Marine Le Goas

Université de Montréal | UdeM · Faculty of Pharmacy

Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine. Various core materials and shapes are explored, but they all display a common hybrid structure, with organic ligands on their surface. These ligands play a key role in the NP colloidal stability and surface properties, and therefore strongly impact the biological...

Here, we propose a new theoretical framework that enables the use of Differential Dynamic Microscopy (DDM) in fluorescence imaging mode to quantify in situ protein adsorption onto nanoparticles (NP) while simultaneously monitoring for NP aggregation. We use this methodology to elucidate the thermodynamic and kinetic properties of the protein corona...

Diffusion of nanomedicines inside the extracellular matrix (ECM) has been identified as a key factor to achieve homogeneous distribution and therefore therapeutic efficacy. Here, we sought to determine the impact of nanoparticles surface properties on their ability to diffuse in the ECM. As model nano-objects, we used a library of gold nanoparticle...

Nanomedicines are considered as promising therapeutics for cancer treatment. However, clinical translation is still scarce, partly because their biological behavior is not well understood. Extracting general guidelines from the great variety of nanoparticles and conditions studied is indeed difficult, and relevant techniques are lacking to obtain i...

Background: Human trials combining external radiotherapy (RT) and metallic nanoparticles are currently underway in cancer patients. For internal RT, in which a radioisotope such as radioiodine is systemically administered into patients, there is also a need for enhancing treatment efficacy, decreasing radiation-induced side effects and overcoming...

La recherche concernant l’utilisation de nanoparticules dans le domaine médical a connu un essor considérable ces vingt dernières années, notamment dans le cadre du traitement du cancer. En particulier, l’effet radiosensibilisant des nanoparticules métalliques a été beaucoup étudié en radiothérapie, dans une perspective de réduction des effets seco...

In the context of cancer treatment, gold nanoparticles (AuNPs) are considered as very promising radiosensitizers. Here, well-defined polymer-grafted AuNPs were synthesized and studied under gamma irradiation to better understand the involved radiosensitizing mechanisms. First, various water-soluble and well-defined thiol-functionalized homopolymers...

Porous materials, when adequately tailored, offer the possibility to entrap various biomolecules without altering their conformation or function. The sol-gel process, ideally versatile to prepare such biohybrid materials, has been applied to the encapsulation of all kinds of biological species, from proteins to whole cells, usually in order to deve...