Marja Laasonen

• PhD
• Professor at University of Eastern Finland

Tässä tutkimuksessa selvitetään aiemmin tehtyjen kokoavien katsaustutkimusten perusteella, onko neuropsykologisella kuntoutuksella vaikutusta lasten ja nuorten muistitoimintojen vahvistamisessa. Systemaattinen kirjallisuushaku tuotti 16 katsausta, joissa oli mukana 5479 lasta tai nuorta. Osallistujat olivat iältään 1,4—20 vuotiaita ja heidän päädia...

The associations between hair cortisol concentration (HCC), a biomarker of chronic stress, and behavior and sleep disturbance symptoms have not been studied in children with psychiatric disorders. While cognitive behavioral therapy (CBT) has proven effective in treating psychiatric symptoms in children, its potential biological implications as dete...

Background: Phonological difficulties are prevalent in children with speech and/or language disorders and may hamper their later language outcomes and academic achievements. These children often form a significant proportion of speech and language therapists’ caseloads. There is a shortage of information on evidence-based interventions for improvin...

Objective In anorexia nervosa (AN), the traits of autism spectrum disorder (ASD) are associated with poor outcomes. However, the subtle nature of these characteristics remains poorly understood. We investigated the in‐depth patterns of ASD traits using Autism Diagnostic Observation Schedule‐Second Edition (ADOS‐2) in women with AN. Methods Of 28 w...

Introduction: The Multilingual-Multicultural Affairs Committee of the International Association of Communication Disorders (IALP) conducted a Survey of Diagnostic Criteria for Developmental Language Disorder (DLD) in Multilingual Children to discover how clinicians apply terminology and diagnostic criteria to multilingual children in different par...

In developmental language disorder (DLD), learning to comprehend and express oneself with spoken language is impaired, but the reason for this remains unknown. Using millisecond-scale magnetoencephalography recordings combined with machine learning models, we investigated whether the possible neural basis of this disruption lies in poor cortical tr...

Objective: To study if interictal epileptiform discharges (IEDs) are associated with language performance or pre-/perinatal factors in children with developmental language disorder (DLD). Methods: We recorded routine EEG in wake and sleep in 205 children aged 2.9-7.1 years with DLD, without neurologic diseases or intellectual disability. We exam...

Cognitive-linguistic functions are an essential part of adequate communication competence. Cognitive-linguistic deficits are common after traumatic diffuse axonal injury (DAI). We aimed to examine the integrity of perisylvian white matter tracts known to be associated with linguistic functions in individuals with DAI and their eventual association...

In this study, we investigated the outcome of goal attainment in individual and group-based neuropsychological intervention for young adults with dyslexia. Participants (N = 120) were randomly assigned to individual intervention, group intervention, or wait-list control group. Attainment of goals set personally before the intervention was evaluated...

Background: Our study addressed the gap in research on the effectiveness of cognitive behavioral therapy (CBT) in treating children with mixed psychiatric disorders. We examined the immediate and long-term effects of group CBT (GCBT), delivered in naturalistic clinical settings, on reducing internalizing and externalizing symptoms in children with...

Purpose Anorexia nervosa (AN) is associated with challenges in recognizing, understanding, and interpreting one’s own and other’s emotional states, feelings, and thoughts. It is unknown whether difficulties in emotion processing occur independently of common comorbid symptoms of AN and predict acute eating disorder characteristics. We aimed to exam...

Purpose This study explores whether the quality of parent–child interaction is associated with language abilities cross-sectionally and longitudinally up to preschool-age among children with developmental language disorder (DLD). Method Participants were 97 monolingual children with DLD and their parents from the Helsinki Longitudinal SLI study, H...

Anorexia nervosa (AN) is a potentially severe eating disorder whose core characteristics include energy intake restriction leading to low body weight. Autism spectrum disorder (ASD) is a developmental disorder characterized by deficits in social interaction and communication as well as repetitive, stereotyped behavior and interests. Both high ASD t...

