Mariyah Hidayat

• MBBS MPhil and PhD in Anatomy, Editor of JUCMD
• Professor at University of Lahore

Writing a research paper is like telling a story of your journey, your discoveries, and your contributions to medical science. It's not something you rush through; it requires careful planning and attention to detail. Each section, from the introduction that sets the stage to the discussion that interprets your results, plays a crucial role. And wh...

Background: Smoking-related interstitial lung diseases (SR-ILDs) are a heterogeneous group of diseases with major clinical significance. Objective: To study the effect of cigarette smoking in causing interstitial lung diseases in cadavers. Study Design: Retrospective descriptive study. Settings:

Objectives: To study the effects of melatonin in preventing neonatal neuronal apoptosis induced by maternal hypothyroidism. Methods: Twelve healthy female Wistar rats, 12-16 weeks, were divided equally into three groups. Group-A was labelled as control. Group-B was made hypothyroid by giving 15mg/kg of propylthiouracyl (PTU) daily whereas Group-...

Background: The adrenal gland is one of the major endocrine glands involved not only in different physiological functions, but also in response to stress This study was done to asses the effects of L-arginine and insulin on streptozotocin (STZ) induced adrenal gland damage in albino rats. Methods: This laboratory based experimental study on anim...

Substantial change in climate over the years in South Asia is directly affecting the diet and health of the population. It is important to analyze the aftermath of this change and its impact on the thyroid status. In recent years, a complex interplay of the changing climate with the environmental, geographical and dietary factors has contributed to...

Today, digital storytelling has emerged as a popular tool in educating the public on health matters as it integrates digital technology with public health. It is predominantly defined as a story in multimedia form, presented as a video or animation for public viewing and used as educational material for healthcare professionals, patients and famili...

Objective: To histologically observe the effects of hypothyroidism on the hippocampus of neonatal rats. Methods: A total of 10 healthy female Wistar rats, between 12-16 weeks old, were randomly divided into 2 groups; Group A was labelled as control and Group B was made hypothyroid by giving 15mg/kg of Propylthiouracyl (PTU) daily mixed in chow. The...

Objective: To investigate the policy barriers leading to hindrance in mass immunization of Covid-19 in Pakistan. Study design: A cross-sectional qualitative study was Duration of study: study was conducted from October 2021 to April 2022 Place of study: was conducted on 106 individuals at 4 vaccination centers of Lahore, including Expo center, Paki...

Online teaching and learning have been in place for the last two decades. COVID-19 pandemic has intensely augmented institutions towards implementation of online teaching. Literature reported benefits of online learning including flexibility and self-direction. In addition, researchers reported that virtual learning pedagogy is encouraging, as it m...

Writing an effective grant proposal is one of the most important skills in ensuring a successful career in academia. To acquire funding for research activities, increase visibility of oneselfor ones’ organization or to facilitate in preparing and launching a product, grant writing has become an essential activity. The art of convincing funding bodi...

Background: Postgraduation programs, including clinical specialties, have inculcated a mandatory research component, yet no initiatives are taken for the promotion of research at the undergraduate MBBS programs across Pakistan. This study has highlighted a research mentoring program at undergraduate level conducted at Central Park Medical College...

OBJECTIVE: To study neuronal damage in brains of first and second-generation pups, born to hypothyroid Wistar rats. METHODS: Ten female adult Wistar rats, randomized into two equal groups-propylthiouracil (Group-P) and control (Group-C) were allowed to conceive. Group-P was given oral propylthiouracil throughout gestational period and weaning unti...

ABSTRACT Background: This experiment was conducted to study the structure of Purkinje neurons of cerebellum of neonate rats born from hypothyroid dams under golgi cox stain and compare it to the control group. Objective: Golgi staining was invented hundreds of years ago but it is still a reliable method to study the anatomy of neurons. Material an...

Objectives: This study investigated the injurious effects of Streptozotocin(STZ) induced diabetes on histology of rat salivary gland along with ameliorationof these effects by the antioxidant melatonin.Methodology: This prospective experimental study was conducted in the departmentof Anatomy, Basic Medical Sciences Institute, JPMC, Karachi for aper...

