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Mario A Alonso Vanegas

Mario A Alonso Vanegas

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122
Publications
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1,442
Citations
Citations since 2016
37 Research Items
813 Citations
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140

Publications

Publications (122)
Article
Frontal lobe epilepsy (FLE) is the second most frequent type of epilepsy and the surgical outcome depends on the etiology. For instance, patients with posttraumatic FLE (PTE) have a worse surgical outcome compared to patients with FLE related to a tumoral lesion (TL). The present study focuses to determine if the FLE etiology is associated with the...
Poster
Full-text available
Referencias 1. Téllez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain. 2005; 128(Pt 5):1188-98. 2. Ladino, L. D., Hernández-Ronquillo, L., & Téllez-Zenteno, J. F. (2014). Management of antiepileptic drugs following epilepsy surgery: a meta-analysis. Epilepsy research,...
Poster
Full-text available
Introducción La NCC es una causa común de epilepsia y cada vez se observan más casos de EF en pacientes con NCC. (1,2). La prevalencia de EF en el INNNMVS se describió de hasta el 56%, incluyendo en esa muestra 2.4% de pacientes con NCC que persistían con crisis. (3) Objetivo Describir las características clínicas y resultado de la cirugía de epi...
Article
The blood-brain barrier (BBB) maintains the optimal microenvironment for brain function. Tight junctions (TJs) allow endothelial cells to adhere to each other, leading to the formation of a barrier that prevents the penetration of most molecules via transcellular routes. Evidence has indicated that seizure-induced vascular endothelial growth factor...
Article
Neuroinflammation leads to cellular dysfunction or vice versa, that occurs during processes of neurodegeneration and epilepsy. Inflammation induces the activation of the microvasculature, disrupting the integrity of the blood-brain barrier (BBB) and increasing its permeability, which has been reported in several neurodegenerative diseases. BBB disr...
Article
Full-text available
In the epilepsy spectrum, temporal lobe epilepsy (TLE) is the most common and devastating focal and symptomatic epilepsy form in adults, where more than 30% of patients develop pharmacoresistance. It is not fully understood how the gene expression contributes to establishing an epileptic phenotype. Cerebrovascular remodeling directed by VEGF (vascu...
Article
Full-text available
Experimental evidence points out that the activation of the endocannabinoid system induces neuroprotective effects and reduces mood disorders. In the hippocampus of patients with mesial temporal lobe epilepsy (MTLE), studies indicated augmented cannabinoid 1 receptor (CB1R) binding, in spite of its low mRNA and protein expressions. Although this si...
Article
Objectives The aim of this study is to analyze changes in the Social Determinants of Health (SDH) in patients undergoing epilepsy surgery in Mexico. Materials and Methods We retrospectively analyzed 102 adult patients who underwent brain resection for focal epilepsy (2002-2014) with at least 4 years of follow-up; described clinical variables (age,...
Article
Full-text available
Alzheimer’s disease (AD) is the most common form of dementia present in older adults; its etiology involves genetic and environmental factors. In recent years, epidemiological studies have shown a correlation between AD and chronic epilepsy since a considerable number of patients with AD may present seizures later on. Although the pathophysiology o...
Article
Full-text available
A 5 year old male with no past medical history presented with generalized tonic clinic seizures. Brain magnetic resonance imaging (MRI) demonstrated blurring of grey-white matter and lobar hypoplasia of right frontal lobe. Right frontal lobectomy with electrocorticography (ECoG) was performed. The final pathological diagnosis was focal cortical dys...
Poster
Full-text available
Purpose : The blood- brain barrier (BBB) integrity is a matter of interest in epilepsy research. Several studies using animal models have proposed the progression of the epilepsy due to disruption of the BBB. However, no studies exist concerning this issue in pharmacoresistant temporal lobe epilepsy (TLE). The present study was focused to evaluate...
Article
The Repressor Element-1 Silencing Transcription factor or Neuron-Restrictive Silencer Factor (REST/NRSF) is a zinc finger repressor transcription factor of the Kruppel family. Several studies in experimental models have shown that overexpression of REST/NRSF occurs after the induction of seizures. In the present study, the expression of REST/NRSF (...
