Mario Inclán

Mario Inclán
University of Valencia | UV · Institute for Molecular Science (ICMol)

PhD

About

30
Publications
2,664
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279
Citations
Introduction
Dr. Mario Inclán obtained his PhD in Nanoscience and Nanotechnology at the U. of Valencia in 2016. He was awarded a Marie S. Curie fellowship as Experienced Researcher (NCSR "Demokritos") in Athens, in the framework of the ITN CyclonHit - Nanocarriers for the delivery of antimicrobial agents to fight resistance mechanisms. His work has led to the publication of 20 scientific articles and one patent. He is currently hired as a Postdoctoral Researcher at the University of Valencia.
Additional affiliations
February 2018 - present
University of Valencia
Position
  • PostDoc Position
March 2016 - February 2017
National Center for Scientific Research Demokritos
Position
  • PostDoc Position
Description
  • PROJECT: “Nanocarriers for the delivery of antimicrobial agents to fight resistance mechanisms”. EU Marie Curie Network CycloN-Hit project nº 608407 (FP7-PEOPLE-ITN-2013)
March 2010 - February 2015
University of Valencia
Position
  • Predoctoral researcher
Description
  • PROJECT: “Supramolecular chemistry applied to the design, synthesis and evaluation of bioactive compounds of antiinflamatory, antitumor or antiparasitic action”. Ministerio de Ciencia e Innovación (CSD2010-00065).