In the current study, we reported the beneficial effects of melatonin in preventing neonatal neuronal apoptosis induced by maternal hypothyroidism. During the gestation and early lactation stages, the mother rats were given propylthiouracil (PTU) to inhibit their thyroid gland activity which resulted in the increased serum TSH and reduced T4 levels...

Background: Loss of motor neurons may underlie some of the deficits in cognitive functions associated with maternal hypothyroidism during fetal and neonatal period. This experiment was performed to highlight the significance of melatonin intake by the mother in hypothyroid state during gestation and lactation to preserve the integrity of motor neu...

Objective: To immunohistochemically localize Bax proteins in pyramidal cells of cerebral cortex in hypothyroid neonates and to observe the effect of melatonin on these cells. Material and Methods: Nine female wistar rats were randomly divided equally into three groups, including control(A), propylthiouracyl(B), melatonin treated propylthiouracyl (C...

Background: The objective of the present investigation was to study the effect of hypothyroidism on the fertility of female wistar rats. Moreover, its effects on the gross morphology of the pups was also observed. Methods: For this purpose. 30 female wistar rats were divided into 2 groups, 15 as control group and 15 rendered hypothyroid and then ma...

Background: It has been demonstrated in experimental animal models that oxidative stress causes persistent and chronic hyperglycaemia, causing reduction in antioxidant defence system, ultimately leading to accumulation of free radicals. This study, was performed to observe the effect of melatonin on serum glucose and body weights in streptozotocin...

Background: In experimental animal models, Streptozotocin (STZ) causes hypertrophy and disruption of the layers of adrenal cortex, and administration of melatonin protects the adrenal cortex damaged by stress-induced oxidative damage. Aim: To observe the effect of melatonin on the body weight, serum glucose and ACTH, and morphology of adrenal corte...

Background: Hyperthyroidism is accompanied by increased rates of bone formation and resorption. Melatonin through its free radical scavenging and antioxidant properties, impairs osteoclast activity and bone resorption in hyperthyroid state. Aim: To study the effect of melatonin on bone density decreased during hyperthyroidism. Duration of study: 01...

Background: Diabetes Mellitus damages the parotid gland by causing accumulation of lipids and increasing serum cholesterol levels and melatonin, as an antioxidant, preserves the morphology of the damaged gland. This study was conducted to observe the injurious effects of Streptozotocin (STZ) induced diabetes on histology of rat parotid gland,...

Background: The role of vitamin D, a steroid hormone that exerts most of its biological activities by binding to the vitamin D receptor, in health and disease is far from understood and the literature is full of contradictory findings. Still, evidence that vitamin D is capable of modulating several features of cancer exist.

Aims: To evaluate the protective role of melatonin and insulin on the morphology of proximal convoluted tubules(PCT) of albino rats made nephrotoxic by a chemotherapeutic drug like streptozotocin (STZ). Study design: Prospective experimental study. Place and duration of study: Department of Anatomy, Basic Medical Sciences Institute (BMSI), Jinnah P...

Aim: To study the renoprotective effect of Vitamin C on the histology of the proximal convoluted tubules in streptozotocin (STZ) induced diabetes in albino rats. Study design: A prospective experimental study. Place: Department of Anatomy, Post Graduate Medical Institute, Lahore. Duration: January to April 2011 for a period of 12 weeks. Material an...

Aim: To observe the nephrotoxic effect of STZ on the morphology of proximal convoluted tubules (P.C.T) of albino rats for three weeks & eight weeks duration. Study design: Prospective experimental study. Place and duration of study: This study was conducted in Department of Anatomy, Post Graduate Medical Institute, Lahore from February to April, 20...

Background: This study has been undertaken to study there renoprotective effect of Vitamin C on the histology of the proximal convoluted tubules in streptozotocin (STZ)induced diabetes in albino rats. The effect of Vit C on the serum glucose and glycated hemoglobin has also been studied in these rodents. Study Design: A prospective experimental stu...

Aims and Objectives: This study was designed to find out the role of Vitamin E on serum glucose and Creatinine concentrations of male albino rats made diabetic by streptozotocin. Study Design: Prospective study. Place and Duration of Study: This study was conducted at the Department of Physiology; Basic Medical Sciences Institute (BMSI), Jinnah Pos...