Marina Mora-Ortiz

Marina Mora-Ortiz
Instituto Maimónides de Investigación Biomédica de Córdoba | IMIBIC · Nutrigenomics and Metabolic Syndrome

PhD, MSc, VMD

About

39
Publications
12,838
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303
Citations
Introduction
II am currently a Marie Curie Fellow in the Group of Nutrigenomics and Metabolic Syndrome at IMIBIC, in association with the University of Cordoba and the Hospital Queen Sofia. My research interests lay on the gut-brain axis and its interactions with mild cognitive impairment. For this purpose, I am combining different approaches which include metagenomics, geriatric assessments, metabolic profiling and bioinformatics.
Additional affiliations
August 2018 - present
King's College London
Position
  • Research Associate
August 2015 - July 2018
University of Reading
Position
  • Research Associate
Education
June 2012 - June 2015
University of Reading
Field of study
  • PhD
September 2010 - July 2011
Universidad de Extremadura
Field of study
  • Food Science
September 2005 - June 2010
Universidad de Extremadura
Field of study
  • Veterinary Medicine

Publications

Publications (39)
Article
Full-text available
Background Sainfoin (Onobrychis viciifolia) is a highly nutritious tannin-containing forage legume. In the diet of ruminants sainfoin can have anti-parasitic effects and reduce methane emissions under in vitro conditions. Many of these benefits have been attributed to condensed tannins or proanthocyanidins in sainfoin. A combination of increased us...
Article
Onobrychis viciifolia (sainfoin) is a forage legume crop with many positive agronomic, environmental, nutritional and nutraceutical attributes. Farmers also benefit from its drought tolerance in areas of low rainfall and light free draining soil, mainly due to its deep taproot. It is resistant to most common pest and diseases and is a valuable reso...
Article
Full-text available
Introduction Death is the permanent cessation of the critical functions of the organism as a whole. However, the shutdown of a complex biological organism does not abruptly terminate at time of death. New high-throughput technologies allow the systematic investigation of the biochemical modulations occurring after death. Recent genomics studies hav...
Article
Full-text available
Introduction: The rapid expansion of Type 2 Diabetes (T2D), that currently affects 90% of people suffering from diabetes, urges us to develop a better understanding of the metabolic processes involved in the disease process in order to develop better therapies. The most commonly used model for T2D research is the db/db (BKS.Cg-Dock7 < m > +/+ Lepr...
Book
Full-text available
Este libro es un manual en español que ayuda al estudiante interesado en aprender bioestadística con R a empezar desde cero con el programa y poder adquirir un nivel básico que le permita desarrollar análisis comunes en el campo.
Poster
Full-text available
The association of Type 2 Diabetes (T2D) with Coronary Heart Disease (CHD) significantly increase mortality and microvascular events in T2DM patients, accounting in total for around 80% of all deaths. This study aimed to identify new biomarkers to assist in therapeutical studies and elucidate pathways of interest in T2DM remission. LC-MS untarget...
Poster
Full-text available
Introducción: La prevalencia de diabetes mellitus tipo 2 (DM2) está aumentando en todo el mundo, siendo esto particularmente importante en pacientes con enfermedad coronaria en los cuales el hecho de ser diabéticos les aumenta su riesgo de recurrencia. Por tanto, la identificación de biomarcadores para la detección precoz del riesgo de desarrollar...
Poster
Full-text available
El síndrome metabólico (MetS) predispone a los pacientes a un mayor riesgo de diabetes tipo 2 y enfermedad cardiovascular. Para prevenirlo se recomiendan dietas ricas en ácidos grasos mono y poli insaturados. A día de hoy hay poca información sobre la modulación metabolómica de MetS en respuesta a diferentes condiciones dietéticas así como durant...
Poster
Full-text available
The association of Type 2 Diabetes (T2D) with Coronary Heart Disease (CHD) significantly increase mortality and macrovascular events in T2DM patients, accounting in total for around 80% of all deaths. The newly diagnosed T2DM patients (n=183) from the CORDIOPREV cohort (n=1,002) were included in this study. LC–TOF/MS, a metabolomics approach, was e...
Article
Tannins are a diverse group of plant phenolic compounds. Condensed tannins (CTs) represent a major subgroup of tannins and were extracted from tilia (Tilia L.) flowers and black locust (Robinia pseudoacacia) leaves. These extracts were examined for their effects on the metabolic profile of chicken caeca. By using in vitro, a nuclear magnetic resona...
Article
Full-text available
Milk products are an important component of human diets, with beneficial effects for human health, but also one of the major sources of nutritionally undesirable saturated fatty acids (SFA). Recent discoveries showing the importance of the rumen microbiome on dairy cattle health, metabolism and performance highlight that milk composition, and poten...
Article
Full-text available
Applications of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy in the discipline of metabolomics have gained increasing interest in the area of foodomics due to their ability to characterise the metabolome of complex matrices. In this review, we report recent studies that have applied NMR and MS-based metabolomics for impr...
Article
Full-text available
Background: The colon is populated by approximately 10 ¹² microorganisms, but the relationships between this microbiome and the host health status are still not completely understood. Here, our objective is to present the cohort characteristics of ExHiBITT – Exploring Host microBIome inTeractions in Twins – including i) biomedical phenotypes, ii) e...
Article
Full-text available
Although sex disparity in immunological function and susceptibility to various inflammatory and infectious disease is recognized in adults, far less is known about the situation in young infants during immune development. We have used an outbred piglet model to explore potential early sex disparity underlying both mucosal immune development and sys...
Preprint
Full-text available
There is growing evidence indicating that gut microbiota contributes to the development of metabolic syndrome and Type 2 Diabetes (T2D). The most widely-used model for T2D research is the leptin deficient db/db mouse model. Yet, a characterisation of the gut microbial composition in this model in relationship with the metabolism is lacking. The obj...