Article
Full-text available
Background Spreading depolarization (SD) is a fundamental pathophysiological mechanism of both pannecrotic and selective neuronal lesions following deprivation of energy. SD with brain injury has been reported including in one patient during an intracranial operation. However, the incidence of SDs in operative resections is unknown. Methods We per...
Article
Full-text available
Abstract Epilepsy surgery is an approved treatment for the management of drug-resistant epilepsy or refractory epilepsy (RE). Approximately one-third of patients with epilepsy will develop RE. RE is considered a serious public health threat carrying important biopsychosocial consequences including seizure-related accidents, professional limitations...
Poster
Full-text available
Objective: To describe changes in employment and income status in a cohort of Mexican patients submitted to epilepsy surgery. Background: Epilepsy is a chronic disease characterized by recurrent unprovoked seizures. Epilepsy is associated with lower employment rate1 as well as social stigmas, low quality of life and a significant economic impact 2....
Article
Epilepsy surgery is an approved treatment for the management of drug-resistant epilepsy. Approximately one third of patients with epilepsy present refractory epilepsy (RE). RE is considered a grave public health threat, carrying important bio-psycho-social consequences including accidents, professional limitations and increased risk of sudden death...
Article
The vascular endothelial growth factor (VEGF) system has been shown to play a crucial role in several neuropathological processes. Temporal lobe epilepsy (TLE) is the most common focal epilepsy type in adult humans. We assessed the protein expression levels of VEGF-A, VEGF-B, and VEGF-C, their specific receptors VEGFR-2 and -3, their accessory rece...
Article
Full-text available
Purpose We believed that the hippocampal complex is a fractal, and we try to demonstrate it. Methods We selected 12 magnetic resonance (MR) studies from healthy brains. Five women and 7 men without neurological or psychiatric disease were analyzed. The age range was 50–71 years old, with a mean 57.1 ± 7.6 years. Image series of MR were obtained thr...
Article
Neuroinflammation has been shown to constitute a crucial mechanism in the pathophysiology of epileptic brain and several genes of inflammatory mediators have been detected in surgically resected hippocampus tissue but not in non-related seizure brain regions. Interestingly, it has been reported an olfactory dysfunction in frontal lobe epilepsy (FLE...
Poster
Objective: Characterizing the modifications that pharmacoresistant temporal lobe epilepsy (PR-TLE) produces over the protein expression level of A-C forms of vascular endothelial growth factor (VEGF) and of type 2 receptor for VEGF (VEGFR- 2) in the human temporal cortex (TCtx). Methodology: We analyzed 18 samples of human TCtx: 6 controls and 12...
Article
Full-text available
A body of evidence supports a relevant role of brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cerebral atrophy extends to regions that are functionally and anatomically connected with the hippocampus, especially the temporal cortex. We previously reported an increased expression of...
Article
Introduction Cortical spreading depressions (CSDs) are waves of near-complete cellular depolarization that spread slowly across the cortical surface (2–5 mm/min) and result in transient loss of cell signaling capabilities. CSDs is a biomarker of neuronal damage described in several clinical hypoxic-ischemic conditions However, only has been found i...
Article
Full-text available
KEYWORDS 5-HT 1A receptor; G-protein; Lateral temporal neocortex; Mesial temporal lobe epilepsy Abstract Background: The 5-hydroxytryptamine-1A receptors are known to be involved in the inhibition of seizures in epilepsy. Objective: The main aim of the present study is to determine the functional coupling to G-protein of the 5-HT 1A receptor throug...
Article
Background and objective: The parahippocampal gyrus (PHG) plays an important role in the epileptogenic pathways of mTLE-HS, it´s resection could be preventing epileptic seizures with less complications. Evaluate the initial efficacy and safety of anterior temporal lobectomy (ATL), selective amygdalo-hipppocampectomy (SAH) and parahippocampectomy (...
Article
Full-text available
Purpose: The role of intraoperative electrocorticography (iECoG) and of its patterns in epilepsy surgery have shown contradictory results. Our aim was to describe iECoG patterns and their association with outcome in epilepsy surgery. Methods: We retrospectively analyzed 104 patients who underwent epilepsy surgery (2009-2015) with pre- and postre...
Article
Temporal lobe resection is the most prevalent epilepsy surgery procedure. However, there is no consensus on the best surgical approach to treat temporal lobe epilepsy. Complication rates are low and efficacy is very high regarding seizures after such procedures. However, there is still ample controversy regarding the best surgical approach to warra...
