Marios Kyriazis

National Gerontology Centre - Cyprus

NB: THE PREPRINT IS AVAILABLE HERE: https://www.qeios.com/read/8QQXWW The impact of neurodiversity conditions such as ASD (Autism Spectrum Disorder), and Attention Deficit Hyperactivity Disorder (ADHD) upon the older individual is considerable but not well studied. Chronic degenerative conditions—such as dementia, which affect the brain, may share...

The impact of neurodiversity conditions such as ASD (Autism Spectrum Disorder), and Attention Deficit Hyperactivity Disorder (ADHD) upon the older individual is considerable but not well studied. Chronic degenerative conditions which affect the brain, such as dementia, may share several symptoms with autism and ADHD, including behavioural, social a...

Introduction: The primary objective of researchers in the biology of aging is to gain a comprehensive understanding of the aging process while developing practical solutions that can enhance the quality of life for older individuals. This involves a continuous effort to bridge the gap between fundamental biological research and its real-world appl...

Eroticism in later life is, on the whole, a taboo subject, and the stigma attached to expressions of sexual intent by older people is widespread in most cultures. However, sexuality and eroticism have an important role to play in maintaining healthy ageing. Sexuality is an essential aspect of our biology and its effects have repercussions in system...

Introduction: The primary objective of researchers in the biology of ageing is to gain a comprehensive understanding of the ageing process while developing practical solutions that can enhance the quality of life for older individuals. This involves a continuous effort to bridge the gap between fundamental biological research and its real-world app...

Eroticism in later life is, on the whole, a taboo subject, and the stigma attached to expressions of sexual intent by older people is widespread in most cultures. However, sexuality and eroticism have an important role to play in maintaining healthy ageing. Sexuality is an essential aspect of our biology and its effects have repercussions in system...

The role of nutrition in health has fascinated humans for millennia. Currently, there is a substantial body of research guiding better practices to prevent or treat age-related conditions through nutritional interventions. Chronic degenerative conditions such as cardiovascular disease, sarcopenia and frailty, diabetes, cancer, osteoporosis, prostat...

Social isolation is associated with a higher risk of morbidity and death in older people. The quarantine and social distancing measures due to Covid-19 imposed in most countries and particularly in Cyprus, aim to isolate individuals from direct contact with others. This has resulted in vulnerable older people being isolated at their places of resid...

It is necessary to define ‘health’ in order to know how to deal with disease. This is particularly important when we deal with real patients in clinical settings, and even more so when the patient is elderly. Here, an attempt is made to define health in a way that reflects the above concerns, and is of practical use to clinicians. The discussion ca...

The full paper is freely available on line here: https://www.frontiersin.org/articles/10.3389/fmed.2020.00371/full

Social isolation is associated with a higher risk of death in older people. The quarantine and social distancing measures due to Covid-19 imposed in Cyprus from the beginning of the pandemic, aim to isolate individuals from direct contact with others. This has resulted in vulnerable older people being isolated at their places of residence for sever...

A report on the health dangers of social isolation in older people who are home-bound due to the Covid-19 pandemic.

It is not surprising that one of the most complex phenomena in nature is that of ageing. It does not only bear biological interest, but it is also associated with cultural, psychological, social and even philosophical issues. It is therefore to be expected that a great deal of research is being performed in order to study the evolution of ageing an...

Eroticism in later life is, on the whole, a taboo subject and the stigma attached to expressions of sexual intent by older people is widespread in most cultures. However, sexuality and eroticism have an important role to play in maintaining healthy ageing. Sexuality is an essential aspect of our biology and its effects have repercussions in systems...

The question whether aging is a disease or not, has been asked by many professionals who are involved in the study of age-related degeneration. However, not only an agreement on this remains elusive, but also effective clinical treatments against human aging have not been forthcoming. In this Opinion paper I suggest that the complexity involved in...

There is a general failure of reductionist and mechanistic approaches to rejuvenation biomedical technologies which aim at providing treatments against aging (defined as “time-dependent dysfunction”). Importantly, it is becoming increasingly recognised that genomic research findings in animals may not adequately be translated into effective human a...

Abstract Our world is becoming progressively more digital, which means that there is more emphasis on cognition and abstraction of thought, rather than on physical qualities. As we grow older, we need to adapt to this changing environment by engaging with technology, and more specifically, digital communication platforms, using this engagement in o...

Advances in technology are setting the pace for an increasingly cognitive world. When we interact with our technological environment we are exposed to a wide variety of new cognitive stimuli, meaningful “challenges,” and high quality digital “information-that-requires-action.” This acts as a hormetic stimulus which upregulates biological responses,...

The pace of technology is steadily increasing, and this has a widespread effect on all areas of health and society. When we interact with this technological environment we are exposed to a wide variety of new stimuli and challenges, which may modulate the stress response and thus change the way we respond and adapt. In this Opinion paper I will exa...

The process of human ageing is significantly dependent upon events which are currently shaping humanity. One such event is the seemingly inexorable progress of technology, and specifically, digital communications technology. Technology and biology are tightly interconnected, and this has a direct relevance on how our own ageing mechanisms are evolv...

While the current paradigm of research into ageing relies heavily upon reductionist premises, and it has clearly not produced any of the dramatic benefits anticipated in our fight against ageing, the majority of scientists are hesitant, unable or unwilling to consider different or alternative models. In this paper I will discuss some of the shortco...

