Mario Francisco Guerrero

Mario Francisco Guerrero
National University of Colombia | UNAL · Departamento de Farmacia (Bogotá)

Doctor of Pharmacy

About

54
Publications
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Introduction
Experimental cardiovascular and central nervous system pharmacology.

Publications

Publications (54)
Article
Full-text available
Background: Ayanin (3,7,4’-Tri-O-methylquercetin) and 3,7-Di-O-methylquercetin (DMQ) are the main active metabolites isolated by bioguided fractionation from Croton schiedeanus, species known popularly in Colombia as “almizclillo”, which has been studied in experimental models in rats, exerting vasodilator and antihypertensive effects. Also, when t...
Article
Full-text available
Background: Passiflora quadrangularis L. has antihypertensive and anxiolytic properties observed in experimental models. Objectives: The aim of this work was to establish the vascular effects exerted by two known monodesmosidic triterpene saponins, 3-O-β-D-glucopyranosyloleanolic acid (Compound 1) (not previously described for this plant) and, 3-O-...
Article
Full-text available
Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new synthetic coumarin, were evaluated. To do this, we used the reserpine model of Parkinson’s disease, an assay of levodopa/carbidop...
Article
Full-text available
Introduction: Parkinson’s disease is the second most common neurodegenerative disease. Monoamine oxidase B inhibitors are used in the treatment of this disease concomitantly with levodopa or as monotherapy. Several substituted coumarins have shown activity as inhibitors of monoamine oxidase B. Objective: To evaluate the possible antiparkinsonian ef...
Article
Full-text available
Background: 4-propil-2H-benzo[h]-cromen-2-ona (FCS-304) is a semisynthetic coumarin with MAO-A inhibitory activity and positive results in forced swimming and tail suspension test in mice, but until now, it has not been studied in other screening antidepressant models in mice and rats. Objectives: The aim of this work was to assess the serotonin l...
Article
Background: 4-propil-2H-benzo[h]-cromen-2-ona (FCS-304) is a semisynthetic coumarin with MAO-A inhibitory activity and positive results in forced swimming and tail suspension test in mice, but until now, it has not been studied in other screening antidepressant models in mice and rats. Objectives: The aim of this work was to assess the serotonin li...
Article
Full-text available
Background: Passiflora quadrangularis L. is among the species used in Colombian folk medicine for hypertension, but until now it has not been studied in experimental models. Objectives : To assess the capacity of P. quadrangularis L. EtOH extract to prevent the hypertension and vascular remodelling induced by nitric oxide (NO) deficit in Wistar ra...
Poster
In this poster I present the results of the evaluation of the novel compound FCS-304 as continuation of previous work performed by Vergel et al. (2010).
Article
Full-text available
Background: The treatment of symptoms of prostatic hyperplasia is among the traditional uses of Achyrocline bogotensis (Kunth) [N.V. “Vira Vira”, Compositae] in Colombia. Pharmacological therapy for this disorder depends mainly on alpha-1 antiadrenergic agents, and the mechanism has not been studied previously using A. bogotensis. Objectives: To a...
Article
Background: Passiflora quadrangularis L. is among the species used in Colombian folk medicine for hypertension, but until now it has not been studied in experimental models. Objectives: To assess the capacity of P. quadrangularis L. EtOH extract to prevent the hypertension and vascular remodelling induced by nitric oxide (NO) deficit in Wistar rats...
Article
Full-text available
Background: Some species of the Lauraceae family are known to produce secondary metabolites that have antiplatelet properties. Studies on the leaves of Nectandra amazonum Nees. have shown antiaggregant activity but the bark of this species has not been studied. Objectives: To assess the antiplatelet effect of the ethanolic fraction obtained from t...
Article
Full-text available
Coumarin (2H-chromen-2-one) microencapsulation in Eudragit® E100 polymer microparticles was performed in order to examining its anticonvulsant activity and antioxidant effects in ICR male mice as experimental model. Microparticles were prepared by a solvent extraction/single emulsion (o/w) method and characterized for morphology, size, coumarin loa...
