Marina Soković

Marina Soković
Institute for Biological resaerch · departemnt of Plant Physiology

PhD

About

509
Publications
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14,705
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Publications

Publications (509)
Article
Ganoderma genus comprises one of the most commonly studied species worldwide, Ganoderma lucidum. However, other Ganoderma species have been also reported as important sources of bioactive compounds. Polysaccharides are important contributors to the medicinal properties reported for Ganoderma species, as demonstrated by the numerous publications, in...
Article
Agrocybe aegerita (Brig.) Sing is a basidiomycete, white rot fungus. Antioxidant, antimicrobial activity and antiqourum effect on Pseudomonas aeruginosa of A. aegerita methanolic extract was investigated. The extract showed very good antimicrobial activity against all the tested microorganisms in a dose dependent manner. Effects of the Sub-MIC, MIC...
Article
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Laetiporus sulphureus is an edible wood-rooting basidiomycete. The nutritional and medicinal properties of this mushroom have long been known by traditional practitioners. The aim of this study was to determine the proximate composition, total phenol antioxidant capacity and antimicrobial activities of different extracts of L. sulphureus. Different...
Article
Chestnut trees are one of the most important crops in the north-eastern part of Portugal, representing millions of euros of yearly income. There are many ancestral claims of the health benefits of the consumption of chestnut flowers in infusions that remain unproven. In this manuscript, the antitumor and antimicrobial potential of chestnut flowers...
Research Proposal
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Dear Colleagues, Nowadays, we are witnessing the global emergence of antibiotic resistance, which is urging the need for discoveries of novel antibiotics. Furthermore, during recent decades, we have gained an insight into one of the most important microbial abilities that enhance its resistance: the ability to establish biofilms. The current panel...
Article
Pineapple is a tropical fruit consumed fresh or processed into various food products. However, the peel and crown of this fruit are not industrially exploited, thus generating tons of by-products that represent an economic and environmental concern. In order to promote the upcycling of these by-products, this work aimed to characterize the phenolic...
Article
This study aimed to characterize mixtures of goat milk proteins and Agaricus blazei Murrill (ABM) extracts (aqueous, AE and polysaccharides, PE). The mixtures showed stable particles with ζ-potential more negative than -41.1 mV. The addition of AMB extracts to goat milk did not result in a significant particle size change, whereas their addition to...
Article
Medicinal and aromatic plants (MAP) have been described as a source of phenolic compounds with potential as antioxidant, antiproliferative and antimicrobial agents. MAP from the Lamiaceae family (Origanum vulgare L., Thymus vulgaris L., Ocimum basilicum L., Salvia officinalis L., Melissa officinalis L., and Matricaria chamomilla L.) were selected t...
Poster
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Since ancient times plants have been used in natural therapies as a remedy against diseases. However, the use of medicinal plants is growing because they have many compounds of great interest with antioxidant, anti-inflammatory, and antimicrobial properties [1]. In particular, Chamaemelum nobile (L) All. belonging to the Asteraceae family is known...
Poster
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The continuous increased resistance of pathogenic microorganisms to antibiotics is a serious public health problem worldwide. In the last decades, numerous studies have been focused on exploring and developing effective natural additives with antimicrobial potential based on natural matrices such as plants and new strategies to prevent this multi-r...
Preprint
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This study aimed at investigating biological activity and chemical composition of Satureja kitaibelii Wierzb. ex Heuff. LC-PDA/MS analyses for the aqueous (A1-ste, leaves and flowers, A2-leves and flowers) and ethyl-acetate (E1-stem, leaves and flowers, E2-leaves and flowers) extracts obrtained by ultrasound-assisted extraction allowed the identifi...
Article
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In the present study, the chemical profile and bioactive properties of the roots of turnip-rooted parsley (Petroselinum crispum spp. tuberosum) germplasm were evaluated. For this purpose, plants from seventeen parsley cultivars were grown in 6 L pots, and the obtained roots were analyzed in terms of nutritional value, chemical composition (tocopher...
Article
The genus Scorzonera is one of the most important genera in the Asteraceae family, and members of the genus have great potential in traditional medicine systems. In this article we aimed to determine skin protective and antimicrobial effects of different extracts from the roots and aerial parts of three Scorzonera species (S. hieraciifolia, S. hisp...
Article
Piliostigma thonningii (Fabaceae) is a versatile medicinal plant used as a traditional remedy, especially in African countries. In the present study, ethyl acetate, methanolic and water extracts of different parts of (fruits, leaves, stem barks) P. thonningii were evaluated for their bioactive contents, enzyme inhibitory, antioxidant and antimicrob...