Background Elevated autism spectrum disorder (ASD) traits are associated with anorexia nervosa (AN). Conversely, eating disturbances, which are core characteristics of AN, are common in ASD. Among individuals with ASD, atypical sensory processing is associated with eating disturbance. Because AN and ASD appear to overlap, it would be crucial to und...

Background Children with Developmental Language Disorder (DLD) have a significant deficit in spoken language ability which affects their communication skills, education, mental health, employment and social inclusion. Aim The present study reports findings from a survey by EU network COST ACTION 1406 and aims to explore differences in service deli...

Purpose Individuals with traumatic brain injury (TBI) often have persistent cognitive-linguistic deficits that negatively influence their life. Our objective was to examine the cognitive-linguistic outcome in individuals with moderate to severe diffuse axonal injury (DAI) with a novel test battery. As fatigue is a common symptom affecting the lives...

Current views on the neural network subserving reading and its deficits in dyslexia rely largely on evidence derived from functional neuroimaging studies. However, understanding the structural organization of reading and its aberrations in dyslexia requires a hodological approach, studies of which have not provided consistent findings. Here, we ado...

Effectiveness of individual‐ and group‐based neuropsychological intervention on aspects of psychological well‐being of dyslexic adults was evaluated. Dyslexic young adults (n = 120) were randomly assigned into individual intervention, group intervention or wait‐list control group. Both interventions focussed on cognitive strategy learning, supporti...

Purpose of review: Traits of autism spectrum disorder (ASD) are overrepresented among individuals with anorexia nervosa (AN) and may also moderate the behavioral manifestation of AN. This review aims to provide an overview of AN and comorbid ASD. Recent findings: Elevated ASD traits do not seem to precede AN among some individuals but are rather...

Background: The role of domain-general short-term memory (STM) in language development remains controversial. A previous finding from the HelSLI study on children with developmental language disorder (DLD) suggested that not only verbal but also non-verbal STMfor temporal order is related to language acquisition in monolingual children with DLD. Ai...

Purpose Developmental language disorder (DLD) is defined by persistent difficulties with language, but a growing body of evidence suggests that it is also associated with domain-general and nonverbal information-processing deficits. However, the interconnections between cognitive functions, both nonverbal and language related, are still unclear. Wi...

Children with Developmental Language Disorder (DLD) have a significant deficit in spoken language ability which affects their communication skills, education, mental health, employment and social inclusion. The present study reports findings from a survey by EU network COST ACTION 1406 and aims to explore differences in service delivery and funding...

Developmental dyslexia (DD) is the most prevalent neurodevelopmental disorder with a substantial negative influence on the individual’s academic achievement and career. Research on its neuroanatomical origins has continued for half a century, yielding, however, inconsistent results, lowered total brain volume being the most consistent finding. We s...

Tässä artikkelissa kootaan yhteen näyttöä neuropsykologisen kuntoutuksen vaikuttavuudesta lapsilla ja nuorilla. Artikkeli liittyy Suomen psykologiliiton ja Suomen psykologisen seuran Tieteellisen neuvottelukunnan hankkeeseen, jossa laaditaan suosituksia psykologisen työn hyvistä käytännöistä psykologian eri sovellusalueilla. Aikuisten neuropsykolog...

Tutkimuksessa selvitettiin lasten neuropsykologisen kuntoutuksen tilannetta Suomessa. Tietoa kerättiin kuntoutuksen toteuttajista, sisällöistä ja kuntoutusprosessien käytännöistä. Kysely toteutettiin verkossa ja tuloksia vertailtiin Pääkaupunkiseudulla ja Etelä-Suomessa toimivien (n=33) ja muualla Suomessa toimivien (n=37) välillä. Vastaajat olivat...

