Mario U Perez-Zepeda

Mario U Perez-Zepeda
Instituto Nacional De Geriatría · Investigación Epidemiologica Clínica Geriátrica

MD PhD
Geriatrician and Aging Researcher focused on Frailty

About

166
Publications
46,597
Reads
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1,752
Citations
Citations since 2016
119 Research Items
1587 Citations
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2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Additional affiliations
June 2019 - present
Universidad Anahuac
Position
  • Associated Researcher
August 2009 - present
Instituto Nacional De Geriatría
Position
  • Researcher
July 2009 - present
Instituto Nacional De Geriatría
Position
  • Medical Science Researcher
Description
  • Research on aging field with special focus on frailty
Education
September 2012 - August 2016
Universidad Nacional Autónoma de México
Field of study
  • Clinical Research
March 2008 - October 2011
Universidad Nacional Autónoma de México
Field of study
  • Clinical Research
March 2006 - February 2008

Publications

Publications (166)
Article
Full-text available
Early detriment in the muscle mass quantity, quality, and functionality, determined by calf circumference (CC), phase angle (PA), gait time (GT), and grip strength (GSt), may be considered a risk factor for sarcopenia. Patterns derived from these parameters could timely identify an early stage of this disease. Thus, the present work aims to identif...
Article
Background: Physical activity (PA) interventions may reduce the burden of frailty and can prevent mobility disability for older adults. We explored whether a 2-year PA intervention would improve frailty trajectory, lead to clinically meaningful frailty changes (CMC), or impact major mobility disability (MMD) across baseline frailty levels. Method...
Article
Full-text available
Introduction: The importance of social networks is growing, impacting everyday life. At this stage of global COVID-19 vaccination roll-out, hesitancy to get immunized is slowing this process; it is thought that this decision could be impacted by information shared on social networks. Objective: Determine whether the use of social networks is associ...
Article
Background: Frailty can be operationalised using the deficit accumulation approach, which considers health deficits across multiple domains. We aimed to develop, validate and compare three different frailty indices (FI) constructed from self-reported health measures (FI-Self Report), blood-based biomarkers (FI-Blood) and examination-based assessme...
Article
Full-text available
Introduction Frailty is recognized as a clinical condition associated with increased vulnerability for developing negative health outcomes but has been little studied in patients with Parkinson's disease (PD). Here, we investigated the risk of frailty in de novo PD patients and its association with subsequent development of dementia. Methods We co...
Article
Background physical activity reduces frailty in community-dwelling older adults. How exercise influences frailty in hospitalised older adults requires additional investigation. Objectives (i) to examine the impact of an exercise intervention on frailty in older adults admitted to an acute care ward, and (ii) to determine the impact of baseline fra...
Article
Full-text available
Depressive symptoms are common in elderly surgical patients and are associatedwith negative outcomes. Although medication can relieve symptoms, only 50% of patients achieve remission usingconventional treatments. Recently, ketamine has been shown to improve depression rapidly. However, its use andtolerability in elderly patients has not been widely...
Article
Purpose: To determine the incidence of geriatric syndromes (GS) in community dwelling older adults with subclinical hypothyroidism. Methods: This is an analysis from the Mexican Health and Aging Study, of a subsample of 2089 subjects with TSH determination. From this last subsample, we included 1628 individuals with TSH levels in the subclinical r...
Article
Full-text available
Objective. To describe the levels of intrinsic capacity and those factors related to its decline in Mexican older adults, using the Mexican Health and Aging Study. Methods. This is a cross-sectional secondary analysis of the 2015 data of the Mexican Health and Aging Study, including adults aged 50 years and above. Selected questions were included t...
Article
Full-text available
Objective. The aim of this study is to describe the mortality among older adults in the first wave of COVID-19 in Colombia and Mexico. Methods. This is an observational, prospective study on data obtained from open data sets that are publicly available on the websites of the health ministries of the respective countries. COVID-19 cases, age, sex, d...
Article
Objective To determine the association of frailty with out-of-pocket expenses (OOPEs) during the last year of life of Mexican older adults. Methods Cross-sectional secondary analysis of the Mexican Health and Aging Study (MHAS), a representative population-based cohort study. Health care expenses were estimated, and a probit model was used to esti...
Article
Full-text available
The social vulnerability index (SVI) independently predicts mortality and others adverse outcomes across different populations. There is no evidence that the SVI can predict adverse outcomes in individuals living in countries with high social vulnerability such as Latin America. The aim of this study was to analyze the association of the SVI with m...
