Marina Cocchi

Marina Cocchi
Università degli Studi di Modena e Reggio Emilia | UNIMO · Department of Chemical and Geological Sciences

PhD

About

154
Publications
13,217
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3,663
Citations
Citations since 2017
30 Research Items
1452 Citations
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250

Publications

Publications (154)
Preprint
Full-text available
Alternating least squares, within the multivariate curve resolution framework has seen a lot of practical applications and shows its distinction with its relatively simple and flexible implementation. However, the limitations of least squares should be considered carefully when deviating from the standard assumed data structure. Within this work we...
Article
The scientific interest in Cannabis sativa L. analysis has been rapidly increasing in recent years, especially for what concerns cannabinoids, plant secondary metabolites which are well known for having many biological properties. High-performance liquid chromatography (HPLC) is frequently used for both the qualitative and quantitative analysis of...
Article
A new self‐consistent empirical potential model based on the BMP potential [Bertani et al., Phys. Rev. Mat. 5 (2021) 045602] has been developed for the simulation of multicomponent borate and borosilicate glasses. We exploited the Bayesian optimization approach to create a set of parameters for the B–O interaction, which depends on the glass compos...
Article
Owing to their antimicrobial and insecticide properties, the use of natural compounds like essential oils and their active components has proven to be an effective alternative to synthetic chemicals in different fields ranging from drug delivery to agriculture and from nutrition to food preservation. Their limited application due to the high volati...
Article
Full-text available
The aim of this work is to assess the potentialities of the synergistic combination of an ultra-fast chromatography-based electronic nose as a fingerprinting technique and multivariate data analysis in the context of food quality control and to investigate the influence of some factors, i.e., basil variety, cut, and year of crop, in the final aroma...
Article
Full-text available
Petrochemical companies aim at assessing final product quality in real time, in order to rapidly deal with possible plant faults and to reduce chemical wastes and staff effort resulting from the many laboratory analyses performed every day. In order to answer these needs, the main purpose of the current work is to explore the feasibility of multibl...
Article
Full-text available
A new ceramic carbon polyaniline electrode material, namely Sonogel-Carbon-polyaniline (SNG-C-PANI), was synthesized using high-power ultrasound. The synthesis conditions were optimized by means of a full factorial design. The electroactivity of polyaniline, previously characterized by means of Raman spectroscopy, is retained into the sonogel matri...
Article
The emergence of new spectral imaging applications in many science fields and in industry has not come to be a surprise, considering the immense potential this technique has to map spectral information. In the case of near-infrared spectral imaging, a rapid evolution of the technology has made it more and more appealing in non-destructive analysis...
Article
Full-text available
Process analytical technology and multivariate process monitoring are nowadays the most effective approaches to achieve real-time quality monitoring/control in production. However, their use is not yet a common practice, and industries benefit much less than they could from the outcome of the hundreds of sensors that constantly monitor production i...
Article
Full-text available
Basil is a plant known worldwide for its culinary and health attributes. It counts more than a hundred and fifty species and many more chemo-types due to its easy cross-breeds. Each species and each chemo-type have a typical aroma pattern and selecting the proper one is crucial for the food industry. Twelve basil varieties have been studied over th...
Article
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In humans, injuries and diseases can result in irreversible tissue or organ loss. This well-known fact has prompted several basic studies on organisms capable of adult regeneration, such as amphibians, bony fish, and invertebrates. These studies have provided important biological information and helped to develop regenerative medicine therapies, bu...
Article
Full-text available
The consumers' interest towards beer consumption has been on the rise during the past decade: new approaches and ingredients get tested, expanding the traditional recipe for brewing beer. As a consequence, the field of "beeromics" has also been constantly growing, as well as the demand for quick and exhaustive analytical methods. In this study, we...
Article
Full-text available
The metal content in some samples of horse chestnut seeds (Aesculus hippocastanum) was monitored over time (years 2016–2019) considering the two most common and representative Mediterranean varieties: the pure species (AHP, which gives white flowers) and a hybrid one (AHH, which gives pink flowers). The selected elemental composition of the samples...
Article
Full-text available
Understanding mechanisms of materials deterioration during service life is fundamental for their confident use in the building sector. This work presents analysis of time series of data related to wood weathering acquired at three scales (molecular, microscopic, macroscopic) with different sensors. By using several complementary techniques, the mat...