Previous studies of verbal short-term memory (STM) indicate that STM for serial order may be linked to language development and developmental language disorder (DLD). To clarify whether a domain-general mechanism is impaired in DLD, we studied the relations between age, non-verbal serial STM, and language competence (expressive language, receptive...

Developmental dyslexia (DD) is the most prevalent neurodevelopmental disorder with a substantial negative influence on the individual’s academic achievement and career. Research on its neuroanatomical origins has continued for half a century, yielding, however, inconsistent results, lowered total brain volume being the most consistent finding. We s...

Background Language exposure is known to be a key factor influencing bilingual vocabulary development in typically developing (TD) children. There is, however, a lack of knowledge in terms of exposure effects in children with developmental language disorder (DLD) and, especially, in interaction with age of onset (AoO) of second language acquisition...

Objectives: Impairments in visual perception are among the most common developmental difficulties related to being born prematurely, and they are often accompanied by problems in other developmental domains. Neural activation in participants born prematurely and full-term during tasks that assess several areas of visual perception has not been stu...

Two themes have puzzled the research on developmental and learning disorders for decades. First, some of the risk and protective factors behind developmental challenges are suggested to be shared and some are suggested to be specific for a given condition. Second, language-based learning difficulties like dyslexia are suggested to result from or co...

Poor neural speech discrimination has been connected to dyslexia, and may represent phonological processing deficits that are hypothesized to be the main cause for reading impairments. Thus far, neural speech discrimination impairments have rarely been investigated in adult dyslexics, and even less by examining sources of neuromagnetic responses. W...

Objective To examine how non-verbal skills at five years of age relate to visual perception and brain activation during visual perception tasks at twelve years of age in very preterm subjects without visual or other neurodevelopmental impairments or major brain pathologies. Methods At five years of age, 36 prematurely born (birth weight ≤ 1500 gra...

Developmental dyslexia (DD) is a highly prevalent neurodevelopmental disorder, which is devastating for individuals in modern societies in which fluent reading skill is mandatory for leading a normal life. Research on the neural origins of DD has continued for half a century, yielding, however, inconsistent results. It has also lacked a thorough ch...

Objective: Anorexia nervosa (AN) is associated with neuropsychological characteristics such as impairments in central coherence, cognitive flexibility, and emotion recognition. The same features also manifest in autism spectrum disorders (ASD) and have been suggested to be associated with illness prolongation in AN. The purpose of this meta-analys...

Objectives: A major issue in the rehabilitation of children with cochlear implants (CIs) is unexplained variance in their language skills, where many of them lag behind children with normal hearing (NH). Here, we assess links between generative language skills and the perception of prosodic stress, and with musical and parental activities in childr...

Dyslexia is thought to result from poor phonological processing. We investigated neuromagnetic speech discrimination in dyslexic and typical readers with mismatch fields (MMF) and determined the associations between MMFs and reading-related skills. We expected weak and atypically lateralized MMFs in dyslexic readers, and associations between readin...

Effectiveness of individual and group-based neuropsychological interventions on cognitive aspects of dyslexia in young adults was evaluated. Dyslexic adults were randomly assigned into individual intervention ( n = 40), group intervention ( n = 40), or wait-list control group ( n = 40). The interventions focused on cognitive strategy learning, supp...

Formation of neural mechanisms for morphosyntactic processing in young children is still poorly understood. Here, we addressed neural processing and rapid online acquisition of familiar and unfamiliar combinations of morphemes. Three different types of morphologically complex words - derived, inflected, and novel (pseudostem + real suffix) - were p...

Objectives: A major issue in the rehabilitation of children with cochlear implants (CIs) is unexplained variance in their language skills, where many of them lag behind children with normal hearing (NH). Here, we assess links between generative language skills and the perception of prosodic stress, and with musical and parental activities in child...

Dyslexia is characterized by poor reading skills, yet often also difficulties in second-language learning. The differences between native- and second-language speech processing and the establishment of new brain representations for spoken second language in dyslexia are not, however, well understood. We used recordings of the mismatch negativity co...

