Marjolein Snaterse

• PhD.
• PostDoc Position at Amsterdam University Medical Center

Introduction The clustering of atherosclerotic risk factors has been associated with an increased risk of cardiovascular disease (CVD) events. However, these studies have been conducted in patients with established CVD, focused on a limited number of outcome events, or were limited by relatively short-term follow-up. We investigated the association...

Background Primary prevention strategies for cardiovascular disease (CVD) conventionally rely on 10-year risk estimates of major adverse cardiovascular events (MACE). However, communicating longer-term total CVD risk may better facilitate informed preventive decisions. Therefore, we aimed to quantify how well 10-year observed incidence reflects 20-...

Background Atherosclerotic risk factors have been associated with cardiovascular disease (CVD) events in specific arterial territories. However, these observations are limited by relatively short-term follow-up (i.e. ten years) and a focus on a limited number of outcome events. We therefore investigated associations between atherosclerotic risk fac...

Background Smoking cessation is associated with a reduced risk of cardiovascular disease (CVD) events, mainly in ischemic heart disease (IHD) and stroke. However, the impact of smoking status (never, former or current smoking) on long-term CVD events across different arterial territories remains understudied. Knowledge of such associations is impor...

Background Low levels of physical activity is a common concern among adults with congenital heart disease (ACHD). Fear of movement, also known as kinesiophobia, has been suggested as an important contributor to these low levels of physical activity in the general cardiovascular disease population. However, levels of kinesiophobia have not been inve...

Background Atherosclerotic risk factors have been associated with cardiovascular disease (CVD) complications in specific arterial territories. However, these observations are limited by relatively short-term follow-up (i.e. ten years) We therefore investigated longer-term associations between atherosclerotic risk factors and specific cardiovascular...

Background Prolonged and intensive physical exercise is associated with cardiac remodelling and more efficient gas exchange profiles. However, it remains unclear which morphological changes have the strongest associations with maximal oxygen uptake (VO2max) and maximal oxygen pulse (O2pulse) in elite athletes when using advanced imaging techniques...

Objective Despite clear evidence on the effectiveness of secondary prevention, patients with coronary artery disease frequently fail to reach guideline-based risk factor targets. Integrating patients’ preferences into treatment decisions has been recommended to reduce this gap. However, this requires knowledge about patient treatment preferences. T...

Johan van Nieuwkerk, verpleegkundig specialist SEH en ambulance, Haaglanden Medisch Centrum (HMC) en Ambulancezorg GGD Haaglanden; Anja Brunsveld-Reinders, senior adviseur EBP, LUMC; Marjolein Snaterse, senior onderzoeker, Hartcentrum

Background The 2021 ESC Prevention guideline recommends a two-step strategy for risk management in patients with atherosclerotic cardiovascular disease (ASCVD). We estimated the potential lifetime benefit of complete implementation of this approach, compared to current practice. Methods In a pooled cohort (N=1,937) of coronary patients >45 years,...

Background In patients with ischaemic heart disease (IHD) aged > 70 years, Dutch and European guidelines recommend different treatment targets: low-density lipoprotein cholesterol (LDL-c) < 2.6 versus < 1.4 mmol/l and systolic blood pressure (SBP) < 140 versus < 130 mm Hg, respectively. How this impacts cardiovascular event-free life expectancy has...

Aims The European Systematic Coronary Risk Evaluation 2 (SCORE2) and SCORE2-Older Persons (OP) models are recommended to identify individuals at high 10-year risk for cardiovascular disease (CVD). Independent validation and assessment of clinical utility is needed. This study aims to assess discrimination, calibration, and clinical utility of low-r...

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): EPIC Norfolk was supported by the Medical Research Council UK (programme grants numbers MRC G0401527, MRC G0701863, MRC G1000143) and Cancer Research UK (programme grant number CRUK 8257). Introduction The Systematic COronary Risk Eval...

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): EPIC-Norfolk is supported by programme grants from the Medical Research Council UK (MRC G0401527, MRC G0701863, MRC G1000143) and Cancer Research UK (CRUK 8257). Introduction The latest European guidelines recommend the use of the Syst...

Purpose: The majority of older patients, scheduled for a cardiac procedure, do not adhere to international dietary intake and physical activity guidelines. The purpose of this study was to explore barriers and facilitators regarding dietary intake and physical activity behaviour change in older patients undergoing transcatheter aortic valve implan...

Background: Most patients with atherosclerotic cardiovascular disease remain at (very) high risk for recurrent events due to suboptimal risk factor control. Aim: This study aimed to quantify the potential of maximal risk factor treatment on ten-year and lifetime risk of recurrent atherosclerotic cardiovascular events in patients one year after a...

Een gezonde leefstijl vormt de basis van primaire en secundaire preventie van hart- en vaatziekten (HVZ). Dit belang wordt benadrukt in alle relevante richtlijnen. De praktijk is echter weerbarstig. Patiënten krijgen suggesties voor leefstijlinterventies waarvan een deel niet effectief en sommige zelfs contraproductief zijn. Leefstijlinterventies v...

