judge cervical softness knowing the cervix softens prior to parturition. Premature softening of the cervix is a risk...
Conference Paper
Current prostate cancer screening methods involve non-targeted needle biopsies and detection of clinically-insignificant lesions that receive excessive treatments, exposing patients to unnecessary adverse side effects and placing a burden on our health care systems. There is a strong clinical need for improved prostate imaging methods that are sens...