A short essay about some expected and unexpected consequences of a human-computer interaction

A short essay about some expected and unexpected consequences of a human-computer interaction

It appears inevitable that technology, and specifically the internet, is set to continue playing a significant role in our lives. The interaction between humans and machines brings unprecedented changes to the way our health is affected. In this editorial, I am exploring four areas where human interaction with technology may impact on health, somet...

There is no doubt that the world is divided and unequal, mostly with respect to wealth. However, the true obstacle preventing the progress of humanity is not the divide between the rich and the poor. It is the divide between the cognitive and the physical. Apart from the social and ethical issues associated with this, there are also medical ones. T...

During the process of ageing there is canalisation of repair resources which tend to flow from the soma towards the germ line. In the early periods of phylogenetic development there was a time when repair of germ line cells became more efficient compared to the repair of somatic cells. The level of somatic repair became just enough to ensure that t...

During the process of ageing there is canalisation of repair resources which tend to flow from the soma towards the germ line. In the early periods of phylogenetic development there was a time when repair of germ line cells became more efficient compared to the repair of somatic cells. The level of somatic repair became just enough to ensure that t...

Our biological response to external challenges frequently obeys hormetic principles. During the phenomenon of hormesis, mild stressful challenges may up-regulate defence and repair pathways, with a subsequent overall improvement in function. It is important to highlight that hormesis is a dose-response, non-linear phenomenon, meaning that a low dos...

The results of a survey and discussion of views of the transhumanist community

The process of aging is a continuum of degeneration which eventually leads to loss of function and clinically manifest disease. Yet, in the purely therapeutic sense, there is a distinct clinical and practical separation between age-related degenerative diseases and the background process of aging itself. It is quite possible that biomedical technol...

The paper is available free on line here: http://journal.frontiersin.org/Journal/10.3389/fnsys.2015.00007/full

Artificial, neurobiological, and social networks are three distinct complex adaptive systems (CAS), each containing discrete processing units (nodes, neurons, and humans respectively). Despite the apparent differences, these three networks are bound by common underlying principles which describe the behaviour of the system in terms of the connectio...

The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by utilising a physical 'repair-oriented' approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the final result impossible to pr...

Emerging empirical and theoretical thinking about human aging places considerable value upon the role of the environment as a major factor which can promote prolonged healthy longevity. Our contemporary, information-rich environment is taken to mean not merely the actual physical surroundings of a person but it is also considered in a more abstract...

For the first time in human history we are exposed to a relentless flow of meaningful information that requires action. This has significant effects on our evolution and basic biological processes. Our new technological environment is placing unprecedented pressure on our survival mechanisms, resulting as I argue here, in a significantly prolonged...

We live within an increasingly technological, information-laden environment for the first time in human evolution.This subjects us, and will continue to subject us in an accelerating fashion, to an unremitting exposure to meaningful information that requires action. Directly dependent upon this new environment are novel evolutionary pressures, whic...

Ageing is characterised by a wide variety of physiological changes and, as a consequence, an anti-ageing compound must fulfil a wide variety of roles to be effective. Carnosine is an antioxidant, antiglycating and neuroprotective compound with well-studied clinical benefits. It is becoming a clinically accepted nutritional supplement with uses acro...

The process of aging is accompanied by a progressive reduction of biological dynamical sophistication, resulting in an increased probability of dysfunction, illness, and death. This loss of sophistication is inherent in all aging organisms. However, it may be possible to retard the rate of loss of biological complexity by introducing an increased a...

The search for Calorie Restriction Mimetics (CRM) -compounds that mimic the genetic, biochemical and physical actions of calorie restriction -is not a search for a 'lazy dieters pill'. It is a quest aiming to clarify the basic mechanisms of calorie restriction and develop strategies in order to prevent, treat or alleviate age-related conditions. Th...

Hormesis is a term describing the beneficial effects of mild and repeated stimulation or stress, which ultimately bolsters defences against deleterious processes. Although hormetic influences are clearly encountered at the cellular and molecular level, little is known about the effects of hormesis at a clinical level. This paper examines the sugges...

When cells are damaged beyond repair, they need to be eliminated. However, the rate of this elimination changes with age, resulting in removal of cells, which could, in fact, be repaired and saved. Striking a balance between excessive and slow cell death is essential in achieving healthy ageing.

There is increasing experimental and clinical evidence that oxidation plays a pivotal role in causing neurodegeneration in general and Parkinson's disease in particular. The protective role of antioxidants in such conditions has not been fully examined, but certain neuroprotective agents that have antioxidant action are now being credited with an a...

From time to time, novel ways of interpreting and modifying ageing mechanisms are proposed. Occasionally, these lead to a conceptual dead end, whereas at other times new and vital insights into basic ageing mechanisms are gained. This review concentrates on one such way of interpreting and manipulating ageing processes, based on chaos (dynamical sy...

Cerebrovascular disease is a condition associated with significant mortality and morbidity. This paper discusses the aetiology, prognosis and treatment of stroke, looking at the most up-to-date interventions.

New developments in the field of chaos theory can help us describe in detail many hitherto unexplained natural phenomena. Some of the developments of this theory can be applied to molecular gerontology to complement existing techniques used in this field. Thus, there is the potential of better description, quantification, and manipulation of some a...