Article
Epilepsy is characterized by spontaneous recurrent seizures and temporal lobe epilepsy (TLE) is the most common serious neurological example of acquired and frequent epilepsy. Oxidative stress is recognized as playing a contributing role in several neurological disorders, and most recently have been implicated in acquired epilepsies. The MTs occur...
Article
Following up on the concepts of epileptogenicity and refractoriness as well as significant technological advances we explore the concept of phar-macologically refractory epilepsy and its high biosocial and psychological burden. Evidence from the first randomized trial and surgical results worldwide warrant arguing for early referral of adequately s...
Article
Following up on the concepts of epileptogenicity and refractoriness as well as significant technological advances we explore the concept of pharmacologically refractory epilepsy and its high biosocial and psychological burden. Evidence from the first randomized trial and surgical results worldwide warrant arguing for early referral of adequately se...
Article
Objective To show surgical results in SMA epilepsy patients in two reference centers in Mexico City. Material and methods Retrospective study (1999–2014), of 52 patients submitted to lesionectomy and/or corticectomy of the SMA guided by electrocorticography (ECoG). We describe the clinical, neurophysiological, neuroimaging and pathological finding...
Article
Persistent trigeminal artery (PTA), also called primitive trigeminal artery represents the most common embryonic remnant of fetal circulation in adulthood, (only after fetal pattern of Posterior Communicating Artery (PComA)), with an estimated incidence of between 0.1 and 0.76%. The permanence of this fetal pattern constitutes an incidental finding...
Article
Full-text available
Experiments were designed to evaluate the tissue content of tele-methylhistamine (t-MeHA) and histamine as well as H3 receptor (H3 Rs) binding and activation of the heterotrimeric guanine nucleotide binding αi/o proteins (Gαi/o) coupled to these receptors in the hippocampus and temporal neocortex of patients (n = 10) with pharmacoresistant mesial t...
Article
Background: The herpes simplex virus (HSV) is the most common cause of sporadic encephalitis worldwide. Even with proper treatment, this infection is associated with a mortality rate of 19%-30% and with potential neurologic sequelae. Recurrences of encephalitis are rare and limited to a few cases in the literature. Although the mechanism of reacti...
Article
A putative role of the Brain Derived Neurotrophic Factor (BDNF) in epilepsy has emerged from in vitro and animal models, but few studies have analyzed human samples. We assessed the BDNF expression of transcripts with exons I (BDNFI), II (BDNFII), IV (BDNFIV) and VI (BDNFVI) and methylation levels of promoters 4 and 6 in the hippocampus of patients...
Chapter
The therapeutic control of seizure activity in patients with epilepsy represents an important achievement. For each patient, the selection of the proper treatment is essential. This article provides a review of different strategies to control epileptic activity. Some of these strategies, such as pharmacotherapy, epilepsy surgery, electrical modulat...
Article
Full-text available
Aim: To describe the general aspects of cavernomas and epilepsy and review the available literature on the utility of electrocorticography (ECoG) in cerebral cavernoma surgery. Methods: We searched studies in PubMed, MedLine, Scopus, Web of Science, and Google Scholar (from January 1969 to December 2013) using the keywords "electrocorticography"...
Article
Cerebral cavernous malformations (CCMs) are well-defined, mostly singular lesions present in 0.4-0.9% of the population. Epileptic seizures are the most frequent symptom in patients with CCMs and have a great impact on social function and quality of life. However, patients with CCM-related epilepsy (CRE) who undergo surgical resection achieve posto...
Article
It is well known that mood disorders are highly prevalent in patients with epilepsy. Although several studies have aimed to characterize alterations in different types of receptors associated with both disturbances, there is a lack of studies focused on identifying the causes of this comorbidity. Here, we described some changes at the biochemical l...
Article
Full-text available
Temporal lobe epilepsy (TLE) is a chronic neurodegenerative disease with a high prevalence of psychiatric disorders. Temporal neocortex contributes to either seizure propagation or generation in TLE, a situation that has been associated with alterations of the γ-amino-butyric acid (GABA) system. On the other hand, an impaired neurotransmission medi...