Background Developmental language disorder (DLD, also called specific language impairment, SLI) is a common developmental disorder comprising the largest disability group in pre-school-aged children. Approximately 7% of the population is expected to have developmental language difficulties. However, the specific etiological factors leading to DLD a...

Modern environments are full of information, and place high demands on the attention control mechanisms that allow the selection of information from one (focused attention) or multiple (divided attention) sources, react to changes in a given situation (stimulus-driven attention), and allocate effort according to demands (task-positive and task-nega...

This review aims to: To identify the methods of intervention used to treat phonological difficulties in children with primary language impairment (PLI) (or Developmental language disorder) and the level of evidence supporting those interventions. To identify the impact of interventions on children’s phonological skills and on secondary outcomes. T...

Sluggish cognitive tempo (SCT) was introduced in 1980s in the field of attention deficit hyperactivity disorder (ADHD). Studies indicate that symptoms of SCT are separate from symptoms of ADHD and independently associated with multiple domains of functioning in clinical groups and in typical development. We assessed whether similar pattern would ap...

Objectives: Performance on neurocognitive tasks develops with age, but it is still unknown whether this performance differs between children from different cultures. We compared cross-sectionally the development of neurocognitive functions in 3- to 15-year-old children from three countries: Finland, Italy, and the United States (N=2745). Methods:...

We studied the relationship between time spent watching TV, using the computer, or reading and performance on neurocognitive tasks of attention/executive functions, language, memory/learning, social perception, and visuospatial processing in 5–12-year-old children (N = 381). The results showed significant positive (for computer use and reading) and...

The Development and Well-Being Assessment (DAWBA) parent interview was used to assess psychiatric symptoms in children and adolescents with higher functioning autism spectrum disorders (ASD) (n = 60; age range 6.5–16.7) and in typically developing (TD) children and adolescents (n = 60; age range 6.9–16.2). Psychiatric symptoms were reported in the...

Monikielisiä ihmisiä on maailmassa koko ajan enemmän. Suomessa virallisten kielten muodostaman kaksikielisyyden lisäksi myös muunlainen monikielisyys on lisääntynyt. Muuta kuin suomea, ruotsia tai saamea äidinkielenään puhuvien alle 10-vuotiaiden määrä on kaksinkertaistunut kymmenessä vuodessa, ja määrän odotetaan kasvavan edelleen nopeasti. Nämä l...

Involuntary switching of attention to distracting sounds was studied by measuring effects of these events on auditory discrimination performance and event-related brain potentials (ERPs) in 6-11-year-old boys with Attention Deficit - Hyperactivity Disorder (ADHD) and comorbid Oppositional Defiant Disorder (ODD) and in age-matched controls. The chil...

Background. Attrition is a major cause of potential bias in longitudinal studies and clinical trials. Attrition rate above 20% raises concern of the reliability of the results. Few studies have looked at the factors behind attrition in follow-ups spanning decades. Methods. We analyzed attrition and associated factors of a 30-year follow-up cohort o...

Objective: To study prosodic perception in early-implanted children in relation to auditory discrimination, auditory working memory, and exposure to music. Design: Word and sentence stress perception, discrimination of fundamental frequency (F0), intensity and duration, and forward digit span were measured twice over approximately 16 months. Mus...

In this study of the project DyAdd, implicit learning was investigated through two paradigms in adults (18-55 years) with dyslexia (n = 36) or with attention deficit/hyperactivity disorder (ADHD, n = 22) and in controls (n = 35). In the serial reaction time (SRT) task, there were no group differences in learning. However, those with ADHD exhibited...

Specific language impairment is one of the most common developmental disturbances in childhood. With the increase of the foreign language population group an increasing number of children assimilating several languages and causing concern in language development attend clinical examinations. Knowledge of factors underlying the specific language imp...