Article
Emerging antimicrobial resistance and side effects associated with antibiotics overuse are driving the need for the novel antimicrobial therapeutics with the natural compounds considered as an appealing alternative. Rosmarinic acid is abundantly present in medicinal plants. This study aimed to elucidate its possible role as an inhibitor of plankton...
Article
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Lentinus crinitus basidiocarps are an alternative to antimicrobials, but the stipe (24% basidiocarp) is discarded even with potential antimicrobial activity. This study evaluated the antimicrobial activity of L. crinitus basidiocarp pileus and stipe extracts against foodborne pathogens and food spoilage microorganisms. Basidiocarps of L. crinitus w...
Article
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The members of Cystus genus are perenial shrubs with a well-established use in traditional medicine. Among these, C. creticus is the most popular, herbal preparations obtained from its aerial parts being recognized as antimicrobial, antitumor and anti-inflammatory agents. The present study aimed to evaluate phytochemical profile and bioactive poten...
Article
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The control of fungal pathogens is increasingly difficult due to the limited number of effective drugs available for antifungal therapy. In addition, both humans and fungi are eukaryotic organisms; antifungal drugs may have significant toxicity due to the inhibition of related human targets. Furthermore, another problem is increased incidents of fu...
Article
Cistus creticus subsp. creticus is a shrubby Mediterranean plant used since ancient times in folk medicine for the treatment of different diseases. C. creticus extracts and resin contain different types of secondary metabolites, such as terpenoids (predominantly labdane type diterpenoids), and phenylpropanoids. Growth conditions seem to influence t...
Article
Herein we report the design and synthesis of thiazolo[4,5‐b]pyridin‐5‐ones and evaluation of their antimicrobial activity. The design was based on a molecular hybridization approach. Evaluation of their antibacterial activity revealed that these compounds generally showed moderate antibacterial activity. The best activity was achieved for compound...
Article
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Herein we report the evaluation of the antimicrobial activity of some previously synthesized 3-(3,4-dihydroxyphenyl)glyceric acid in benzylated and in free 3,4 hydroxy groups in catechol moiety along with some caffeic and 3-(3,4-dihydroxyphenyl)glyceric acid amides using the microdilution method. The evaluation revealed that compounds showed in gen...
Article
Full-text available
Pygidial gland secretions are used as repellent defensive allomones in ground beetles. We provide the first precise data on the chemical composition and antimicrobial potency of the secretion of the blue ground beetle, as well as on the morphology of its pygidial glands. The latter structures were not previously studied chemoecologically and morpho...
Article
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The cosmetic industry is constantly searching for bioactive ingredients, namely, those obtained from natural sources with environmentally friendly connotations and less toxic effects. A previous study of our research group optimized the extraction of phenolic compounds from Juglans regia by heat-assisted extraction. Due to its richness in different...
Article
Full-text available
Wine lees, a sub-exploited byproduct of vinification, is considered a rich source of bioactive compounds, such as (poly)phenols, anthocyanins and tannins. Thus, the effective and rapid recovery of these biomolecules and the assessment of the bioactive properties of wine lees extracts is of utmost importance. Towards this direction, microwave-assist...
Article
Full-text available
The rising incidence of antibiotic resistant microorganisms urges novel antimicrobials development with polyphenols as appealing potential therapeutics. We aimed to reveal the most promising polyphenols among hesperetin, hesperidin, naringenin, naringin, taxifolin, rutin, isoquercitrin, morin, chlorogenic acid, ferulic acid, p-coumaric acid, and ga...
Article
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Herein, we report computational and experimental evaluations of the antimicrobial activity of twenty one 2,3-diaryl-thiazolidin-4-ones. All synthesized compounds exhibited an antibacterial activity against six Gram-positive and Gram-negative bacteria to different extents. Thus, the MIC was in the range of 0.008–0.24 mg/mL, while the MBC was 0.0016–...
Article
Cardoon seeds collected in Greece at four different maturity stages (samples S1 to S4) were analysed in terms of chemical composition and in vitro bioactivities. The content of phenolic compounds (six compounds in total) increased with increasing maturity, and 3,5-O-dicaffeyolquinic (14.8–33.8 mg/g extract) acid was the compound detected in higher...
Article
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Natural extracts have been used in several traditional medicine applications and culinary purposes. Their biological properties (antioxidant and antimicrobial) are due to the presence of several active aromatic compounds. Herein, different natural extracts were evaluated, namely structural and thermal characterization and biological activity, in it...
Article
Despite the significant advances in drug development we are witnessing the inability of health systems to combat both neurodegenerative diseases and cancers, especially glioblastoma. Hence, natural products are comprehensively studied in order to provide novel therapeutic options. This study aimed to explore anti-neurodegenerative and anti-glioblas...