Article
Full-text available
Raman spectroscopy, and handheld spectrometers in particular, are gaining increasing attention in food quality control as a fast, portable, non-destructive technique. Furthermore, this technology also allows for measuring the intact sample through the packaging and, with respect to near infrared spectroscopy, it is not affected by the water content...
Article
We propose a methodological framework to extract spatial features in hyperspectral imaging data and establish a link between these features and the spectral regions, capturing the observed structural patterns. The proposed approach consists of five main steps: (i) two‐dimensional stationary wavelet transform (2D‐SWT) is applied to a hyperspectral d...
Chapter
In this Chapter, the state-of-the-art approaches for the classification of multi-way data is presented and discussed. The theoretical basis and applicative guidelines for multilinear (or multi-way) Partial Least Squares Discriminant Analysis (NPLS-DA) and Multi-way Soft Independent Modeling of Class Analogy (NSIMCA) are detailed. Furthermore, two-d...
Article
Magnetic resonance imaging (MRI) is the current gold standard for the diagnosis of brain tumors. However, despite the development of MRI techniques, the differential diagnosis of central nervous system (CNS) primary pathologies, such as lymphoma and glioblastoma or tumor‐like brain lesions and glioma, is often challenging. MRI can be supported by i...
Article
Spainisoneofthemajorproducersofhigh-qualitywinevinegarshavingthreeprotecteddesignationsoforigin (a.k.a. PDOs): “Vinagre de Jerez”, “Vinagre de Condado de Huelva” and “Vinagre de Montilla-Moriles”. Their highpricesduetotheirhighqualityandtheirhighproductioncostsexplaintheneedfordevelopinganadequate qualitycontroltechniqueandtheinterestinextensivecha...
Article
Multivariate exploratory data analysis allows revealing patterns and extracting information from complex multivariate data sets. However, highly complex data may not show evident groupings or trends in the principal component space, e.g. because the variation of the variables are not grouped but rather continuous. In these cases, classical explorat...
Chapter
With the growing availability of high throughput methodologies for food characterization and analysis, more and more data are being collected on food products that can be used for the authentication of their quality. In this context, the availability of different multi-block strategies, each with its own peculiarities and providing specific details...
Article
This study summarizes the results obtained from a systematic and long-term project aimed at the development of tools to assess the provenance of food in the oenological sector. In particular, ⁸⁷Sr/⁸⁶Sr isotope ratios were measured on statistically representative set of soils, vine branches and wines sampled in the production district of Modena, wor...
Chapter
Classification methods, i.e., the chemometric strategies for predicting a qualitative response, find many applications in the omic sciences, where often data are collected in order to categorize individuals (e.g. according to whether they were treated or administered a placebo or, for instance, depending on if they were healthy or ill). After a bri...
Article
The use of 2D discrete wavelet transform in the feature enhancement phase of multivariate image analysis is discussed and implemented in a comparative way with respect to previous publications. In the proposed approach, all the resulting subimages obtained by discrete wavelet transform decomposition are unfolded pixel‐wise and midlevel data fused t...
Chapter
The concern of society about food nowadays extends to the several aspects linked to food consumption encompassing nutritional value, health, safety, and quality, as well as ethics, sustainability, tradition, communication, marketing, and so on. The increased information available to the consumers, the awareness of the impact of diet on healthiness,...
Chapter
The need to consider variability due to raw materials, seasonality, agricultural practices, and food processing, that are aspects which all play a role in authenticity tasks, justifies the need for chemometrics methods. This chapter presents a few basic chemometrics methods, such as exploratory data analysis, multiway data analysis, and data fusion...
Chapter
Full-text available
The direct chemical analysis allows investigating samples without altering them, keeping the sample available for further analysis. For the qualitative investigation, analytical procedures like gas-chromatography, Raman microscopy, and Infra Red spectroscopy are available, however, the univariate approach is not exhaustive in the case of very compl...
Article
The study aimed at investigating the correlations among the physical and bulk properties of carrier based dry powder inhaler formulations and the performance of the powder inhaler device estimated by in-vitro tests for a specific active pharmaceutical ingredient (API), and at obtaining predictive models for the in-vitro performance. Samples from sc...
Chapter
The chapter illustrates the benefits and improvements of the integration of the wavelet transform with multivariate data analysis upon multiresolution analysis. This approach can be used for feature extraction both in signals and in images in a broad sense, focusing on the capability to simultaneously accomplish denoising and feature enhancement/se...