We cross-sectionally examined the development of the ability to recognize facial expressions of emotions in preschool-aged children and the relationship between this ability and other neurocognitive capacities, that is, attention/executive functions, language, memory/learning, sensorimotor functions, theory of mind, and visuospatial processing. Chi...

In this study of the project DyAdd, three aspects of visual attention were investigated in adults (18-55years) with dyslexia (n=35) or attention deficit/hyperactivity disorder (ADHD, n=22), and in healthy controls (n=35). Temporal characteristics of visual attention were assessed with Attentional Blink (AB), capacity of visual attention with Multip...

In this study of the project DyAdd (Adult Dyslexia and Attention Deficit Disorder in Finland), classical eyeblink conditioning (EBC) was investigated in both delay and trace paradigms in adults (18-55 years) with dyslexia (n = 37), attention deficit-hyperactivity disorder (ADHD; n = 21), their comorbid combination (n = 8), and healthy controls (n =...

Objective: Letter-speech sound integration in fluent readers takes place automatically and is dependent on temporal synchrony between letters and sounds. In developmental dyslexia, however, letter-speech sound associations are hard to learn, compromising accurate and fluent reading. We studied the effect of printed text on processing speech sounds...

Executive functions are thought to be the latest functions to mature. However, this view has not been tested by assessing simultaneously memory, perception of emotions, visuospatial perception, and visuoconstructional skills. NEPSY II norm data from 1000 5- to 16-year-old U.S. children were obtained. Fifteen NEPSY II subtests with no floor or ceili...

The existence and stability of subgroups among adult dyslexic readers of a shallow orthography was explored by comparing three different cluster analyses based on previously suggested combinations of two variables. These were oral reading speed versus accuracy, word versus pseudoword reading speed, and pho-nological awareness versus rapid naming. T...

Objective To examine the discriminatory validity of the Wender Utah Rating Scale (WURS) and its five suggested subscales (Conduct Problems, Impulsivity Problems, Mood Difficulties, Inattention/Anxiety, Academic Concerns) in a Finnish sample. Method WURS was administered to 114 adults, aged 18 to 55 years. Participants with ADHD (n = 37) and dyslex...

We investigated whether poor short-term memory (STM) in developmental dyslexia affects the processing of sensory stimulus sequences in addition to phonological material. STM for brief binary non-verbal stimuli (light flashes, tone bursts, finger touches, and their crossmodal combinations) was studied in 20 Finnish adults with dyslexia and 24 health...

This study focuses on the development of face recognition in typically-developing pre-school and school-aged children (5—15 years, n = 611, 336 girls). Social predictors include sex differences and own-sex bias. At younger ages, the development of face recognition was rapid, becoming more gradual as the age increased up until the age of 11, after w...

In the cognitive theories of Attention Deficit Hyperactivity Disorder (ADHD) impaired behavioral adjustment has been linked to a deficit in learning to detect regularities or irregularities in the environment. In the neural level, the P3 component of event-related potential (ERP) is modulated by stimulus probability and has been suggested to index...

The P3 response has been one of the most extensively studied event-related potential (ERP) components. Still, the exact functional role and cortical basis of P3 has remained unsettled. To explore the cortical processes underlying the generation of late positivities, we recorded the activation evoked by frequent Go and infrequent NoGo stimuli and co...

Difficulties in phonological processing and reading that characterize developmental dyslexia have been suggested also to affect those with attention-deficit/hyperactivity disorder (ADHD). However, it is not known to what extent various intervening factors, such as low intelligence quotient or age, explain the observed difficulties. In this study, t...

The project Adult Dyslexia and Attention Deficit Disorder in Finland (Project DyAdd) compares adults (n = 119, 18-55 years) with dyslexia, attention-deficit/hyperactivity disorder (ADHD), dyslexia together with ADHD (comorbid), and healthy controls with neuropsychological, psychophysical, and biological methods. The focus of this article is on the...