Article
Full-text available
Background: the Clinical Frailty Scale (CFS) was originally developed to summarise a Comprehensive Geriatric Assessment and yield a care plan. Especially since COVID-19, the CFS is being used widely by health care professionals without training in frailty care as a resource allocation tool and for care rationing. CFS scoring by inexperienced rater...
Article
Vulnerability is a concept associated with the effects of social inequities to access health care services. On a hospital level, vulnerable populations must be identified and favored over others. The aims of this study were the analysis of the conceptions and practices of social workers regarding vulnerable patients, and the identification of theor...
Article
Full-text available
Background Cognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico. Methods Cross-sectional study conducted in individuals aged 60 years or elderly participat...
Technical Report
Full-text available
It shows a summary of the Mexican and Health Aging Study (MHAS) studies of clinical and sociodemographic variables associated to risk of frailty in older Mexicans
Article
Objective: To assess depressive symptoms as a mediator in the association between polyvictimization and recurrent falling. Methods: Using data from the Salud, Bienestar y Envejecimiento (Health, Well-being, and Aging) Ecuador Study, we analyzed community-dwelling adults 60 years and older (n = 5227). Recurrent falling was determined as ≥2 falls dur...
Article
Full-text available
Objectives: To describe the association of frailty level on admittance to the Emergency Department (ED) with various hospital complications including delirium, low phase angle, and low handgrip strength. Design: Prospective cohort. Setting: ED rooms of two public general hospitals in Mexico City. Participants: A total of 548 persons 60 years or old...
Article
Background: frailty is a public health priority now that the global population is ageing at a rapid rate. A scientifically sound tool to measure frailty and generate population-based reference values is a starting point. Objective: in this report, our objectives were to operationalize frailty as deficit accumulation using a standard frailty inde...
Preprint
Full-text available
Background Cognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico. Methods Cross-sectional study conducted in individuals aged 60 years or elderly participat...
Preprint
Full-text available
Background Cognitive impairment is twice more frequent in elderly with type 2 diabetes mellitus (DM). This study was conducted to determine the association between glycemic control and cognitive performance among community-dwelling elderly persons in Mexico. Methods Cross-sectional study conducted in individuals aged 60 years or elderly participati...
Article
Full-text available
Introduction As the world's population ages, the prevalence of cognitive impairment associated with age increases. This increase is particularly pronounced in Asia and South-America. The objective of this study was to investigate separately the longitudinal association of physical activity and cognitive function in; older adults in Mexico and South...
Article
Full-text available
Background While physical frailty and malnutrition/obesity (parameters easily measured by a nurse) are not the same, older persons who are malnourished/obese are more likely to be frail and there is a potential overlap between these conditions. The objective was to examine the relationship between gait speed (GS) and body mass index (BMI) in men an...
Article
Objectives: To examine the relationship between gender roles and self-rated health in older men and women from different contexts. Methods: 2002 community-dwelling older adults from the International Mobility in Aging Study were recruited from 5 research sites. Gender role was measured with the 12-item Bem Sex Role Inventory, which categorized s...
Article
Full-text available
Frail older adults are vulnerable to stressors and are more likely to experience adverse outcomes. Post-traumatic stress is common in older adults, and can be related to common adverse outcomes, such as falls. We examined whether falls are associated with post-traumatic stress in middle-aged and older Canadians, by levels of frailty. We conducted c...
Article
Full-text available
Frailty remains a challenge in the aging research area with a number of gaps in knowledge still to be filled. New approaches to its study have been proposed, including the one discussed in this article. We tested frailty as through the use of graphical probabilistic models (bayesian networks) with empirical data. Data from the Mexican Health and Ag...
Article
Full-text available
Background: Frailty is a clinical state defined as an increase in an individual's vulnerability to developing adverse health-related outcomes. Objectives: We propose that healthy behaviors could lower the incidence of frailty. The aim is to describe the association between healthy behaviors (physical activity, vaccination, tobacco use, and cance...
Article
Background: Frailty remains a challenge in the aging research area with a number of gaps in knowledge still to be filled. Frailty seems to behave as a network, and in silico evidence is available on this matter. Having in vivo evidence that frailty behaves as a complex network was the main purpose of our study. Methods: Data from the Mexican Hea...
Poster
Full-text available
Un posible mecanismo causal del desarrollo de demencia es la hipertensión arterial (HTA). Es importante identificar e intervenir factores de riesgo modificables para prevenir el desarrollo de demencia. La HTA altera la dinámica vascular cerebral, afectando los circuitos frontoestriatales. Esto se manifiesta tempranamente con síntomas depresivos (SD...