Research
Full-text available
The present study deals with the isolation and identification of three valepotriate hydrines that are first reported in Valeriana pavonii Poepp. & Endl. (Valerianaceae), which were obtained from a dichloromethane fraction showing anticonvulsant activity in vivo.
Article
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Background: Epilepsy is a complex chronic disorder which affects health-related quality of life (HRQOL), especially in women. Methods: This study is a pragmatic randomised controlled trial involving women with epilepsy (WWE) over 18 years of age. Results: One hundred eighty-two WWE entered the study and 144 (79.1%) completed it. The t-test for...
Article
Full-text available
Resumen Giving that the pyrazolo[1,5-a][1,3,5]triazine system is a potential source of pharmacological agents for treatment of central nervous system disorders this work was aimed to asses anticonvulsant and acute neurotoxic effects of six molecules obtained by synthesis, using experimental models in mice. A series of six pyrazolo[1,5-a] [1,3,5]tr...
Article
Full-text available
Croton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacity of a 96% EtOH extract to prevent the hypertension induced...
Article
The butanolic fraction obtained from the extract of Cecropia peltata L (NV: "Yarumo"), medicinal plant used by popular tradition in Colombia as tranquilizer, displays in ICR albino mice an anticonvulsant, anxiolytic and sedative profile, according to electroshock, pentylenetetrazole, marble burying and barbiturate sleeping tests (80 mg/kg, p. o., p...
Article
Full-text available
El extracto etanólico de Croton schiedeanus Schlecht, especie medicinal utilizada por la tradición popular en Colombia con fines antihipertensivos, relaja los anillos vasculares de la aorta de ratas Wistar contraídos con fenilefrina (10-6 M, agonista del receptor adrenérgico alfa), en función de la dosis, con una CE50 de 1,3 × 10-5 g/mL. Este efect...
Article
Full-text available
The leaves of Calea prunifolia H.B.K., medicinal specie used in Colombian folk medicine for hypertension have been analysed for their chemical constituents, resulting in the isolation of one flavonoid glycoside, one quinic acid derivative and one kaurane diterpenoid glycoside. Their chemical structures were elucidated on the basis of spectral analy...
Poster
The anticonvulsant activity of some 4-aryl-2-ethylthio-7-methylpyrazolo[1,5-a][1,3,5]triazines (MH4a-c) was evaluated by two methods namely, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) models. Phenytoin (20 mg/Kg) and clonazepam (0,5 mg/Kg) were used as standard drugs for comparison. ICR male mice weighing 25-30 g...
Article
Full-text available
Introduction: This study shows the relaxant effect induced by ayanin in aorta rings from Wistar rats linked to nitric oxide/cyclic-GMP pathway. This flavonoid is the prevalent compound obtained from Croton schiedeanus Schlecht (Euphorbiaceae), specie used in Colombian folk medicine for the treatment of arterial hypertension.Objectives: To identify...
Article
Full-text available
Introduction: One of the most frequent problems found in medicinal plants is the absence of clinical, toxicological, and pharmacological studies. Valeriana pavonii is one of the species used in Colombia as an anxiolytic. Further study of this specie is rendered to add information in the toxicological area.Objective: The acute and subchronic oral to...
Article
Full-text available
Fractioning of an extract of Valeriana pavonii, a native species used in Colombian folk medicine as tranquilizer, led to the isolation and identification of isovaleramide, one of the active constituents responsible for its central nervous system activity as anticonvulsant. Description of the isolation and identification of isovaleramide, an active...
Article
To evaluate the central nervous pharmacological profile of 4-propyl-2H-benzo[h]-chromen-2-one (FCS-304) in ICR mice and its monoamine oxidase inhibitor activity. FCS-304 was evaluated in screening test of central nervous system in ICR mice and against MAO activity. FCS-304 (25-200mg/Kg, p.o.) significantly reduced immobility time during the forced...