In project DyAdd, we compared the fatty acid (FA) profiles of serum phospholipids in adults with attention deficit hyperactivity disorder (ADHD) (n=26), dyslexia (n=36), their comorbid combination (n=9), and healthy controls (n=36). FA proportions were analyzed in a 2x2 design with Bonferroni corrected post hoc comparisons. A questionnaire was used...

Both attention deficit hyperactivity disorder (ADHD) and dyslexia are suggested to co-occur with altered fatty acid (FA) metabolism, but it is unknown how FAs are associated with the cognitive domains that characterize these disorders. In the project DyAdd, we investigated the associations between FAs in serum phospholipids and phonological process...

We have previously found that, in children with certain oral clefts, the rate of sequential information processing is significantly impaired in vision and tactile somatosensation but not so clearly in audition. Here, we studied crossmodal functions by investigating temporal processing acuity of cleft children with audiovisual, audiotactile, and vis...

We investigated the relation between a biological factor (fatty acids, FA) and a cognitive processing speed factor (temporal processing acuity, TPA) that are both suggested to relate to neuronal and cognitive functioning. Blood samples of 49 ten-year-old children with oral clefts were collected for FA analysis in serum triglycerides, cholesteryl es...

Dyslexia is associated with impairments in the phonological system or with more general auditory dysfunctions. We determined the discrimination of 5 sound contrasts (pitch, duration, intensity, location, and the presence of a gap) in dyslexia with the mismatch negativity (MMN). We compared MMNs of 9 adult dyslexic and 11 control subjects with a new...

We presented phonetically matching and conflicting audiovisual vowels to 10 dyslexic and 10 fluent-reading young adults during "clustered volume acquisition" functional magnetic resonance imaging (fMRI) at 3 T. We further assessed co-variation between the dyslexic readers' phonological processing abilities, as indexed by neuropsychological test sco...

Reading skill is suggested to be related to phonological processing ability and polyunsaturated fatty acids (PUFAs). Here we investigated whether fatty acids (FAs) are related to phonological processing, whether the relations between PUFAs and reading generalize to other FAs, whether these relations are mediated by phonological processing, and whet...

Neurocognitive disorders may compromise the outcome of surgical cleft lip palate repair and thus need to be identified. Processing of rapidly changing sequential information (temporal processing) is a fundamental neurocognitive capacity that may contribute to various communication functions and has been found impaired in several developmental disor...

Temporal processing has been found to be impaired in developmental dyslexia. We investigated how aging affects crossmodal temporal processing impairment with 39 dyslexic and 40 fluent 20-59-year-old readers. Cognitive temporal acuity was measured at millisecond levels in six tasks. They consisted of order judgments of two brief non-speech stimulus...

Several studies show that although function may recover after brain damage the insult can nevertheless cause accelerated deterioration in old age. This has been interpreted as indicating reduced neuronal capacity to counteract age-related decline with plastic changes. Psychosocial and compensatory factors obscure the neuronal explanation. Since the...

We investigated crossmodal temporal performance in processing rapid sequential nonlinguistic events in developmentally dyslexic young adults (ages 20-36 years) and an age- and IQ-matched control group in audiotactile, visuotactile, and audiovisual combinations. Two methods were used for estimating 84% correct temporal acuity thresholds: temporal or...

We studied the temporal acuity of 16 developmentally dyslexic young adults in three perceptual modalities. The control group consisted of 16 age- and IQ-matched normal readers. Two methods were used. In the temporal order judgment (TOJ) method, the stimuli were spatially separate fingertip indentations in the tactile system, tone bursts of differen...

Slowed processing of sequential perceptual information is related to developmental dyslexia. We investigated this unimodally and crossmodally in developmentally dyslexic children and controls ages 8-12 years. The participants judged whether two spatially separate trains of brief stimuli, presented at various stimulus onset asynchronies (SOA) in one...

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