Preprint
The colon is populated by approximately 10 ¹² microorganisms, but the relationships between this microbiome and the host health status are still not completely understood. Participants from the TwinsUK cohort were recruited to study the interactions between the microbiome and host adaptive immunity. In total, 205 monozygotic twins were recruited fr...
Poster
Full-text available
Abstract: Despite major advances in gut microbiota research, changes in microbiota between different locations in the gut are not completely clear; consequently, ideal sampling location is still under debate. Here, we compare microbial differences between sampling sites in the colon and how it correlates with the host metabolism. To study these i...
Poster
Full-text available
The colon is populated by approximately 1012 microorganisms, but the relationships between this microbiome and the host are still not completely understood. The aim of this project is to recruit a twin cohort to study interactions between colon microbiota and host genomics. Here, our objective is to introduce this new cohort called ExHiBITT – Explo...
Presentation
Full-text available
Abstract: The colon is populated by approximately 1012 microorganisms, but the relationships between this microbiome and the host are still not completely understood. The aim of this project is to recruit a twin cohort to study interactions between colon microbiota and host genomics. Here, our objective is to introduce this new cohort called ExHiBI...
Article
Full-text available
Applications of mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy in the discipline of metabolomics have gained increasing interest in the area of foodomics due to their ability to characterise the metabolome of complex matrices. In this review, we report recent studies that have applied NMR and MS-based metabolomics for impr...
Article
Full-text available
Condensed tannins (CTs) account for up to 20% of the dry matter in forage legumes used as ruminant feeds. Beneficial animal responses to CTs have included improved growth, milk and wool production, fertility, and reduced methane emissions and ammonia volatilization from dung or urine. Most important is the ability of such forages to combat the effe...
Article
Choline is a crucial methyl donor necessary for epigenetic regulation. In this issue of Cell Host & Microbe, Romano et al. (2017)) demonstrate that choline-utilizing gut bacteria compete with their host for this essential resource, calling for a systematic consideration of gut microbial composition for personalized diet recommendations.
Article
Full-text available
Background Sainfoin is a perennial forage legume with beneficial properties for animal husbandry due to the presence of secondary metabolites. However, worldwide cultivation of sainfoin is marginal due to the lack of varieties with good agronomic performance, adapted to a broad range of environmental conditions. Little is known about the genetics o...
Poster
Full-text available
Type 2 Diabetes (T2D) is a epidemic of devastating proportions. This research identified metabolic changes in liver fingerprint from healthy and diabetic individuals.
Research
Marina Mora‐Ortiz, NIAB Onobrychis viciifolia is an emerging leguminous forage crop, traditionally grown in grassland across Eurasia and North America, where it is used primarily for livestock feed. There has been a decline in the area of O. viciifolia and other temperate legumes across Europe since 1950, especially in the 1970s during the Green Re...
Book
Full-text available
Sainfoin, surprising science behind a forgotten forage can also be found athttps://www.cotswoldseeds.com/files/cotswoldseeds/Sainfoin_Growers_Guide_website.pdf.
Thesis
Onobrychis viciifolia, commonly known as sainfoin, is a tanniniferous forage crop, traditionally grown as a long term perennial ley across Eurasia and North America, where it is used primarily for livestock feed. Over the last decade, there has been some resurgence in interest in cultivation of sainfoin due to its beneficial nutraceutical and envir...
Article
Full-text available
Tannin-containing legumes have attracted much interest due to their animal health and nutritional benefits. Although several tannins are anti-nutritional, a few can generate valuable benefits for controlling parasitic nematodes that are resistant to anthelmintic drugs, for improving protein utilization by ruminants and fatty acid profiles in meat a...
Conference Paper
Full-text available
Onobrychis viciifolia is a tanniferous leguminous forage crop with several desirable qualities in the context of sustainable farming. Unfortunately its rather poor competitive ability against weeds and often low yields during the establishment year, especially in cool wet conditions, can deter growers from choosing this forage crop. In this study a...
Poster
Full-text available
Weed control in sainfoin; pre-emergence and post-emergence treatments for the development of new strategies for the establishment of Onobrychis viciifolia Introduction • Onobrychis viciifolia, also known as sainfoin, is a re-emerging tanniferous leguminous forage crop, traditionally grown as a long term perennial ley across Europe, Asia and North...
Poster
Full-text available
Onobrychis viciifolia (sainfoin) is an emerging tanniniferous leguminous forage crop, traditionally grown as a long term perennial ley across Eurasia and North America, where it is used primarily for livestock feed [1]. Sainfoin has beneficial biopharmaceutical, nutritional and environmental attributes, mainly attributed to the presence of condense...
Poster
Full-text available
Onobrychis viciifolia is an emerging leguminous forage crop, traditionally grown across Eurasia and North America, where it is used primarily for livestock feed [1]. O. viciifolia could re-emerge as an important forage legume due to multiple beneficial properties, however, the knowledge surrounding this species is under developed. We have embarked...
Conference Paper
Full-text available
Marina Mora‐Ortiz, NIAB Onobrychis viciifolia is an emerging leguminous forage crop, traditionally grown in grassland across Eurasia and North America, where it is used primarily for livestock feed. There has been a decline in the area of O. viciifolia and other temperate legumes across Europe since 1950, especially in the 1970s during the Green Re...