Article
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Background: Infectious diseases represent a significant global strain on public health security and impact on socio-economic stability all over the world. The increasing resistance to the current antimicrobial treatment has resulted in the crucial need for the discovery and development of novel entities for the infectious treatment with different...
Article
Cytinus hypocistis (L.) L. is a comestible holoparasite with great potential for cosmeceutical application. Although its high tannin content has been associated with its bioactive and inhibitory enzyme properties, this is the first report establishing a relationship between parasite and host (Halimium lasianthum (Lam.) Greuter) phenolic profile and...
Article
Dehydration of the edible seaweed Chondrus crispus was performed by freeze-drying, conventional oven-drying and emerging microwave hydrodiffusion and gravity (MHG). In this work, the drying kinetics and modelling, estimating specific energy consumption and environmental impact of distinct processes were tested. Color and microstructural features of...
Article
Abies cephalonica Loudon consists one of the three fir species occurring in Greece. The aim of this study was to evaluate the chemical composition of the essential oil (EO) from needles of A. cephalonica from Mt. Aenos (Kefalonia Island, Greece) and to investigate its antimicrobial activity. The EO was obtained by hydrodistillation and 68 constitue...
Article
Edible mushrooms have been appreciated globally for their organoleptic, nutritional and chemical properties. In the present study, fruiting body of Calocybe gambosa , wild growing in Serbia, has been chemically characterized (content of macronutrients, soluble sugars, tocopherols, fatty and organic acids) and its bioactive (antimicrobial and antiox...
Article
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Telekia speciosa (Schreb.) Baumg., Asteraceae, is widespread in Eastern and Central Europe and the Balkan Peninsula. Previous phytochemical investigations have revealed T. speciosa as a rich source of sesquiterpene lactone-isoalantolactone, especially in its underground parts. The aim of the present study was to analyze the essential oils from aeri...
Article
Full-text available
The objective of this study was to test four-dimensional LC-ESIMSMS chromatography in analysis of complex mixture such as ethanol extracts of different propolis samples. In total more than 1200 picks were identified and only for 185 literature conformation was found. The given data represent the result of tentative identification, and summarized re...
Article
Bioactive compounds extracted from plants such as antimicrobials have attracted the attention of consumers and the food industry. This study aimed to determine the antimicrobial activity and chemical composition of Annona muricata leaf oleoresin obtained by supercritical CO2 extraction. The oleoresin was obtained by supercritical CO2 extraction and...
Article
This study aimed to determine a complete chemical composition of eight different varieties of whole hemp seeds and eight samples of commercial dehulled hemp seeds. We also evaluated the phenolic profiles and antioxidant, cytotoxic, and antimicrobial properties of hydromethanolic seed extracts. Whole hemp seeds contain much more fibre than dehulled...
Article
Full-text available
Hydroethanolic extracts of cardoon petioles collected at sixteen growth stages (P1-P16) were characterized in terms of their phenolic composition and bioactive potential (antioxidant, cy-totoxic, anti-inflammatory, and antimicrobial activities). Fifteen phenolic compounds were tentatively identified (i.e., ten phenolic acids and five flavonoid glyc...
Conference Paper
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Citation: Añibarro-Ortega, M.; Pinela, J.; Petrović, J.; Prieto, M.A.; Soković, M.; Ferreira, I.C.F.R.; Simal-Gandara, J.; Barros, L. Nutritional Composition and Biological Activity of Goldenberry (Physalis peruviana L.): An Emerging Fruit Crop in Portugal. Biol. Life Sci. Forum 2021, 6, 3. https://doi. Abstract: European consumers have a growing i...
Article
Full-text available
This manuscript deals with the synthesis and computational and experimental evaluation of the antimicrobial activity of twenty-nine 4-(indol-3-yl)thiazole-2-amines and 4-ιndol-3-yl)thiazole acylamines. An evaluation of antibacterial activity against Gram (+) and Gram (−) bacteria revealed that the MIC of indole derivatives is in the range of 0.06–1...
Article
The following study was designed to explore antimicrobial properties of the by-product obtained in a hydro-distillation process of essential oil from Nepeta nuda L. Based on the obtained decoction of N. nuda and apple juice, we strived to develop a novel drink that would have antimicrobial self-preserving properties. By using 96-well plate microdil...
Article
In this paper, the methanol and water extracts of Phyllanthus reticulatus Poir. leaves and stem bark parts were considered as source of bioactive constituents; thus, chemical analysis and bioactivity assays...