Article
Full-text available
Desde el contexto de la farmacología experimental, en este ensayo se discuten algunos criterios que pueden ser útiles para estimar el potencial de productos naturales con posible actividad farmacológica para el tratamiento de la hipertensión, una de las enfermedades de mayor impacto epidemiológico en Colombia y en el mundo. Se acude para ello al an...
Article
Full-text available
Within the context of experimental pharmacology, some criteria are discussed for estimating the potential of natural products with possible pharmacological activity for the treatment of hypertension. This disorder has great epidemiological impact in Colombia as well as elsewhere. Discovery of these products can be accomplished by use of accessible...
Article
Full-text available
This study evaluates the effects on arterial pressure and pithed heart frequency rate induced by the ethanolic extract of Solanum tuberosum, a species used in Colombian folk medicine for the treatment or arterial hypertension, compared with α-solanine and α-chaconine -the main glycoalcaloids of S. tuberosum- the mixture of both glycoalcaloids (50:5...
Article
Full-text available
The main objective of this study was to evaluate the interaction between the concentrated ethanolic extract of Hygrophila tyttha (500 mg/kg, per os) and the cholinergic antagonist scopolamine (0.3 mg/kg, intraperitoneal) in an animal model of episodic memory. The extract was obtained by percolation from fresh vegetal material and was administered 3...
Article
Full-text available
The present study evaluated the neuropharmacological effect exerted by the hydroalcoholic extract (40%) obtained from leaves of Annona muricata (0.5 g/kg, po) in ICR albino mice using tests to detect anticonvulsant (electroshock-pentylenetetrazol), antidepressant (forced swimming test), hypnotic (barbiturate sleeping time) and anxiolytic activities...
Article
Full-text available
Introduction: This study shows the vasorelaxant profile in isolated aortic rings from Wistar rats of the ethanolic extract and the acetylated flavonoid fraction obtained from Calea prunifolia , specie used in Colombian folk medicine for the treatment of arterial hypertension. Objectives: To study possible action mechanisms implicated in the respons...
Article
Full-text available
Antecedentes. El Croton schiedeanus Schelecht (N.V: "almizclillo" Euporbiaceae), es una especie popularmente utilizada en Colombia para el tratamiento de la hipertensión arterial. Objetivo. Evaluar el efecto vasodilatador de los flavonoides: 3-O-metilquercetina, 3,7-di-O-metilquercetina, y 3,3',4',7-tetra-O-metilquercetina; y los fenilbutanoides: (...
Article
Full-text available
Introducción: Este estudio muestra el perfil vasodilatador en anillos aislados de aorta de ratas Wistar del extracto etanólico y de la fracción de flavonoides acetilada de Calea prunifolia HBK, especie utilizada popularmente en Colombia para el tratamiento de hipertensión arterial. Objetivos: Estudiar posibles mecanismos de acción inducidos por el...
Article
Full-text available
Antecedentes. El Croton schiedeanus Schelecht (N.V: “almizclillo” Euporbiaceae), es una especie popularmente utilizada en Colombia para el tratamiento de la hipertensión arterial. Objetivo. Evaluar el efecto vasodilatador de los flavonoides: 3-O-metilquercetina, 3,7-di-O-metilquercetina, y 3,3’,4’,7-tetra-O-metilquercetina; y los fenilbutanoides: (...
Article
Full-text available
This study shows the isolation, identification and pharmacological profile on the central nervous system induced by coumarin (1-2 benzpyrone), molecule obtained from Hygrophila tyttha Leonard (Acanthaceae. Vulgar name:: "amansamachos"). This specie is a medicinal plant used in Colombian traditional medicine for the treatment of anxiety. Tests desti...
Article
Full-text available
This study shows the isolation, identification and pharmacological profile on the central nervous system induced by coumarin (1-2 benzpyrone), molecule obtained from Hygrophila tyttha Leonard (Acanthaceae. Vulgar name:: “amansamachos”). This specie is a medicinal plant used in Colombian traditional medicine for the treatment of anxiety. Tests desti...