Introduction Current primary prevention strategies in cardiovascular (CV) disease focus on initiating preventive interventions in people at high 10-year risk of CV mortality. However, initiating such strategies should be beneficial not only in the first 10 years, but throughout life. Established risk algorithms estimate the risk of 10-year CV morta...

Patients’ perceptions of cause(s) of cardiovascular disease (CVD) are central in achieving lifestyle changes during cardiac rehabilitation (CR). We investigated patients’ perceived causative CVD risk factors as compared with physicians’ reported risk factors, and how this relates to CR programme choices. Methods In 693 acute coronary syndrome (ACS...

Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): NWO-grant Title (Dutch): Het centraal stellen van behandelvoorkeuren van de individuele patiënt met een chronische hartziekte. Subtitle: Persoonsgerichte zorg voor hartpatiënten Introduction Motivated patients are more likely to succes...

Conclusion Q1 what applies to you? Results Background and purpose Methods and population How patients with coronary artery disease (CAD) perceive their risk factors and their willingness to improve is an integral part of their motivation to improve unhealthy lifestyles. We aimed to investigate preferences in risk factor treatment in patients with C...

Funding Acknowledgements Type of funding sources: None. Introduction New risk prediction models estimate and employ individual ‘treatment benefit’, which can be used to motivate patients with atherosclerotic cardiovascular disease (ASCVD) to quit smoking and to adhere to beneficial pharmacological interventions. However, this treatment benefit is...

Funding Acknowledgements Type of funding sources: None. Introduction Most risk models for patients with established atherosclerotic cardiovascular disease (ASCVD) calculate short-term risk of recurrent events and death, typically for a duration of 10 years. However, lifetime risk estimates may better support the healthcare professional in selectin...

Lifestyle management is the cornerstone of both primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) and the importance of lifestyle management is emphasised by all major guidelines. Despite this, actual implementation of lifestyle management is poor. Lifestyle modification includes smoking cessation, weight loss, diet...

Introduction The major modifiable risk factors for atherosclerosis – lifestyle, hypertension, diabetes and cholesterol – collectively account for 80 to 90% of disease burden. Currently, the majority of coronary patients does not meet the guideline-directed treatment targets for these risk factors, resulting in high levels of residual risk. An incre...

The high prevalence and burden of cardiovascular diseases (CVD) is largely attributable to unhealthy lifestyle factors such as smoking, alcohol consumption, physical inactivity and unhealthy food habits. Prevention of CVD, through the promotion of healthy lifestyles, appears to be a Sisyphean task for healthcare professionals, as the root causes of...

Background The COVID-19 pandemic has led to a national lockdown in the Netherlands, which also affected transcatheter aortic valve implantation (TAVI) patients. The objective of the study was to describe physical activity, dietary intake and quality of life (QoL) in patients on the waiting list for TAVI pre-lockdown and during lockdown. Methods Co...

Objective: To study the effects of a comprehensive secondary prevention programme on weight loss and to identify determinants of weight change in patients with coronary artery disease (CAD). Methods: We performed a secondary analysis focusing on the subgroup of overweight CAD patients (BMI ≥27 kg/m2) in the Randomised Evaluation of Secondary Pre...

Background: For patients with coronary artery disease (CAD), smoking is an important risk factor for the recurrence of a cardiovascular event. Motivational interviewing (MI) may increase the motivation of the smokers to stop smoking. Data on MI for smoking cessation in patients with CAD are limited, and the active ingredients and working mechanisms...

Background Marital status is associated with prognosis in patients with cardiovascular disease (CVD). However, the influence of partners on successful modification of lifestyle-related risk factors (LRFs) in secondary CVD prevention is unclear. Therefore, we studied the association between the presence of a partner, partner participation in lifesty...

Background The aim of this study was to describe barriers and facilitators for shared decision making (SDM) as experienced by older patients with multiple chronic conditions (MCCs), informal caregivers and health professionals. Methods A structured literature search was conducted with 5 databases. Two reviewers independently assessed studies for e...

Background lifestyle-related secondary prevention reduces cardiac events and is recommended irrespective of age. However, motivation may be influenced by age and disease progression. Objective to explore older cardiac patients’ perspectives toward lifestyle-related secondary prevention after a hospital admission. Methods a generic qualitative des...

Background Having a partner is associated with better prognosis in patients with cardiovascular disease. However, the influence of partners on modification of patients' lifestyle-related risk factors (LRFs) is unclear. Therefore, we studied the influence of partners and the level of partner participation on LRF modification in patients after an acu...

Introduction Interventions to reduce lifestyle-related risk factors (LRFs) such as overweight, physical inactivity and smoking are effective in the secondary prevention of cardiovascular events. However, evidence of the effects of lifestyle-related secondary prevention programmes in older patients with coronary artery disease (CAD) is less conclusi...