Conference Paper
Full-text available
Dry powder Inhalers (DPI) are pharmaceutical drug products for respiratory diseases treatment. In such drug products, a micronized Active Pharmaceutical Ingredient (API) is mixed with other excipients able to improve the API delivery during patient inhalation. Micronization affects API particle size, and it is a critical step during development of...
Article
When trying to analyze spatial relationships in image analysis, wavelets appear as one of the state-of-the-art tools. However, image analysis is a problem-dependent issue, and different applications might require different wavelets in order to gather the main sources of variation in the acquired images with respect to the specific task to be perfor...
Article
Geographical origin and authenticity of food are topics of interest for both consumers and producers. Among the different indicators used for traceability studies, (87)Sr/(86)Sr isotopic ratio has provided excellent results. In this study, two analytical approaches for wine sample pre-treatment, microwave and low temperature mineralisation, were in...
Article
Nowadays the necessity to reveal the hidden information from complex data sets is increasing due to the development of high-throughput instrumentation. The possibility to jointly analyze data sets arising from different sources (e.g. different analytical determinations/platforms) allows capturing the latent information that would not be extracted b...
Chapter
Food chain traceability, identification of adulteration and the control of labelling compliance are areas that require evaluation of foodstuff in its entirety. More and more researchers are investigating the possibility of using multidimensional or hyphenated techniques for fingerprinting of food products. However, these techniques produce data str...
Article
In the last decades, mankind has become totally aware about the importance of food quality: nowadays authentication and traceability are words of general use.Food authentication verifies how much a food is in accordance with its label description and law and it could be considered a further guarantee for the quality and safety of a foodstuff.The tr...
Article
In the food research and production field, system complexity is increasing and several new challenges are emerging every day. This implies an urgent necessity to extract information and obtain models capable of inferring the underlying relationships that link all the variability sources which characterize food or its production process (e.g. compos...
Article
The main goal of this study was to evaluate (87)Sr/(86)Sr ratio in different matrices, namely soils, branches, and grape juices, of an oenological food chain in order to develop a robust analytical strategy able to link the investigated food to its territory of origin. The (87)Sr/(86)Sr has been used as traceability marker and several aspects, affe...
Article
Multilinear PLS (NPLS) and its discriminant version (NPLS-DA) are very diffuse tools to model multi-way data arrays. Analysis of NPLS weights and NPLS regression coefficients allows data patterns, feature correlation and covariance structure to be depicted. In this study we propose an extension of the Variable Importance in Projection (VIP) paramet...
Conference Paper
Full-text available
The interest of consumers, as well as of producers, toward origin and quality of food has increased over the last years. As regards the oenological field, the quality of wine is in many cases related to the concept of terroir (history, geographical origin, typical raw materials and methods, ecc.). In this context, the assessment of the link between...
Article
In the baking industry, a difficult task is to keep the quality perceived by the consumer as constant as possible, given the inner variability of flour, e.g. due to different wheat mixtures, harvesting time, etc. Here, we evaluated the influence of flour batches properties on bread quality, considering an industrial bread making process. In particu...
Article
The present research is part of a project dealing with the development of analytical methodologies mainly based on primary indicators, such as isotopic ratios of stable and radiogenic elements, for the authenticity and geographical traceability of oenological food, typical of the Modena district. In particular, considering the objective of establis...
Article
A hierarchical data fusion approach has been developed proposing multivariate curve resolution (MCR) as a variable reduction tool. The case study presented concerns the characterization of soil samples of the Modena District. It was performed in order to understand, at a pilot study stage, the geographical variability of the zone prior to planning...
Article
A mixture design of experiment approach was followed to explore formulation effects on the technological properties of wheat flours optimized for industrial bread-making purposes. Ten different flour mixtures were investigated by means of near infrared spectroscopy (NIRS) to obtain information on flour performance in a critical phase such as dough...
Article
This work proposes a fast and simple method for detection and quantification of phenolic compounds in PDO Lambrusco wines using HPLC-DAD and chemometric techniques. Samples belonging to three different varieties of Lambrusco (Grasparossa, Salamino and Sorbara) were analyzed to provide a methodology appropriate for routine analysis. Given the high c...
Article
Aim of this work is to assess the potentialities of the X-ray powder diffraction technique as fingerprinting technique, i.e. as a preliminary tool to assess soil samples variability, in terms of geochemical features, in the context of food geographical traceability. A correct approach to sampling procedure is always a critical issue in scientific i...