Article
Full-text available
The impact of two extraction solvents on the phenolic composition, antioxidant, and enzymes inhibitory and antimicrobial activities of two parts (leaves and stem bark) of P. kotschyi was studied. Two different LC-DAD-MSn approaches were used to identify and quantify the bioactive compounds in the different extracts. A total of thirty-two compounds...
Article
Full-text available
The berries of Rubus discolor are considered a rich source of phytochemicals which could play an important role in the prevention of prevalent contemporary chronic diseases. Thus, the goal of the presented study was to determine the profile of phenolic acids and anthocyanins of aqueous and ethanol extracts of R. discolor fruit, and their free radic...
Article
Full-text available
Aloesin is an aromatic chromone with increasing applications in the cosmetic and health food industries. To optimize its extraction from the Aloe vera leaf rind, the independent variables time (10–210 min), temperature (25–95 °C) and organic solvent composition (0–100%, w/w) were combined in a central composite design coupled with response surface...
Article
Full-text available
Chicory (Cichorium intybus L.) is an important industrial crop cultivated mainly to extract the dietary fiber inulin. However, chicory also contains bioactive compounds such as sesquiterpene lactones and certain polyphenols, which are currently discarded as waste. Plants are an important source of active pharmaceutical ingredients, including novel...
Article
Full-text available
Consumers have given preferences to food products that, in addition to the nutritional properties, also present bioactive characteristics with beneficial health effects. The use of Nonconventional Food Plants (NCFP) has been an asset for the food industry, not only due to its abundance but, also, because it does not compete with other vegetable mat...
Article
Full-text available
Flowers of the genus Impatiens are classified as edible; however, their inclusion in the human diet is not yet a common practice. Its attractive colours have stirred great interest by the food industry. In this sense, rose (BP) and orange (BO) I. balsamina flowers were nutritionally studied, followed by an in-depth chemical study profile. The non-a...
Presentation
Full-text available
The family Asteraceae constitutes a plant family that contains a wide range of medicinal plants, especially in Galicia (NW Spain), where some species have been used in traditional medicine. In this work, five Asteraceae species were selected to develop their phenolic profiling and determine their associated bioactivities, namely Achillea millefoliu...
Article
Moringa oleifera Lam. is a nutraceutical edible plant used to fight malnutrition in developing countries. This investigation describes the nutritional, chemical and bioactive assets of wild and commercially acquired M. oleifera leaves from Guinea-Bissau. Both samples presented significant differences in the contents of almost all the analysed param...
Article
Full-text available
Artemisia absinthium L. (Asteraceae) is traditionally used for gastrointestinal ailments and disorders linked to numerous risk factors including microbial infections. We aimed to provide contemporary evidence for its ethnopharmacological use and determine its antimicrobial capacity and mode of action, cytotoxicity, and phenolic constituents. Ethnop...
Article
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Herein we report the synthesis of some new 1H-1,2,4-triazole functionalized chromenols (3a–3n) via tandem reactions of 1-(alkyl/aryl)-2-(1H-1,2,4-triazole-1-yl) with salicylic aldehydes and the evaluation of their antifungal activity. In silico prediction of biological activity spectra with computer program PASS indicate that the compounds have a h...
Article
Full-text available
The nutritional quality of kiwifruit has been highlighted by several studies, while its peel is typically discarded as a by-product with no commercial value. This study was carried out to optimize the ultrasound-assisted extraction (UAE) of phenolic compounds from kiwi peel. Three independent variables (time (t), ultrasonic power (P) and ethanol co...
Conference Paper
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The present study focused on the biological analysis of five plants: Achillea millefolium, Arnica montana, Calendula officinalis, Chamaemelum nobile and Taraxacum officinale. The results indicated that A. montana extracts showed the highest content of phenolic compounds. Regarding the biological properties, A. millefolium had outstanding antioxidan...
Poster
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Plants have been widely employed in traditional medicine, known as medicinal plants, and, currently, they play an important role in the design of modern drugs and healthy foods. Numerous studies have reported that the health-enhancing properties of medicinal plants (e.g., antioxidant, antimicrobial, antitumor, etc.) are a consequence of the biosynt...
Article
Full-text available
Background: Infectious diseases still affect large populations causing significant morbidity and mortality. Bacterial and fungal infections for centuries were the main factors of death and disability of millions of humans. Despite the progress in the control of infectious diseases, the appearance of resistance of microbes to existing drugs creates...
Article
Full-text available
The goal of this research is to investigate the antimicrobial activity of nineteen previously synthesized 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. The compounds were tested against a panel of three Gram-positive and three Gram-negative bacteria, three resistant strains, and six fungi. Minimal inhibitory, bactericidal,...