Background We performed an extended follow-up of the RESPONSE-2 trial, which evaluated a new secondary prevention strategy for patients with coronary artery disease (CAD). Selective loss to follow-up (LTFU) however, may induce biased results. Objectives To assess LTFU and its implications on the internal validity of the trial at extended follow-up...

While the beneficial effects of secondary prevention of cardiovascular disease are undisputed, implementation remains challenging. A gap between guideline-mandated risk factor targets and clinical reality was documented as early as the 1990s. To address this issue, research groups in the Netherlands have performed several major projects. These proj...

Objective To compare the treatment effect on lifestyle-related risk factors (LRFs) in older (≥65 years) versus younger (<65 years) patients with coronary artery disease (CAD) in The Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists 2 (RESPONSE-2) trial. Methods The RESPONSE-2 trial was a community-based lifestyle interv...

BACKGROUND AND AIMS: One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. METHODS: Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the medic...

Objective: The objective of this study was to investigate the characteristics of successful quitters, their use of a smoking cessation programme and the use of other lifestyle interventions to improve lifestyle-related risk factors, within a nurse-coordinated care programme. Methods: We used data from the multicentre randomised controlled RESPON...

I am a highly motivated (postdoc) researcher who wants to contribute to improve practice by investigating clinical issues. Started as an (ICU) nurse, ended up in research through teaching. I finished a PhD programme that focuses on nurse-coordinated care in secondary prevention of coronary heart disease patients and lifestyle changes, in particular...

Background: If nurses have the communication skills and the time, they can play an important role in increasing the intrinsic motivation of patients with coronary artery disease (CAD) to change their lifestyle. Motivational Interviewing (Mo-Int) can be used to further support this role. However, few nurses are sufficiently proficient in applying M...

Objective: We investigated smoking cessation rates in coronary heart disease (CHD) patients throughout Europe; current and as compared to earlier EUROASPIRE surveys, and we studied characteristics of successful quitters. Methods: Analyses were done on 7998 patients from the EUROASPIRE-IV survey admitted for myocardial infarction, unstable angina...

Background: Among patients with coronary artery disease (CAD), improvement of lifestyle-related risk factors (LRFs) reduces cardiovascular morbidity and mortality. However, modification of LRFs is highly challenging. Objectives: This study sought to evaluate the impact of combining community-based lifestyle programs with regular hospital-based s...

Background Nurse-coordinated care (NCC) improves the achievement of low-density lipoprotein-cholesterol (LDL-C) targets after an acute coronary syndrome (ACS). We hypothesised that NCC improves achievement of LDL-C targets through more intensive medication titration. Methods We used data from Randomised Evaluation of Secondary Prevention by Outpat...

Objective: Secondary prevention is an important part of cardiovascular risk management. Since 1996, an inventory of cardiovascular risk factors and their treatment has been carried out periodically among patients with coronary heart disease within the framework of the European Action on Secondary Prevention by Intervention to Reduce Events (Euroas...

Background: Unhealthy diets and inactivity are still common among patients with cardiovascular diseases. This study evaluates the effects of the telephonic lifestyle intervention 'Hartcoach' on risk factors and self-management in patients with recent coronary events. Design: This was a randomised trial in five Dutch hospitals. Methods: Patient...

: Current guidelines on secondary prevention of cardiovascular disease recommend nurse-coordinated care (NCC) as an effective intervention. However, NCC programmes differ widely and the efficacy of NCC components has not been studied. To investigate the efficacy of NCC and its components in secondary prevention of coronary heart disease by means of...

Background Cardiovascular disease (CVD) prevention guidelines stress the importance of smoking cessation and recommend intensive follow-up. To guide the development of such cessation support strategies, we analysed the characteristics that are associated with successful smoking cessation after an acute coronary syndrome (ACS). Methods We used data...

Patients with coronary artery disease (CAD) are at high risk of recurrent events. A healthy lifestyle can significantly reduce this risk. A previous trial, Randomized Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists (RESPONSE), demonstrated that nurse-coordinated outpatient clinics improve drug treatment of cardiovascular risk fac...

Dit artikel is besproken tijdens een van de Journal Clubs (JC) met de verpleegkundige docenten van de Amsterdam School of Health Professionals. Om de week wordt een JC gehouden over een artikel dat aansluit bij een recent probleem, dilemma of onzekerheid uit de dagelijkse verpleegkundige praktijk. Hoe u een dergelijke bespreking op de afdeling of i...

Centraal veneuze katheters (CVK’s) worden regelmatig gebruikt voor de toediening van intraveneus vocht, medicatie of voorof voor de bewaking van hemodynamische parameters. Helaas is het gebruik van deze katheters geassocieerd met een verhoogd risico op de bewaking van hemodynamische parameters. Helaas is het gebruik van deze katheters geassocieerd...

Catheter-related bloodstream infection (CRBSI) is associated with high rates of morbidity. This systematic review assesses the efficacy of antibiotic-based lock solutions to prevent CRBSI. A secondary goal of our review is to determine which antibiotic-based lock solution is most effective in reducing CRBSI. We searched Medline and the Cochrane Lib...