Questions

Question (1)
Question
I am interested in extracting RNA for sequencing. The samples are from human tissues and are degraded. Is it any kit/protocol especially recommended for these type of samples? Thank you very much!

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Projects

Projects (4)
Project
What is IMIBIC-P2Med? IMIBIC Fellowship Programme for Personalised and Precision Medicine is a new Marie Skłodowska-Curie COFUND Programme (H2020 Grant Agreement No. 847468) at the Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain. The Fellows will develop projects within the Institute’s 5 scientific programmes: I Active aging and Frailty II Nutrition and endocrine and metabolic diseases III Infectious and immunological diseases and organ transplantation IV Cancer (Oncology and Oncohematology) V Chronic and Inflammatory Diseases A step ahead in Personalised and Precision Medicine Biomedical research is a truly multidisciplinary field. Advances in all areas of science and technology are allowing new developments in biomedicine that are having an impact in health research and ultimately in health care, with improved patient outcomes and benefiting society as a whole. The latest developments in biomedical research have shown a shift toward a patient-centred medicine that allows for more tailored or personalised interventions. While this approach allows for more innovative solutions in diagnostics and medical treatments, it also requires a different set of skills for biomedical researchers. In this context, IMIBIC-P2Med will contribute to bridging the gap between the medical, biological and computational worlds, by facilitating the access for clinical researchers as well as welcoming bioinformaticians and basic researchers to carry out research projects in close collaboration within clinical research groups. The IMIBIC Fellowship Programme for Personalised and Precision Medicine offers trans-national mobility for experienced researchers and relevant, top-notch training that improves their career prospects. The selected fellows will perform forward-looking research in a field which is set to become the standard of medical practice, situating them in an advantaged position to continue their research careers. Funding The IMIBIC Fellowship Programme for Personalised and Precision Medicine has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 847468. It is jointly funded by the University of Cordoba, the Regional Government of Andalusia (Junta de Andalucía) and the Fundación para la Investigación Biomédica de Córdoba (FIBICO). What is COFUND? MSCA-COFUND programmes are European Commission initiatives that offer additional funding for new or existing regional, national and international programmes to provide an international and intersectoral dimension to research training and career development. Within this programme, doctoral programmes, as well as fellowship programmes for experienced researchers, can be supported.
Project
ExHiBITT – Exploring Host microBIome inTeraction in Twins- is a new project from TwinsUK which will enable scientist access to a large number of OMICS’ (microbiome, metabolome, genome, transcriptome and inmune system in multiple tissues) data related to the colon.
Archived project
The main goal of this study is to characterise the mechanisms underlying the role of the microbial component that contributes towards the development of Type 2 Diabetes (T2D). We aim to study the impact of the gut microbiota in some metabolic disorders associated with T2D by influencing key energy metabolic pathways in the host. We will also look at the impact of bacterias from the environment in the development of T2D.