Publications

Publications (30)
Article
Green catalysts with excellent performance in Cu-free Sonogashira coupling reactions can be prepared by the supramolecular decoration of graphene surfaces with Pd(II) complexes. Here we report the synthesis, characterization, and catalytic properties of new catalysts obtained by the surface decoration of multiwalled carbon nanotubes (MWCNTs), graph...
Article
Full-text available
Living organisms depend on superoxide dismutase (SOD) enzymes to shield themselves from the deleterious effects of superoxide radical. In humans, alterations of these protective mechanisms have been linked to the pathogenesis of many diseases. However, the therapeutic use of the native enzyme is hindered by, among other things, its high molecular s...
Article
Full-text available
Polyamine ligands are water-soluble receptors that are able to coordinate, depending on their protonation degree, either metal ions, anionic, or neutral species. Furthermore, the presence of fluorescent signaling units allows an immediate visual response/signal. For these reasons, they can find applications in a wide variety of fields, mainly those...
Article
Full-text available
Nucleic acids are essential biomolecules in living systems and represent one of the main targets of chemists, biophysics, biologists, and nanotechnologists. New small molecules are continuously developed to target the duplex (ds) structure of DNA and, most recently, RNA to be used as therapeutics and/or biological tools. Stimuli-triggered systems c...
Article
Full-text available
A scorpionate Zn2+ complex, constituted by a macrocyclic pyridinophane core attached to a pendant arm containing a fluorescent pyridyl-oxadiazole-phenyl unit (PyPD), has been shown to selectively recognize chloride anions, giving rise to changes in fluorescence emission that are clearly visible under a 365 nm UV lamp. This recognition event has bee...
Article
A ligand constituted by a macrocyclic pyridinophane core having a pendant arm containing a secondary amine group linked through a methylene spacer to a pyridyl-oxadiazole-phenyl (PyPD) fluorescent system has been prepared (L). The crystal structures of [ZnL](ClO4)2 and [CuL](ClO4)2 show that the M2+ is coordinated by all the nitrogen atoms of the m...
Article
Full-text available
A new G-(H2L)-Pd heterogeneous catalyst has been prepared via a self-assembly process consisting in the spontaneous adsorption, in water at room temperature, of a macrocyclic H2L ligand on graphene (G) (G + H2L = G-(H2L)), followed by decoration of the macrocycle with Pd2+ ions (G-(H2L) + Pd2+ = G-(H2L)-Pd) under the same mild conditions. This supr...
Poster
In this work we evaluated the catalytic efficiency of functionalized multi-walled carbons nanotubes (FMWCNTS) in Oxygen Reduction Reaction (ORR) by using a Rotating Ring-Disk Electrode (RRDE) [1]. The results obtained from the sample were compared with data relating to the MWCNTs and Pt-electrode. We observed that onset potentials for all the sampl...
Article
The affinity and the binding mode of two benzo[g]phthalazine compounds, functionalized with one or two 2-(imidazole-4-yl)-ethylamine groups, to DNA and RNA models have been evaluated by means of UV-Vis, emission fluorescence and circular dichroism (CD) spectroscopies in combination with viscometry and dynamic modelling studies. Both organic molecul...
Article
We report here the remarkable catalytic efficiency observed for two Pd(II) azamacrocyclic complexes supported on multiwalled carbon nanotubes (MWCNTs) toward oxygen reduction reactions. Beyond a main (>90%) 4e- process and an onset potential close to or better than those of commercial Pt electrodes, the MWCNTs functionalization strategy, aimed at c...
Article
A new series of triphenylamine‐based ligands with one (TPA1PY), two (TPA2PY) or three pending aza‐macrocycle(s) (TPA3PY) have been synthesised and studied by means of pH‐metric titrations, UV/Vis spectroscopy and fluorescence experiments. The affinity of these ligands for G‐quadruplex (G4) DNA and its selectivity over duplex DNA were investigated b...
Article
Full-text available
Two polytopic aza-scorpiand-like ligands, 6-[7-(diaminoethyl)-3,7-diazaheptyl]-3,6,9-triaza-1-(2,6-pyridina)cyclodecaphane (L1) and 6-[6'-[3,6,9-triaza-1-(2,6-pyridina)cyclodecaphan-6-yl]-3-azahexyl]-3,6,9-triaza-1-(2,6-pyridina)cyclodecaphane (L2), have been synthesized. The acid-base behavior and Cu(2+), Zn(2+), and Cu(2+)/Zn(2+) mixed coordinati...
Article
Green nanostructured heterogeneous catalysts were prepared via a bottom-up strategy. Designed ligands were synthesized joining covalently an electrondeficient pyrimidine residue and a scorpiand azamacrocycle. The desired molecular properties were easily transferred to nanostructured materials in two steps: first, exploiting their spontaneous chemis...
Article
The interaction of a polyazacyclophane ligand, having an ethylamine pendant arm functionalized with an anthryl group (L), with the ss-polynucleotides poly A, poly G, poly U and poly C as well as with the ds-polynucleotides poly A - poly U, poly (dAT)2 and poly (dGC)2 has been followed by UV-Vis, steady state fluorescence spectroscopy and thermal de...
Article
Full-text available