Article
The results obtained by means of Molecular Dynamics simulations and Multiway Explorative Data Analysis on ADAMTS4, ADAMTS5 and MMP13 complexed with Marimastat and two cis-1(S)2(R)-amino-2-indanol ligands suggest that determinant characteristics for ligand binding and selectivity among the three enzymes are to be found in the different protein confo...
Article
The p38 mitogen-activated protein kinase is activated by environmental stress and cytokines and plays a role in transcriptional regulation and inflammatory responses. Factors influencing the activity and selectivity of the p38α mitogen-activated protein kinase inhibitors have been investigated in this paper by inspecting the binding orientation and...
Article
Hierarchical grid transformation is a powerful approach to SDS 2DPAGE maps warping. The hierarchy of the warping transformation is able to model both global and local deformations of the gels and the algorithm can be stopped when a certain degree of accuracy in the image alignment is obtained. The numerical optimization of the position of the nodes...
Article
Potentially bioactive fluorine-containing glasses of formula 46.2SiO(2)·24.3Na(2)O·(26.9-x)CaO·2.6P(2)O(5)·xCaF(2) [x = (0), 5, 10, 15] have been studied: the study was carried out as a function of fluorine percentage, dimensions and time of soaking in SBF. The results are compared to those obtained in the same conditions for Bioglass(®) 45S5. Due...
Chapter
An approach, based on multivariate control chart (MCC) methodology, was proposed by Li Vigni et al., that allows monitoring of flour quality and early identification of flour batches potentially leading to poor performance in production. Using this approach, all rheological properties of incoming flour batches are evaluated multivariately, and thes...
Article
This chapter appraises the seeds of horse chestnuts (. Aesculus hippocastanum [AH]) and their derived products. Escin, the major bioactive principle in AH seeds, has shown satisfactory evidence of clinically significant activity in the treatment of chronic venous insufficiency, hemorrhoids, postoperative edema, and mammary induration. There is some...
Article
The use of a Dynamic Headspace System (DHS) device combined with a Thermal Desorption Unit (TDU) interfaced to a Gas Chromatography/Mass Spectrometry (GC/MS) system is proposed for the determination of furfurals in oenological products. An experimental design protocol has been employed for the optimization of the instrumental settings concerning DH...
Article
Full-text available
In the literature there are only fewpapers concernedwith classification methods for multi-way arrays. Themost common procedure, by far, is to unfold the multi-way data array into an ordinary matrix and then to apply the traditional multivariate tools for classification. As opposed to unfolding the data several possibilities exist for building class...
Article
The aim of this work is to investigate the performance of multivariate classification techniques like partial least squares-discriminant analysis (PLS-DA) and linear discriminant analysis (LDA) when using Zernike moments as global image descriptors, in the classification of sodium dodecyl sulphate (SDS) two-dimensional polyacrylamide gel electropho...
Article
The present investigation focuses on the monitoring of furfurals along the production chain of the aged vinegar Aceto Balsamico Tradizionale di Modena, from the starting raw material to the final product, in order to control the quality and safety of this food. In particular, the aim of the study is to achieve a reduction in the furfurals content a...
Article
The possibility to use NIR scanning microscopy for the detection of bone fragments in feedingstuffs has been evaluated analysing sediments derived from commercial feedingstuffs samples spiked with MBM. The method appeared sensitive enough to reveal the presence of bone fragments for MBM concentration in the feedingstuffs as low as 0.05 wt.%. The id...
Article
Wheat flour plays a pivotal role in determining the overall quality of bread (loaf dimensions, crumb texture and consistency). A precise knowledge of flour chemical and technological properties is of paramount importance for the baking industry, to tune the modifications of the recipe and production parameters. However, it is still common to have t...
Article
Full-text available
The performance of the molecular dynamics (MD) simulations to obtain the structure of silica glasses containing different concentrations of alkali oxides has been tested. An optimal WD simulation procedure (including cooling cycle, MD constants and ensemble used) has been developed by means of experimental design methodologies (DOE), firstly restri...
Article
The Synthetic Quality Index method (Indice Sintetico di Qualità, ISQ) is used in the Italian cereal trade context for the classification of bread wheat in different quality categories, and consists in the assignation by an expert assessor of each wheat sample to the most fitting class, on the basis of parameters reflecting chemical and rheological...