Article
Full-text available
Frailty has been recognized as a common condition in older adults, however, there is scarce information on the association between frailty and commonly used biomarkers. The aim of this study was to assess the individual and cumulative association of biomarkers with frailty status. This is a cross-sectional analysis of the 2012 wave of the Mexican H...
Article
Objectives Intrinsic capacity (IC) is one of the latest views of positive aging. In its current status lacks a biological substrate amenable to be intervened. The aim of this study was to determine the association of allostatic load (AL) with IC. Design We present a cross-sectional analysis of the Costa Rican Longevity and Healthy Aging Study. Se...
Article
Full-text available
Frailty is an age-associated condition, characterized by an inappropriate response to stress that results in a higher frequency of adverse outcomes (e.g., mortality, institutionalization and disability). Some light has been shed over its genetic background, but this is still a matter of debate. In the present study, we used network biology to analy...
Article
Full-text available
Introducción: el aumento de enfermedades crónicas ha motivado la creación de métodos de evaluación del adulto mayor que permitan estimar su estado general de salud. Entre estos, se ha propuesto la fuerza de prensión. El objetivo de este estudio fue buscar la asociación entre el número de comorbilidades y la fuerza de prensión. Materiales y métodos...
Article
Full-text available
bold<>italic /italic<>/bold< The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). >bold<>italic /italic<>/bold< This is a secondary analysis of the Dementia Study of Western Norway (Demvest). For this study, we analysed a sam...
Article
Background and purpose: Age-related hearing loss is a prevalent condition among the growing elderly population, which has been associated with both cognitive decline and decreased daily functioning. Decreased functioning is linked to lower performance, predominantly regarding instrumental activities of daily living (IADLs). The present study aims t...
Article
Full-text available
Objective: To estimate the out-of-pocket expenses (OOPE) during the last year of life in Mexican older adults (OA). Materials and methods: Estimation of the OOPE corresponding to the last year of life of OA, adjusting by type of management, affiliation and cause of death. Data from the National Health and Aging Study in Mexico (2012) were used....
Article
Full-text available
Purpose: High blood pressure is a relevant risk factor for vascular damage, leading to development of depressive symptoms and dementia in older adults. Moreover, subjective memory complaints are recognized as an early marker of cognitive impairment. However, it has been established that subjective memory complaints could also be a reflection of de...
Article
Full-text available
AIM: Chronic obstructive pulmonary disease (COPD) is a pro-inflammatory condition leading to wasting states such as sarcopenia. We aimed to describe the effect of COPD and sarcopenia on mortality in Costa Rican older adults in the Costa Rican Longevity and Healthy Aging Study (CRELES). METHOD: This is a secondary analysis of the CRELES, a cohort st...
Article
Objective: To explore the association between educational level and the scores obtained in each of the domains of the Montreal Cognitive Assessment test. Methods: This is a secondary analysis of the SABE/2012 Bogotá survey; a cross-sectional study including 2000 subjects aged ≥60years. The MoCA test was the dependent variable and was stratified...
Poster
Positive models of aging, including aging well, and active, healthy or successful aging models, are increasingly receiving attention from gerontologists and geriatricians. Yet important challenges remain in defining and measuring positive aging consistently and in line with older adults’ perspectives for research, practice and policy purposes. The...
Book
This second edition of Aging Research - Methodological Issues is presented after 3 years of our first appearance. Drivers of the first edition are the same for this second edition and remain as relevant as in the first one. Aging population process represents the most important demographic issue in the world and particularly in low and middle econo...
Chapter
Descriptive studies can be the point of departure for more complex studies both in geriatrics and in gerontology. The ongoing need of information regarding new conditions highly prevalent in the older adults, begins with a thorough description of these phenomenon in addition to the magnitude of them in specific populations and its associations with...
Chapter
Clinical trials are considered to be one of the best methodologies in health research and they are used primarily to test interventions in medicine. Aging research is no exception for this goal, and clinical trials are used to test different interventions in older adults with a number of variations in this particular research. In addition to drugs,...
Chapter
Science never before faced such a complex, dynamic and time-dependent process as human aging. Longitudinal studies are a source of fundamental evidence of multi-factor changes over time, especially those that have contributed to understanding the aging process through research questions related to the course or prognosis of physical or cognitive fu...