Article
Full-text available
The plant Solanum tuberosum is used in Colombian folk medicine for the treatment of hypertension. We evaluated the antiaggregant properties on human platelets of an ethanolic extract (96%) obtained from the skin of tubers of this species. Extracts from two varieties, sabanera and pastusa revealed in vitro dose-dependent (10-100 mg/mL) antiaggregant...
Article
Full-text available
This work shows the pharmacological effect on the central nervous system induced by an alkaloid fraction obtained from Valeriana pavonii . Traditional medicine uses this specie in Colombia for the same purpose of Valeriana officinalis , although there are differences in their chemical structure, particularly in the presence of alkaloid compounds, f...
Article
Full-text available
El extracto etanólico y una fracción alcaloidal, obtenidos de Valeriana pavonii, presentaron actividad protectora (40 y 70% respectivamente) contra las convulsiones inducidas por electroshock, modelo murino experimental de las crisis tipo tónico clónico en el humano. A través del análisis fitoquímico preliminar del extracto etanólico, se determinó...
Article
Full-text available
Se evaluó en ratones albinos ICR el perfil de actividad que sobre el sistema nervioso central ejercen el extracto etanólico y las fracciones acuosa, clorofórmica, metanólica y hexánica obtenidas de Hygrophila tyttha (Acanthaceae. NV: amansamachos). Para tal fin se utilizaron pruebas destinadas a detectar posible actividad ansiolítica (laberinto en...
Article
The acid fraction of extracts from the aerial part of Croton schiedeanus afforded six cis-clerodane type diterpenoids. Two of them (1 and 4) are new natural compounds. Structural elucidation was achieved on the basis of their spectral data.
Article
The vasorelaxant effect of two new neo-clerodane diterpenoids, (12R)-12-hydroxycascarillone and 5beta-hydroxy-cis-dehydrocrotonin, in addition to the known cis-dehydrocrotonin and trans-dehydrocrotonin, all them previously isolated by us from Croton schiedeanus Schlecht, was studied in isolated aorta rings contracted by high K+ (80 mM) or phenyleph...
Article
Two new neo-clerodane type furano diterpenoids were isolated from the aerial part of Croton schiedeanus, besides the clerodane diterpenes cis- and trans-dehydrocrotonin, previously isolated from other species of Croton. Structural elucidation was achieved on basis of extensive NMR experiments, including X-ray diffraction analysis and molecular mech...
Article
Full-text available
The vasorelaxant profile of quercetin 3,7-dimethyl ether, a flavonoid isolated from Croton schiedeanus Schlecht (Euphorbiaceae), was assessed in aortic rings isolated from Wistar rats. To gain insight into its structure-activity relationship, we compared this substance with quercetin 3,4',7-trimethyl ether (ayanin), another flavonoid isolated from...
Article
Full-text available
In this study we evaluated the anti-adrenergic response elicited by ayanin, a flavonoid compound isolated from Croton schiedeanus Schlecht, in the pithed rat, and the inhibitory effect of NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME), and its acute toxicity profile in mice. In pithed rats ayanin (5 - 50 mg/kg i. v.) caused a dos...
Article
The antihypertensive and vasodilator effects of ethanolic extracts prepared from Calea glomerata Klatt, Croton schiedeanus Schlecht, Curatella americana L., Lippia alba (Mill)n N.E.Br. and Lupinus amandus, which are medicinal plants used in Colombian folk medicine for the treatment of hypertension, were assayed both in SHR and Wistar rats and in ra...
Article
Antihypertensive and vasorelaxant effects of treatment with the aqueous extract of Croton schiedeanus Schlecht (AECS) were investigated in anaesthetized spontaneously hypertensive rats (SHR). Intravenous bolus injections of AECS (5-100 mg/kg) elicited dose-dependent decreases in mean arterial pressure (MAP) and heart rate (HR). Additionally, AECS (...