Article
The present study is aimed at evaluating the possibility to predict bread specifications, for an industrial bread-making process, on the basis of the properties of flour employed in production. The flour delivered at the production plant, of which rheological and chemical properties were available, were analysed by means of Near Infrared Spectrosco...
Article
The metabolic profile of human healthy and neoplastic colorectal tissues was obtained using ex vivo High-Resolution Magic Angle Spinning (HR-MAS) NMR spectroscopy. Principal Components Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) were applied to NMR data in order to highlight the biochemical differences between healthy an...
Article
The combination of different point mutations in mitochondrial DNA (mtDNA), which are defined as haplogroups, may cause modification in organelle function and may be involved in several pathologies. We analyzed the distribution of mtDNA polymorphisms in human immunodeficiency virus (HIV)-infected patients with lipodystrophy, a relevant adverse event...
Article
Cooked must is the starting raw material in Aceto Balsamico Tradizionale di Modena (ABTM) production, and the cooking process is a crucial step to ensure quality and safety standards. In particular, the furfural content has to be strictly monitored. In this study, we followed, directly at the production plant, nine cooking processes, differing for...
Article
The potential of near infrared (NIR) spectroscopy to characterise doughs for industrial bread making, directly at the production plant, was investigated. Different stages of dough processing have been monitored at-line, employing a Fourier transform-NIR instrument equipped with an optical fibre. Parallel, factors analysis has been used to study the...
Article
Full-text available
Chemometric methods have been applied to resolve mixture of phenols; phenolic compounds are amongst the most interesting chemical species from an environmental viewpoint. However, the number of papers that apply multivariate calibration methods to resolve electroanalytical signals of mixture of phenols is low.In this paper, we propose a new chemome...
Article
The present research is aimed at monitoring the evolution of the volatile organic compounds of different samples of aceto balsamico tradizionale of modena (ABTM) during ageing. The flavouring compounds, headspace fraction, of the vinegars of four batterie were sampled by solid phase microextraction technique (SPME), and successively analysed by gas...
Article
Full-text available
Investigations have been conducted on some samples of naturally desiccated horse-chestnuts (Aesculus hippocastanum), representative of the two most common mediterranean varieties: the pure species (AHP, giving white flowers), and a hybrid (AHH, giving pink flowers). Different experimental techniques have been used to gain more information on morpho...
Article
Polychromatic flow cytometry (PFC) allows the simultaneous determination of multiple antigens in the same cell, resulting in the generation of a high number of subsets. As a consequence, data analysis is the main difficulty with this technology. Here we show the use of cluster analysis (CA) and principal component analyses (PCA) to simplify multico...
Article
This work can be seen as an attempt to develop an analytical procedure in the context of quality control and authenticity assessment of typical food. To this aim, head-space mass spectrometry (HS-MS) coupled with multivariate data analysis, is proposed as a fast technique for furnishing a clear visualization and a suitable interpretation of the age...
Article
Cooked must is the starting raw material used to produce Aceto Balsamico Tradizionale (ABT). It is obtained from grape musts that are condensed by a gentle simmering in uncovered pans over an open fire. Concentrations of fructose, glucose, furfural and 5-Hydroxymethylfurfural (HMF) during must preparation were evaluated as quality indicator of the...
Article
Full-text available
Aceto Balsamico Tradizionale di Modena is a typical Italian food product of protected denomination of origin, obtained by alcoholic fermentation and acetic bio-oxidation of cooked musts, and it is aged for at least 12 years in series of wooden casks. The product suitable for marketing is qualified by sensory examination on the whole of 13 sensory p...
Article
Aceto Balsamico Tradizionale of Modena (ABTM) is a typical product (PDO denomination) of the province of Modena produced by cooked grape must which undergoes a long ageing period (at least 12 years) in series of wooden casks (batterie). The study of the transformations of this product during ageing is extremely relevant in order to control the auth...
Article
The application of multi-way models in food analysis as in many other research fields is rapidly increasing, above all because it can significantly help to improve visualization and interpretation of complex multivariate data characterized by different sources of variability. Furthermore, in food authentication tasks a fingerprinting strategy is fr...
Article
In the present work, we explored the possibility of using near-infrared spectroscopy in order to quantify the degree of adulteration of durum wheat flour with common bread wheat flour. The multivariate calibration techniques adopted to this aim were PLS and a wavelet-based calibration algorithm, recently developed by some of us, called WILMA. Both...