Chapter
The world population is aging, and this phenomenon is expected to continue for the next decades. The demographic modifications are substantially altering the socio-economic structure of our societies and pose serious burdens to the sustainability of healthcare systems worldwide. In order to guarantee that models of care are responsive to the novel...
Chapter
The global phenomenon of population aging has increased the need of accurate information in the last few years. In order to improve current status of the older adult’s care, quality information should be generated by standardized research methodology. Specific issues arise when it comes to aging research, different from those found in younger stage...
Conference Paper
Full-text available
Background and objectives Religion is recognized as an external experience of formal expression with associated traditions and practices shared by a faith-based group. In the elderly, it has been studied that religion have a positive role in individuals' health and well-being. As religion is highly important in older adults lives, the maintaining o...
Article
Objectives The objectives of this study were to explore the perspectives of older adults about the most important domains of aging well and to identify the social determinants of a person-centered index capturing these domains. Methods We conducted a mixed-methods study of 40 semi-structured interviews and epidemiological data from 670 older adult...
Article
Full-text available
AimsTo describe the associations of frailty with diabetes mellitus and related conditions in older adults. Methods We conducted a cross-sectional analysis of a representative sample of older adults (n = 5379). We generated a 35-item frailty index (FI) and obtained information on diabetes and related conditions (peripheral neuropathy, lower limb amp...
Article
Full-text available
Background: Multimorbidity and depressive symptoms (DSs) are common in older adults. Self-rated health (SRH) allows detection of elderly adults with a high burden of multimorbidity plus depression. The aim of this study was to test the association of groups of multimorbidity and DS on SRH in Colombian older adults. Methods: We conducted a cross-...
Article
Full-text available
Background: Older emergency department patients are more vulnerable than younger patients, yet many risk factors that contribute to the mortality of older patients remain unclear and under investigation. This study endeavored to determine mortality and factors associated with mortality in patients over 60 years of age who were admitted to the emer...
Article
Objectives The aim of this study was to investigate socioeconomic inequalities in frailty among older adults in six low- and middle-income countries (LMICs), and to examine to what extent chronic diseases account for these inequalities. Study design Data were used from the Study on global AGEing and adult health (SAGE) wave 1 (2007–2010). National...
Article
Background: As the number of older adults increases, so does the number of frail older adults. Although anthropometry has been widely used as a way to stratify the overall mortality risk of a person, the significance of these measurements becomes blurred in the case of frail older adults who have changes in body composition. Therefore, the aim of t...
Article
Full-text available
El adulto mayor frágil es una persona más vulnerable a sufrir de desenlaces adversos. Esta condición se establece por un compromiso de múltiples dominios que van más allá de las manifestaciones neurológicas. Esto crea la necesidad de un manejo interdisciplinario integral. Este abordaje inte- grado requiere consideraciones especiales para la prescri...
Article
Full-text available
Introduction: Frailty is a common condition in older adults, which consists in an increased vulnerability to stressors and a higher frequency of adverse outcomes, after this exposure. Objective: The objective of this study was to conduct a systematic review and meta-analysis on the prevalence of frailty in Mexican older adults and explain the cause...
Article
Full-text available
RESUMO OBJETIVO: Os cuidados intensivos têm algumas complicações em idosos, e uma frequentemente negligenciada é a sobrecarga do cuidador, sobre a qual pouca informação está disponível. Desse modo, o objetivo deste trabalho é descrever os fatores associados com a sobrecarga do cuidador na alta hospitalar de um paciente idoso no contexto médico mexi...
Article
Full-text available
Due to the phenomenon of demographic transition, the amount of elderly individuals is on the rise. This is an enormous success for humanity, however it does imply some challenges for modern societies. As our population ages, the prevalence and burden of chronic diseases also increase, and these pathologies raise the frequency of admission of elderl...
Article
Full-text available
Edentulism is related to a number of conditions in older adults, impacting their overall health status and thus their quality of life and relationship with the environment. At the same time, self­rated health has been shown to be an accurate marker of overall health status. However there is little information on how edentulism relates to self­rated...
Chapter
Sarcopenia is a muscle wasting condition that develops gradually during ageing and results in a loss of muscle mass and strength, leading to impairment in physical performance ability with loss of mobility and function, falls, and mortality. Diagnostic criteria include measurements of physical performance, muscle strength, and body composition. Sar...
Conference Paper
Full-text available
There is a continuously growing interest in how social determinants impact health in older adults. In particular neighborhood characteristics are well-known to affect older adult´s health. Frailty has been considered a condition that renders the older adult prone to adverse outcomes. Some authors have hypothesized that frailty leads to disability (...