Chapter
Full-text available
Despite the availability of various newly developed antiepileptic drugs (AEDs), pharmacoresistance remains a major challenge in epilepsy management. Unraveling the mechanisms underlying AED resistance has been the focus of intense efforts, in order to develop new rationally designed therapies for as yet refractory epilepsies. Based on experimental...
Article
Vagus nerve stimulation (VNS) is the most widely used non-pharmacological treatment for pharmacoresistant epilepsy since 1988 based on experimental and clinical observations over several decades. In 1997, the FDA approved VNS as an adjunctive treatment for partial refractory epilepsy in adults and adolescents over 12 years of age. Considering that...
Article
Full-text available
Aim: This work explores the effects of clinical variables on self-reported quality of life (QoL) in pharmacoresistant temporal lobe epilepsy (TLE), correlating this information with results from the Quality of Life in Epilepsy questionnaire (QOLIE-31) and selective memory tests of the Barcelona Battery and the Rey-Osterrieth figure. Methods: We...
Article
Periodic epileptiform discharges (PEDs) are an uncommon, abnormal EEG pattern seen usually in patients with acute diseases and less frequently in chronic conditions, such as mesial temporal lobe epilepsy (mTLE). Evaluate the clinical histories, neuroimaging findings, and serial electrophysiological studies prior to the appearance of PEDs in patient...
Article
Full-text available
Epilepsy affects 1 and 2% of the worldwide population, while temporal lobe epilepsy (TLE) covers 40% of all epilepsy cases. Controversy in defining epilepsy as a neurodegenerative disease exists because, no there is enough evidence to show seizures and status epilepticus (SE) as cause for irreversible neuronal damage. Epileptogenic insult at the be...
Article
Epilepsy affects 1 and 2% of the worldwide population, while temporal lobe epilepsy (TLE) covers 40% of all epilepsy cases. Controversy in defining epilepsy as a neurodegenerative disease exists because, no there is enough evidence to show seizures and status epilepticus (SE) as cause for irreversible neuronal damage. Epileptogenic insult at the be...
Article
We report the achievements obtained, over a period of 4years, by the collaborative partnering effort of the Epilepsy Program at Western University in Canada and the Instituto of Ciencias Neurologicas in Lima, Peru, building an epilepsy program in Peru.
Poster
Full-text available
Objetivo: Presentar el caso de un paciente con diagnóstico de Dike-Davidoff-Masson y epilepsia de difícil control.
Poster
Full-text available
Objective: To describe our surgical series of patients presenting cortical dysplasia (CD) along with another pathology and intractable temporal lobe epilepsy.
Article
Cerebral cavernous malformations (CCMs) are well-defined, mostly singular lesions present in 0.4-0.9% of the population. Epileptic seizures are the most frequent symptom in patients with CCMs and have a great impact on social function and quality of life. However, patients with CCM-related epilepsy (CRE) who undergo surgical resection achieve posto...
Article
Craniopharyngioma is a rare and mostly benign epithelial tumor of the central nervous system, mostly affecting children. Considering that most of the published series of craniopharyngioma are based on pediatric populations, studies in adults gain importance based mainly on the reduced number of cases and the possible differences emerging from a mos...
Article
Callosotomy by radioneurosurgery induces slow and progressive axonal degeneration of white matter fibers, a key consequence of neuronal or axonal injury (radionecrosis). However, the acute effects are not apparent when using conventional MRI techniques. Diffusion tensor imaging (DTI) during the first week following radioneurosurgical callosotomy al...
Article
Mu opioid receptors (MOR) are known to be involved in seizure activity. The main goal of the present study was to characterize the MOR mRNA expression, binding, as well as G protein activation mediated by these receptors in epileptic hippocampus of patients with pharmacoresistant mesial temporal lobe epilepsy (TLE). In contrast with autopsy samples...
Poster
Full-text available
Objetivo: Presentar el caso del 1º paciente con epilepsia de difícil control diagnosticado mediante reconstrucción curvilínea con displasia cortical del Área Motora Suplementaria (AMS) izquierda en México.
Poster
Full-text available
Objetivo: Presentar los casos de 2 pacientes sometidos a cirugía de epilepsia de difícil control diagnosticados con cavernoma quienes en el periodo postquirúrgico presentan cavernomas de novo extracraneales.