The enantioselectivity of β-cyclodextrin (β-CD) towards L- and D-N-acetyltryptophan (NAcTrp) has been studied in aqueous solution and the crystalline state. NMR studies in solution show that β-CD forms complexes of very similar but not identical geometry with both L- and D-NAcTrp and exhibits stronger binding with L-NAcTrp. In the crystalline state...
Data
Experimental data containing geometry data of the β-CD hosts; H-bonding interactions in the β-CD dimer; NMR data (Job plots and 2D maps of the observed dipolar interactions); packing, origin selection and comparison of monomeric β-CD complexes; modeling results of D-NAcTrp/β-CD.
Presentation
Great efforts have been made in order to understand the interaction of polyamines with nucleic acids since it was found, in the 1960s, that they were bound to various cellular anions, including DNA and RNA. In this line, we have previously prepared a polyamine compound based on a macrocyclic core appended with an arm containing extra donor atoms. T...
Article
This article describes the preparation and characterization of a hybrid oxidation catalyst for decontamination of organic pollutants which involves a bifunctional dicopper(II) complex and the niobium(V) oxyhydroxide as the active species, the later one being also a solid support. The pH range for the existence of the active species was determined b...
Article
Full-text available
Two simple fluorescent sensors for Cu(II) ions were synthesized in two reaction steps, using recently developed C–H functionalization reactions for boron dipyrrins, starting from a standard 8-aryl-BODIPY dye and a tris(2-aminoethyl)amine (TREN) ligand. At pH 5, the resulting BODIPY–TREN conjugates are demonstrated to be promising, highly selective,...
Article
The complexing ability of copper(II) in solution by the ligand N,N'-2,6-pyridinebis(oxamic acid) (H4mpyba, H4L) was determined through potentiometric and UV-vis spectroscopy at 25 °C and 0.15 M NaCl. The logarithms of the equilibrium constants for its copper(II) complexes according to the eqs 2H2L + 2Cu ⇆ [Cu2(H2L)2], 2H2L + 2Cu ⇆ [Cu2(H2L) (HL)] +...
Article
Full-text available
The in vitro leishmanicidal activity of a series of nine aza-scorpiand-like macrocycles, recently synthesized, was tested on Leishmania infantum, Leishmania braziliensis and Leishmania donovani parasites,˜ using promastigotes and intracellular amastigotes forms. The cytotoxicity of the tested compounds on J774.2 macrophage cells was also measured....
Article
Full-text available
The anti-chagasic activity of a series of eleven derivatives of aza-scorpiand-like macrocycles, some of them newly synthesised, was assayed. The four compounds with the best selectivity indices in vitro were subjected to in vivo assays. Tests in a murine model of the acute phase of Chagas disease showed a two-fold reduction in parasitaemia compared...
Article
Full-text available
Microparticulate deposits of scorpiand-like azamacrocyclic receptors (L1-L4) attached to graphite electrodes provide distinctive voltammetric features in contact with aqueous DNA solutions at biological pH, denoting the formation of DNA surface complexes. This voltammetry allows for screening dsDNA, ssDNA and G-Quadruplex DNA using L4-modified elec...
Article
The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand-based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π-π stacking, and hydrogen-bonding interactions. This behavior has be...
Article
Full-text available
The preparation, X-ray structure, and variable temperature magnetic study of the new compound {Ba(H2O)3/2[Cr(pyim)(C2O4)2]2}n ·9/2nH2O (1) [pyim = 2-(2′-pyridyl)imidazole and C2O42− = dianion of oxalic acid], together with the potentiometric and spectrophotometric studies of the protonation/deprotonation equilibria of the pyim ligand and the ternar...
Article
Full-text available
Mn(II) complexes of scorpiand-type azamacrocycles constituted by a tretrazapyridinophane core appended with an ethylamino tail including 2- or 4-quinoline functionalities show very appealing in vitro SOD activity. The observed behaviour is related to structural and electrochemical parameters.

Projects

Projects (4)
Project
Supramolecular chemistry has always found a source of inspiration in living systems. Although we cannot yet compete with the beautiful complexity of biological systems, the knowledge acquired in the past decades regarding the non-covalent interactions of biomolecules with synthetic ligands, supramolecular assemblies and nanoparticles, has led to a wide range of biomedical applications. In a time when society is demanding new solutions to health challenges (e.g. respiratory infectious diseases, antimicrobial resistance, cancer and neurological disorders) supramolecular chemistry might have a lot to say. This is the driving force behind this Special Issue. https://www.mdpi.com/journal/applsci/special_issues/biomedical_supramolecular_chemistry Deadline for manuscript submissions: 10 June 2022.
Archived project
Synthesizing BODIPY–TREN chemosensors using new C–H functionalization reactions and studying their sensing properties.
Archived project
The world-wide spread of antibiotic-resistant microorganisms can be viewed as an ecological consequence of the systematic use of antimicrobial agents. Resistant bacteria prevail in healthcare environments where antibiotic selective pressure is intensive.